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Carbon Energy 2021年第2期3卷 375-383页

作者： Tae-Yeol Jeon seung-Ho Yu Sung J.yoo Hee-Young Park Sang-Kyung Kim Beamline Department Pohang Accelerator Laboratory(PAL)PohangRepublic of Korea Department of Chemical and Biological Engineering Korea UniversitySeoulRepublic of Korea Fuel Cell Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea Fuel Cell Research Center Korea Institute of Energy Research(KIER)DaejeonRepublic of Korea

Pt-Ni alloy nanocrystals with Pt-enriched shells were prepared by selective etching of surface Ni using sulfuric acid and *** changes in the electronic and geometric structure of the alloy nanoparticles at the surface were elucidated from the electrochemical surface area,the potential of zero total charge(PZTC),and relative surface roughness,which were determined from CO-and CO_(2)-displacement experiments before and after 3000 potential cycles under oxygen reduction reaction *** the highest activity and durability were achieved in hydroquinone-treated Pt–Ni,sulfuric acidtreated one showed the lower activity and durability despite its higher surface Pt concentration and alloying *** PZTC and QCO_(2)/QCO ratio(desorption charge of reductively adsorbed CO_(2) normalized by COad-stripping charge)depend on surface *** particular,QCO_(2)/QCO ratio change better reflects the roughness on an atomic scale,and PZTC is also affected by the electronic modification of Pt atoms in surface *** this study,a comparative study is presented to find a relationship between surface structure and electrochemical properties,which reveals that surface roughness plays a critical role to improve the electrochemical performance of Pt-Ni alloy catalysts with Pt-rich surfaces.

关键词： electrocatalyst fuel cell oxygen reduction reaction Pt-Ni surface roughness

Changes in peak inspiratory flow rate and peak airway pressure with endotracheal tube size during chest compression

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World Journal of Emergency Medicine 2020年第2期11卷 97-101页

作者： Jung Wan Kim Jin Woong Lee seung Ryu Jung Soo Park InSool yoo Yong Chul Cho Hong Joon Ahn Department of Emergency Medicine Chungnam National University HospitalJung-guDaejeonRepublic of Korea Department of Emergency Medicine College of MedicineChungnam National UniversityJung-guDaejeonRepublic of Korea

BACKGROUND:Adequate airway management plays an important role in high-quality cardiopulmonary resuscitation(CPR).Airway management is usually performed using an endotracheal tube(ETT)during ***,no study has assessed the effect of ETT size on the fl ow rate and airway pressure during ***:We measured changes in peak inspiratory fl ow rate(PIFR),peak airway pressure(Ppeak),and mean airway pressure(Pmean)according to changes in ETT size(internal diameter 6.0,7.0,and 8.0 mm)and with or without CPR.A tidal volume of 500 mL was supplied at a rate of 10 times per minute using a mechanical *** compressions were maintained at a constant compression depth and speed using a mechanical chest compression device(LUCAS2,mode:active continuous,chest compression rate:102±2/minute,chest compression depth 2–2.5 inches).RESULTS:The median of several respiratory physiological parameters during CPR was significantly different according to the diameter of each ETT(6.0 vs.8.0 mm):PIFR(32.1 L/min[30.5–35.3]vs.28.9 L/min[27.5–30.8],P<0.001),Ppeak(48.84 cmH2O[27.46–52.11]vs.27.45 cmH2O[22.53–52.57],P<0.001),and Pmean(18.34 cmH2O[14.61–21.66]vs.13.66 cmH2O[8.41–19.24],P<0.001).CONCLUSION:The changes in PIFR,Ppeak,and Pmean were related to the internal diameter of ETT,and these values tended to decrease with an increase in ETT *** airway pressures were measured in the CPR group than in the no CPR group.

关键词： Cardiopulmonary resuscitation Intratracheal intubation Airway pressure

Brain-derived neurotrophic factor mediates macrophage migration inhibitory factor to protect neurons against oxygen-glucose deprivation

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Neural Regeneration Research 2020年第8期15卷 1483-1489页

作者： Su hwan Bae Mi Ran yoo Ye Yeong Kim In Kyung Hong Mi Hee Kim seung Hak Lee Dae Yul Kim Department of Rehabilitation Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea

