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Gene Expression Profile of Human Skeletal Muscle and Adipose Tissue of Chinese Han Patients with Type 2 Diabetes Mellitus

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Biomedical and Environmental Sciences 2009年第5期22卷 359-368页

作者： YAN-LI YANG RUO-LAN XIANG chang YANG XIAO-JUN LIU WEN-JUN SHEN JIN ZUO yong-sheng chang Fu-DE FANG Department of Internal Medicine Peking Union Medical College Hospital Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100730 China Department of Physiology and Pathophysiology Peking University Health Science Center BeiJing 100083 China National Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Peking Union Medical College & Chinese Academy of Medical Sciences Beijing 100005 China Division of Endocrinology Stanford University and VA Palo Alto Health Care System 3801 Miranda Avenue Palo Alto CA 94304 USA

Objective To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus （T2DM） patients and healthy subjects using DNA microarray analysis, Methods T2DM patiens were divided into female group, young male group and old male group. DNA microarray analysis and quantitative real-time PCR were carried out to anaIyze the relation between gene expressions and T2DM. Results The mRNA expression of 298, 578, and 350 genes was changed in the skeletal muscle of diabetes mellitus patients compared with control subjects. The 1320, 1143, and 2847 genes were modified in adipose tissue of the three groups. Among the genes surveyed, the change of 25 and 39 gene transcripts in skeletal muscle and adipose tissue was ≥2 folds, These differentially expressed genes were classified into 15 categories according to their functions. Conclusion New genes are found and T2DM can be prevented or cured.

关键词： Type 2 diabetes mellitus (T2DM) Microacray technology Skeletal muscle Adipose tissue

Expression of microRNA-29b2-c Cluster is Positively Regulated by MyoD in L6 Cells

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Chinese Medical Sciences Journal 2013年第3期28卷 140-146页

作者： chang-zheng Liu Jing-jing Li Jin-mei Su Tao Jiao Li-juan Gou Xiao-dong He yong-sheng chang Department of Biochemistry National Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Rheumatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objectives To evaluate the expression profile of myoD microRNA-29 （miR-29） family in L6 myoblast differentiated to myotube or L6 myotube treated by glucose and insulin, and to further probe the molecular mechanism o... 详细信息

关键词： myogenesis myoD microRNA-29

Efficacy of radiofrequency ablation combined with sorafenib for treating liver cancer complicated with portal hypertension and prognostic factors

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World Journal of Gastroenterology 2024年第11期30卷 1533-1544页

作者： Li-Min Yang Hong-Juan Wang Shan-Lin Li Guan-Hua Gan Wen-Wen Deng yong-sheng chang Lian-Feng Zhang Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Gastroenterology Zhoukou Central Hospital of Henan ProvinceZhoukou 466000Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453000Henan ProvinceChina

BACKGROUND Patients with liver cancer complicated by portal hypertension present complex challenges in *** To evaluate the efficacy of radiofrequency ablation in combination with sorafenib for improving liver function and its impact on the prognosis of patients with this *** Data from 100 patients with liver cancer complicated with portal hypertension from May 2014 to March 2019 were analyzed and divided into a study group(n=50)and a control group(n=50)according to the treatment *** research group received radiofrequency ablation(RFA)in combination with sorafenib,and the control group only received *** short-term efficacy of both the research and control groups was *** function and portal hypertension were compared before and after ***-fetoprotein(AFP),glypican-3(GPC-3),and AFP-L3 levels were compared between the two groups prior to and after *** occurrence of adverse reactions in both groups was *** 3-year survival rate was compared between the two *** data were compared between the survival and non-surviving *** identify the independent risk factors for poor prognosis in patients with liver cancer complicated by portal hypertension,multivariate logistic regression analysis was *** When comparing the two groups,the research group's total effective rate(82.00%)was significantly greater than that of the control group(56.00%;P<0.05).Following treatment,alanine aminotransferase and aspartate aminotransferase levels increased,and portal vein pressure decreased in both *** degree of improvement for every index was substantially greater in the research group than in the control group(P<0.05).Following treatment,the AFP,GPC-3,and AFP-L3 levels in both groups decreased,with the research group having significantly lower levels than the control group(P<0.05).The incidence of diarrhea,rash,nausea and vomiting,and fatigue in the research group was significantly great

关键词： Radiofrequency ablation Sorafenib Liver cancer Portal hypertension Efficacy Prognosis analysis

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小肠间质瘤的临床特点及误诊因素

世界华人消化杂志 2016年第32期24卷 4409-4414页

作者：常勇生王进郑州大学第一附属医院消化内科河南省郑州市450052

目的探讨小肠间质瘤(small intestine stromal tumors,SIST)的临床特点及误诊因素.方法回顾性分析郑州大学第一附属医院2010-01/2015-01收治的104例经病理证实为S I S T患者的临床表现、病变部位、肿瘤大小、诊断方法、危险度分级等临... 详细信息

