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Chinese Journal of Polymer Science 2019年第11期37卷 1119-1129页

作者： Han Jia Kun Chang Shu-ying gu Department of Polymeric Materials School of Materials Science and Engineering Tongji University Shanghai 201804 China Key Laboratory of Advanced Civil Engineering Materials Ministry of Education Tongji University Shanghai 201804 China

A reversible disulfide bond-based self-healing polyurethane with triple shape memory properties was prepared by chain extending of random copolymer poly(lactide-co-caprolactone)(PCLA), hexamethylene diisocyanate (HDI), polytetrahydrofuran (PTMEG), and 4,4,-aminophenyl disulfide. The chemical structures were characterized using 1H nuclear magnetic resonance (^1H-NMR) spectroscopy, Fourier transform infrared spectroscopy (FTIR), and gel permeation chromatography (GPC). The thermal properties, selfhealing properties, triple-shape memory effect, and quantitative shape memory response were evaluated by differential scanning calorimetry (DSC), tensile tests, two-step programming process thermal mechanical experiments, and subsequent progressive thermal recovery. The self-healing mechanism and procedures were investigated using polarizing optical microscopy (POM) and an optical profiler. It was concluded that self-healing properties (up to 60%) and triple-shape memory properties around 35 and 50℃(with shape fixation ratios of 94.3% and 98.3%, shape recovery ratios of 76.6% and 85.1%, respectively) were integrated to the shape memory polyurethane. As-prepared polyurethane is expected to have potential applications in multi-shape coatings, films, and step-by-step deploying structures.

关键词： Self-healing Reversible disulfide bond Triple shape memory Polyurethane

Factors Influencing Glucoraphanin and Sulforaphane Formation in Brassica Plants:A Review

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Journal of Integrative Agriculture 2012年第11期11卷 1804-1816页

作者： gu Zhen-xin guO Qiang-hui gu ying-juan College of Food Science and Technology Nanjing Agricultural University Nanjing 210095 P.R.China

Sulforaphane is a type of sulfur-containing isothiocyanates hydrolyzed from glucosinolates by myrosinase found in Brassica plants. Sulforaphane is a naturally occurring inducer of phase II enzymes in human and animal bodies to detoxify cancer-causing chemicals. Glucoraphanin is the precursor of sulforaphane and its content is greatly influenced by plant species and genotype, plant organs, pre-harvest factors, and post-harvest processing, thus sulforaphane formation is also directly influenced. Here, we review the formation mechanism of sulforaphane and the factors influencing sulforaphane formation. In the end, the future directions are also discussed.

关键词： Brassica plant glucosinolate sulforaphane glucoraphanin influencing factor

Event-triggered fault detection for T-S fuzzy systems with local nonlinear models in finite-frequency domain

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Journal of Control and Decision 2023年第2期10卷 250-259页

作者： ying gu Ming Huangfu School of Science Dalian Jiaotong UniversityDalianPeople’s Republic of China

This article investigates the issue of event-triggered fault detection(FD)filter design for T-S fuzzy systems with local nonlinear models.A novel H−/H∞FD filter subject to the event triggering transmission mechanism is designed in finite-frequency ***,a novel lemma,in which the nonlinear part and the event triggering mechanism are dealt appropriately,is presented to capture the sensitivity and robustness *** addition,the slack matrices are utilised to derive optimal filter parameters by solving a convex optimisation *** less conservative FD method can get better detection performances than those entire-frequency ***,an example is introduced to verify the new results.

关键词： T-S fuzzy nonlinear systems fault detection event-triggered mechanism finite-frequency domain linear matrix inequalities(LMIs)

Lobe-dominatedγ-Ray Emission of Compact Symmetric Objects

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Research in Astronomy and Astrophysics 2024年第2期24卷 196-205页

作者： ying-ying Gan Hai-Ming Zhang Xing Yang ying gu Jin Zhang School of Physics Beijing Institute of TechnologyBeijing 100081China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

Theγ-ray emitting compact symmetric objects(CSOs)PKS 1718-649,NGC 3894,and TXS 0128+554 are lobedominated in the radio *** order to investigate theirγ-ray radiation properties,we analyze the~14yr Fermi/LAT observation data of the three *** all show the low luminosity(1041-1043 erg s-1)and no significant variability in theγ-ray ***γ-ray average spectra can be well fitted by a power-law *** properties ofγ-rays are clearly different from theγ-ray emitting CSOs CTD 135 and PKS 1413+135,for which theγ-rays are produced by a restarted aligned *** the L_(γ)-Γ_(γ)plane,the three CSOs are also located at the region occupied by radio galaxies(RGs)while CTD 135 and PKS 1413+135 display a similar feature to *** with a similar radio emission property toγ-ray emitting RGs Cen A and Fornax A,we speculate that theγ-rays of the three CSOs stem from their extended *** broadband spectral energy distributions of the three CSOs can be well explained by the two-zone leptonic model,where theirγ-rays are produced by the inverse Compton process of the relativistic electrons in extended *** extrapolating the observed Fermi/LAT spectra to the very high energy band,we find that TXS 0128+554 among the three CSOs may be detected by the Cherenkov Telescope Array in the future.

