检索结果-南通市图书馆

Study on the Interaction between CdSe Quantum Dots and Bovine Serum Albumin with Ultraviolet Visible Absorption Spectroscopy

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2006年第7期17卷 961-964页

作者： He you HAN de hong HU Jian Gong LIANG Zong Hai SHENG College of Science MOA Key Laboratory of Food Safety Evaluation Huazhong Agricultural University Wuhan 430070

The interaction of CdSe quantum dots （QDs） with bovine serum albumin （BSA） has been investigated with ultraviolet visible absorption spectroscopy （UVAS）. It was found that the absorption intensity of CdSe QDs significantly decreased after adding BSA solution, showing that CdSe QDs were bonded to BSA. The binding molar ratio was 1：1 and the binding constant was 9.7 × 10^6 L mol^-1.

关键词： CdSe quantum dots bovine serum albumin interaction.

Hydrocarbon gas huff-n-puff optimization of multiple horizontal wells with complex fracture networks in the M unconventional reservoir

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2024年第2期21卷 1018-1031页

作者： Hao-Chuan Zhang Yong Tang you-Wei He Yong Qin Jian-hong Luo Yu Sun Ning Wang de-Qiang Wang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina CNPC Research Institute of Petroleum Exploration&development Beijing100083China Southwest Oil&Gas Field Company PetroChinaChengdu610051SichuanChina State Key Laboratory of Offshore Oil Exploitation CNOOC Research Institute Co.LtdBeijing100027China

The oil production of the multi-fractured horizontal wells(MFHWs) declines quickly in unconventional oil reservoirs due to the fast depletion of natural energy. Gas injection has been acknowledged as an effective method to improve oil recovery factor from unconventional oil reservoirs. Hydrocarbon gas huff-n-puff becomes preferable when the CO_(2) source is limited. However, the impact of complex fracture networks and well interference on the EOR performance of multiple MFHWs is still unclear. The optimal gas huff-n-puff parameters are significant for enhancing oil recovery. This work aims to optimize the hydrocarbon gas injection and production parameters for multiple MFHWs with complex fracture networks in unconventional oil reservoirs. Firstly, the numerical model based on unstructured grids is developed to characterize the complex fracture networks and capture the dynamic fracture ***, the PVT phase behavior simulation was carried out to provide the fluid model for numerical simulation. Thirdly, the optimal parameters for hydrocarbon gas huff-n-puff were obtained. Finally, the dominant factors of hydrocarbon gas huff-n-puff under complex fracture networks are obtained by fuzzy mathematical method. Results reveal that the current pressure of hydrocarbon gas injection can achieve miscible displacement. The optimal injection and production parameters are obtained by single-factor analysis to analyze the effect of individual parameter. Gas injection time is the dominant factor of hydrocarbon gas huff-n-puff in unconventional oil reservoirs with complex fracture networks. This work can offer engineers guidance for hydrocarbon gas huff-n-puff of multiple MFHWs considering the complex fracture networks.

关键词： Unconventional oil reservoir Complex fracture network Hydrocarbon gas huff-n-puff Parameter optimization Numerical simulation

Impurity formation mechanism of silicon carbide crystals smelted by Acheson process

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第6期31卷 1367-1375页

作者： Dong Feng hong-qiang Ru Xu-dong Luo Jie-gang you Ling Zhang School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051LiaoningChina Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) Institute of Advanced CeramicsSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819LiaoningChina Liaoning Institute of Science and Technology Benxi 117004LiaoningChina

In order to further promote the application of SiC refractories in modern steel metallurgy,the occurrence forms and formation mechanism of impurities in SiC crystals smelted by Acheson process were *** techniques of inductively coupled plasma-atomic emission spectrometry,X-ray diffraction,and scanning electron microscopy were combined to examine the types and occurrence forms of impurities in smelted SiC *** results showed that the main impurities in the SiC are free Si,free C,oxides(CaO·Al_(2)O_(3)·2SiO_(2),3Al_(2)O_(3)·2SiO_(2),CaO·SiO_(2) and SiO_(2))and alloy phases(Fe_(x)Si_(y),Fe_(x)Si_(y)Ti_(z) and Fe_(x)Al_(y)Si_(z)).The formation process of impurities during the smelting of SiC can be described as follows:At high temperature,the SiO_(2) and Fe,Ti related oxide impurities present in the raw materials are reduced to Si,Fe,and Ti metal *** the reduction process,the free Si,Fe_(x)Si_(y) and Fe_(x)Si_(y)Ti_(z) are precipitated from the melt during *** Si primarily exists in aggregated form within the SiC crystal,while the alloy phase is predominantly found at the interface between SiC and free Si,with Fe_(x)Si_(y)Ti_(z) embedded within *** the end of the cooling process,other impurity oxides such as Al_(2)O_(3),CaO,and some unreduced SiO_(2) solidify to form calcium-aluminum-silicate glass phases,predominantly located between SiC *** remaining C from the reaction is mainly dispersed as free C within the SiC crystal and at the interface between SiC and free Si.

