检索结果-南通市图书馆

World Journal of Clinical Cases 2022年第11期10卷 3587-3592页

作者： Toshiyuki Kakinuma Kaoru Kakinuma yoshio Matsuda Michitaka Ohwada Kaoru Yanagida Hirotsune Kaijima Department of Obstetrics and Gynecology International University of Health and Welfare HospitalNasushiobara 329-2763Japan Minatomirai Yume Clinic Yokohama 220-0012Japan

BACKGROUND The incidence of cervical pregnancy is increasing due to the recent widespread application of assisted reproductive *** hysterectomy has been a treatment option,high-sensitivity human chorionic gonadotropin testing and improved accuracy of transvaginal ultrasound imaging have increased possibility of uterine *** and curettage with methotrexate therapy and uterine artery embolization have been reported as treatments with fertility preservation;however,certain disadvantages limit their *** SUMMARY In our two reported cases,we avoided massive bleeding and immediately resumed infertility treatment using ultrasound-guided local ethanol injection for cervical pregnancies with fetal *** This treatment may be a new fertility-preserving option for cervical pregnancy.

关键词： Ultrasonography Ethanol Infertility Fertility preservation Methotrexate Case report

Endoscopic submucosal dissection as excisional biopsy for anorectal malignant melanoma:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2019年第13期7卷 1652-1659页

作者： Shigeo Manabe yoshio Boku Michiyo Takeda Fumitaka Usui Ikuhiro Hirata Shuji Takahashi Department of Gastroenterology Kouseikai Takeda Hospital Kyoto 600-8558 Japan Fujita Clinic 67 Gokiya-cho Oomiya-dori Shichijo-kudaru Shimogyo-ku Kyoto 600-8267 Japan

BACKGROUND Anorectal malignant melanoma(AMM)is a rare disorder with an extremely poor *** there is currently no consensus on the treatment methods for AMM,surgical procedures have been the most common treatment methods used until *** recently encountered a case of AMM that we diagnosed using endoscopic submucosal dissection(ESD).To our knowledge,this is the first case of ESD for AMM,suggesting that ESD can potentially be a diagnostic and treatment method for *** S UMA/MARY A 77-year-old woman visited our hospital with a chief complaint of anal bleeding and a palpable rectal *** revealed a 20-mm protruded lesion in the lower *** obtaining biopsy specimens from the lesion,although a malignant rectal tumor was suspected,a definitive diagnosis was not *** ultrasonography revealed tumor invasion into the submucosal layer but not the muscular ***,we performed an excisional biopsy using *** examination of the ESD-resected specimen revealed tumor cells positive for Human Melanin Black-45,Melan-A,and ***,the tumor cells lacked melanin pigment;thus,a diagnosis of amelanotic AMM was *** the AMM had massively invaded the submucosal layer and both lymphatic and venous invasion were present,we closely monitored the patient without any additional therapy on the basis of her *** months after ESD,local recurrence was detected,and the patient consented to wide local *** USION It is suggested that ESD is a potential diagnostic and treatment method for AMM.

关键词： Endoscopic submucosal dissection Anorectal malignant melanoma Endoscopic mucosal resection Case report

The Reliability of Assessment of Ki-67 Expression on Core Needle Biopsy and the Surgical Specimens of Invasive Breast Cancer: Comparison of Local Pathologists’ Assessment and Central Review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2012年第5期3卷 841-845页

作者： yoshio Mizuno Tsuneo Natori Naoko Takeda Junichi Yamada Hiroaki Abe Yuko inoue Hiroshi Seto Kazuhiko Sato Clinical Testing Business Testing Division Special Reference Laboratories Inc. Tokyo Japan Department of Breast Oncology Tokyo-West Tokushukai Hospital Tokyo Japan Department of Clinical Pathology Tokyo-West Tokushukai Hospital Tokyo Japan inoue Ladies Clinic Tokyo Japan Seto Hospital Saitama Japan

