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Transcutaneous electrical acupoint stimulation benefits postoperative pain relief of oocyte retrieval:A randomized controlled trial

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Journal of Integrative Medicine 2024年第1期22卷 32-38页

作者： Li-ying Liu Yang Su Rong-rong Wang Yuan-yuan Lai Lei Huang Yi-ting Li Xin-yue Tao meng-hua Su Xiao-yan Zheng Shi-chen Huang yong-na Wu Si-yi Yu Fan-rong Liang Jie Yang Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610000Sichuan ProvinceChina Traditional Chinese Medicine Department Sichuan Jinxin Xi’nan Women's and Children's HospitalChengdu 610000Sichuan ProvinceChina

Background Transvaginal oocyte retrieval is frequently followed by adverse events related to anesthesia and the *** research showed that transcutaneous electrical acupoint stimulation(TEAS)can relieve intraoperative pain and postoperative *** This study examined whether TEAS can alleviate pain and relieve adverse symptoms after oocyte ***,setting,participants and interventions Altogether 128 patients were randomly divided into the TEAS group and the mock TEAS *** two groups received a 30-minute-long TEAS or mock TEAS treatment that began 30 min after oocyte *** outcome measures The primary outcome was the visual analog scale(VAS)pain *** outcomes were pressure pain threshold,McGill score,pain rating index(PRI),present pain intensity(PPI),VAS stress score,VAS anxiety score,and postoperative adverse *** The baseline characteristics of the two groups were comparable(P>0.05).The VAS pain scores of the TEAS group were lower than those of the mock TEAS group at 60 and 90 min after oocyte retrieval(P0.05).The TEAS group was superior to the mock TEAS group for relieving postoperative adverse symptoms(P<0.05).Conclusion TEAS treatment can relieve postoperative pain and postoperative adverse symptoms for patients undergoing oocyte retrieval.

关键词： Transcutaneous electrical acupoint stimulation Fertilization Embryo transfer Oocyte retrieval Pain Randomized controlled trial

治疗前血清尿酸对高血压性急性心力衰竭患者预后的预测价值

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中国急救复苏与灾害医学杂志 2024年第7期19卷 841-844,854页

作者：赵俊凤张楠孟永黄骅市人民医院心内科河北沧州061100 昆明医科大学基础医学院药理学系云南昆明650000 昆明医科大学第二附属医院心内科云南昆明650106

目的探讨高血压性急性心力衰竭患者治疗前的血清尿酸(sua)水平与治疗后疾病严重程度及5年病死率的相关性。方法选取了河北省沧州市黄骅市人民医院2019年9月—2022年9月收治的122例高血压性急性心力衰竭患者,根据入院时的sua水平将其... 详细信息

目的探讨高血压性急性心力衰竭患者治疗前的血清尿酸(sua)水平与治疗后疾病严重程度及5年病死率的相关性。方法选取了河北省沧州市黄骅市人民医院2019年9月—2022年9月收治的122例高血压性急性心力衰竭患者,根据入院时的sua水平将其分为高尿酸血症组(男性sua≥420μmol/L,女性sua≥360μmol/L)和正常尿酸组,比较两组患者的基线特征、临床表现和5年随访结果。采用多变量Cox回归模型评估sua水平对5年病死率的影响,并使用Kaplan-Meier生存曲线进行生存分析。比较两组左心室功能和心血管不良事件(MACE)。结果高尿酸血症组患者的BMI、白细胞、白蛋白、肌酐、尿素氮、胆固醇、低密度脂蛋白胆固醇sua水平显著高于正常尿酸组,血小板和肾小球滤过率显著低于正常尿酸组(P0.05)。此外,尽管高尿酸血症组的MACE发生率偏高,但两组间差异并无统计学意义(P>0.05)。结论在高血压性急性心力衰竭患者群体中,治疗前sua水平与疾病严重程度以及5年病死率增加相关。治疗前高水平sua可预测高血压性急性心力衰竭患者的不良结局。

关键词：高血压性急性心力衰竭尿酸预后

老年2型糖尿病患者肌少症与血尿酸相关性的研究

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中国糖尿病杂志 2024年第8期32卷 613-616页

