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Ferroptosis molecular inducers:A future direction for malignant tumor chemotherapy

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BIOCELL 2022年第7期46卷 1599-1611页

作者： ZIQIAN WANG YAQI LI DONGYANG WANG yingqiang shen State Key Laboratory of Oral Diseases Chengdu610041China West China School of Stomatology Sichuan UniversityChengdu610041China National Clinical Research Center for Oral Diseases Chengdu610041China Chinese Academy of Medical Sciences Research Unit of Oral Medicine of Carcinogenesis and Management Chengdu610041China West China Hospital of Stomatology Sichuan UniversityChengdu610041China

Iron-dependent ferroptosis is a form of cell death dependent on iron *** that undergo ferroptosis have glutathione(GSH)deficiency,reduced Glutathione peroxidase-4(GPX4)activity and intracellular lipid peroxidation,Mitochondria,lysosomes and many signal pathways are involved in the regulation of *** importantly,many tumor cells resistant to other cell death methods exhibit sensitivity to ***,over recent years,a number of ferroptosis-induced drugs have been recommended for the treatment of malignant ***,the study of ferroptosis is of great significance for future cancer *** this review,we discussed the metabolic process of ferroptosis,the role of different organelles,the typical signaling pathways involved in ferroptosis,as well as natural and synthetic compounds that can induce ferroptosis,aiming to point out new conceptual avenues for utilizing ferroptosis in future cancer treatments.

关键词： Ferroptosis Cancer Organelle Pathways Ferroptosis-induced drugs

Glucocorticoid reduces the efficacy of afatinib on the head and neck squamous cell carcinoma

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BIOCELL 2023年第2期47卷 329-338页

作者： DONGYANG WANG YI CHEN JING HUANG YOU ZHANG CHONGKUI SUN yingqiang shen State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesChinese Academy of Medical Sciences Research Unit of Oral Medicine of Carcinogenesis and ManagementWest China Hospital of StomatologySichuan UniversityChengdu610041China

Glucocorticoids(GC)are widely used to counter the adverse events during cancer therapy;nonetheless,previous studies pointed out that GC may reduce the efficacy of chemotherapy on cancer cells,especially in epidermal growth factor receptor(EGFR)-targeted therapy of head and neck squamous cell carcinoma(HNSCC)remaining to be *** primary aim of the present study was to probe into the GC-induced resistance of EGFR-targeted drug afatinib and the underlying *** cell lines(HSC-3,SCC-25,SCC-9,and H-400)and the human oral keratinocyte(HOK)cell lines were assessed for GC receptor(GR)*** promoting tumor growth effect of GC was evaluated by the CCK-8 assay and flow *** of signaling pathways participants GR,mTOR,and EGFR were determined by quantitative polymerase chain reaction and western *** increased the proliferation of HNSCC cells in a GR-dependent manner and promoted AKT/mTOR *** GC failed in counteracting the inhibition of rapamycin in the mTOR signaling ***,GC also induced resistance to EGFR-targeted drug afatinib through AKT/mTOR instead of the EGFR/ERK signaling ***,GCs reduce the efficacy of afatinib on HNSCC,implicating a cautious use of glucocorticoids in clinical practice.

关键词： Glucocorticoid Head and neck squamous cell carcinoma Afatinib EGFR Targeted therapy mTOR

Emerging roles of circular RNAs in the invasion and metastasis of head and neck cancer:Possible functions and mechanisms

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Cancer Innovation 2023年第6期2卷 463-487页

作者： Shouyi Tang Luyao Cai Zhen Wang Dan Pan Qing Wang yingqiang shen Yu Zhou Qianming Chen State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesChinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and ManagementWest China Hospital of StomatologySichuan UniversityChengduChina State Institute of Drug/Medical Device Clinical Trial West China Hospital of StomatologyChengduChina

Head and neck cancer(HNC)is the seventh most prevalent malignancy worldwide in *** metastasis is the main cause of poor prognosis in HNC ***,circular RNAs(circRNAs),initially thought to have no biological function,are attracting increasing attention,and their crucial roles in mediating HNC metastasis are being extensively *** studies have shown that circRNAs primarily function through miRNA sponges,transcriptional regulation,interacting with RNA-binding proteins(RBPs)and as translation *** these functions,the function of miRNA sponge is the most *** this review,we summarized the reported circRNAs involved in HNC metastasis,aiming to elucidate the regulatory relationship between circRNAs and HNC ***,we summarized the latest advances in the epidemiological information of HNC metastasis and the tumor metastasis theories,the biogenesis,characterization and functional mechanisms of circRNAs,and their potential clinical *** the research on circRNAs is still in its infancy,circRNAs are expected to serve as prognostic markers and effective therapeutic targets to inhibit HNC metastasis and significantly improve the prognosis of HNC patients.

