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Effects of pulse width and repetition rate of pulsed laser on kinetics and production of singlet oxygen luminescence

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Journal of Innovative Optical Health Sciences 2016年第6期9卷 26-34页

作者： Defu Chen ying Wang Buhong Li Huiyun Lin Xuechun Lin ying gu School of Information and Electronics Beijing Institute of Technology Beijing 100081P.R.China Department of Laser Medicine Chinese People's Liberation Army General Hospital Beijing 100853 P.R.China Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education Fujian Normal University Fujian 350007P.R.China Fujian Provincial Key Laboratory for Photonics Technology Fujian Normal University Fujian 350007P.R.China Laboratory of All-Solid-State Light Sources Institute of Semiconductors Chinese Academy of Sciences Beijing 100083P.R.China

Pulsed and continuous-wave(CW)lasers have been widely used as the light sources for photodynamic therapy(PDT)*** oxygen(^(1)O_(2))is known to be a major cytotoxic agent in type-II PDT and can be directly detected by its near-infrared luminescence at 1270 *** compared to CW laser excitation,the effiects of pulse width and repetition rate of pulsed laser on the kinetics and production of^(1)O_(2)luminescence were quantitatively studied during photosensitization of Rose *** di®erence in kinetics of^(1)O_(2)luminescence was found under the excitation with various pulse widths of nanosecond,microsecond and CW irradiation with power of *** peak intensity and duration of^(1)O_(2)production varied with the pulse widths for pulsed laser excitation,while the^(1)O_(2)was generated continuously and its production reached a steady state with CW ***,no significant di®erence(P>0:05)in integral^(1)O_(2)production was *** results suggest that the PDT efficacy using pulsed laser may be identical to the CW laser with the same wavelength and the same average°uence rate below a threshold in solution.

关键词： Photodynamic therapy pulsed laser continuous-wave laser singlet oxygen luminescence

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Underlying mechanisms of mindfulness meditation:Genomics,circuits,and networks

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World Journal of Psychiatry 2022年第9期12卷 1141-1149页

作者： ying-Qi gu Yi Zhu Department of Psychology Zhejiang Sci-Tech UniversityHangzhou 310018Zhejiang ProvinceChina School of Psychology Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Psychology The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102Hainan ProvinceChina

Understanding neuropsychological mechanisms of mindfulness meditation(MM)has been a hot topic in recent *** review was conducted with the goal of synthesizing empirical relationships via the genomics,circuits and networks between MM and mental *** describe progress made in assessing the effects of MM on gene expression in immune cells,with particular focus on stressrelated inflammatory markers and associated biological *** then focus on key brain circuits associated with mindfulness practices and effects on symptoms of mental disorders,and expand our discussion to identify three key brain networks associated with mindfulness practices including default mode network,central executive network,and salience *** research efforts need to be devoted into identifying underlying neuropsychological mechanisms of MM on how it alleviates the symptoms of mental disorders.

关键词： Mindfulness meditation Gene expression Neural circuits Neural networks

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贝伐珠单抗与阿帕替尼联合化疗方案对复发性脑胶质瘤治疗效果的比较研究

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实用心脑肺血管病杂志 2025年第1期33卷 98-102页

作者：丁铃周静顾莹江棋江苏省南通市肿瘤医院药剂科 226000 江苏省南通市肿瘤医院血液淋巴瘤科 226000

目的比较贝伐珠单抗与阿帕替尼联合化疗方案对复发性脑胶质瘤的治疗效果。方法选取2021年1月—2022年10月于南通市肿瘤医院就诊的复发性脑胶质瘤患者92例,采用随机数字表法将患者分为贝伐珠单抗组和阿帕替尼组,每组46例。贝伐珠单抗组... 详细信息