作者：顾思雯徐静樊勇新疆医科大学第一附属医院内分泌科乌鲁木齐830000

目的探讨老年T2DM患者肌少症与血尿酸(_(sua))的相关性。方法选取2022年1月至2023年9月于新疆医科大学第一附属医院内分泌科住院治疗的T2DM患者522例,根据是否合并肌少症分为单纯T2DM组(n=431)和T2DM合并肌少症组(Sar,n=91)。按照_(BMI... 详细信息

目的探讨老年T2DM患者肌少症与血尿酸(_(sua))的相关性。方法选取2022年1月至2023年9月于新疆医科大学第一附属医院内分泌科住院治疗的T2DM患者522例,根据是否合并肌少症分为单纯T2DM组(n=431)和T2DM合并肌少症组(Sar,n=91)。按照_(BMI)四分位数分为Q1_(BMI)组(≤23.70 kg/m^(2))、Q2_(BMI)组(23.80~26.10 kg/m^(2))、Q3_(BMI)组(26.20~29.00 kg/m^(2))、Q4_(BMI)组(>29.00 kg/m^(2)),另按照_(sua)四分位数分为Q1_(sua)组(≤269.00μmol/L)、Q2_(sua)组(269.01~313.00μmol/L)、Q3_(sua)组(313.01~363.00μmol/L)、Q4_(sua)组(>363.00μmol/L)。比较各组一般资料及生化指标,Pearson相关分析四肢骨骼肌质量指数(ASMI)与其他指标的相关性,Logistic回归分析老年T2DM合并患肌少症的影响因素。结果Sar组年龄、Hb A1c、2 hPG高于T2DM组,_(BMI)、FC-P、_(sua)、ASMI、握力、步速低于T2DM组(Psua)呈正相关(Psua)仍是老年T2DM合并肌少症的影响因素。Q1_(BMI)、Q2_(BMI)组肌少症发生风险高于Q4_(BMI)组(Psua)组肌少症发生风险高于Q4_(sua)组(Psua)是老年T2DM合并肌少症的保护因素,_(sua)偏低的老年T2DM患者更易发生肌少症。

关键词：糖尿病,2型肌少症血尿酸影响因素

脑血管病急性期血尿酸/血肌酐比值与脑血管事件复发及死亡的关系:一项前瞻性队列研究

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中国全科医学 2025年第2期28卷 175-182,192页

作者：任小乔王盼吴昊纪勇石志鸿天津医科大学神经内外科及神经康复临床学院天津市300070 天津市环湖医院 300350

背景脑卒中在世界各地有较高的死亡率和复发率。血尿酸(sua)是嘌呤代谢的产物,已被认为是心脑血管病的危险因素。血尿酸/血肌酐比值(sua/Scr)是代表肾功能标准化的sua,目前有关sua/Scr在急性脑血管病中的作用仍有争议。目的探讨脑血管... 详细信息