Macrophage migration inhibitory factor(MIF)is a chemokine that plays an essential role in immune system *** studies suggested that MIF protects neurons in ischemic ***,few studies are reported on the role of MIF in neurological recovery after ischemic *** purpose of this study is to identify the molecular mechanism of neuroprotection mediated by *** neuroblastoma cells were incubated in Dulbecco’s modified Eagle’s medium under oxygen-glucose deprivation(OGD)for 4 hours and then returned to normal aerobic environment for reperfusion(OGD/R).30 ng/mL MIF recombinant(30 ng/mL)or ISO-1(MIF antagonist;50μM)was administered to human neuroblastoma *** cell cultures were assigned to one of four groups:control,OGD/R,OGD/R with MIF,OGD/R with *** viability was analyzed using WST-1 *** levels of brain-derived neurotrophic factor(BDNF),microtubule-associated protein 2(MAP2),Caspase-3,Bcl2,and Bax were detected by western blot assay and immunocytochemistry in each group to measure apoptotic ***-1 assay results revealed that compared to the OGD/R group,cell survival rate was significantly higher in the OGD/R with MIF group and lower in the OGD/R with ISO-1 *** blot assay and immunocytochemistry results revealed that expression levels of BDNF,Bcl2,and MAP2 were significantly higher,and expression levels of Caspase-3 and Bax were significantly lower in the MIF group than in the OGD/R *** levels of BDNF,Bcl2,and MAP2 were significantly lower,and expression levels of Caspase-3 and Bax were significantly higher in the ISO-1 group than in the OGD/R *** administration promoted neuronal cell survival and induced high expression levels of BDNF,MAP2,and Bcl2(anti-apoptosis)and low expression levels of Caspase-3 and Bax(pro-apoptosis)in an OGD/R *** results suggest that MIF administration is effective for inducing expression of BDNF and leads to neuroprotection of neuronal cells

关键词： apoptosis brain-derived neurotrophic factor hypoxia in vitro ischemic stroke macrophage migration inhibitory factor nerve regeneration neuroprotective effect reperfusion

Comparison of the clinical efficacy of medical treatment of symptomatic benign prostatic hyperplasia between normal and obese patients

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Asian Journal of Andrology 2011年第5期13卷 728-731页

作者： seung hwan Lee Cheol Young Oh Kyung Kgi Park Mutt Su Chung Se Jeong yoo Byung Ha Chung Department of Urology Yonsei University Health System Seoul Korea Department of Urology Hallym University Anyang 431-070 Chuncheon

We aimed to investigate the difference in efficacy of medical treatment of symptomatic benign prostatic hyperplasia （BPH） between normal and obese patients with BPH; obesity was determined by either body mass index （BMI） or waist circumference （WC）. In this 12-week prospective observational study, a total of 175 patients aged ≥40 years with International Prostate Symptom Scores （IPSS） ≥12 points and prostate volume≥20 ml were prospectively enrolled. The patients were divided into two groups according to BMI or WC. Patients received the doxazosin gastrointestinal therapeutic system （GITS） at a dose of 4 mg once per day for 12 weeks. The changes from baseline in the IPSS, maximal urinary flow rate （Qmax）, post-void residual volume, quality of life （QoL） scores and adverse events （AEs） were analysed. Of the 175 enrolled patients, 132 completed the study. Sixty-seven patients had BMI 〉23 kg m-2, and 43 had WC 〉90 cm. Obese patients represented by WC 〉90 cm or BMI≥ 23 kg m-2 had a significantly greater prostate volume compared with non-obese patients at baseline. Total IPSS was significantly higher in the WC 〉90 cm group compared to the WC ≤ 90 cm group. Total I PSS was positively correlated with prostate volume （P=-0.031） and WC （P=0.045）. All groups showed significant improvements in total IPSS and QoL at 12 weeks. However, the improvement of total IPSS was greater in the high-BMI and high-WC groups. The most frequent AE was dizziness （n= 13）, and it was significantly lower in the obese BPH patients. Obesity was associated with increased prostate volume and lower urinary tract symptoms. Alpha-blockers appear to be efficacious for controlling symptoms, especially in obese men.