Purpose: The aim of this study was to assess the reliability of Ki-67 expression on core needle biopsy (CNB) and the surgical specimens of invasive breast cancer. We examined the concordance rate of Ki-67 expressions, hormone receptors, and human epidermal growth factor receptor 2 (HER2) status from a CNB with from a surgery in invasive breast cancer. Methods: A retrospective study was conducted on a clinical database of patients who underwent surgery for early breast cancer. Of these, 193 patients who underwent CNB before the surgery were enrolled. A cut-off value of 20% was used for Ki-67-positive criteria. Expression of estrogen receptor (ER), progesterone receptor (PgR), and HER2 were examined and compared with that of Ki-67. To evaluate discordance between the pathologists’ earlier assessments, we re-examined Ki-67 expression among the Ki-67 discordant group in a central laboratory. Results: The concordance rate for Ki-67 expression between the two specimen types was 77.7%, which was significantly lower than that for ER, PgR, and HER2 expression (95.9%, 88.1%, and 91.6%, respectively). The concordance rate for re-examined Ki-67 expression among the Ki-67 discordant group improved to 93.8% and was not significantly different from that for the other receptors. Conclusion: The concordance rate for Ki-67 expression between biopsy and surgical specimens was significantly lower than that for ER, PgR, and HER2 expressions, but re-examination of Ki-67 expression in a central laboratory revealed no significant difference among the receptors, suggesting the need for standard pathological assessment of Ki-67 expression for clinical use as a predictive marker of breast cancer.

关键词： Ki-67 CNB Concordance Rate Standard Assessment

Standardized Assessment of Ki-67 in Breast Cancer Patients Using Virtual Slides and an Automated Analyzer in Comparison to Central/Local Pathological Assessments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2014年第2期5卷 141-146页

作者： yoshio Mizuno Hiromi Fuchikami Tsuneo Natori Naoko Takeda Yuko inoue Junichi Yamada Hiroaki Abe Hiroshi Seto Kazuhiko Sato Clinical Testing Business Testing Division SRL Inc. Tokyo Japan Department of Breast Oncology Tokyo-West Tokushukai Hospital Tokyo Japan Department of Clinical Pathology Tokyo-West Tokushukai Hospital Tokyo Japan inoue Ladies Clinic Tokyo Japan Seto Hospital Tokorozawa Japan

Purpose: To standardize the methods to measure Ki-67, there is an interest in automating the assessment of Ki-67. Therefore, we reviewed the possibility of introducing an automated analyzer to standardize the Ki-67 evaluation method. Methods: We retrospectively reviewed a clinical database of patients who underwent surgery for early breast cancer at Tokyo-West Tokushukai Hospital. Among them, those who underwent preoperative core needle biopsy (CNB) were enrolled. The concordance rates of estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), and Ki-67 by local pathologists were reviewed (valuations made by local pathologists), and nonmatching cases (from August 2008 to October 2011) were reassessed both by central review and using an automated analyzer with virtual slides. The results were compared with the evaluations made by local pathologists, and we reexamined the concordance rate by using central review and the automated analyzer. Results: The concordance rate of Ki-67 evaluations made by local pathologists in the preoperative CNB and surgical specimens was 78.7% in 287 cases pathologically assessed from October 2008 to March 2013. This rate was significantly lower (p < 0.01) than that of ER (95.6%), PgR (88.5%), and HER2 (91.6%). Reassessment of the 37 cases of nonmatching Ki-67 values from 2008 to October 2011 using central review and an automated analyzer resulted in clear improvement in matching of 22 (92.1%) and 24 (93.1%) of 37 cases, respectively. Conclusion: The concordance rate of Ki-67 in preoperative CNB and surgical specimens was lower than that of other biological markers;however, they were nearly equal by reassessment using central review and an automated analyzer.