背景脑卒中在世界各地有较高的死亡率和复发率。血尿酸(sua)是嘌呤代谢的产物,已被认为是心脑血管病的危险因素。血尿酸/血肌酐比值(sua/Scr)是代表肾功能标准化的sua,目前有关sua/Scr在急性脑血管病中的作用仍有争议。目的探讨脑血管病急性期sua/Scr与脑血管事件复发和死亡的关系。方法本研究为前瞻性队列研究,选取2006年9月—2019年9月天津市环湖医院连续收治的首次发生脑血管事件的13313例患者为研究队列,并对患者进行随访,随访截至2020年9月。随访方式为门诊及电话相结合。随访主要终点事件为全因死亡,次要终点事件为脑血管事件复发、心血管事件复发、其他血管事件发生(如下肢动静脉栓塞)。采用Cox比例风险回归模型探究sua/Scr与脑血管事件复发与死亡的关系。结果根据脑血管病急性期sua/Scr四分位数,将患者分为Q1组(sua/Scr≤3.16,n=3520)、Q2组(3.16sua/Scr≤3.94,n=3280)、Q3组(3.94sua/Scr≤4.92,n=3270)、Q4组(sua/Scr>4.92,n=3243)。截至随访结束,774例(5.8%)患者死亡,2064例(15.5%)患者复发脑血管事件。脑血管病急性期sua/Scr位于Q1~Q4的患者中,男性复发脑血管病的例数依次为302、375、408、337例,女性依次为99、125、169、249例;男性复发脑梗死的例数依次为261、314、345、283例,女性依次为90、101、142、205例;男性复发大动脉粥样硬化型脑梗死的例数依次为154、191、214、183例,女性依次为58、52、45、31例;男性全因死亡的例数依次为165、128、131、88例,女性依次为57、63、62、80例;男性因脑梗死死亡的例数依次为93、72、70、46例,女性依次为31、33、36、44例;男性因大动脉粥样硬化型脑梗死死亡的例数依次为58、52、45、31例,女性依次为17、18、27、24例。调整多项混杂因素后,sua/Scr位于Q4相较于Q1是男性急性脑梗死复发的影响因素(HR=0.690,95%CI=0.500~0.953,P=0.026);sua/Scr位于Q4相较于Q1是男性脑梗死亚组患者大动脉粥样硬化型脑梗死复发的影响因素(HR=0.740,95%CI=0.578~0.947,P=0.017)。sua/Scr位于Q4相较于Q1是男性全因死亡、因脑梗死死亡的影响因素(HR=0.575,95%CI=0.368~0.901,P=0.003;HR=0.610,95%CI=0.353~0.814,P=0.011)。sua/Scr位于Q3、Q4相较于Q1是男性出院后死亡的影响因素(HR=0.656,95%CI=0.476~0.904,P=0.010;HR=0.582,95%CI=0.409~0.829,P=0.001)。sua/Scr位于Q4相较于Q1是男性脑梗死亚组患者因大动脉粥样硬化型脑梗死死亡的影响因素(HR=0.580,95%CI=0.386~0.873,P=0.007)。结论一定范围内,脑血管病急性期sua/Scr升高对男性患者脑血管事件复发及死亡有一定的保护作用,低sua/Scr与男性大动脉粥样硬化型脑梗死的死亡和复发风险升高有关,但与小动脉闭塞型脑梗死和心源性卒中复发和死亡无关。在女性患者中没有观察到sua/Scr与脑血管事件复发及死亡的关系。

关键词：脑血管障碍脑卒中血尿酸/血肌酐比值动脉粥样硬化男性复发死亡队列研究前瞻性研究 Cox比例风险回归模型

Influence Factors and Kinetics on Crystal Violet Degradation by Fenton and Optimization Parameters using Response Surface Methodology

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Influence Factors and Kinetics on Crystal Violet Degradation...

Detection of antimicrobial resistance and virulence-related genes in Streptococcus uberis and Streptococcus parauberis isolated from clinical bovine mastitis cases in northwestern China

International Conference on Environmental and Agriculture Engineering（ICEAE 2011）

作者： Chengyuan sua b yong Wanga a. School of Municiple and Environmental Engineering Harbin Institute of Technology Harbin China b. School of Environment and Resources Guangxi Normal University The Guangxi Key Lab of Environmental Engineering Protection and Assessment Guilin China

This work investigated influence factors and kinetics on crystal degradation violet dye by Fenton. For FeSO4 dose, fitted the date of crystal violet concentration and time, it conformed to first-order kinetic. At 0.1ml H2O2, decolorization rate was 98.2% and it increased to 98.7% when H2O2 was raised to 0.2ml at 15 min. However, H2O2 doses higher than 0.4ml, no obvious increased in the removal was observed. An important pH effect was found, reaching its degradation at pH 2.0 with decolorization rate of 97% at 30min. However, when pH was 4 and 6, the removal was only 79% and 72% at 40min. The Box-Behnken Response Surface Methodology was utilized for mathematical modeling for decolorization rate as a response by Fenton. The determinate coefficient of model was 0.9851. The optimum operating conditions were that FeSO4 dose was 4.55ml, H2O2 dose was 0.20ml and reaction time was 15min. Under such conditions, the error of the model predicted and experimental values was 1.85%.

