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Nanostructured ZnO/ZnS with Type-II Hetero-junction for Efficient CO_(2) Photoreduction

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Chemical Research in Chinese Universities 2024年第3期40卷 484-489页

作者： XIAO Qi LIU Ting ZHOU Qianhe LI Liangyu CHANG Chuntao GAO Dawei LI Danyang you feifei School of Textile Garment and Design Changshu Institute of TechnologyChangshu 215500P.R.China School of Civil and Environmental Engineering The University of New South WalesAustralia College of Textile and Clothing Yancheng Institute of Technology.Yancheng 224051P.R.China Jiangsu Yueda Cotton Spinning Co. Ltd.Yancheng 224051P.R.China

Photocatalytic CO_(2) reduction driven by solar light is a green approach that can decrease the greenhouse effect induced by high CO_(2) concentration in the atmosphere and generate carbon-based chemicals/fuels as *** this paper,non-metal co-catalysts ZnO/ZnS type-II hetero-junction nanoparticles with a rough surface were prepared through a hydrothermal *** used as a photocatalyst for CO_(2) reduction,the optimal one showed good cycle stability and a higher yield rate of 27.8µmol·g^(−1)·h^(−1) for CO_(2) conversion into *** outstanding catalytic activity originated from i)the rich interfaces between ZnO and ZnS in the nanoscale could significantly reduce the delivery path of carriers and improve the utilization efficiency of photo-excited electron/hole pairs and ii)enriched surface oxygen defects could supply much more reaction active sites for CO_(2) adsorption.

关键词： ZnO/ZnS Photocatalytic CO_(2)reduction Oxygen defect

Enhanced light harvesting ability in hollow Pt/TiO2 nanoreactor for boosting tetracycline photodegradation

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Progress in Natural Science:Materials International 2024年第4期34卷 767-775页

作者： Danyang Li Yongqi Li Dagui Liao Mengqing Cao Lulu Zhang Shasha Zhang Ling Chen Yawen Chen Huan Wang Jian Qi feifei you College of Textile and Clothing Yancheng Institute of Technology Hebei Key Laboratory of Flexible Functionals Materials School of Materials Science and Engineering Hebei University of Science and Technology State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences School of Chemical Engineering University of Chinese Academy of Sciences

Utilizing solar energy to decompose tetracycline（TC） is a green strategy to treat wastewater. Herein, a heterogeneous hollow structured TiO2decorated Pt nanoparticles were successfully designed and synthesized via hardtemplate approach and photo-deposition process toward TC photodegradation. The Pt nanoparticles loaded on the surface of hollow structured TiO2can increase the visible light absorption due to the local surface plasmon resonance（LSPR） effect. Furthermore, owing to the tough electron oscillation of the LSPR excitation, the plasmonic hot holes on the surface of Pt nanoparticles can capture the electrons of TiO2, effectively facilitating the separation of photo-excited charge carriers because of the formation of Schottky junction constructed between Pt and TiO2. Combined the natural merits of shorten conveying path of charge carriers and physical structural stability for hollow structure, the optimal Pt/TiO2hetero-junction hybrid showed superior photocatalytic activity and durability for TC photodegradation with the degradation efficiency of 93.8 % after 30 min and the rate constant of 0.09196 min-1under 300 W Xe lamp irradiation. This work displays a heterogeneous hybrids catalyst based on eco-friendly metal and semiconductor materials which can be used in the fields including without limitation TC photodegradation.

关键词： Hollow structure Photodegradation Tetracycline Hetero-junction

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

残疾人Photoshop网络化教学方法探析

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绥化学院学报 2013年第7期33卷 31-34页

作者：尤菲菲张睿楠尚晓丽绥化学院黑龙江绥化152061

针对高校残疾大学生教育,探讨一种适合听障学生学习photoshop的教学方法,以网络化教学为基础,因材施教,满足听力障碍学生的特殊需要,促进其中、高等特殊教育的衔接,体现教育的公平性和社会的进步性。

关键词：听力障碍网络化教学特殊教育

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang Ge feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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大数据环境下信息素养教育拓展与创新研究

绥化学院学报 2020年第6期40卷 136-140页

作者：郑丽娟刘春萍尤菲菲绥化学院学报编辑部黑龙江绥化152061

大数据环境下,信息素养以更加广泛的内容,更加宏观的视野,全新的理念和新型的技术逐步嵌入到社会生活的各种应用场景,信息素养教育内容和方式也随之发生了变化。文章对国内外信息素养教育相关研究进行梳理,分析大数据带给信息素养教育... 详细信息

大数据环境下,信息素养以更加广泛的内容,更加宏观的视野,全新的理念和新型的技术逐步嵌入到社会生活的各种应用场景,信息素养教育内容和方式也随之发生了变化。文章对国内外信息素养教育相关研究进行梳理,分析大数据带给信息素养教育的变化,探讨信息素养教育内容的泛化、深化与细化,研究信息素养教育范畴的拓展,考量信息素养教育模式的多元创新,并展望信息素养教育的未来发展方向,以期为加速信息素养教育向更高层次创新发展提供参考。

关键词：信息素养教育内容教育模式发展方向

High-entropy(La_(0.2)Nd_(0.2)Sm_(0.2)Gd_(0.2)Yb_(0.2))_(2)(Zr_(0.75)Ce_(0.25))_(2)O_(7)thermal barrier coating material with significantly enhanced fracture toughness