目的比较贝伐珠单抗与阿帕替尼联合化疗方案对复发性脑胶质瘤的治疗效果。方法选取2021年1月—2022年10月于南通市肿瘤医院就诊的复发性脑胶质瘤患者92例,采用随机数字表法将患者分为贝伐珠单抗组和阿帕替尼组,每组46例。贝伐珠单抗组患者给予替莫唑胺胶囊口服及贝伐珠单抗注射液静脉滴注;阿帕替尼组患者给予替莫唑胺胶囊及甲磺酸阿帕替尼片口服,4周为1个治疗周期,两组均治疗3个治疗周期。比较两组临床疗效,治疗前后血清学指标[血管内皮生长因子(VEGF)、表皮生长因子受体(EGFR)、胶质纤维酸性蛋白(GFAP)、甲壳质酶蛋白40(YKL-40)]和卡氏评分,生存率,治疗期间毒副作用发生率。结果阿帕替尼组客观缓解率高于贝伐珠单抗组(P0.05)。治疗后,阿帕替尼组VEGF、EGFR、GFAP、YKL-40低于贝伐珠单抗组(P<0.05)。治疗后,阿帕替尼组卡氏评分高于贝伐珠单抗组(P<0.05)。阿帕替尼组累积生存率高于贝伐珠单抗组(P<0.05)。阿帕替尼组高血压、蛋白尿发生率低于贝伐珠单抗组(P<0.05)。结论与贝伐珠单抗联合化疗方案比较,阿帕替尼联合化疗方案可提高复发性脑胶质瘤患者客观缓解率,降低细胞因子,提高生活质量、生存率并减少毒副作用的发生率。

关键词：神经胶质瘤贝伐珠单抗阿帕替尼治疗结果

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Synthesis of MnZn Ferrite Nanoscale Particles by Hydrothermal Method

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Journal of Central South University 2000年第1期12卷 37-39页

作者： gu ying-ying SANG Shang-bin HUANG Ke-long LIU Jian-shen College of Chemistry and Chemical Engineering Central South University of TechnologyChangsha 410083China

Hydrothermal method was used to synthesize nanoscale particles of MnZn ferrites. The crystallites were characterized by XRD, TEM and SEM. The effects of the reaction time, temperature and additives on the product were investigated. Crystallization process would be carried out above 160 ℃ for 5 h or more, higher temperature can reduce the reaction time. Additives were used to remove impurities such as Fe 2O 3, ZnMnO 3.10～15 nm pure slightly agglomerated MnZn ferrite crystallites with a narrow grain size distribution were obtained.

关键词： hydrothermal method MnZn ferrite nanoscale particles additives

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Two-dimensional porous Cu-CuO nanosheets: Integration of heterojunction and morphology engineering to achieve high-effective and stable reduction of the aromatic nitro-compounds

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Chinese Chemical Letters 2023年第2期34卷 598-603页

作者： Xinran Dong Zexu Fang ying gu Xiaoguang Zhou Chungui Tian College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin 150040China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of ChinaHeilongjiang UniversityHarbin 150080China

The morphology and heterojunction engineering are effective ways to boost the performance of Cubased catalysts. Herein, we have reported the designed synthesis of two-dimensional Cu-Cu O heterojunction nanosheets(2D Cu-Cu O NS) based on 3-aminopropyl-triethoxysilane(APTES, KH550) aided synthetic strategy. The APTES can act as both the ligand and alkali(-OH) source to guide the large-scale synthesis of 2D Cu-based precursor, which can transform into 2D Cu-Cu O NS by the controllable *** Si species from APTES can protect the particles from the severe aggregation and growth, guaranteeing the formation of 2D sheets composed of small-sized Cu-Cu O heterojunction(about 20 nm). The heterojunction interfaces can provide plentiful active sites to boost the catalytic ability. The 2D sheets can provide large accessible surface, being conducive to the contact of the catalyst and reactants. Benefiting from above virtues, the 2D Cu-Cu O NS showed the superior catalytic performance for the reduction of a series of nitro compounds, being superior to most reported non-noble metal-based catalysts. Notably,it exhibited good re-cycled performance with no obvious performance degradation after 10 consecutive catalysis. The present study will be promising to promote the application of the Cu-based catalysts, due to its ability to control the morphology and potential for the large-scale synthesis.