关键词： galaxies active-galaxies jets-radio continuum galaxies-gamma-rays galaxies

An advection fog event response to future climate forcing in the 2030s-2080s:a case study for Shanghai

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Frontiers of Earth Science 2023年第2期17卷 527-546页

作者： ying gu Hiroyuki KUSAKA Quang-Van DOAN School of Air Transportation Shanghai University of Engineering ScienceShanghai 201620China Center for Computational Sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8577Japan

Fog may continue to inhibit industry in the ***,we focused on a specific advection fog event in Shanghai,China,and applied a pseudo global warming method to examine advection fog under the RCP8.5 highemission *** method involved downscaling the future atmospheric conditions over the ensemble average of 19 global climate models from the fifth phase of the Coupled Model Intercomparison Project(CMIP5).We used the Weather Research and Forecasting Model coupled with a single-layer urban canopy model(WRF‒UCM)to run four sensitivity experiments and examined the advection fog and its relationship to changes in meteorological *** results showed that:1)The advection fog event tended to remain in Shanghai despite global warming;2)advection fog will not change greatly in the future;however,the onset and dissipation times will change slightly;3)relative humidity(RH)locally increases prior to the onset of the advection fog,and decreases at the dissipating stage,despite the current and future experiments having the same RH initial and boundary conditions;4)a small increase in surface air temperature and an increase in RH contribute to the early advection fog onset,and vice *** facilitates the early onset and dissipation of advection fog.

关键词： advection fog global warming PGW DDS WRF-UCM Shanghai

Fault detection for sector-bounded non-linear systems with servo inputs and sensor stuck faults

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Journal of Control and Decision 2019年第3期6卷 147-165页

作者： ying gu Xiao-Jian Li School of Science Dalian Jiaotong UniversityDalianChina College of Information Science and Engineering Northeastern UniversityShenyangChina State Key Laboratory of Synthetical Automation of Process Industries Northeastern UniversityShenyangChina

This paper addresses the fault detection(FD)problem for discretetime sector-bounded non-linear systems with finite-frequency servo *** non-linear systems are firstly modelled as *** main contributions are that a novel FD filter which combines the finite-frequency H∞and H−indices is *** from the existing methods,the proposed FD scheme guarantees that the generated residuals are robust against the servo inputs in fault-free case and sensitive to them in faulty ***,the small sensor stuck faults including outagefaults can be *** this class of systems,the existing finite-frequency FD filter design methods are invalid.A new lemma is developed to characterise the system performances in finite-frequency *** addition,sufficient conditions for the existence of such a FD filter are derived by introducing slack variable and linear matrix inequalities ***,an example is presented to demonstrate the method and its effectiveness.

关键词： Fault detection servo inputs sensor stuck faults sector-bounded nonlinearity finite-frequency domain

Efficient Dual Algorithms for Image Segmentation Using TV-Allen-Cahn Type Models

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Communications in Computational Physics 2011年第4期9卷 859-877页

作者： Li-Lian Wang ying gu Division of Mathematical Sciences School of Physical and Mathematical SciencesNanyang Technological University637371Singapore

Variational image segmentation based on the Mumford and Shah model[31],together with implementation by the piecewise constant level-set method(PCLSM)[26],leads to fully nonlinear Total Variation(TV)-Allen-Cahn *** commonlyused numerical approaches usually suffer from the difficulties not only with the nondifferentiability of the TV-term,but also with directly evolving the discontinuous piecewise constant-structured *** this paper,we propose efficient dual algorithms to overcome these *** use of a splitting-penalty method results in TVAllen-Cahn type models associated with different"double-well"potentials,which allow for the implementation of the dual algorithm of Chambolle[8].Moreover,we present a new dual algorithm based on an edge-featured penalty of the dual variable,which only requires to solve a vectorial Allen-Cahn type equation with linear∇(div)-diffusion rather than fully nonlinear diffusion in the Chambolle’s ***,more efficient numerical algorithms such as time-splitting method and Fast Fourier Transform(FFT)can be *** numerical tests show that two dual algorithms are much faster and more stable than the primal gradient descent approach,and the new dual algorithm is at least as efficient as the Chambolle’s algorithm but is more *** demonstrate that the new method also provides a viable alternative for image restoration.

