检索结果-南通市图书馆

Metadynamics sampling in atomic environment space for collecting training data for machine learning potentials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational Materials 2021年第1期7卷 1171-1179页

作者： Dongsun yoo Jisu Jung Wonseok Jeong seungwu Han Department of Materials Science and Engineering and Research Institute of Advanced Materials Seoul National UniversitySeoulKorea Samsung Display Co. Ltd.1Samsung-roGiheung-guYongin-siGyeonggi-doKorea

The universal mathematical form of machine-learning potentials(MLPs)shifts the core of development of interatomic potentials to collecting proper training ***,the training set should encompass diverse local atomic environments but conventional approaches are prone to sampling similar configurations repeatedly,mainly due to the Boltzmann *** such,practitioners handpick a large pool of distinct configurations manually,stretching the development period *** overcome this hurdle,methods are being proposed that automatically generate training ***,we suggest a sampling method optimized for gathering diverse yet relevant configurations *** is achieved by applying the metadynamics with the descriptor for the local atomic environment as a collective *** a result,the simulation is automatically steered toward unvisited local environment space such that each atom experiences diverse chemical environments without *** apply the proposed metadynamics sampling to H:Pt(111),GeTe,and Si *** these examples,a small number of metadynamics trajectories can provide reference structures necessary for training high-fidelity *** proposing a semiautomatic sampling method tuned for MLPs,the present work paves the way to wider applications of MLPs to many challenging applications.

关键词： dynamics collective stretching

Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第30期25卷 4125-4147页

作者： Jun-hwan yoo Mark Donowitz Department of Medicine Division of Gastroenterology and HepatologyJohns Hopkins University School of MedicineBaltimoreMD 21205United States Digestive Disease Center CHA Bundang Medical CenterCHA UniversitySeongnam 13496South Korea

The introduction of biologics such as anti-tumor necrosis factor(TNF)monoclonal antibodies followed by anti-integrins has dramatically changed the therapeutic paradigm of inflammatory bowel diseases(IBD).Furthermore,a newly developed anti-p40 subunit of interleukin(IL)-12 and IL-23(ustekinumab)has been recently approved in the United States for patients with moderate to severe Crohn’s disease who have failed treatment with ***,these immunosuppressive therapeutics which focus on anti-inflammatory mechanisms or immune cells still fail to achieve long-term remission in a significant percentage of *** strongly underlines the need to identify novel treatment targets beyond immune suppression to treat *** studies have revealed the critical role of intestinal epithelial cells(IECs)in the pathogenesis of ***,biochemical and immunologic driven barrier dysfunctions of epithelial cells contribute to the development of *** addition,the recent establishment of adult stem cell-derived intestinal enteroid/organoid culture technology has allowed an exciting opportunity to study human IECs comprising all normal epithelial *** long-term epithelial culture model can be generated from endoscopic biopsies or surgical resections and recapitulates the tissue of origin,representing a promising platform for novel drug discovery in *** review describes the advantages of intestinal enteroids/organoids as a research tool for intestinal diseases,introduces studies with these models in IBD,and gives a description of the current status of therapeutic approaches in ***,we provide an overview of the current endeavors to identify a novel drug target for IBD therapy based on studies with human enteroids/organoids and describe the challenges in using enteroids/organoids as an IBD model.

关键词： Enteroids Organoids Inflammatory bowel diseases Crohn’s disease Ulcerative colitis

Prospective Analysis on Survival Outcomes of Nonsmall Cell Lung Cancer Stages over Ⅲb Treated with HangAm-Dan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国肺癌杂志 2010年第11期13卷 1009-1015页

作者： Tae-Young JEONG Bong-Ky PARK Yeon-Weol LEE Chong-Kwan CHO hwa-seung yoo East-West Cancer Center College of Oriental MedicineDaejeon University