关键词： Ki-67 Core Needle Biopsy Concordance Rate Virtual Slides Automated Analyzer Standardized Assessment

Fabrication of Silver Nanowire Transparent Electrodes at Room Temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2011年第12期4卷 1215-1222页

作者： Takehiro Tokuno Masaya Nogi Makoto Karakawa Jinting Jiu Thi Thi Nge yoshio Aso Katsuaki Suganuma The Institute of Scientific and Industrial Research （ISIR） Osaka University 8-1 Mihogaoka Ibaraki Osaka 567-0047 Japan

Silver nanowires （AgNWs） surrounded by insulating poly（vinylpyrrolidone） have been synthesized by a polyol process and employed as transparent electrodes. The AgNW transparent electrodes can be fabricated by heattreatment at about 200 ℃ which forms connecting junctions between AgNWs. Such a heating process is, however, one of the drawbacks of the fabrication of AgNW electrodes on heat-sensitive substrates. Here it has been demonstrated that the electrical conductivity of AgNW electrodes can be improved by mechanical pressing at 25 MPa for 5 s at room temperature. This simple process results in a low sheet resistance of 8.6 Ω/square and a transparency of 80.0%, equivalent to the properties of the AgNW electrodes heated at 200 ℃. This technique makes it possible to fabricate AgNW transparent electrodes on heat-sensitive substrates. The AgNW electrodes on poly（ethylene terephthalate） films exhibited high stability of their electrical conductivities against the repeated bending test. In addition, the surface roughness of the pressed AgNW electrodes is one-third of that of the heat-treated electrode because the AgNW junctions are mechanically compressed. As a result, an organic solar cell fabricated on the pressed AgNW electrodes exhibited a power conversion as much as those fabricated on indium tin oxide electrodes. These findings enable continuous roll-to-roll processing at room temperature, resulting in relatively simple, inexpensive, and scalable processing that is suitable for forthcoming technologies such as organic solar cells, flexible displays, and touch screens.

关键词： Silver nanowire transparent electrode room temperature flexibility organic solar cell

Intraoperative Open-Cavity Implant for Accelerated Partial Breast Irradiation Using High-Dose Rate Multicatheter Brachytherapy in Japanese Breast Cancer Patients: A Single-Institution Registry Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2012年第5期3卷 822-830页

作者： Kazuhiko Sato yoshio Mizuno Masahiro Kato Takahiro Shimo Jun Kubota Naoko Takeda Yuko inoue Hiroshi Seto Tomohiko Okawa Department of Breast Oncology Tokyo-West Tokushukai Hospital Tokyo Japan Department of Radiation Oncology Tokyo-West Tokushukai Hospital Tokyo Japan Health Evaluation Center Utsunomiya Memorial Hospital Tochigi Japan inoue Ladies Clinic Tokyo Japan Seto Hospital Saitama Japan

Background: Previous research has compared the efficacies of accelerated partial breast irradiation (APBI) and wholebreast irradiation (WBI). APBI immediately after surgery may provide more benefit after intraoperative insertion of catheters. Although balloon catheter-based APBI is available in the US, it is difficult in Japanese women, who have relatively small breasts. With the applicators being implanted during tumor removal, APBI can be started immediately after surgery. The aim of this study was to assess the safety and efficacy of APBI using the intraoperative open-cavity implant technique. Method: Patients (age≥40 years) with invasive breast cancer (diameter≤3 cm) were enrolled. Before lumpectomy, the insertion of applicators and delivery doses were simulated by computed tomography (CT). After confirmation of free margins and negative sentinel nodes (SNs) using frozen section analysis, applicators were inserted. Postoperative CT-based dose distribution analysis was performed using dose-volume histograms. APBI was started on the day of surgery, delivering 32 Gy in 8 fractions over the following 5-6 days, and it covered a distance of 2 cm from tumor margins. This observational study was approved by the institutional review board of our hospital. Results: From October 2008 to July 2012, 157 women (160 lesions) were enrolled (age 55.0 years, <40:9, SN+: 25, for patients’ request). The mean number of applicators used was 6.4 (2-15) and mean planning target volume was 35.8 cm3 (6.5-137.1 cm3). All radiotherapy-related toxicities were mild. However, 12 patients (7.5%) experienced wound breakdown because of surgical site infection. Two patients developed ipsilateral breast tumor recurrence (1 marginal, 1 at a distant site). Conclusions: Despite the small number of participants and a short follow-up period, our results suggest that this technique could be helpful in establishing clinical safety and efficacy.