目的探讨小肠间质瘤(small intestine stromal tumors,SIST)的临床特点及误诊因素.方法回顾性分析郑州大学第一附属医院2010-01/2015-01收治的104例经病理证实为S I S T患者的临床表现、病变部位、肿瘤大小、诊断方法、危险度分级等临床资料.结果临床常见症状主要包括腹部包块6 7例(64.5%)、消化道出血47例(52.8%)、腹痛47例(52.8%).病变部位以空肠多见,占45.2%,其次是回肠(29.8%)、十二指肠(25.0%).本研究中该病误诊率高达34.6%,极易误诊为妇科肿瘤(15/36)、消化系平滑肌瘤(6/36)等疾病,其误诊与临床表现、肿瘤部位、肿瘤大小、生长方式、检查方法等因素有关.结论S I S T是多发于空肠且以腹部包块、消化道出血等为常见临床表现的胃肠道间质瘤,其临床误诊率较高,故对于彩超、CT及消化内镜不能明确诊断的反复消化道出血、腹部包块患者及时行手术活检及免疫组化等检查,以便早期诊断,避免误诊.

关键词：小肠间质瘤临床特点误诊

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： Yu‑Ze Wang Yu‑chang Wang Ting‑Ting Liu Quan‑Liang Zhao Chen‑Sha Li Mao‑sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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一种磨机矿浆浓度监测调节系统

有色矿冶 2019年第1期35卷 49-52页

作者：雍长胜中国有色(沈阳)冶金机械有限公司辽宁沈阳110027

随着国家政策和产业结构的调整,装备制造业将朝着大型化、智能化、绿色环保、工艺系统集成化等趋势发展。针对溢流型球磨机在选矿系统中的应用,从工艺、结构和原理等多方面详细阐述了一种球磨机的矿浆浓度监测调节系统。该系统主要用于... 详细信息

随着国家政策和产业结构的调整,装备制造业将朝着大型化、智能化、绿色环保、工艺系统集成化等趋势发展。针对溢流型球磨机在选矿系统中的应用,从工艺、结构和原理等多方面详细阐述了一种球磨机的矿浆浓度监测调节系统。该系统主要用于解决选矿工艺系统中上下工序处理能力不平衡的问题,有效地避免了矿浆堆积、溢出,殃及周边设施的现象发生,减免了清理溢出矿浆的麻烦劳动,保证了选矿系统处理能力的平衡和系统设备的长期稳定生产。并有效地利用了资源,节省了能源,使选矿系统环保高效。

关键词：球磨机矿浆堆积浓度检测平衡环保

Constructing 2D bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction

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Tungsten 2025年第1期7卷 71-79页

作者： Ruo-Hang Xu Hao-Yu Jiang Dan-Dan Cui Kun-Rong Du Hong-Run Zhang sheng-Jie Xu Ya-Qi Li Zhi-Zhen Ren Liang Wang Wei-chang Hao Yi Du School of Physics and BUAA-UOW Joint Research Centre Beihang University Shenzhen Institute of Beihang University Centre for Catalysis and Clean Energy School of Environment and Science Griffith University

Reforming carbon dioxide（CO2） into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply *** recombination of photocarriers remains a major obstacle,however,to enhancing solar energy conversion efficiency in the photocatalytic reaction *** two-dimensional materials,constructing heterogeneous structures has emerged as an effective strategy to enhance the separation of photoexcited carriers by leveraging the internal electric field at the heterogeneous ***,we present a facile strategy for preparing Bi4NbO8Br/Bi2WO6plate-on-plate Z-scheme junctions with a strong internal electric field by in situ *** unique heterostructure facilitates efficient separation and transport of photoexcited charges by harnessing the internal electric field induced by chemical bonding at the lateral ***,the Bi4NbO8Br/Bi2WO6heterostructure exhibits enhanced CO2photoreduction properties,along with a CO yield rate of approximately 35 μmol·g-1·h-1under full light *** work offers novel insights into the synthesis of unique hetero structures intended to enhance the efficiency of photocatalytic CO2reduction.

关键词： Bi4NbO8Br/Bi2WO6 CO2 reduction Heterostructures Photocatalysts

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期68卷 46-95页

作者： Zhong-Liang Gong Hong-Jie Zhang Yan Cheng Jianxun Liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong yong Chen chang-Jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry

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变频器在多功能电解天车中的应用

有色矿冶 2011年第3期27卷 81-83页

作者：苏玉飞雍长胜中国有色(沈阳)冶金机械有限公司辽宁沈阳110141

随着科技水平的不断提高,铝行业设备也进入了自动化控制的领域。交流变频器由于其转速可控、运行稳定、观察方便、故障可见和减少故障等特点,被应用到铝行业当中。本文介绍电解天车采用交流变频器来实现其调速功能,详细叙述了变频的无... 详细信息

随着科技水平的不断提高,铝行业设备也进入了自动化控制的领域。交流变频器由于其转速可控、运行稳定、观察方便、故障可见和减少故障等特点,被应用到铝行业当中。本文介绍电解天车采用交流变频器来实现其调速功能,详细叙述了变频的无级调速方式。

关键词：变频器电解车 PLC 无级调速