关键词： Impurity element Formation mechanism Smelted SiC crystal SiC refractory Occurrence form

High-order time-reversal symmetry breaking normal state

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 136-148页

作者： Meng Zeng Lun-Hui Hu hong-Ye Hu Yi-Zhuang you Congjun Wu department of Physics University of CaliforniaSan DiegoCalifornia 92093USA department of Physics Zhejiang UniversityHangzhou 310058China New Cornerstone Science Laboratory Department of PhysicsSchoolof ScienceWestlake UniversityHangzhou 30024China Institute for Theoretical Sciences Westlake UniversityHangzhou 310024China Key Laboratory for Quantum Materials of Zhejiang Province School of ScienceWestlake UniversityHangzhou 310024China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Spontaneous time-reversal symmetry breaking plays an important role in studying strongly correlated unconventional *** two superconducting gap functions with different symmetries compete,the relative phase channel(θ_(-)≡θ_(1)-θ_(2))exhibits an Ising-type Z_(2) symmetry due to the second order Josephson coupling,where θ_(1,2) are the phases of two gap *** contrast,the U(1) symmetry in the channel of θ_(+)≡(θ_(1)+θ_(2))/2 is *** phase locking,i.e.,ordering of θ_(-),can take place in the phase fluctuation regime before the onset of superconductivity,i.e.,when θ_(+) is *** θ_(-) is pinned at ±π/2,then timereversal symmetry is broken in the normal state,otherwise,if θ_(-)=0,or,π,rotational symmetry is broken,leading to a nematic normal *** both cases,the order parameters possess a 4-fermion structure beyond the scope of mean-field theory,which can be viewed as a high order symmetry *** employ an effective two-component XY-model assisted by a renormalization group analysis to address this *** a natural by-product,we also find the other interesting intermediate phase corresponds to ordering of θ_+ but with θ_(-)*** is the quartetting,or,charge-4e,superconductivity,which occurs above the low temperature Z_(2)-breaking charge-2e superconducting *** results provide useful guidance for studying novel symmetry breaking phases in strongly correlated superconductors.

关键词： superconductivity strong correlation time-reversal breaking charge-4e

Neoantigen cancer vaccines:a new star on the horizon

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2024年第4期21卷 274-311页

作者： Xiaoling Li Jian you Liping hong Weijiang Liu Peng Guo Xishan Hao Cell Biotechnology Laboratory Tianjin Cancer Hospital Airport HospitalTianjin 300308China National Clinical Research Center for Cancer Tianjin 300060China Haihe Laboratory of Synthetic Biology Tianjin 300090China department of Thoracic Oncology Tianjin Cancer Hospital Airport HospitalTianjin 300308China department of Thoracic Oncology Surgery Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Tianjin Medical University Cancer Institute&Hospital Tianjin 300060China

Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient's own immune system and eliminate cancer *** of the most exciting advances within this field is the targeting of neoantigens,which are peptides derived from non-synonymous somatic mutations that are found exclusively within cancer cells and absent in normal *** neoantigen-based therapeutic vaccines have not received approval for standard cancer treatment,early clinical trials have yielded encouraging outcomes as standalone monotherapy or when combined with checkpoint *** made in high-throughput sequencing and bioinformatics have greatly facilitated the precise and efficient identification of ***,personalized neoantigen-based vaccines tailored to each patient have been developed that are capable of eliciting a robust and long-lasting immune response which effectively eliminates tumors and prevents *** review provides a concise overview consolidating the latest clinical advances in neoantigen-based therapeutic vaccines,and also discusses challenges and future perspectives for this innovative approach,particularly emphasizing the potential of neoantigen-based therapeutic vaccines to enhance clinical efficacy against advanced solid tumors.

关键词： Immunotherapy neoantigen cancer vaccine solid tumors high-throughput sequencing bioinformatics PDOs AI HLA TCR

Stratigraphic identification using real-time drilling data

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3452-3464页

作者： Minglong you Zhikai hong Fei Tan Hao Wen Zhanrong Zhang Jiahe Lv Faculty of Engineering China University of GeosciencesWuhan430074China China Railway Siyuan Survey and design Group Co. Wuhan430063China

Identification of stratigraphic interfaces and lithology is a key aspect in geological and geotechnical *** this study,a monitoring while-drilling system was developed,along with a corresponding data pre-processing *** method can handle invalid drilling data generated during manual *** correlation between various drilling parameters was analyzed,and a database of stratigraphic interfaces and key lithology identification based on the monitoring parameters was *** average drilling speed was found to be the most suitable parameter for stratigraphic and lithology identification,and when the average drilling speed varied over a wide range,it corresponded to a stratigraphic *** average drilling speeds in sandy mudstone and sandstone strata were in the ranges of 0.1e0.2 m/min and 0.2e0.29 m/min,*** results obtained using the present method were consistent with geotechnical survey *** proposed method can be used for realtime lithology identification and represents a novel approach for intelligent geotechnical surveying.