关键词： circRNA head and neck cancer invasion metastsais

毒蕈碱受体通过Yes相关蛋白信号对口腔鳞状细胞癌生物学行为的实验研究

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国际口腔医学杂志 2022年第2期49卷 138-143页

作者：江涵神应强陈谦明口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心口腔黏膜病国家临床重点专科中国医学科学院口腔黏膜癌变与防治创新单元四川大学华西口腔医院口腔黏膜病科成都610041

目的研究毒蕈碱(m)受体在口腔鳞状细胞癌(OSCC)中发挥的作用及机制。方法分析癌症基因图谱(TCGA)数据库,并利用实时定量聚合酶链式反应(RT-qPCR)荧光定量查询和检测m受体基因在头颈部肿瘤和OSCC细胞中的表达水平,再采用m受体激动剂卡巴... 详细信息

目的研究毒蕈碱(m)受体在口腔鳞状细胞癌(OSCC)中发挥的作用及机制。方法分析癌症基因图谱(TCGA)数据库,并利用实时定量聚合酶链式反应(RT-qPCR)荧光定量查询和检测m受体基因在头颈部肿瘤和OSCC细胞中的表达水平,再采用m受体激动剂卡巴胆碱进一步研究其对OSCC细胞增殖和侵袭的影响,最终利用免疫荧光探究激活m受体对OSCC细胞内Yes相关蛋白(YAP)核转位的影响。结果m受体基因在头颈部肿瘤中有表达差异:在5种OSCC细胞系中HN4和HN12的m3受体基因高表达(P<0.05)。激活m受体具有促进OSCC细胞增殖和侵袭的潜能,促进YAP的核转位可能是m受体的作用机制。结论m受体在OSCC发生发展中发挥重要作用,靶向m受体可能是未来治疗OSCC的新策略。

关键词：毒蕈碱受体口腔鳞状细胞癌卡巴胆碱

Bi_(3.79)Er_(0.03)Yb_(0.18)Ti_(2.97)W_(0.03)O_(12):xSi上转换荧光体的结构和性能

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激光与光电子学进展 2023年第13期60卷 230-236页

作者：周金磊雷西虎邹本善沈应墙高锋广西大学资源环境与材料学院广西有色金属及特色材料加工重点实验室广西南宁530004

通过高温固相烧结法制备出一系列Si掺杂的Bi_(3.79)Er_(0.03)Yb_(0.18)Ti_(2.97)W_(0.03)O_(12):xSi荧光体,探索其结构和上转换荧光性能。实验与测试结果表明,在不同气氛下制备的Bi_(3.79)Er_(0.03)Yb_(0.18)Ti_(2.97)W_(0.03)O_(12)∶xSi荧光体均为单一层状类钙钛矿结构的Bi_(4)Ti_(3)O_(12)相。Si在荧光体中以Si^(4+)为主,说明即使在氩气氛围中,掺入的大部分Si也发生了氧化。Si掺杂增加了材料的致密性和表面平整度,同时减小了材料的光学带隙并增强了光吸收。在980 nm红外光激发下,所有样品的上转换发射光谱均显示以525 nm、545 nm和765 nm为中心的三个发射带,分别对应Er^(3+)4f电子层内的电子跃迁。掺硅6%摩尔分数的样品的发光强度和荧光寿命约为未掺杂Si的样品2倍,表明Si掺杂可以明显提升稀土掺杂钛酸铋基荧光体的光致发光性能。

关键词：材料上转换荧光光吸收光学带隙荧光寿命

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煤加压热解过程中C和H的转变规律

煤炭转化 2009年第1期32卷 5-9页

作者：鞠付栋陈汉平杨海平沈应强张世红华中科技大学煤燃烧国家重点实验室

主要采用加压热天平进行了不同工况(压力、温度)下煤焦样品的制备,并利用元素分析仪对煤焦进行了元素分析,研究了不同热解压力和温度下煤热解过程中C和H的转变规律.在1000℃时,随热解压力的增加(从常压到5MPa)煤焦产量增加,煤焦中的nC/n... 详细信息

主要采用加压热天平进行了不同工况(压力、温度)下煤焦样品的制备,并利用元素分析仪对煤焦进行了元素分析,研究了不同热解压力和温度下煤热解过程中C和H的转变规律.在1000℃时,随热解压力的增加(从常压到5MPa)煤焦产量增加,煤焦中的nC/nH(C/H摩尔比)也增加,从而增加了转化到煤焦中的碳量Cchar,而Hchar则先减小而后趋于恒定.在常压和加压下(3MPa)时,随着热解温度的提高(500℃～1000℃),热解煤焦的产量都减少,煤焦中的nC/nH增加,转化到煤焦中的碳量Cchar和氢量Hchar都减小.但加压热解与常压热解相比,煤焦产量的减小速率要小,煤焦中的nC/nH在650℃～800℃的增加速率要大,从而使得转化到煤焦中的碳量Cchar较大.这主要是由加压热解加快了半焦和焦油的二次反应而引起的.nC/nH随热解压力的变化表明加压热解加快了煤焦微晶结构的有序化,这对煤焦的反应性将产生重要影响.