Background and objective Non-small cell lung cancer (NSCLC) stages over IIIb still remain as an intractable *** rate of NSCLC stages over IIIb could be increased through chemotherapy and radiation,but results are not *** medicine herbal formula,HangAm-Dan (HAD) has been developed for anti-tumor purpose and several previous studies have already reported its *** aim of this study is to assess HAD's efficacy on prolonging the survival rate of NSCLC stages over *** We have administered 3 000 mg of HAD daily to *** study included 74 first visit patients of East-West Cancer Center (EWCC) from November 2007 to April 2008,diagnosed with inoperable NSCLC stages over *** them,30 patients were in HAD group and 44 patients were in combined group with conventional therapy and *** have observed and analyzed their overall *** Of total 74 patients,overall 1 year,2 year survival rates and the median survival time were 62.1%,34.9% and 17.0 months (95%CI: 12.9-21.1).NSCLC stage IIIb patients showed higher survival rates than NSCLC stage IV patients (P=0.408).The 1 year,2 year survival rates and the median survival time of the combined group were 70.5%,37.9% and 20.0 months (95%CI: 16.4-24.6).In HAD group,the 1 year,2 year survival rates and the median survival time were 50.0%,25.7% and 12.0 months (95%CI: 6.6-17.4).The combined therapy group showed higher survival rates than the HAD group (P=0.034).Each groups treated with HAD for more than 4 weeks showed higher survival rates than those treated for less than 4 weeks,but there was no significant difference (P=0.278).In hazard ratio,the combined therapy group showed lower mortality rate than the HAD group with statistical significance (P=0.040).Conclusion HAD could prolong the survival rate of inoperable NSCLC stages over *** is more effective when combined with conventional *** the future,more controlled clinical trials with larger sample in mu

关键词：《中国肺癌杂志》期刊 NSCLC 摘要

Deep Learning-Based Action Classification Using One-Shot Object Detection

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2023年第8期76卷 1343-1359页

作者： Hyun yoo Seo-El Lee Kyungyong Chung Contents Convergence Software Research Institute Kyonggi UniversitySuwon-si16227Korea Department of Public Safety Bigdata Kyonggi UniversitySuwon-si16227Korea Division of Computer Science and Engineering Kyonggi UniversitySuwon-si16227Korea

Deep learning-based action classification technology has been applied to various fields,such as social safety,medical services,and *** an action on a practical level requires tracking multiple human bodies in an image in real-time and simultaneously classifying their *** are various related studies on the real-time classification of actions in an ***,existing deep learning-based action classification models have prolonged response speeds,so there is a limit to real-time *** addition,it has low accuracy of action of each object ifmultiple objects appear in the ***,it needs to be improved since it has a memory overhead in processing image *** learning-based action classification using one-shot object detection is proposed to overcome the limitations of multiframe-based analysis *** proposed method uses a one-shot object detection model and a multi-object tracking algorithm to detect and track multiple objects in the ***,a deep learning-based pattern classification model is used to classify the body action of the object in the image by reducing the data for each object to an action *** to the existing studies,the constructed model shows higher accuracy of 74.95%,and in terms of speed,it offered better performance than the current studies at 0.234 s per *** proposed model makes it possible to classify some actions only through action vector learning without additional image learning because of the vector learning feature of the posterior neural ***,it is expected to contribute significantly to commercializing realistic streaming data analysis technologies,such as CCTV.

关键词： Human action classification artificial intelligence deep neural network pattern analysis video analysis

Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第43期12卷 6992-6997页

作者： Do Young Kim Moon Seok Choi Joon Hyoek Lee Kwang Cheol Koh seung Woon Paik Byung Chul yoo Sung Wook Shin Sung Wook Choo Young Soo Do Jong Chul Rhee Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea Depart- ment of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea

AIM: To evaluate whether the Milan criteria are useful in patients with hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) before liver transplantation (LT). METHODS: Thirty-six HCC patients who fulfilled the Milan criteria after having received TACE and subsequently underwent LT were included (TACE + LT group) in the study. As controls, 21 patients who also met the Milan criteria and underwent LT without prior treatment were selected (LT group). Post-LT clinical outcomes, such as HCC recurrence, survival rate, and histologic features of explanted livers, were compared between the two groups. RESULTS: Baseline characteristics were not different between the two groups. Pre-LT maximal tumor diameter in TACE + LT group was similar to that of LT group (2.0 ± 0.6 cm vs 2.3 ± 0.9 cm; P = 0.10). Post-LT histologic findings also revealed similar maximal tumor diameter in the two groups (2.4 ± 1.4 cm vs 2.3 ± 0.9 cm; P = 0.70). Explanted livers showed similar incidence of unfavorable pathologic features. The morality within 60 d after transplantation was not different between the two groups (8.3% vs 9.5%; P = 0.99). Post-LT 5-year survival rate (57% vs 74%; P = 0.70) and cumulative recurrence rate (8.3% vs 4.8%; P = 0.90) were not significantly different between the two groups. CONCLUSION: The Milan criteria are still a useful selec- tion criteria showing favorable outcomes in HCC patientsreceiving TACE before LT.