关键词： Alpha-blocker benign prostatic hyperplasia body mass index prostate waist circumference

Ground settlement during tunneling in groundwater drawdown environment-Influencing factors

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Underground Space 2016年第1期1卷 20-29页

作者： Chungsik yoo School of Civil Architectural Engineering and Landscape ArchitectureSungkyunkwan University2066 Seoboo RoJan-An GuSuwonKyong-Gi Do 16419Republic of Korea

In this paper,the results of a parametric study on groundwater drawdown-induced surface settlement during tunneling in waterbearing ground are presented.A calibrated stress–pore pressure coupled finite element model was adopted for the parametric *** results were analyzed to establish the relationships between key design issues,such as the ground surface settlement and groundwater drawdown,and influencing *** artificial neural network(ANN)-based sensitivity analysis was performed to obtain insight into the relative importance of the influencing *** results indicated that the primary influencing factors on the settlement development are the thickness and stiffness of the soil layer within the drawdown zone and the lining permeability,while the initial void ratio and the permeability of the soil layer were considered secondary influencing *** implications and findings of the study are discussed.

关键词： Conventional tunneling Ground settlement Groundwater Finite element method Stress-pore pressure coupled analysis

Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27

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Bone Research 2018年第3期6卷 238-251页

作者： Sung Won Lee Jee Hyun Rho Sang Yeob Lee Won Tae Chung yoo Jin Oh Jung Ha Kim seung Hee yoo Woo Young Kwon Ju Yong Bae Su Young Seo Hokeun Sun Hye Young Kim Young Hyun yoo Department of Rheumatology Dong-A University College of Medicine Department of Anatomy and Cell Biology Dong-A University College of Medicine and Mitochondria Hub Regulation Center Department of Microbiology Dong-A University College of Medicine Department of Statistics Pusan National University

Free fatty acids(FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity and induce osteoarthritis remains largely unknown. We here observed that oleate at the usual clinical range does not exert lipotoxicity while oleate at high pathological ranges exerted lipotoxicity through apoptosis in articular chondrocytes. By investigating the differential effect of oleate at toxic and nontoxic concentrations, we revealed that lipid droplet(LD) accumulation confers articular chondrocytes, the resistance to lipotoxicity. Using high fat diet-induced osteoarthritis models and articular chondrocytes treated with oleate alone or oleate plus palmitate, we demonstrated that articular chondrocytes gain resistance to lipotoxicity through protein kinase casein kinase 2(PKCK2)—six-transmembrane protein of prostate 2(STAMP2)—and fat-specific protein 27(FSP27)-mediated LD accumulation. We further observed that the exertion of FFAs-induced lipotoxicity was correlated with the increased concentration of cellular FFAs freed from LDs, whether FFAs are saturated or not. In conclusion, PKCK2/STAMP2/FSP27-mediated sequestration of FFAs in LD rescues osteoarthritic chondrocytes. PKCK2/STAMP2/FSP27 should be considered for interventions against metabolic OA.

关键词： osteoarthritis remains articular chondrocytes

Prospective Analysis on Survival Outcomes of Nonsmall Cell Lung Cancer Stages over Ⅲb Treated with HangAm-Dan

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中国肺癌杂志 2010年第11期13卷 1009-1015页

作者： Tae-Young JEONG Bong-Ky PARK Yeon-Weol LEE Chong-Kwan CHO hwa-seung yoo East-West Cancer Center College of Oriental MedicineDaejeon University

Background and objective Non-small cell lung cancer (NSCLC) stages over IIIb still remain as an intractable *** rate of NSCLC stages over IIIb could be increased through chemotherapy and radiation,but results are not *** medicine herbal formula,HangAm-Dan (HAD) has been developed for anti-tumor purpose and several previous studies have already reported its *** aim of this study is to assess HAD's efficacy on prolonging the survival rate of NSCLC stages over *** We have administered 3 000 mg of HAD daily to *** study included 74 first visit patients of East-West Cancer Center (EWCC) from November 2007 to April 2008,diagnosed with inoperable NSCLC stages over *** them,30 patients were in HAD group and 44 patients were in combined group with conventional therapy and *** have observed and analyzed their overall *** Of total 74 patients,overall 1 year,2 year survival rates and the median survival time were 62.1%,34.9% and 17.0 months (95%CI: 12.9-21.1).NSCLC stage IIIb patients showed higher survival rates than NSCLC stage IV patients (P=0.408).The 1 year,2 year survival rates and the median survival time of the combined group were 70.5%,37.9% and 20.0 months (95%CI: 16.4-24.6).In HAD group,the 1 year,2 year survival rates and the median survival time were 50.0%,25.7% and 12.0 months (95%CI: 6.6-17.4).The combined therapy group showed higher survival rates than the HAD group (P=0.034).Each groups treated with HAD for more than 4 weeks showed higher survival rates than those treated for less than 4 weeks,but there was no significant difference (P=0.278).In hazard ratio,the combined therapy group showed lower mortality rate than the HAD group with statistical significance (P=0.040).Conclusion HAD could prolong the survival rate of inoperable NSCLC stages over *** is more effective when combined with conventional *** the future,more controlled clinical trials with larger sample in mu