关键词： Variational models image segmentation TV-Allen-Cahn type equations dual algorithms splitting-penalty methods FFT.

Targeting“undruggable”c-Myc protein by synthetic lethality

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Frontiers of Medicine 2021年第4期15卷 541-550页

作者： Chen Wang Hui Fang Jiawei Zhang ying gu Division of Genome Medicine and Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Institute of Genetics Zhejiang University and Department of GeneticsZhejiang University School of MedicineHangzhou 310058China Zhejiang Laboratory for Systems&Precision Medicine Zhejiang University Medical CenterHangzhou 311121China

Synthetic lethal screening,which exploits the combination of mutations that result in cell death,is a promising method for identifying novel drug *** method provides a new avenue for targeting Uundruggable,9 proteins,such as ***,we revisit current methods used to target c-Myc and discuss the important functional nodes related to c-Myc in non-oncogene addicted network,whose inhibition may cause a catastrophe for tumor cell destiny but not for normal *** further discuss strategies to identify these functional nodes in the context of synthetic *** review the progress and shortcomings of this research field and look forward to opportunities offered by synthetic lethal screening to treat tumors potently.

关键词： synthetic lethality undruggable transcription factor c-Myc

Elsinochrome A photosensitizers:Alternative drugs for photodynamic therapy

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 4-13页

作者： Tinghui Li Hong Deng Jingquan Zhao ying gu Department of Laser Medicine Chinese PLA General HospitalBeijing 100853 People's Republic of China Department of Dermatology 309 Hospital of PLABeijing 100091People's Republic of China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of PhotochemistryInstitute of Chemistry Chinese Academy of SciencesBeijing 100190 People's Republic of China

Photodynamic therapy(PDT)has already been a multifunctional modality for various tumors and nontumorous ***,the development of photosensitizers is relatively delayed,compared with the tremendous progress in laser *** A(EA),a per-ylenequinonoid pigment from China,has all the typical advantages of ***-over,singlet oxygen quantum yield of EA is superior to other kinds of photosensitizers and EA could be artifially biosynthesized at present,which make it an alternative candidate for *** review,the photophysics,photochemistry,photobiology and chemical or biological syntheses of EA photosensitizers are brielty ***,the future prospects of EA photosensitizers are also proposed.

关键词： Elsinochrome A photodynamic therapy potochemisty photophysics photobiology

AtPRK2 Promotes ROP1 Activation via RopGEFs in the Control of Polarized Pollen Tube Growth

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Molecular Plant 2013年第4期6卷 1187-1201页

作者： Fang Chang ying gu Hong Ma Zhenbiao Yang State Key Laboratory of Genetic Engineering Institute of Plant Biology School of Life Sciences Fudan University Shanghai 200433 China National Key Laboratory of Plant Physiology and Biochemistry China Agricultural University Beijing 100094 China Center for Plant Cell Biology and Department of Botany and Plant Sciences University of California Riverside CA 92521 USA Present address: Department of Biochemistry and Molecular Biology Pennsylvania State University University Park PA 16802 USA Center for Evolutionary Biology School of Life Sciences Fudan University Shanghai 200433 China

The ROP1 GTPase-based signaling network controls tip growth in Arabidopsis pollen tubes. Our previous studies imply that ROP1 might be directly activated by RopGEF1, which belongs to a plant-specific family of Rho guanine nucleotide exchange factors （RopGEFs） and in turn may be activated by an unknown factor through releasing RopGEFI＇s auto-inhibition. In this study, we found that RopGEF1 forms a complex with ROP1 and AtPRK2, a receptor-like protein kinase previously shown to interact with RopGEFs. AtPRK2 phosphorylated RopGEF1 in vitro and the atprkl,2,5 tri- ple mutant showed defective pollen tube growth, similar to the phenotype of the ropgef1,9,12,14 quadruple mutant. Overexpression of a dominant negative form of AtPRK2 （DN-PRK2） inhibited pollen germination in Arabidopsis and reduced pollen elongation in tobacco. The DN-PRK2-induced pollen germination defect was rescued by overexpressing a constitutively active form of RopGEF1, RopGEF1（90-457）, implying that RopGEF1 acts downstream of AtPRK2. Moreover, AtPRK2 increased ROP1 activity at the apical plasma membrane whereas DN-PRK2 reduced ROP1 activity. Finally, two mutations at the C-terminal putative phosphorylation sites of RopGEF1 （RopGEF1S460A and RopGEF1S480A） eliminated the function of RopGEF1 in vivo. Taken together, our results support the hypothesis that AtPRK2 acts as a positive regula- tor of the ROP1 signaling pathway most likely by activating RopGEF1 through phosphorylation.

关键词： AtPRK2 RopGEF1 ROP GTPase auto-inhibition polarity growth.