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World Journal of Gastroenterology 2000年第3期6卷 371-373页

作者： Yang SZ Huang YD Jie XF Feng ym niu JY Chinese Acad Sci Shanghai Inst Biochem Shanghai 200031 Peoples R China

AIM To study the relationship between insulinA chain regions and insulin biological activities,we designed a series of insulin analogues withchanges at A21,A12-18 of C-terminal helicalregion and A8-10 Iocated in the region of A6-A11intra-chain disulphide *** Insulin A-chain analogues wereprepared by stepwise Fmoc solid-phase manualsynthesis and then combined with natural B-chain of porcine insulin to yield correspondinginsulin *** biological activitieswere tested by receptor binding,mouseconvulsion and immunological ***[A21Ala]Ins retains 70.3% receptorbinding capacity and 60% in vivo biologicalactivity.[DesA13-14,A21Ala]Ins and[DesA12-13-14-15,A21Ala]Ins still have definite biologicalactivity,7.9% and 4.0% receptor binding,and6.2% and 3.3% in vivo biological activityrespectively.[A15Asn,A17Pro,A21Ala]Insmaintains 10.4% receptor binding and 10% invivo biological activity.[A8His,A9Arg,A10Pro,A21Ala]Ins,[A8His,A9Lys,A10Pro,A21Ala]Insand [A8His,A9Lys,A10Arg,A21Ala]Ins have51.9%,44.3% and 32.1% receptor bindingrespectively,50%,40% and 30% in vivobiological activity respectively,and 28.8%,29.6% and 15.4% immunological activityrespectively. CONCLUSION A21Asn can be replaced bysimple amino acid *** A chains withgradually damaged structural integrity in A12-18helical region and the demolition of the A12-18helical region by the substitution of Pro and Asnfor A17Glu and A15Gln respectively can combinewith the B chain and the combination productsshow definite biological activity,the helicalstructure of A12-18 is essential for biologicalactivities of insulin.A8-10 is not muchconcerned with biological activities,but is muchmore important antigenically in binding to itsantibodies,these results may help us design anew type of insulin analogue molecule.

关键词： insulin/chemistry biological activities A chain analogues

Study on Speciation of Pr(III) in Human Blood Plasma by Computer Simulation

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Chinese Chemical Letters 2000年第3期11卷 263-264页

作者： Liu, ym Han, JF Wu, ZJ Wang, Y Yang, KY niu, CJ Ni, JZ Chinese Acad Sci Changchun Inst Appl Chem Lab Rare Earth Chem & Phys Changchun 130022 Peoples R China

Speciation of Pr(III) in human blood plasma has been investigated by computer simulation. The speciation and distribution of Pr(III) has been obtained. It has been found that most of Pr(III) is bound to phosphate and ... 详细信息

关键词： speciation praseodymium(III) computer simulation

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Reconstitution activity of partial metallocluster-deficient molybdenum-iron protein of nitrogenase with a series of molybdenum-sulfur compounds

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Chinese Science Bulletin 1997年第10期42卷 868-871页

作者： Xu, JQ Nan, ym Liu, Y Zhou, XH Chen, YD niu, SY Wang, TG Huang, JF Luo, AL Wang, ZP Zhong, ZP Li, JG Department of Chemistry Jilin University Changchun China Institute of Botany Chinese Academy of Sciences Beijing China

RECENTLY,the structure of MoFe protein from Azotobacter vinelandii has been deter-mined,and based on this,the structural models of FeMo-co and P-clusters in MoFe proteinhave been *** to the model,FeMo-co consists of two clusters,Fe4S3 andMoFe3S3 with a homocitrate ligand coordinated to Mo atom,bridged by three nonprotein lig-ands,two of which are inorganic sulfur atoms and the other is nitrogen- or

关键词： MoFe protein nitrogenase molybdenum-sulfur compound.