关键词： Response surface methodology Box-Behnken design crystal violet decolorization

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Journal of Integrative Agriculture 2020年第11期19卷 2784-2791页

作者： ZHANG Hang YANG Feng LI Xin-pu LUO Jin-yin WANG Ling ZHOU Yu-long YAN yong WANG Xurong LI Hong-sheng Lanzhou Institute of Husbandry and Pharmaceutical Sciences Chinese Academy of Agricultural Sciences/Key Lab of Veterinary Pharmaceutical DevelopmentMinistry of Agriculture and Rural Affairs/Engineering and Technology Research Center of Traditional Chinese Veterinary MedicineLanzhou 730050P.R.China

The objectives of this study were to investigate antimicrobial resistance of Streptococcus uberis and Streptococcus parauberis isolated from cows with bovine clinical mastitis in China and to examine the distribution of resistance-and virulence-related gene *** susceptibility was determined by the *** encoding antimicrobial resistance and invasiveness factors were examined by PCR.A total of 27 strains were obtained from 326 mastitis milk *** parauberis isolates(n=11)showed high resistance to erythromycin(90.9%),followed by tetracycline(45.5%),chloramphenicol(36.4%)and clindamycin(27.3%).Streptococcus uberis isolates(n=16)were highly resistant to tetracycline(81.3%)and clindamycin(62.5%).Both species were susceptible to *** most prevalent resistance gene in *** was tetM(80.0%),followed by blaZ(62.5%)and ermB(62.5%).However,tetM,blaZ,and ermB genes were only found in 27.3,45.5,and 27.3%,respectively,of *** addition,all of the isolates carried at least one selected virulence-related *** most prevalent virulence-associated gene pattern in the current study was sua+pauA/skc+gapC+hasC detected in 22.2%of the *** *** strain carried 7 virulence-associated genes and belonged to the sua+pauA/skc+gapC+cfu+hasA+hasB+hasC *** than 59.3%of analysed strains carried 4 to 7 virulence-related *** findings demonstrated that *** and *** isolated from clinical bovine mastitis cases in China exhibited diverse molecular ecology,and that the strains were highly resistant to antibiotics commonly used in the dairy cow *** data obtained in the current study contribute to a better understanding of the pathogenesis of bacteria in mastitis caused by these pathogens,and the findings are relevant to the development of multivalent vaccines and targeted prevention procedures.

关键词： bovine mastitis Streptococcus uberis Streptococcus parauberis antimicrobial resistance virulence gene

随机尿尿酸/肌酐在克拉玛依地区高尿酸血症患者分型诊断中的应用

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检验医学 2024年第9期39卷 859-864页

作者：王晓妹罗超帖阳贺勇杨喜奎刘雅琳孙悦王福刚何訸克拉玛依市中西医结合医院(市人民医院)检验科新疆克拉玛依834000 四川大学华西医院实验医学科四川成都610072

目的探讨随机尿尿酸/肌酐(UA/Cr)在克拉玛依地区高尿酸血症(HUA)患者分型诊断中的应用价值。方法选取2022年4月—2023年5月克拉玛依市中西医结合医院(市人民医院)HUA患者126例(HUA)组、健康体检者124名(对照组)。检测所有研究对象总胆固... 详细信息

目的探讨随机尿尿酸/肌酐(UA/Cr)在克拉玛依地区高尿酸血症(HUA)患者分型诊断中的应用价值。方法选取2022年4月—2023年5月克拉玛依市中西医结合医院(市人民医院)HUA患者126例(HUA)组、健康体检者124名(对照组)。检测所有研究对象总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)、血清尿素(SU)、血清尿酸(sua)、血清肌酐(SCr)、尿尿酸(UUA)、尿肌酐(UCr)水平。采用Spearman分析评价HUA组随机尿UA/Cr与24 h尿尿酸排泄量(UUE)和肾脏尿酸排泄分数(FEUA)的相关性。采用受试者工作特征(ROC)曲线评价随机尿UA/Cr判断HUA患者分型的效能。结果HUA组和对照组性别、年龄、TC、HDL-C、SU、肾小球滤过率(eGFR)差异均无统计学意义(P>0.05)。HUA组体重指数、TG、FBG、sua、SCr均显著高于对照组(P0.302;其他型随机尿UA/Cr分型临界值为≥0.297且≤0.302;混合型无法依据统计学结果筛选。结论随机尿UA/Cr对克拉玛依地区HUA分型有一定参考价值。