关键词：加压热解二次反应 C和H的转化

Remaining Life Prediction Method for Photovoltaic Modules Based on Two-Stage Wiener Process

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Energy Engineering 2025年第1期122卷 331-347页

作者： Jie Lin Hongchi shen Tingting Pei Yan Wu School of Electrical Engineering and Information Engineering Lanzhou University of TechnologyLanzhou730050China

Photovoltaic (PV) modules, as essential components of solar power generation systems, significantly influence unitpower generation *** service life of these modules directly affects these costs. Over time, the performanceof PV modules gradually declines due to internal degradation and external environmental *** cumulativedegradation impacts the overall reliability of photovoltaic power generation. This study addresses the complexdegradation process of PV modules by developing a two-stage Wiener process model. This approach accountsfor the distinct phases of degradation resulting from module aging and environmental influences. A powerdegradation model based on the two-stage Wiener process is constructed to describe individual differences inmodule degradation processes. To estimate the model parameters, a combination of the Expectation-Maximization(EM) algorithm and the Bayesian method is employed. Furthermore, the Schwarz Information Criterion (SIC) isutilized to identify critical change points in PV module degradation trajectories. To validate the universality andeffectiveness of the proposed method, a comparative analysis is conducted against other established life predictiontechniques for PV modules.

关键词： Photovoltaic modules degradation stochastic processes lifetime prediction

Optimizing Fine-Tuning in Quantized Language Models:An In-Depth Analysis of Key Variables

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Computers, Materials & Continua 2025年第1期82卷 307-325页

作者： Ao shen Zhiquan Lai Dongsheng Li Xiaoyu Hu National Key Laboratory of Parallel and Distributed Computing National University of Defense TechnologyChangsha410073China Strategic Assessments and Consultation Institute Academy of Military ScienceBeijing100091China

Large-scale Language Models(LLMs)have achieved significant breakthroughs in Natural Language Processing(NLP),driven by the pre-training and fine-tuning *** this approach allows models to specialize in specific tasks with reduced training costs,the substantial memory requirements during fine-tuning present a barrier to broader ***-Efficient Fine-Tuning(PEFT)techniques,such as Low-Rank Adaptation(LoRA),and parameter quantization methods have emerged as solutions to address these challenges by optimizing memory usage and computational *** these,QLoRA,which combines PEFT and quantization,has demonstrated notable success in reducing memory footprints during fine-tuning,prompting the development of various QLoRA *** these advancements,the quantitative impact of key variables on the fine-tuning performance of quantized LLMs remains *** study presents a comprehensive analysis of these key variables,focusing on their influence across different layer types and depths within LLM *** investigation uncovers several critical findings:(1)Larger layers,such as MLP layers,can maintain performance despite reductions in adapter rank,while smaller layers,like self-attention layers,aremore sensitive to such changes;(2)The effectiveness of balancing factors depends more on specific values rather than layer type or depth;(3)In quantization-aware fine-tuning,larger layers can effectively utilize smaller adapters,whereas smaller layers struggle to do *** insights suggest that layer type is a more significant determinant of fine-tuning success than layer depth when optimizing quantized ***,for the same discount of trainable parameters,reducing the trainable parameters in a larger layer is more effective in preserving fine-tuning accuracy than in a smaller *** study provides valuable guidance for more efficient fine-tuning strategies and opens avenues for further research into optimizing LLM

关键词： Large-scale Language Model Parameter-Efficient Fine-Tuning parameter quantization key variable trainable parameters experimental analysis

Estimation of Chloride Diffusivity in Hydrated Tricalcium Silicate Using a Hydration-Diffusion Integrated Method

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 49-64页

作者： WANG Xin shen Dejian TAO Sijie LIU Ruixin WU shengxing College of Civil and Transportation Engineering Hohai UniversityNanjing 210098China

This study aims to develop a chloride diffusion simulation method that considers the hydration microstructure and pore solution properties during the hydration of tricalcium silicate(C3S).The method combines the hydration simulation,thermodynamic calculation,and finite element analysis to examine the effects of pore solution,including effect of electrochemical potential,effect of chemical activity,and effect of mechanical interactions between ions,on the chloride effective diffusion coefficient of hydrated C3S *** results indicate that the effect of electrochemical potential on chloride diffusion becomes stronger with increasing hydration age due to the increase in the content of hydrated calcium silicate;as the hydration age increases,the effect of chemical activity on chloride diffusion weakens when the number of diffusible elements decreases;the effect of mechanical interactions between ions on chloride diffusion decreases with the increase of hydration age.

关键词： tricalcium silicate simulation method chloride diffusion coefficient pore solution