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The Cognition of Palliative Nursing among Nursing Students at Different Levels after Clinical Practice: A Survey Study

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Yangtze Medicine 2018年第2期2卷 73-81页

作者： Zhenjun niu Hong Zhou Department of Medicine Yangtze University Jingzhou China

Objective: To understand the status of cognition of palliative nursing among nursing students at different levels, and provide a basis for palliative nursing education. Methods: 268 nursing students from different levels were investigated by the palliative nursing cognition questionnaire and Chinese version of palliative nursing knowledge questionnaire (PCQN). Results: Students with clinical probation and from non single parent family normally have higher knowledge scores than those without clinical probation and from single parent families (p Conclusion: It’s important for schools and hospitals to strengthen the theory teaching of palliative nursing, combine clinical practice with the theory education closely and improve the teaching level of teachers, which are aimed to promote the rapid development of palliative care.

关键词： Nursing Students Palliative Nursing Cognition

POLAR COORDINATES FOR THE GENERALIZED BAOUENDI-GRUSHIN OPERATOR AND APPLICATIONS

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Journal of Partial Differential Equations 2007年第4期20卷 322-336页

作者： Dou Jingbo niu Pengcheng Han Junqiang Department of Applied Mathematics Northwestern Polytechnical University Xi'an 710072 China

In this parer, by using the polar coordinates for the generalized Baouendi- Grushin operatorLα=∑i=1^n 偏d^2/偏dxi^2＋∑j=1^m｜x｜^2α偏d^2/偏dy^2j,where x = （x1,x2,……,Xn）∈R^n,y = （y1,y2,… ,ym） ∈,α 〉 0, we obtain the volume of the ball associated to Lα and prove the nonexistence for a second order evolution inequality which is relative to Lα.

关键词： Generalized Baouendi-Grushin operator polar coordinate nonexistence second order evolution inequality.

Antitumor Effect of Ginsenosides: A Systematic Review

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Yangtze Medicine 2021年第3期5卷 207-225页

作者： Jing Wu Shuaishuai niu Guan Li Qing Tian Ying Xiang Department of Morphology School of Basic Medicine Health Science Center Yangtze University Jingzhou China Laboratory of Oncology Center for Molecular Medicine School of Basic Medicine Health Science Center Yangtze University Jingzhou China Department of Cell Biology and Genetics School of Basic Medicine Health Science Center Yangtze University Jingzhou China

Tumor is a serious disease that threatens human health and has a high mortality. Chemotherapy is the most commonly used treatment, but it has a lot of side effects due to its toxicity. It has been found that ginsenosides exert an effective antitumor role. Ginsenosides are a class of triterpenoid saponins primarily found in the plant genus Panax. Many monomer components are studied, the most often investigated are Rg3, and Rh2, etc. Reports have shown that ginsenosides can inhibit tumor cells by suppressing proliferation and metastasis, and promoting apoptosis. In addition, ginsenosides can enhance sensitivity to conventional chemotherapeutic drugs. In this review, the recent articles about anti-tumor of ginsenosides were reviewed to promote the further development of anti-tumor therapy.

关键词： Ginsenosides Autophagy Apoptosis Proliferation Metastasis

两点边值问题的一个新数值法——插值矩阵法[注]

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合肥工业大学学报(自然科学版) 1987年第5期 92-102页

作者：牛忠荣

本文建立了一个新的数值法一插值矩阵法以及它的通用程序,用于求解单个的任意阶线性常微分方程边值问题和特征值问题。与常用的差分法,试射法和配点法相比,本法使用方便,计算中的稳定性好,收敛快。求得的y(x)、y′(x)、y″(x)、…,有相... 详细信息

本文建立了一个新的数值法一插值矩阵法以及它的通用程序,用于求解单个的任意阶线性常微分方程边值问题和特征值问题。与常用的差分法,试射法和配点法相比,本法使用方便,计算中的稳定性好,收敛快。求得的y(x)、y′(x)、y″(x)、…,有相同的有效位数。

