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Chinese Science Bulletin 2010年第24期55卷 2608-2617页

作者： gu ying LI Jia MARTIN Olivier J F GONG QiHuang State Key Laboratory for Mesoscopic Physics Department of Physics Peking University Beijing 100871 China Nanophotonics and Metrology Laboratory Swiss Federal Institute of Technology Lausanne (EPFL) CH-1015 Lausanne Switzerland

With the development of nanotechnology,many new optical phenomena in nanoscale have been *** the coupling of optical waves and collective oscillations of free electrons in metallic nanostructures,surface plasmon polaritons can be excited accompanying a strong near field enhancement that decays in a subwavelength scale,which have potential applications in the surface-enhanced Raman scattering,biosensor,optical communication,solar cells,and nonlinear optical frequency *** the present article,we review the Green's matrix method for solving the surface plasmon resonances and near field in arbitrarily shaped nanostructures and in binary metallic *** this method,we design the plasmonic nanostructures whose resonances are tunable from the visible to near-infrared,study the interplay of plasmon resonances,and propose a new way to control plasmonic resonances in binary metallic nanostructures.

关键词：表面等离子体共振纳米结构二元金属矩阵方法近场应用表面增强拉曼散射表面等离子激元

Reactive TiO_(2) Nanoparticles Compatibilized PLLA/PBSU Blends:Fully Biodegradable Polymer Composites with Improved Physical,Antibacterial and Degradable Properties

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Chinese Journal of Polymer Science 2021年第12期39卷 1645-1656页

作者： Xiao-ying gu Ling-Min Hu Zhi-Ang Fu Heng-Ti Wang Yong-Jin Li College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China

The fully biodegradable polymer blends remain challenges for the application due to their undesirable comprehensive *** n,remarkable combi nation of superior mechanical performa nee,bacterial resista nee,and con trollable degradability is realized in the biodegradable poly(L-lactide)/poly(butylene succinate)(PLLA/PBSU)blends by stabilizing the epoxide group modified titanium dioxide nan oparticles(m-TiO_(2))at the PLLA-PBSU in terface through reactive *** m-TiO_(2) can not only act as in terfacial compatibilizer but also play the role of photodegradation catalyst:on the one hand,binary grafted nanoparticles were in situ formed and stabilized at the interface to enhance the compatibility between polymer *** a consequence,the mechanical properties of the blend,such as the elongation at break,notched impact strength and tensile yield strength,were simultaneously *** the other hand,antibacterial and photocatalytic degradation performance of the composite films was synergistically *** was found that the m-TiO_(2 )incorporated PLLA/PBSU films exhibit more effective antibacterial activity than the neat PLLA/PBSU ***,the analysis of photodegradable properties revealed that that m-TiO_(2) nan oparticles could act as a photocatalyst to accelerate the photodegradati on rate of *** study paves a new strategy to fabricate advaneed PLLA/PBSU blend materials with excellent mechanical performance,antibacterial and photocatalytic degradation performance,which enables the potential utilization of fully degradable polymers.

关键词： Reactive TiO_(2)nan oparticles PLLA/PBSU blend composites Compatibilization Photodegradati on

Linkages of transboundary water allocation and its eco-thresholds with international laws

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Chinese Science Bulletin 2006年第B11期51卷 25-32页

作者： FENG Yan HE Daming GAN Shu gu ying Asian International Rivers Center at Yunnan University Kunming 650091 China Nanjing Hydraulic Research Institute Nanjing 210024 China

Based on the case study of Lancang-Mekong river, analyses have been made on the database of bilateral and multilateral treaties/agreement of transboundary water resources in the world and the regional agreements of Mekong River, the principles of the equitable and reasonable utilization, and causing no significant harm, index system and related models on transboundary water allocation have been worked out, and the key ecologic thresholds of the maximum and minimum water flow and water level of water allocation have been defined. By using the data of water resources development and utilization at present and development objectives of the riparian states, to ensure the ecological environment demand of water in the river basin and based on the water yields in the riparian states, 5 types of 3 kinds of water allocation schemes with water volume as the core have been set up, viz., the whole allocation, the project allocation and the river-basin-integrated allocation. By comparing the beneficial effect of each scheme, the results show that (1) the whole allocation scheme can equitably define the available water consumption volume of each state, but cannot sustain the ecological objectives in the river basin; (2) the project allocation scheme can meet the needs of the most riparian states, but cannot meet the drainage ecologic need (esp. to prevent the intrusion of saltwater in Mekong Delta) and the development objectives of Vietnam; (3) the integrated allocation scheme can meet the development need of each state in the predictable period and sustainability of drainage ecology, but the beneficial countries should make compensation to the others so as to materialize the fairness of transboundary water allocation.