关键词： Cu-CuO heterojunction Two-dimensional sheets Porous Nitro-compounds Hydrogenation

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The trafficking and behavior of cellulose synthase and a glimpse of potential cellulose synthesis regulators

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Frontiers in Biology 2011年第5期6卷 377-383页

作者： Logan BASHLINE Juan DU ying gu The Center for Lignocellulose Structure and Formation Department of Biochemistry and Molecular BiologyPennsylvania State UniversityUniversity ParkPA 16802USA

Cellulose biosynthesis is a topic of intensive research not only due to the significance of cellulose in the integrity of plant cell walls,but also due to the potential of using cellulose,a natural carbon source,in the production of *** of the composition,regulation,and trafficking of cellulose synthase complexes(CSCs)is critical to an understanding of cellulose biosynthesis as well as the characterization of additional proteins that contribute to the production of cellulose either through direct interactions with CSCs or through indirect *** this review,a highlight of a few proteins that appear to affect cellulose biosynthesis,which includes:KORRIGAN(KOR),Cellulose Synthase-Interactive Protein 1(CSI1),and the poplar microtubule-associated protein,PttMAP20,will accompany a description of cellulose synthase(CESA)behavior and a discussion of CESA trafficking compartments that might act in the regulation of cellulose biosynthesis.

关键词： cellulose synthesis cellulose synthase complex(CSC) dynamics trafficking

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Genome Writing： Current Progress and Related Applications

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Genomics, Proteomics & Bioinformatics 2018年第1期16卷 10-16页

作者： Yueqiang Wang Yue Shen ying gu Shida Zhu Ye Yin BGI-Shenzhen Shenzhen 518083 China China National GeneBank BGI-Shenzhen Shenzhen 518083 China BGI-Qingdao Qingdao 266555 China Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics BGI-Shenzhen Shenzhen 518083 China guangdong Provincial Key Laboratory of Genome Read and Write Shenzhen 518120 China BGI Genomics BGI-Shenzhen Shenzhen 518083 China School of Life Science and Biotechnology Dalian University of Technology Dalian 116023 China Laboratory of Genomics and Molecular Biomedicine Department of Biology University of Copenhagen Copenhagen 2100 Denmark

The ultimate goal of synthetic biology is to build customized cells or organisms to meet specific industrial or medical needs. The most important part of the customized cell is a synthetic genome. Advanced genomic writing technologies are required to build such an artificial genome. Recently, the partially-completed synthetic yeast genome project represents a milestone in this field. In this mini review, we briefly introduce the techniques for de novo genome synthesis and genome editing. Furthermore, we summarize recent research progresses and highlight several applications in the synthetic genome field. Finally, we discuss current challenges and future prospects.

关键词： Synthetic biology Genome writing Genome editing Bioethics Biosafety

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Influence of Nucleation Agents Concentration on Crystallization Structure and Properties of Glass-ceramics

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Chinese Journal of Structural Chemistry 2007年第5期26卷 562-566页

作者： WU Ren-Ping YU Yan gu ying Yun guO Jin-Yu School of Materials Science and Engineering Fuzhou University Fuzhou Fujian 350002 China

Deep color glass-ceramics is prepared by using gold tailings as the main raw material, and Cr2O3 is added as nucleation agent. Influence of different Cr2O3 additions on crystallization structure and properties of CaO-MgO-Al2O3-SiO2 glass-ceramics has been discussed so as to select optimum additions. DTA is employed to determine optimum crystallization and nucleation temperatures; XRD and SEM are used to characterize microstructure of each sample; and performance indexes, such as water absorption, bulk density, flexural strength and so on, are also determined. Experimental results show that when 3wt% Cr2O3 is introduced, fine glass-ceramics with diopside as the main crystal and Ca-Fe diopside as the second-crystal is obtained, and its corresponding performance indexes are as follows： water absorption 0.12%, bulk density 2.56 g/cm^3, and flexural strength 70.01 Mpa.