关键词：《中国肺癌杂志》期刊 NSCLC 摘要

Representation of Urban Buildings Using Modified Relief Mapping

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Journal of Computer Science & Technology 2006年第2期21卷 204-208页

作者： Byounghynn yoo Soonhung Han Department of Mechanical Enginccring Koren Aduanced Institute of Science and TechnologyDeajeon305-701Korea

This paper describes the real-time mapping displacement of buildings onto the polygon model of base terrain of geo-spatial information,The buildings are represented as height maps,lcading to low memory requirements and not involving changes of the original geometry（*** vertices are created or displaced）.The displacement of buildings is mapped toward the protruding direction,The base of textrue which represents the ground in topography is correctly mapped onto base polygon without any *** approach can exhibit the correct,occlusions between buildings and ground due to parallax and correct self-occlusion.

关键词： acrial photograph digital map displacement mapping gco-visualization image-based rendering

Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes

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Acta Pharmacologica Sinica 2007年第6期28卷 901-907页

作者： Myung-hyun YIM Jang-woo SHIN Jin-young SON Se-mi OH seung-hyun HAN Jung-hyo CHO Chong-kwan CHO hwa-seung yoo Yeon-weol LEE Chang-gue SON East-West Cancer Center Dunsan Oriental Hospital of Daejeon UniversityDaejeon 302-122Korea

Aim:To investigate the immunoregulatory functions of water extracts of Hericiumerinaceum （WEHE） focusing on natural killer （NK） cell-based anticancer ***:Mouse splenocytes or purely isolated NK ceils were stimulated with1-100 mg/L WEHE for 24 h followed by co-culture with51Cr-labled Yac-1 cells for4 h,then NK cell-derived cytolytic activity was measured using a *** antibodies against mouse interleukin-12 （IL-12） were addedinto the WEHE-stimulated splenocytes,thereafter,cytotoxicity was measured toexamine the involvement of ***-PCR and ELISA analyses were performed toconfirm the induction of transcription and the translation of IL-12 and interferon-gamma （IFN-gamma） in the WEHE-treated ***:WEHE enhancedthe cytolytic activity of total splenocytes towards Yac-1 ceils in a ***,this activation was not observed when the NK cells isolatedfrom the splenocytes were treated with ***,the treatment withantibodies against IL-12 abolished the effect of WEHE on splenocyte-derivedcytolytic ***-PCR and ELISA analyses showed the induction of IL-12 andIFN-gamma in the WEHE-treated ***:WEHE indirectlyactivates the cytolytic ability of NK cells via the induction of IL-12 in totalsplenocytes,and possibly via other immuno-mediators or cellular components.

关键词： Hericium erinaceum NK cells interleukin-12

Highly efficient blue organic light-emitting diodes using various hole and electron confinement layers

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Chinese Optics Letters 2015年第3期13卷 72-75页

作者： Jin Sung Kang Ju-An yoon seung Il yoo Jin Wook Kim Bo Mi Lee Hyeong hwa Yu C.-B.Moon Woo Young Kim Department of Green Energy and Semiconductor Engineering Hoseo University Department of Engineering Physics Mc Master University

In this Letter, blue phosphorescence organic light-emitting diodes （PHOLEDs） employ structures for electron and/or hole confinement; 1,3,5-tris（N-phenylbenzimiazole-2-yl）benzene is used as a hole confinement layer and tris-（phenylpyrazole）iridium [Ir（ppz）3] is utilized for an electron confinement layer （ECL）. The electrical and optical properties of the fabricated blue PHOLEDs with various carrier-confinement structures are analyzed. Structures with a large ehergy offset between the carrier confinement and emitting layers enhance the charge-carrier balance in the emitting region, resulting from the effective carrier confinement. The maximum external quantum efficiency of the blue PHOLEDs with the double-ECLs is 24.02% at 1500 cd/m^2 and its luminous efficiency is 43.76 cd/A, which is 70.47% improved compared to the device without a carrier-confinement layer.

关键词： blue Highly efficient blue organic light-emitting diodes using various hole and electron confinement layers OLEDs EML ECL