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Radar false alarm plots elimination based on multi-feature extraction and classification

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The Journal of China Universities of Posts and Telecommunications 2024年第1期31卷 83-92页

作者： Cheng Yi Zhao Yan yin Peiwen School of Control Science and Engineering Tiangong UniversityTianjin 300387China Tianjin Key Laboratory of Intelligent Control of Electrical Equipment Tianjin 300387China

Caused by the environment clutter,the radar false alarm plots are *** false alarm points has always been a key issue in Radar plots *** this paper,a radar false alarm plots elimination method based on multi-feature extraction and classification is proposed to effectively eliminate false alarm ***,the density based spatial clustering of applications with noise(DBSCAN)algorithm is used to cluster the radar echo data processed by constant false-alarm rate(CFAR).The multi-features including the scale features,time domain features and transform domain features are ***,a feature evaluation method combining pearson correlation coefficient(PCC)and entropy weight method(EWM)is proposed to evaluate interrelation among features,effective feature combination sets are selected as inputs of the ***,False alarm plots classified as clutters are *** experimental results show that proposed method can eliminate about 90%false alarm plots with less target loss rate.

关键词： radar plots elimination density based spatial clustering of applications with noise multi-feature extraction classifier

Metaphors of Despair and Enlightenment: A Case Study Based on Du Fu's Four Poems on Sick or Withered Trees

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2024年第2期18卷 168-181页

作者： JIANG yin School of Chinese Language and Literature South China Normal UniversityGuangzhou 510006China

In the second year of the Shangyuan period(761),Du Fu wrote a quartet of poems on sick or withered *** are“The Sick Cypress,”“The Withered Palms,”“The Sick Orange Tree,”and“The Withered Nanmu Tree.”Different from his previous practice of using trees to embody personal aspirations,the poet employed sick or withered trees to allude social *** poems,rich with profound contemplation on individuals,society,and the Tang Dynasty,cover many important topics,such as the poet's bleak future,the decline of people's livelihoods,the immorality of rulers,and even the decline of the Tang *** poems reveal his disappointment with the future of his country and his personal *** disenchantment reflects the pivotal shift in Du Fu's later thoughts,revealing the impetus behind his relinquishment of political aspirations in favor of poetic *** this regard,this quartet of poems is the most thought-provoking exploration,with an undeniable value among Du Fu's later works.

关键词： Tang poetry Du Fu sick or withered trees despair enlightenment

Structural and Chemical Characterization of the Ediacaran Embryo-Like Fossils via the Combination of 3D-XRM and FIB-SEM Approaches

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Journal of Earth Science 2024年第4期35卷 1204-1214页

作者： Qian Chen Weichen Sun Suping Wu Zongjun yin State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing210008China University of Chinese Academy of Sciences Nanjing211135China

The three-dimensional(3D)morphology,anatomy,and in-situ chemical composition analysis of fossils are crucial for systematic paleontology and determining their phylogenetic *** electron microscopy(SEM)coupled with energy-dispersive X-ray spectroscopy(EDS),offers valuable structural and chemical information for the analysis of ***,its primary limitation is the restriction to two-dimensional surface data,which limits the exploration of fossils’3D ***,3D X-ray microscopy(3D-XRM),also known as a novel form of micro-computed tomography(micro-CT)facilitates the non-destructive 3D reconstruction of fossil ***,it lacks the capability to provide in-situ compositional *** the constraints inherent in these individual techniques,and in response to the evolving requirements of paleontological research,this study introduces an integrated approach that combines 3D-XRM with EDS-coupled focused ion beam scanning electron microscopy(FIB-SEM).This innovative strategy is designed to synergize the advantages of both techniques,thereby addressing challenges that conventional methods *** enables the rapid identification of regions of interest(ROI)within fossil specimens at micrometer ***,this method collects detailed data on both 3D structures and chemical compositions at the nanometer scale for the identified *** integrated approach represents a significant advancement in paleontological and geological research methodologies,promising to meet the increasing demands of these fields.