关键词： Monitoring while-drilling Drilling parameters Geotechnical stratigraphy Lithology identification

Highly efficient expression of human extracellular superoxide dismutase(rhEcSOD)with ultraviolet-B-induced damage-resistance activity in transgenic silkworm cocoons

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2024年第4期31卷 1150-1164页

作者： Feng Wang Ri-Yuan Wang de-Bin Zhong Ping Zhao Qing-you Xia Integrative Science Center of Germplasm Creation in Western China(ChongQING)Science City Biological Science Research CenterSouthwest UniversityChongqingChina Century Legend Biotechnology Research Institute(Chongqing)Co. Ltd.ChongqingChina

Extracellular superoxide dismutase(EcSOD)protects tissues from oxidative stress,and thus is considered as a therapeutic agent for many diseases such as atherosclerosis,hypertension,and ***,cost-effective production of bioactive recombinant human EcSOD(rhEcSOD)remains a ***,we developed an efficient strategy for producing active rhEcSOD by transgenic *** was successfully synthesized as homodimers and homotetramers in the middle silk gland and spun into the cocoons with a concentration of 9.48±0.21 mg/*** of rhEcSOD from the cocoons could be conveniently achieved with a purity of 99.50%and a yield of 3.5±0.5 mg/***,N-glycosylation at the only site of N89 in rhEcSOD with 10 types were *** purified rhEcSOD gained the potent enzymatic activity of 4162±293 U/mg after Cu/Zn ions *** importantly,rhEcSOD was capable of penetrating and accumulating in the nuclei of cells to maintain cell morphology and attenuate ultraviolet B-induced cell apoptosis by eliminating reactive oxygen species and inhibiting the C-Jun N-terminal kinase signaling *** results demonstrated that the transgenic silkworm could successfully produce rhEcSOD with enzymatic and biological activities for biomedical applications.

关键词： antioxidant human extracellular superoxide dismutase recombinant expression silkworm silk gland

Sparse Reconstructive Evidential Clustering for Multi-View Data

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 459-473页

作者： Chaoyu Gong Yang you School of Computing National University of SingaporeSingapore

Although many multi-view clustering(MVC) algorithms with acceptable performances have been presented, to the best of our knowledge, nearly all of them need to be fed with the correct number of clusters. In addition, these existing algorithms create only the hard and fuzzy partitions for multi-view objects,which are often located in highly-overlapping areas of multi-view feature space. The adoption of hard and fuzzy partition ignores the ambiguity and uncertainty in the assignment of objects, likely leading to performance degradation. To address these issues, we propose a novel sparse reconstructive multi-view evidential clustering algorithm(SRMVEC). Based on a sparse reconstructive procedure, SRMVEC learns a shared affinity matrix across views, and maps multi-view objects to a 2-dimensional humanreadable chart by calculating 2 newly defined mathematical metrics for each object. From this chart, users can detect the number of clusters and select several objects existing in the dataset as cluster centers. Then, SRMVEC derives a credal partition under the framework of evidence theory, improving the fault tolerance of clustering. Ablation studies show the benefits of adopting the sparse reconstructive procedure and evidence theory. Besides,SRMVEC delivers effectiveness on benchmark datasets by outperforming some state-of-the-art methods.

关键词： Evidence theory multi-view clustering(MVC) optimization sparse reconstruction

Non-deterministic Liveness-Enforcing Supervisor Tolerant to Sensor-Reading Modification Attacks

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 240-248页

作者： Dan you Shouguang Wang IEEE the School of Information and Electronic Engineering Sussex Artificial Intelligence InstituteZhejiang Gongshang UniversityHangzhou 310018China

In this paper, we study the supervisory control problem of discrete event systems assuming that cyber-attacks might occur. In particular, we focus on the problem of liveness enforcement and consider a sensor-reading modification attack(SM-attack) that may disguise the occurrence of an event as that of another event by intruding sensor communication channels. To solve the problem, we introduce non-deterministic supervisors in the paper, which associate to every observed sequence a set of possible control actions offline and choose a control action from the set randomly online to control the system. Specifically, given a bounded Petri net(PN) as the reference formalism and an SMattack, an algorithm that synthesizes a liveness-enforcing nondeterministic supervisor tolerant to the SM-attack is proposed for the first time.

关键词： Cyber-attacks cyber-physical system(CPS) liveness non-deterministic supervisors Petri net(PN)