关键词： Milan criteria Hepatocellular carcinoma Transarterial chemoembolization Liver transplantation

Surgical outcome of pancreatic cancer using radical antegrade modular pancreatosplenectomy procedure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第39期18卷 5595-5600页

作者： Ye Rim Chang Sung-Sik Han Sang-Jae Park seung Duk Lee Tae Suk yoo Young-Kyu Kim Tae Hyun Kim Sang Myung Woo Woo Jin Lee Eun Kyung Hong Department of Surgery Seoul National University HospitalSeoul 110-744South Korea Center for Liver Cancer National Cancer CenterGyeonggido 411-764South Korea

AIM:To evaluate the surgical outcomes following radical antegrade modular pancreatosplenectomy (RAMPS) for pancreatic cancer. METHODS:Twenty-four patients underwent RAMPS with curative intent between January 2005 and June 2009 at the National Cancer Center, South Korea. Clinicopathologic data, including age, sex, operative findings, pathologic results, adjuvant therapy, postop-erative clinical course and follow-up data were retro-spectively collected and analyzed for this study. RESULTS:Twenty-one patients (87.5%) underwent distal pancreatectomy and 3 patients (12.5%) underwent total pancreatectomy using RAMPS. Nine patients (37.5%) underwent combined vessel resection, including 8 superior mesenteric-portal vein resections and 1 celiac axis resection. Two patients (8.3%) underwent combined resection of other organs, including the colon, stomach or duodenum. Negative tangential margins were achieved in 22 patients (91.7%). The mean tumor diameter for all patients was 4.09 ± 2.15 cm. The 2 patients with positive margins had a mean diameter of 7.25 cm. The mean number of retrieved lymph nodes was 20.92 ± 11.24 and the node positivity rate was 70.8%. The median survival of the 24 patients was 18.23 ± 6.02 mo. Patients with negative margins had a median survival of 21.80 ± 5.30 mo and those with positive margins had a median survival of 6.47 mo (P = 0.021). Nine patients (37.5%) had postoperative complications, but there were no postoperative mortalities. Pancreatic fistula occurred in 4 patients (16.7%):2 patients had a grade A fistula and 2 had a grade B fistula. On univariate analysis, histologic grade, positive tangential margin, pancreatic fistula and adjuvant therapy were significant prognostic factors for survival. CONCLUSION:RAMPS is a feasible procedure for achieving negative tangential margins in patients with carcinoma of the body and tail of the pancreas.

关键词： Carcinoma Pancreas Surgical resection Sur-vival Radical antegrade modular pancreatosplenectomy

Direct synthesis of highly conductive poly（3,4- ethylenedioxythiophene）：poly（4-styrenesulfonate）（PEDOT：PSS）/graphene composites and their applications in energy harvesting systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2014年第5期7卷 717-730页

作者： Dohyuk yoo Jeonghun Kim Jung Hyun Kim Department of Chemical and Biomolecular Engineering Yonsei University 50 Yonsei-ro Seodaemun-gu Seou1120-749 Republic of Korea Electronic Materials Division R&D Center Dongjin Semichem Co. Ltd. 625-3 Yodang-Ri Yanggam-Myeon Hwaseong-Gun Gyeonggi-Do Republic of Korea