关键词： Embryo-like microfossils structural and chemical characterization 3D-XRM FIB-SEM 3D reconstruction

Targeting RAF dimers in RAS mutant tumors:From biology to clinic

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Acta Pharmaceutica Sinica B 2024年第5期14卷 1895-1923页

作者： Huanhuan yin Qiulin Tang Hongwei Xia Feng Bi Division of Abdominal Cancer Department of Medical OncologyCancer Center and Laboratory of Molecular Targeted Therapy in OncologyWest China HospitalSichuan UniversityChengdu 610041China

RAS mutations occur in approximately 30%of tumors worldwide and have a poor prognosis due to limited *** targeting of KRAS G12C has achieved significant success in recent years,but there is still a lack of efficient therapeutic approaches for tumors with non-G12C KRAS mutations.A highly promising approach is to target the MAPK pathway downstream of RAS,with a particular focus on RAF ***-generation RAF inhibitors have been authorized to treat BRAF mutant tumors for over a ***,their use in RAS-mutated tumors is not recommended due to the paradoxical ERK activation mainly caused by RAF *** address the issue of RAF dimerization,type II RAF inhibitors have emerged as leading *** clinical studies have shown the initial effectiveness of these agents against RAS mutant ***,type II RAF inhibitors in combination with MEK or ERK inhibitors have demonstrated impressive efficacy in RAS mutant *** review aims to clarify the importance of RAF dimerization in cellular signaling and resistance to treatment in tumors with RAS mutations,as well as recent progress in therapeutic approaches to address the problem of RAF dimerization in RAS mutant tumors.

关键词： RAS mutations RAF dimerization RAF inhibitors Cancer therapy Drug resistance

Aggressive fibromatosis of the sigmoid colon:A case report

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3716-3722页

作者： Pan-Pan Yu Xin-Chun Liu Lu yin Guang yin Department of Gastrointestinal and Anal Surgery The Affiliated Hangzhou First People's HospitalSchool of MedicineWestlake UniversityHangzhou 310006Zhejiang ProvinceChina Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina Department of Pathology The Affiliated Hangzhou First People's HospitalSchool of MedicineWestlake UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Aggressive fibromatosis(AF),also known as desmoid tumor or desmoid-type fibromatosis,is a rare soft tissue neoplasm that can occur in almost any part of the *** it is a benign disease,AF is aggressive and infiltrative and has a high recurrence rate after *** sites for intra-abdominal AF are the small bowel mesentery,retroperitoneum,and *** in the colon is extremely *** SUMMARY Here,we report the first case of sigmoid colon AF,which was accidentally discovered in a 27-year-old woman during laparoscopic *** tomography confirmed a slightly enhanced mass in the sigmoid *** colonoscopy did not reveal a mass in the colonic lumen,but a suspected external compress was found in the sigmoid *** disease involving a gastrointestinal stromal tumor was *** patient underwent laparoscopic exploration,and sigmoidectomy with a negative margin was performed to excise the *** immunohistochemistry revealed that the mass was an *** patient recovered well and was recurrence-free at the 30-month follow-up without adjuvant *** AF should be considered in the differential diagnosis of subepithelial colon *** resection alone can achieve good outcomes.

关键词： Aggressive fibromatosis Desmoid tumor Sigmoid mass Subepithelial tumor Case report

Joint Optimization of Resource Allocation and Trajectory Based on User Trajectory for UAV-Assisted Backscatter Communication System

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China Communications 2024年第2期21卷 197-209页

作者： Peizhong Xie Junjie Jiang Ting Li yin Lu School of Communication and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China Key Lab of Broadband Wireless Communication and Sensor Network Technology(Nanjing University of Posts and Telecommunications) Ministry of EducationNanjing 210003China

The Backscatter communication has gained widespread attention from academia and industry in recent years. In this paper, A method of resource allocation and trajectory optimization is proposed for UAV-assisted backscatter communication based on user trajectory. This paper will establish an optimization problem of jointly optimizing the UAV trajectories, UAV transmission power and BD scheduling based on the large-scale channel state signals estimated in advance of the known user trajectories, taking into account the constraints of BD data and working energy consumption, to maximize the energy efficiency of the system. The problem is a non-convex optimization problem in fractional form, and there is nonlinear coupling between optimization *** iterative algorithm is proposed based on Dinkelbach algorithm, block coordinate descent method and continuous convex optimization technology. First, the objective function is converted into a non-fractional programming problem based on Dinkelbach method,and then the block coordinate descent method is used to decompose the original complex problem into three independent sub-problems. Finally, the successive convex approximation method is used to solve the trajectory optimization sub-problem. The simulation results show that the proposed scheme and algorithm have obvious energy efficiency gains compared with the comparison scheme.

