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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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Effect of Heat Treatment on Prior Grain Size and Mechanical Property of a Maraging Stainless Steel

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Journal of Materials Science & Technology 2006年第6期22卷 769-774页

作者： Kai LIU yiyin SHAN Zhiyong YANG Jianxiong LIANG Lun LU Ke YANG Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Graduate School of Chinese Academy of Sciences Beijing 100039 China General Research Institute for Iron and Steel Beijing 100081 China Technical Center Dongbei Special Steel Group Co. Fushun 113001 China

Effect of the heat treatment, including solution treatment （ST） and aging treatment （AT）, on the prior austenite grain （PAG） size, microstructure and mechanical properties of a precipitation hardening maraging stainless steel was investigated. The results indicate that the relations between PAG size and yield strength （σy） under both ST and AT conditions obey the HalI-Petch relationship. Furthermore, after ST at 1050℃ for 1 h＋cryogenic treated （CT） at -70℃ for 8 h＋AT at 535℃ for 4 h, the tested steel showed its ultimate tensile strength （σb） and σy over 1900 MPa and 1750 MPa, respectively.

关键词： Martensite Microstructure Precipitation hardening Heat treatment

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Mitigating methodology of hardware non-ideal characteristics for non-volatile memory based neural networks

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Science China(Information Sciences) 2025年

作者： Lixia HAN Peng HUANG Yijiao WANG Zheng zhou Haozhang YANG Yiyang CHEN Xiaoyan LIU Jinfeng KANG School of Integrated Circuits Peking University Beijing Advanced Innovation Center for Integrated Circuits School of Integrated Circuit Science and Engineering Beihang University

Non-volatile memory-based computing-in-memory (nvCIM) paradigm has been extensively studied to boost the energy efficiency of neural network accelerators in edge ***,the degradation of inference accuracy induced by the non-ideal characteristics across circuits,arrays,and devices is becoming a crucial *** this work,we establish a hardware characteristic behavior model to analyze the impact of nvCIM non-ideal characteristics on neural network *** we propose a hardware aware training and weight mapping correction methods to mitigate inference accuracy *** simulation verification,about 95%inference accuracy degradation is recovered by adopting the proposed mitigation method for various non-ideal characteristics and various neural network *** feasibility of the proposed method is further proved in an experimental example with a flash-based LeNet recognition system.

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Thermally triggered topological polymerization in diacetylene-functionalized covalent organic framework toward enhanced memristive properties

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Science China Chemistry 2025年

作者： Panke zhou Yuxing Huang Ziyue Yu Cong Zhang Qian Chen Yiping Li Chao Lin Xiong Chen State Key Laboratory of Photocatalysis on Energy and Environment Key Laboratory of Advanced Carbon-Based Functional MaterialsCollege of Chemistry Fuzhou University

The development of stimuli-responsive switching memory devices and the elucidation of their switching mechanisms in specific environments are crucial for advancing the field of molecular electronics. Herein, we propose two distinct two-dimensional covalent organic frameworks (COFs), namely Py-EDA and Py-BDA, incorporating acetylene (-C≡C-) or diacetylene(-C≡C-C≡C-) moieties, respectively, targeting fabricate memory devices exhibiting stimuli-responsive switching *** findings demonstrate that the incorporation of acetylene units effectively modulates the electronic band structure and enhances the degree ofπ-conjugation, resulting in devices that exhibit typical bipolar nonvolatile memory performance. Notably,upon thermal treatment, the memory behavior of the ITO/Py-BDA/Ag device transitions to a write-once-read-many-times(WORM) mode, displaying decreased SET voltage, increased ON/OFF current ratio, and remarkable retention reliability and cycle stability. This switching behavior is attributed to the occurrence of interlayer solid-state topological polymerization at 350℃, leading to the transformation of diacetylene columnar arrays into enyne chains within Py-BDA, thereby further promoting interlayer charge transfer and separation.

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Enhanced Bio-corrosion Resistance by Cu Alloying in a Micro-alloyed Pipeline Steel

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Acta Metallurgica Sinica(English Letters) 2022年第10期35卷 1731-1743页

作者： Yunpeng Zeng Wei Yan Xianbo Shi Maocheng Yan yiyin Shan Ke Yang School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang110016China CAS Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

On the composition base of commercial X65 grade pipeline steels,a Cu modified pipeline steel was designed to show improved resistance to microbially induced corrosion(MIC).The mechanical properties of the Cu-added steel and its corrosion behavior in a soil solution inoculated with sulfate-reducing bacteria(SRB)were investigated in this *** results demonstrated that Cu-added steel exhibits a good combination of strength and *** ions released from the Cu-added steel could effectively kill the SRB attaching on the steel surface,thus evidently decreased the pit depth and diameter of Cu-added ***,during the long-term immersion,the Cu-rich film formed by the enrichment of Cu in the corrosion product layer on the steel surface could also contribute to the improvement of the bio-corrosion resistance of Cu-added steel.