关键词：贯穿边界水分配索引系统澜沧江-湄公河水文学

Effect of Fe on NO release during char combustion in air and O2/CO2

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Frontiers in Energy 2012年第2期6卷 200-206页

作者： ying gu Xiaowei LIU Bo ZHAO Minghou XU State Key Laboratory of Coal Combustion Huazhong University of Science and TechnologyWuhan 430074China

The chemistry nitrogen release under the of char was probed by studying reactions with air and oxy-fuel combustion. The experiments were conducted in a drop tube furnace and a fixed bed flow reactor. NO was observed during those experiments. The results show that the particle size of char generated at 1073 K in CO2 is larger than that in N2. However, at 1573 K, it is smaller in CO2 atmosphere due to particle breaking by gasification of char and CO2. The Fe addition increases the NO conversion ratio, and the effect of Fe rises steeply with the process going until it becomes stable in the end. The results also indicate that the release of NO increases more significantly with the Fe addition in oxy-fuel environment.

关键词： NO Fe char combustion CO2

Current progress in the development of prophylactic and therapeutic vaccines

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Science China(Life Sciences) 2023年第4期66卷 679-710页

作者： Tingting Li Ciying Qian ying gu Jun Zhang Shaowei Li Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Life SciencesSchool of Public HealthXiamen UniversityXiamen 361102China National Institute of Diagnostics and Vaccine Development in Infectious Diseases Xiamen UniversityXiamen 361102China Xiang An Biomedicine Laboratory Xiamen 361102China The Research Unit of Frontier Technology of Structural Vaccinology of Chinese Academy of Medical Sciences Xiamen 361102China

Vaccines are essential public health tools and play an important role in reducing the burden of infectious diseases in the *** infectious diseases and outbreaks pose new challenges for vaccine development,requiring the rapid design and production of safe and effective vaccines against diseases with limited ***,we focus on the development of vaccines in broad fields ranging from conventional prophylactic vaccines against infectious diseases to therapeutic vaccines against chronic diseases and cancer,providing a comprehensive overview of recent advances in eight different vaccine forms(live attenuated vaccines,inactivated vaccines,polysaccharide and polysaccharide conjugate vaccines,recombinant subunit vaccines,virus-like particle and nanoparticle vaccines,polypeptide vaccines,DNA vaccines,and m RNA vaccines)and the therapeutic vaccines against five solid tumors(lung cancer,breast cancer,colorectal cancer,liver cancer and gastric cancer),three infectious diseases(human immunodeficiency virus,hepatitis B virus and human papillomavirus-induced diseases)and three common chronic diseases(hypertension,diabetes mellitus and dyslipidemia).We aim to provide new insights into vaccine technologies,platforms,applications and understanding of potential next-generation preventive and therapeutic vaccine technologies,paving the way for the vaccines design in the future.

关键词： prophylactic vaccine therapeutic vaccine immune response infectious diseases cancers chronic diseases

Determination of haloacetic acids in hospital effuent after chlorination by ion chromatography

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Journal of Environmental Sciences 2007年第7期19卷 885-891页

作者： SUN ying-xue gu Ping School of Environmental Science and Engineering Tianjin University Tianjin 300072 China.

The ion chromatography combined solid phase extraction （SPE） method was developed for the analysis of low concentration haloacetic acids （HAAs）, a class of disinfection by-products formed from chlorination of hospital wastewater. The monitored HAAs included monochloroacetic acid, monobromoacetic acid, dichloroacetic acid, dibromoacetic acid and trichloroacetic acid. The method employed a sodium hydroxide eluent at a flow rate of 0.8 ml/min, electrolytically generated gradients, and suppressed conductivity detection. To analyze the HAAs in real hospital wastewater samples, C18 pretreatment cartridge was utilized to reduce samples＇ turbidity. Preconcentration with SPE and matrix elimination with treatment cartridges were investigated and found to be able to obtain acceptable detection limits. Linearity, repeatability and detection limits of the above method were evaluated. The detection limits of monobromoacetic acid and dibromoacetic acid were 2.61 μg/L and 1.30 μg/L, respectively, and the other three acids are ranging from 0.48 to 0.82μg/L under 25-fold preconcentration. When the above optimization procedure was applied to three hospital wastewater samples with different treatment processes in Tianjin, it was found that the dichloroacetic acid was the major compound, and the growth ratios of the HAAs after disinfection by sodium hypochlorite were 91.28%, 63.61% and 79.50%, respectively.

关键词： hospital wastewater analysis ion chromatography (IC) sample pretreatment solid phase extraction (SPE) chlorination haloacetic acids (HAAs)

A Trade-off between Propagation Length and Light Confinement in Cylindrical Metal-Dielectric Waveguides

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Chinese Physics Letters 2011年第5期28卷 222-225页

作者： SUN Bao-Qing gu ying HU Xiao-Yong GONG Qi-Huang State Key Laboratory for Mesoscopic Physics Department of PhysicsPeking UniversityBeijing 100871

We theoretically investigate the hybrid plasmonic modes of cylindrical nanocables with gold nanocore and two dielectric nanolayers(SiO2 and BN).By solving a complete set of Maxwell's equations,the propagation constants and effective radii depending on geometrical parameters are numerically *** declining a trade-off between propagation length and light confinement,high quality hybrid modes which can travel a long range of 120-200λwith a subwavelength effective radius are obtained at the optical *** modes in one-dimensional cylindrical waveguides should have potential applications in nanoscale optical device designs.