关键词： Breast Cancer Partial Breast Irradiation Multicatheter Brachytherapy

Mucosal patterns change after Helicobacter pylori eradication:Evaluation using blue laser imaging in patients with atrophic gastritis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第17期29卷 2657-2665页

作者： Yoshiyuki Nishikawa yoshio Ikeda Hidehiro Murakami Shin-Ichiro Hori Megumi Yoshimatsu Naoki Nishikawa Department of Gastroenterology Nishikawa Gastrointestinal ClinicMatsuyama 790-0878EhimeJapan Endoscopy Center Ehime University HospitalToon 791-0295EhimeJapan Department of Internal Medicine Saiseikai Matsuyama HospitalMatsuyama 791-8026EhimeJapan Department of Gastroenterology Himeji Red Cross HospitalHimeji 670-8540HyogoJapan Department of Gastroenterology National Hospital Organization Shikoku Cancer CenterMatsuyama 791-0280EhimeJapan Department of Gastroenterology Matsuyama Shimin HospitalMatsuyama 790-0067EhimeJapan

BACKGROUND Mucosal patterns(MPs)observed on blue laser imaging in patients with atrophic gastritis can be classified as spotty,cracked,and ***,we hypothesized that the spotty pattern may change to the cracked pattern after Helicobacter pylori(***)*** To further substantiate and comprehensively investigate MP changes after *** eradication in a larger number of *** We included 768 patients who were diagnosed with atrophic gastritis with evaluable MP using upper gastrointestinal endoscopy at the Nishikawa Gastrointestinal Clinic,*** them,325 patients were ***-positive,and of them,101 patients who underwent upper gastrointestinal endoscopy before and after *** eradication were evaluated for post-eradication MP *** patients’MPs were interpreted by three experienced endoscopists who were blinded to their clinical *** Among 76 patients with the spotty pattern before or after *** eradication,the pattern disappeared or decreased in 67 patients[88.2%,95%confidence interval(CI):79.0%-93.6%),appeared or increased in 8 patients(10.5%,95%CI:5.4%-19.4%),and showed no change in 1 patient(1.3%,95%CI:0.2%-7.1%).In 90 patients with the cracked pattern before or after *** eradication,the pattern disappeared or decreased in 7 patients(7.8%,95%CI:3.8%-15.2%),appeared or increased in 79 patients(87.8%,95%CI:79.4%-93.0%),and showed no change in 4 patients(4.4%,95%CI:1.7%-10.9%).In 70 patients with the mottled pattern before or after *** eradication,the pattern disappeared or decreased in 28 patients(40.0%,95%CI:29.3%-51.7%),appeared or increased in 35 patients(50.0%,95%CI:38.6%-61.4%),and showed no change in 7 patients(10.0%,95%CI:4.9%-19.2%).CONCLUSION After *** eradication,MPs changed from spotty to cracked in most patients,which may help endoscopists easily and precisely evaluate ***-related gastritis status.

关键词： Atrophic gastritis Helicobacter pylori Gastrointestinal endoscopy Image enhancement Classification

Intraocular lens implantation and vitrectomy using 0.025% povidone-iodine in irrigation solution for bleb-related endophthalmitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2020年第9期13卷 1499-1502页

作者： Yorihisa Kitagawa Hiroyuki Shimada Hiroyuki Nakashizuka Takayuki Hattori yoshio Yamazaki Department of Ophthalmology School of MedicineNihon UniversityChiyodakuTokyo 101-8309Japan Department of Ophthalmology Tokai University Tokyo HospitalShibuyakuTokyo 151-0053Japan

Dear Editor,We report the results of using Balanced Salt Solution(BSS)Plus containing 0.025%povidone-iodine,a microbicidal and safe solution[1-2],in combined intraocular lens(IOL)implantation and vitrectomy in two cas... 详细信息