关键词： energy efficiency joint optimization UAV-assisted backscatter communication user trajectory

Constructing the metabolic network of wheat kernels based on structure-guided chemical modification and multi-omics data

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Journal of Genetics and Genomics 2024年第7期51卷 714-722页

作者： Zhitao Tian Jingqi Jia Bo yin Wei Chen National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research(Wuhan) Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

Metabolic network construction plays a pivotal role in unraveling the regulatory mechanism of biological activities,although it often proves to be challenging and labor-intensive,particularly with non-model *** this study,we develop a computational approach that employs reaction models based on the structure-guided chemical modification and related compounds to construct a metabolic network in *** construction results in a comprehensive structure-guided network,including 625 identified metabolites and additional 333 putative reactions compared with the Kyoto Encyclopedia of Genes and Genomes *** a combination of gene annotation,reaction classification,structure similarity,and correlations from transcriptome and metabolome analysis,a total of 229 potential genes related to these reactions are identified within this *** validate the network,the functionality of a hydroxycinnamoyltransferase(TraesCS3D01G314900)for the synthesis of polyphenols and a rhamnosyltransferase(TraesCS2D01G078700)for the modification of flavonoids are verified through in vitro enzymatic studies and wheat mutant tests,*** research thus supports the utility of structure-guided chemical modification as an effective tool in identifying causal candidate genes for constructing metabolic networks and further in metabolomic genetic studies.

关键词： Metabolic network Chemical modification Genetic study Wheat kernel Multi-omics

Annexin A1 in the nervous and ocular systems

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Neural Regeneration Research 2024年第3期19卷 591-597页

作者： Aijia Wang Hong Zhang Xing Li yin Zhao Department of Ophthalmology 2Department of AnesthesiologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

The therapeutic potential of Annexin A1,an important member of the Annexin superfamily,has become evident in results of experiments with multiple human systems and animal *** anti-inflammatory and pro-resolving effects of Annexin A1 are characteristic of pathologies involving the nervous *** this review,we initially describe the expression sites of Annexin A1,then outline the mechanisms by which Annexin A1 maintains the neurological homeostasis through either formyl peptide receptor 2 or other molecular approaches;and,finally,we discuss the neuroregenerative potential qualities of Annexin *** eye and the nervous system are anatomically and functionally connected,but the association between visual system pathogenesis,especially in the retina,and Annexin A1 alterations has not been well ***,we explain the beneficial effects of Annexin A1 for ocular diseases,especially for retinal diseases and glaucoma on the basis of published findings,and we explore present and future delivery strategies for Annexin A1 to the retina.

关键词： Annexin A1(ANXA1) glaucoma nervous system neuroprotection neuroregeneration ocular disease retina

Progress in approved drugs from natural product resources

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Chinese Journal of Natural Medicines 2024年第3期22卷 195-211页

作者： LUO Zhongwen yin Fucheng WANG Xiaobing KONG Lingyi State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Natural products (NPs) have consistently played a pivotal role in pharmaceutical research, exerting profound impactson the treatment of human diseases. A significant proportion of approved molecular entity drugs are either directly derived from NPs orindirectly through modifications of NPs. This review presents an overview of NP drugs recently approved in China, the United States,and other countries, spanning various disease categories, including cancers, cardiovascular and cerebrovascular diseases, centralnervous system disorders, and infectious diseases. The article provides a succinct introduction to the origin, activity, development process, approval details, and mechanism of action of these NP drugs.

关键词： New drugs Natural products Structural modification