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Chinese Journal of Aeronautics 2023年第4期36卷 556-564页

作者： Donghui GUO feifei ZHOU Baosheng XU Yiguang WANG you WANG Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China Department of Materials Science School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China

Poor fracture toughness leads to premature failure of La_(2)(Zr_(0.75)Ce_(0.25))_(2)O_(7)(LCZ)ther-mal barrier coatings in an elevated temperature service environment.A novel coating material,namely(La_(0.2)Nd_(0.2)Sm_(0.2)Gd_(0.2)Yb_(0.2))_(2)(Zr_(0.75)Ce_(0.25))_(2)O_(7)(LNSGY)based on the high-entropy con-cept,was successfully fabricated by solid-state *** microstructure of LCZ and LNSGY was investigated by X-Ray Diffraction(XRD),Raman Spectrometer(RS),Transmission Electronic Microscopy(TEM)and Scanning Electron Microscopy(SEM).The fracture toughness of the LCZ and LNSGY ceramics was *** LNSGY has excellent high-temperature phase stability,and the grain size of LNSGY ceramic is smaller than that of LCZ ceramic at an elevated temper-ature due to the sluggish diffusion *** with LCZ(fracture toughness is(1.4±0.1)MPa·m^(1/2)),the fracture toughness of LNSGY is significantly enhanced(fracture toughness is(2.0±0.3)MPa·m^(1/2)).Therefore,the LNSGY can be a promising advanced thermal barrier coat-ing material in the future.

关键词： Fracture toughness High-entropy ceramics High-temperature phase sta-bility Rare-earth zirconate Thermal barrier coatings

Expression and prognosis analyses of Dectin-1 cluster genes in patients with lung adenocarcinoma (LUAD) and the association with immune checkpoint molecules

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BIOCELL 2021年第3期45卷 649-663页

作者： LITING you feifei NA JUAN ZHOU LIN JIAO YI ZHOU BINWU YING West China School of Medicine West China HospitalSichuan UniversityChengdu610041China Department of Thoracic Cancer West China HospitalSichuan UniversityChengdu610041China Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu610041China

Reviews The Dectin-1 cluster comprises seven members:CLEC-12A,CLEC-12B,CLEC-1A,CLEC-7A,CLEC-2,CLEC-9A and *** members have been demonstrated to be involved in the tumorigenesis,progression,and metastasis of several ***,little is known about their roles in human lung adenocarcinoma(LUAD).The expression patterns of the Dectin-1 cluster were analyzed via the ONCOMINE and GEPIA *** evaluated the prognostic value of the Dectin-1 cluster in patients with LUAD using the Kaplan-Meier plotter and *** expression was validated with the EMBL-EBI database,and protein expression was analyzed with the HPA *** addition,protein-protein interaction network,GO,and KEGG analyses were ***,the correlations between CLEC-12A and immune molecules(immune inhibitors and MHC molecules)were investigated via TISIDB and *** expression levels of Dectin-1 cluster genes were downregulated in LUAD tissues compared to those in normal lung *** expression levels of CLEC-12A,CLEC-12B,CLEC-2,and CLEC-9A correlated with tumor stage,and CLEC-12A and CLEC-12B were significantly associated with survival in patients with *** seven genes mostly participated in immune regulation processes and were involved in autoimmune disorders and hematological ***,correlation analyses revealed CLEC-12A expression was associated with most immune inhibitors and ***-12A was positively related to PD-1,PD-L1,PD-L2,CTLA4,TIM3,and *** conclusion,our findings suggest that CLEC-12A and CLEC-12B can be used as prognostic biomarkers in ***-12A expression was associated with immune checkpoint molecules,and CLEC-12A may be a potential assistant target to improve the efficacy of immune checkpoint inhibitors immunotherapy.

关键词： CLEC-12A CLEC-12B Lung cancer Prognosis Immune regulation

Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1658-1668页

作者： Liying May Haojie Wangy Yinghua you Chaoya Ma Yuejiao Liu feifei Yang Yichao Zheng Hongmin Liu Collaborative Innovation Center of New Drug Research and Safety Evaluation Henan ProvinceKey Laboratory of Technology of Drug Preparation(Zhengzhou University)Ministry of Education of ChinaKey Laboratory of Henan Province for Drug Quality and EvaluationSchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

Histone lysine specific demethylase 1(LSD1)has become a potential therapeutic target for the treatment of *** and develop novel and potent LSD1 inhibitors is a challenge,although several of them have already entered into clinical ***,for the first time,we reported the discovery of a series of 5-cyano-6-phenylpyrimidine derivatives as LSD1 inhibitors using flavin adenine dinucleotide(FAD)similarity-based designing strategy,of which compound 14 q was finally identified to repress LSD1 with IC50=183 nmol/*** analysis suggested that compound 14 q fitted well into the FAD-binding *** mechanism studies showed that compound 14 q may inhibit LSD1 activity competitively by occupying the FAD binding sites of LSD1 and inhibit cell migration and invasion by reversing epithelial to mesenchymal transition(EMT).Overall,these findings showed that compound14 q is a suitable candidate for further development of novel FAD similarity-based LSD1 inhibitors.

关键词： LSD1 inhibitors Pyrimidine Anticancer Flavin adenine dinucleotide(FAD) Gastric cancer