关键词： optical cylindrical propagation

AUTOMATED ASSESSMENT OF EPIDERMAL THICKNESS AND VASCULAR DENSITY OF PORT WINE STAINS OCT IMAGE

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Journal of Innovative Optical Health Sciences 2014年第1期7卷 45-51页

作者： CHENGMING WANG TIANCHENG HUO JING-GAO ZHENG NING ZHANG TIANYUAN CHEN WENCHAO LIAO ying WANG ying gu PING XUE Department of Physics and State Key Laboratory of Low-dimensional Quantum Physics Tsinghua University Beijing 100084P.R.China Department of Laser Medicine Chinese PLA General Hospital Beijing 100853P.R.China

Optical coherence tomography(OCT)enables in vivo imaging of port wine stains(PWS)*** knowledge of vascular struct ure and epidermal thickness(ET)of PWS may aid the objectivediagnosis and optimal *** obtain the structural parameters more rapidly and avoiduser intervention,an automated algorithm of energy map is introduced based on intensity andedge information to extract the skin surface using dynamic programming ***,an averaged A-scan analysis is performed to obtain the mean ET and the relative intensity ofdermis indicating the corresponding vascular *** approach is currently successfullyapplied in clinical diagnosis and shows promising guidance and assessment of PDT treatment.

关键词： Optical coherence tomography port wine stains epidermal thickness image proces.sing photodynamic therapy

Alternative approaches to target Myc for cancer treatment

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1157-1170页

作者： Chen Wang Jiawei Zhang Jie Yin Yichao Gan Senlin Xu ying gu Wendong Huang Division of Medical Genomics and Cancer Institute(Key Laboratory of Cancer Prevention and Intervention Ministry of Education)the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Institute of Genetics Zhejiang University and Department of GeneticsSchool of MedicineZhejiang UniversityHangzhouChina Zhejiang Provincial Key Lab of Genetic and Developmental Disorder HangzhouZhejiang 310058China Molecular and Cellular Biology of Cancer Program&Department of Diabetes Complications and Metabolism Beckman Research InstituteCity of HopeDuarteCAUSA Irell&Manella Graduate School of Biological Sciences Beckman Research InstituteCity of HopeDuarteCAUSA Zhejiang Laboratory for Systems&Precision Medicine Zhejiang University Medical CenterHangzhou 311121China

The Myc proto-oncogene family consists of three members,C-MYC,MYCN,and MYCL,which encodes the transcription factor c-Myc(hereafter Myc),N-Myc,and L-Myc,*** protein orchestrates diverse physiological processes,including cell proliferation,differentiation,survival,and *** modulates about 15%of the global transcriptome,and its deregulation rewires the cellular signaling modules inside tumor cells,thereby acquiring selective *** deregulation of Myc occurs in>70%of human cancers,and is related to poor prognosis;hence,hyperactivated Myc oncoprotein has been proposed as an ideal drug target for ***,no specific drug is currently available to directly target Myc,mainly because of its"undruggable"properties:lack of enzymatic pocket for conventional small molecules to bind;inaccessibility for antibody due to the predominant nucleus localization of *** the topic of targeting Myc has actively been reviewed in the past decades,exciting new progresses in this field keep *** this review,after a comprehensive summarization of valuable sources for potential druggable targets of Myc-driven cancer,we also peer into the promising future of utilizing macropinocytosis to deliver peptides like Omomyc or antibody agents to intracellular compartment for cancer treatment.

关键词： treatment utilizing thereby

Morphological and heterojunctional engineering of two-dimensional porous Mo-Ni based catalysts for highly effective catalytic reduction of aromatic nitro compounds

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Chinese Chemical Letters 2023年第9期34卷 310-316页

作者： Zexu Fang ying gu Xinran Dong Gen Zhang Lin Li Xiaoguang Zhou Chungui Tian College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin 150040China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

Hydrogenation reactions play crucial roles on chemical synthesis and pollutant *** improvement of the ability to activate reactants and increase of the contact probability between the catalysts and reactants are positive to improve the catalytic ***,we have reported the design of two-dimensional porous Ni-Ni_(3)N-Ni Mo N heterojunction sheets(2D Mo-Ni based nanosheets)for efficient catalytic hydrogenation of the aromatic *** heterojunction interfaces provide plentiful active sites to improve the activating ability of the catalyst on the ***,the 2D porous structure facilitates not only the contact of catalytic sites with reactants but also mass transfer and diffusion,both of which are favorable to accelerating the hydrogenation *** a result,the optimized sample of 2D Mo-Ni sheet exhibits good activity for the hydrogenation of aromatic nitro-compounds by converting 0.2 mmol/L(30 mL)of p-nitrophenol to p-aminophenol within 45 s with good *** activation energy and the reaction rate at 25℃ is 31.11 k J/mol and 0.0796 s^(-1),respectively,both of which surpass most of reported non-noble metal catalysts and rivals with most noble metal-based *** combination of late and early transition metals provides an innovative way to obtain outstanding catalysts for the hydrogenation.

关键词： Hydrogenation Nitro compounds Two-dimensional sheets Heterojunction Nitrides