关键词：积分矩阵配点法抛物线插值差分法数值分析插值基函数两点边值问题多项式插值插值矩阵法数值法

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多囊卵巢综合征代谢异常分析

第四军医大学学报 2005年第17期26卷 1569-1569页

作者：牛芳李亚梅张淑杰上海市青浦区中医医院妇产科上海市宝山区罗店医院妇产科上海市嘉定区南翔医院中医内科上海20170

1临床资料 2000-10／2005-3我院妇科内分泌门诊的多囊卵巢综合征（PCOS）患者25例，根据体质量指数（BMI）〉27（肥胖）及〈24（正常）分为肥胖PCOS组和非肥胖PCOS组，肥胖PCOS组：BMI 27．1±0．8，17例，年龄（24．2±2．9）岁；非肥... 详细信息

1临床资料 2000-10／2005-3我院妇科内分泌门诊的多囊卵巢综合征（PCOS）患者25例，根据体质量指数（BMI）〉27（肥胖）及〈24（正常）分为肥胖PCOS组和非肥胖PCOS组，肥胖PCOS组：BMI 27．1±0．8，17例，年龄（24．2±2．9）岁；非肥胖PCOS组：BMI 20．0±0．6，13例，年龄（23．7±3．2）岁，选择正常育龄妇女25例为对照组，也根据BMI分为肥胖对照组及非肥胖对照组。[第一段]

关键词：多囊卵巢综合征代谢疾病女性激素糖代谢脂代谢

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Ginsenoside Rg1 and Resveratrol Alleviate Acute Kidney Injury Induced by Cisplatin via Downregulation of Autophagy in Mice

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Yangtze Medicine 2021年第1期5卷 12-22页

作者： Yu Liu Jiao Qiu Ruiqiao Tan Qing Tian Li Guan Shuaishuai niu Sijia Huang Jing Huang Yunbo Yan Ying Xiang Laboratory of Oncology Center for Molecular Medicine School of Basic Medicine Health Science Center Yangtze University Jingzhou China Department of Cell Biology and Genetics School of Basic Medicine Health Science Center Yangtze University Jingzhou China

Background: Cisplatin, a chemotherapeutic agent, is widely used in the treatment of malignant tumors. Nephrotoxicity, especially acute kidney injury (AKI), is the most common and severe adverse reaction of cisplatin. Resveratrol and ginsenoside Rg1, two natural products, have been found to have renal protective effects. However, the effects and the mechanisms in cisplatin-induced AKI need further investigation. Methods: The mouse models of cisplatin-induced AKI and several treatment groups were established. Male C57BL/6 mice were divided into five groups: saline control group, cisplatin injury group, resveratrol treatment group, Rg1 treatment group, resveratrol and Rg1 combined treatment group. Serological analysis of serum urea nitrogen was aimed to reflect the function of kidney, and histological analysis of renal tissue sections was aimed to assess the damage of proximal convoluted tubules. The expression levels of autophagy-related proteins Beclin 1 and LC3 were detected by western blotting and qRT-PCR respectively. Results: The renal function was improved and renal damage was alleviated in Rg1 and resveratrol alone or combined treatment groups compared with the cisplatin injury group. For the mechanism, treatment with Rg1 and resveratrol alone or in combination decreased the expressions of Beclin 1 both at protein and mRNA levels, decreased LC3II/I protein levels, indicating that autophagy was inhibited by treatment with Rg1 and resveratrol alone or in combination. Conclusion: Resveratrol and Rg1 alleviated the kidney damage caused by cisplatin, and reduced autophagy was involved in the renoprotective effects of resveratrol and Rg1 against cisplatin-induced AKI. This study may provide new evidence to alleviate cisplatin-induced AKI.

关键词： Cisplatin Acute Kidney Injury Resveratrol Ginsenoside Rg1 Autophagy