关键词：随机尿尿酸/肌酐高尿酸血症尿酸排泄量尿酸排泄分数

Association between Physical Activity and Higher Serum Creatinine/Uric Acid by Dose-response Association

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Biomedical and Environmental Sciences 2018年第10期31卷 769-772页

作者： XU Chun Jie LIU Xiao Yu WANG yong Bin GUO Chun Yue YIN Su Feng FAN Hong Min FENG FU Min YUAN Ju Xiang HU Bo School of Public Health North China University of Science and Technology Department of Respiratory Medicine Kailuan General Hospital North China University of Science and Technology

Serum creatinine （Scr） and serum uric acid （sua）arecloselyrelatedchronicdiseaseorassociated *** elevated Scr or higher sua level are independent risk factors for cardiovascular disease as well as gout and insulin ... 详细信息

关键词： CI PA RCS SAS

Predictive value of serum uric acid on cardiovascular disease and all-cause mortality in urban Chinese patients

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Chinese Medical Journal 2010年第11期123卷 1387-1391页

作者： WU yong-quan LI Jue XU Yuan-xi WANG yong-liang LUO Ying-yi HU Da-yi LIU Wei-jing YANG Ming PI Lin WANG Ming-sheng WANG Ji-yun ZHAO Shu-mei LI Mei-jing Department of Cardiology Beijing Friendship Hospital affiliated toCapital Medical University Beijing 100050 China Heart Lung and Blood Vessel Centre Medical School of TongjiUniversity Shanghai 200065 China Department of Cardiology Tongji Hospital of Tongji UniversityShanghai 200065 China Department of Cardiology Shanghai 10th Hospital Shanghai200072 China Department of Cardiology Beijing Fuxing Hospital affiliated toCapital Medical University Beijing 100038 China Department of Cardiology - B-eijing Chuiyangliu HospitalBeijing100022 China Department of cardiology Beijing Shijingshan HospitalBeijing100043 China Department of Cardiology Beijing Tongren Hospital Affiliated toCapital Medical University Beijing 100005 China Department of Cardiology Shanghai Oriental Hospital Shanghai200120 China

Background The association between increased serum uric acid （sua） levels and cardiovascular risk has been debated for decades. Several large studies have provided conflicting results regarding the clinical significance of elevated sua levels in cardiovascular disease （CVD） or cerebrovascular disease. The aim of this study was to investigate the relationship between sua and CVD and all-cause mortality and their potential diagnostic value. Methods A total of 3570 in-patients ranging in age from 56 to 95 years （mean （67.36_＋11.36） years） were selected from 20 hospitals in Beijing and Shanghai. A carefully designed questionnaire was used to gather baseline data of each patient All patients were divided into two main groups according to their sua levels： high sua and normal sua groups. Serum indices and other important parameters were measured. Results Compared with normal sua group, high sua group had significant difference in systolic blood pressure （SBP）, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, body mass index （BMI）, and age （P 〈0.05 or P 〈0.01）. High sua prevailed in female and patients with history of essential hypertension, while history of smoking and diabetes showed no significant difference between two groups. All-cause and CVD mortality occurred more frequently in high sua group than in normal sua group. In the accumulative survival analysis, high sua group had lower survival rate than normal sua group both in CVD and all-cause mortality. COX regression analysis indicated that the history of smoking, age and high sua were independent risk factors for the development of CVD. Conclusions These preliminary observations suggest that patients with high sua levels would face higher risk of mortality. sua measurement may be applied as a routine predictor for clinical assessment.

关键词： serum uric acid, cardiovascular disease mortality