关键词： gold railings glass-ceramics nucleation agent crystallization structure property

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Hollow Ni Mo-based nitride heterojunction with super-hydrophilic/aerophobic surface for efficient urea-assisted hydrogen production

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Journal of Energy Chemistry 2024年第8期95卷 428-439,I0009页

作者： Yuying Fan ying gu Dongxu Wang Yanqing Jiao Aiping Wu Chungui Tian Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080HeilongjiangChina College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry UniversityHarbin 150040HeilongjiangChina

Hydrogen evolution reaction(HER)and urea oxidation reaction(UOR)are key reactions of the watercycling associated catalytic process/*** design of catalysts with a super-hydrophilic/aerophobic structure and optimized electron distribution holds great ***,we have designed a threedimensional(3D)hollow Ni/NiMoN hierarchical structure with arrayed-sheet surface based on a onepot hydrothermal route for efficient urea-assisted HER based on a simple hydrothermal *** Ni/NiMoN catalyst exhibits super-hydrophilic/aerophobic properties with a small droplet contact angle of 6.07°and an underwater bubble contact angle of 155.7°,thus facilitating an escape of bubbles from the *** functional theory calculations and X-ray photoelectron spectroscopy results indicate the optimized electronic structure at the interface of Ni and NiMoN,which can promote the adsorption/desorption of reactants and *** virtues combining with a large specific surface area endow Ni/NiMoN with efficient catalytic activity of low potentials of 25 mV for HER and 1.33 V for UOR at10 mA cm^(-2).The coupled HER and UOR system demonstrates a low cell voltage of 1.42 V at 10 mA cm^(-2),which is approximately 209 mV lower than water electrolysis.

关键词： Hydrogen evolution Transition metal nitrides Hollow heterojunctions Urea electrooxidation Super hydrophilic/aerophobic

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Strongly coupled Ag/TiO2 heterojunctions for effective and stable photothermal catalytic reduction of 4-nitrophenol

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Nano Research 2018年第1期11卷 126-141页

作者： ying gu Yanqing Jiao Xiaoguang Zhou Aiping Wu Bater Buhe Honggang Fu College of Science Northeast Forestry University Harbin 150040 China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China Heilongjiang University Harbin 150080 China

The development of effective catalysts for the catalytic conversion of the harmful nitrophenol （NP） into the useful aminophenol （AP） has received extensive interest. Herein, we report the easy and large-scale synthesis of strongly coupled Ag/TiO2 heterojunctions based on the coordinated action of organic components with a multi-kind metal precursor. The heterojunctions were effective and stable catalysts for the photothermal catalytic reduction of 4-NP to 4-AP. In the synthesis, critic acid, ethylene glycol AgNO3, and tetrabutyl titanate were dissolved and coordinated in water. Under heating, a precursor gel having a uniform distribution of Ag and Ti was gradually formed. Via calcination in air, the Ti precursor was transformed into TiO2, accompanied by the reduction of Ag＋ to Ag nanoparticles. The formation of Ag/TiO2 composites with intimate interface contact benefited from the uniform distribution of different components in the precursor gel. The Ag/TiO2 functioned as an effective catalyst for the reduction of 4-NP, exhibiting higher activity than the many reported Ag-based catalysts. The catalytic reaction over Ag/TiO2 had a small to with good activity and reuse performance. After 10 cycles of reuse, the conversion efficiency exhibited no obvious change. Importantly, the conversion of 4-NP was significantly enhanced under light irradiation provided by a 150-W Xe lamp （the visible light from cutoff have equal function）, but ultraviolet light did not promote the conversion. The conversion time was reduced from 620 to 270 s with light irradiation （15 ~C）. The reaction rate under light irradiation （0.014 s-1） was approximately three times higher than that in the dark at 15 ~C （0.0044 s-1） and even better than that in the dark at 25 ~C （0.01 s-l）. A series of experiments indicated that the light irradiation promoted the conversion of 4-NP because of the localized surface plasmon resonance effect of Ag, which generated hot e- and h~ particles and local heating around

关键词： Ag TiO2 4-nitrophenol heterojunction photothermal catalysis

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