We report for the first time highly conductive poly（3,4-ethylenedioxythiophene）： poly（4-styrenesulfonate）（PEDOT：PSS）/graphene composites fabricated by in situ polymerization and their applications in a thermoelectric device and a platinum （Pt）-free dye-sensitized solar cell （DSSC） as energy harvesting systems. Graphene was dispersed in a solution of poly（4-styrenesulfonate）（PSS） and polymerization was directly carried out by addition of 3,4-ethylenedioxythiophene （EDOT） monomer to the dispersion. The content of the graphene was varied and optimized to give the highest electrical conductivity. The composite solution was ready to use without any reduction process because reduced graphene oxide was used. The fabricated film had a conductivity of 637 ***-1, corresponding to an enhancement of 41%, after the introduction of 3 wt.% graphene without any further complicated reduction processes of graphene being required. The highly conductive composite films were employed in an organic thermoelectric device, and the device showed a power factor of 45.7 μW·m^-1K^-2 which is 93% higher than a device based on pristine PEDOT：PSS. In addition, the highly conductive composite films were used in Pt-free DSSCs, showing an energy conversion efficiency of 5.4%, which is 21% higher than that of a DSSC based on PEDOT：PSS.

关键词： direct synthesis conductive polymer graphene composite thermoelectric material dye-sensitized solar cell

Oxidative coupling of methane over LaAlO3 perovskite catalysts prepared by a co-precipitation method: Effect of co-precipitation pH value

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2019年第8期28卷 1-8,I0001页

作者： Yujin Sim Jihoon yoo Jeong-Myeong Ha Ji Chul Jung Department of Chemical Engineering Myongji UniversityYongin 17058 Republic of Korea Clean Energy Research Center Korea Institute of Science and TechnologySeoul 02792 Republic of Korea

Oxidative coupling of methane(OCM) was conducted over LaAlO3X catalysts that were prepared by a coprecipitation method using different co-precipitation pH values(X = 6–10). The aim is to investigate the effect of p H values on the catalytic activity of La AlO3 catalysts in this reaction. The results showed that the co-precipitation pH value affected greatly on the formation of chemical species of precipitate precursors in the co-precipitation step, leading to different phases of the finally obtained LaAlO3 *** the co-precipitation pH value increased up to 8, the lanthanum-related phases such as La2 O3 and La(OH)3 were gradually formed as by-products, preventing the formation of LaAlO3 perovskite crystalline structure and facilitating the formation of oxygen vacancies on catalyst surface. However, at pH value of9 or higher, the lanthanum content in the precipitate precursor was increased greatly. Not LaAlO3 perovskite but lanthanum-related phases were developed as main phases, reducing their catalytic activities in this reaction. Among LaAlO3 catalysts, the one prepared at pH = 8 showed the highest C2 yield due to its well-developed oxygen vacancies and electrophilic lattice oxygen. Therefore, the co-precipitation pH value strongly affected the LaAlO3 catalyst activity in OCM reaction. A precious pH control should be required to prepare various perovskite catalysts for the OCM.

关键词： LaAlO3 Perovskite Oxidative coupling of methane Co-precipitation pH value

Irritable bowel syndrome:Emerging paradigm in pathophysiology

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第10期20卷 2456-2469页

作者： yoo Jin Lee Kyung Sik Park Division of Gastroenterology and Hepatology Department of Internal Medicine Keimyung University School of Medicine Daegu 700-712 South Korea

Irritable bowel syndrome(IBS)is one of the most common gastrointestinal disorders,characterized by abdominal pain,bloating,and changes in bowel *** symptoms cannot be explained by structural abnormalities and there is no specific laboratory test or biomarker for ***,IBS is classified as a functional disorder with diagnosis dependent on the history taking about manifested symptoms and careful physical *** a great deal of research has been carried out in this area,the pathophysiology of IBS is complex and not completely *** factors are thought to contribute to the symptoms in IBS patients;altered gastrointestinal motility,visceral hypersensitivity,and the brain-gut interaction are important classical concepts in IBS *** areas of research in this arena include inflammation,postinfectious low-grade inflammation,genetic and immunologic factors,an altered microbiota,dietary factors,and enteroendocrine *** emerging studies have not shown consistent results,provoking controversy in the IBS ***,certain lines of evidence suggest that these mechanisms are important at least a subset of IBS patients,confirming that IBS symptoms cannot be explained by a single etiological ***,it is important to keep in mind that IBS requires a more holistic approach to determining effective treatment and understanding the underlying mechanisms.

关键词： Pathophysiology Irritable bowel syndrome Inflammation Immunologic Genetics Microbiota Diet Enteroendocrine cell