关键词： Pipeline steel Mechanical property Microbiologically influenced corrosion Cu alloyed steel Corrosion mechanism Sulfate-reducing bacteria(SRB)

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生育支持与欠发达地区育龄女性的生育意愿——基于贵州省88个区县的生育意愿调查

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河南社会科学 2025年第1期33卷 91-101页

作者：周文贵州省社会科学院博士后工作站贵州贵阳550002 贵州财经大学经济学院贵州贵阳550025

生育支持已经成为强化青年生育意愿和生育行为的重要举措,然而受限于研究数据,以往的研究很少对欠发达地区各类生育支持及其效果进行研究。为了研究欠发达地区各类生育支持对育龄女性生育意愿的作用,基于贵州省88个区县的生育意愿调查数... 详细信息

生育支持已经成为强化青年生育意愿和生育行为的重要举措,然而受限于研究数据,以往的研究很少对欠发达地区各类生育支持及其效果进行研究。为了研究欠发达地区各类生育支持对育龄女性生育意愿的作用,基于贵州省88个区县的生育意愿调查数据,从政府政策支持、社会托育支持和家庭代际支持三个维度研究了生育支持对欠发达地区育龄女性生育意愿的影响。研究发现:(1)当前贵州育龄女性的生育意愿已经下降到了较低水平,未来生育水平有进一步下降的风险。(2)家庭代际支持、社会托育支持和政府政策支持对育龄女性的总体生育意愿都具有显著的促进作用,但只有政府政策支持和家庭代际支持对三孩生育意愿具有显著的影响,社会托育支持对三孩生育意愿的影响不显著。(3)异质性分析则发现各类生育支持对35岁以上的育龄女性影响较大,是对35岁以下年轻群体影响的两倍左右。各类支持对不同学历育龄女性的影响也出现了分化,总体上呈现出低学历女性受到家庭支持与政府政策支持影响较大,而高学历女性受到托育服务影响较大的特征。(4)各类生育支持方式对育龄女性生育意愿的协同效应十分显著,当各类生育支持都较强时,对育龄女性生育意愿的影响较大。基于上述结论,一方面,生育支持体系与生育支持政策既要坚持普惠性,又要兼顾不同群体差异化需求;另一方面,需要进一步完善生育支持体系,充分发挥各类生育支持的协同效应,让育龄女性在生育决策时有更多生育支持方式的选择。

关键词：生育支持体系生育意愿欠发达地区被访者驱动抽样调查

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Effect of Aging on Microstructure and Mechanical Property of 1900 MPa Grade Maraging Stainless Steel

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Journal of Materials Science & Technology 2007年第3期23卷 312-318页

The 18%Ni alloy steels provide high strength and toughness, while age-hardenable or PH stainless steels also have good corrosion resistance. This paper focuses on an investigation of the heat treatment, mechanical properties and microstructural development of a new maraging stainless steel. It is reported that the heat treatment process should consist of solution treatment and cryogenic cooling to attain a fully martensitic structure, followed by aging at 813 K. This heat treatment resulted in an ultimate tensile strength of over 1900 MPa combined with good impact toughness. Transmission electron microscopy is used to show that, for the peak-aged condition （813 K/4 h）, nano-sized precipitates, e.g. Ni3Mo and/or R-phase, and a high density of dislocations were uniformly dispersed in the lath martensite matrix. The calculated yield strength, based on a revised Orowan mechanism, is in good agreement with the test data. The steel studied has an ultimate tensile strength over 1900 MPa, excellent fracture toughness, and good resistance against over-aging and relatively good corrosion resistance as well.

关键词： Maraging stainless steels Precipitation High strength steels Aging treatment

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Government subsidies, dual-credit policy, and enterprise performance: Empirical evidence from Chinese listed new energy vehicle companies

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Chinese Journal of Population,Resources and Environment 2023年第2期21卷 71-81页

作者： Lingling Pei Hui Kong yiyin Xu School of Business Administration Zhejiang University of Finance&EconomicsHangzhou 310018China Business School Chengdu UniversityChengdu 611130China

The development of the new energy vehicle industry has become a key force driving the goals of carbon peak and carbon *** better guide future strategies,this study investigates the dual impact of subsidy and dual-integral policies on the performance of new energy vehicle *** study first theorizes the influential mechanism according to the institutional-based approach and technical innovation theory,and then collects data from listed companies in the new energy vehicle industry from 2016 to *** hypotheses are examined using a two-way fixed-effects *** findings show that:(1)subsidy policies are can still improve enterprise performance,but not through green technology innovation;(2)the dual-credit policy can improve enterprise performance through green technology innovation;and(3)under current policy conditions,with subsidies declining annually,the interaction effects between the subsidy and dual-integral policies will also ***,this study suggests that non-monetary industrial policy,represented by the dual credit policy is a more effective alternative to government subsidies.

关键词： New energy vehicles Enterprise performance Dual-credit policy Government subsidy policy Green technology innovation

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Integrated guidance and control with input saturation and disturbance observer

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Journal of Control and Decision 2018年第3期5卷 277-299页

作者： Wangkui Liu yiyin Wei Guangren Duan Mingzhe Hou Center for Control Theory and Guidance Technology Harbin Institute of TechnologyHarbinChina ChinaAerospace Science and Industry Corporation BeijingChina

In presence of input saturation,a novel integrated guidance and control(IGC)law based on the backstepping technique is proposed for missiles attacking manoeuvring target in this paper.A modified saturation function and an auxiliary system are proposed to deal with the input *** state of the auxiliary system is used in the IGC law design process and stability *** the uncertainties caused by target manoeuvres,model errors and variation of the aerodynamic parameters,disturbance observers which converge in finite time are introduced to estimate and compensate *** on the Lyapunov theory,the detailed stability analysis of the closedloop system is *** non-linear numerical simulations are presented to illustrate the effectiveness of the proposed IGC law.

关键词： Integrated guidance and control(IGC) input saturation backstepping disturbance observer manoeuvring target

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