关键词： implantation iodine vitrectomy

Bipolar I disorder and expressed emotion of families: A cohort study in Japan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Psychiatry 2012年第4期2卷 258-261页

作者： Shinji Shimodera Yukiko Yonekura Sosei Yamaguchi Aoi Kawamura Masafumi Mizuno Shimpei inoue Toshi A. Furukawa yoshio Mino Department of Cognitive-Behavioral Medicine Kyoto University Graduate School of Medicine/School of Public Health Kyoto Japan Department of Neuropsychiatry Kochi Medical School Kochi University Kochi Japan Department of Neuropsychiatry Toho University School of Medicine Tokyo Japan Department of Psychiatric Rehabilitation National Institute of Mental Health National Center of Neurology and Psychiatry Tokyo Japan Department of Psychiatry Mino Clinic Okayama Japan Department of Social Welfare Kansai University of Social Welfare Hyogo Japan

The relationships between expressed emotion (EE) of the families and the course of bipolar disorder have been examined only in a limited number of cohort studies. No study has yet been reported from Asia. The subjects were 12 patients that had been diagnosed with bipolar I disorder according to DSM-IV and their 12 key family members. The families of the patients were interviewed using the Camberwell Family Interview (CFI) within 2 weeks of the admission of the patients, and their EE were evaluated. The patients were then followed up for 9 months after their discharge from the hospital. The patients were divided into a high-EE group and a low-EE group using the cut-off based on the number of critical comments (CC) and emotional overinvolvement (EOI), and the 9-month relapse risk was compared. When the subjects with 3 or more CC or an EOI score of 3 or more were regarded as the high-EE group, and the others as the low-EE group, the 9-month relapse risk was 100% (3/3) for the high EE group and 0% (0/9) for the low EE group. (Fisher’s exact test p = 0.005) EE based on the CFI appear to be correlated with relapse in bipolar I disorder in Japan.

关键词： Expressed Emotion Family Bipolar Disorder

A newly developed soft-type turtle releasing device(Soft-TRD)for setnet fisheries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2021年第4期6卷 359-366页

作者： Daisuke Shiode Maika Shiozawa Fuxiang Hu Tadashi Tokai yoshio Hirai Tokyo University of Marine Science and Technology MinatoTokyo108-8477Japan NITTO SEIMO Co. LTD.MinatoTokyo105-0004Japan

This study investigated a newly developed soft-type turtle releasing device(Soft-TRD)for *** setnet fish chambers(bag nets)are open at the sea surface,while others are closed(with ceiling netting)and *** turtles that stray into submerged bag nets often drown because the ceiling netting prevents them from swimming up to the surface to *** Soft-TRD has a slit that functions as an escape outlet at the center of a 2 m×2 m *** escape slit remains closed,due to the buoyancy of a float attached at each end of the slit,and prevents fish from getting *** can push the escape slit upward,which opens and allows the turtles to *** decide the optimum design of the Soft-TRD,a turtle releasing trial was conducted in an outdoor water *** loggerhead turtles(Caretta caretta)(standard carapace length(SCL):67.1-72.8 cm)and five green turtles(Chelonia mydas)(SCL:42.4-63.4 cm)were used for the trial.A single turtle was placed into the experimental bag net where the Soft-TRD(six models in total)was mounted at the center part of the ceiling,and its behavior was *** turtles successfully escaped the model with a 150 cm length escape slit,10 cm overlaying width,and a 4 kgf buoyancy float at each *** escape slit immediately closed after the turtles escaped.A sea trial(same model)was also performed using a submerged bag net(30×10×10 m)for two *** 90%(seven of the eight)of the entrapped loggerhead turtles successfully escaped out through the *** was not interrupted by the introduction of this *** use of the Soft-TRD would be helpful in releasing sea turtles from the setnets and contribute to sea turtle conservation efforts.

关键词： Bycatch Push-up Setnet Soft-TRD Turtle releasing device Turtle releasing system