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中医经典名方西黄丸处方考证、历史沿革应用及其质量标志物预测分析

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辽宁中医药大学学报 2024年第6期26卷 65-72页

作者：陈怡名瞿光友王连芝张淑香顾媛媛黑龙江中医药大学中医药研究院黑龙江哈尔滨150040

经典名方西黄丸出自《外科证治全生集·卷四》,为清代名医王洪绪所创,是中医治疗乳腺癌的经典方剂,由牛黄、麝香、乳香、没药4味药物组成。功效清热解毒、消肿散结,主治热毒壅结所致痈疽疔毒、瘰疬、流注、癌肿,临床常用于治疗肺癌、乳... 详细信息

经典名方西黄丸出自《外科证治全生集·卷四》,为清代名医王洪绪所创,是中医治疗乳腺癌的经典方剂,由牛黄、麝香、乳香、没药4味药物组成。功效清热解毒、消肿散结,主治热毒壅结所致痈疽疔毒、瘰疬、流注、癌肿,临床常用于治疗肺癌、乳腺癌、胃癌等,在肿瘤辅助治疗方面疗效显著。该文通过医药典籍系统梳理该处方的出处,对处方用量、处方中各药味进行了考证,并对西黄丸的历史沿革应用进行分析,同时以质量标志物(Q-Marker)的“五原则”为纲领预测了西黄丸的质量标志物,结果发现麝香酮、α-乳香酸、β-乳香酸、3-乙酰基-11-酮基-β-乳香酸、3-乙酰基-α-乳香酸、3-乙酰基-β-乳香酸、11-酮基-β-乳香酸、β-榄香烯等可作为西黄丸主要的Q-Marker,为西黄丸的质量控制、后续的研究开发以及临床应用提供了科学的理论依据。

关键词：西黄丸处方考证历史应用乳腺癌质量标志物

维普期刊数据库博看期刊

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乙醇溶剂法制备橡胶促进剂DCBS的研究

化学推进剂与高分子材料 2024年第5期22卷 54-57页

作者：孟凡虎郭彦锁张俊宋晓举张杨刘园园山东尚舜化工有限公司山东菏泽274300

以2-巯基苯并噻唑(促进剂M)、二环己胺为原料,乙醇为溶剂,次氯酸钠为氧化剂合成了N,N-二环己基-2-苯并噻唑次磺酰胺(DCBS),探索了乙醇质量分数、原料配比、反应温度、反应时间对产品质量和收率的影响,确定了最佳工艺条件:n(M):n(二环己... 详细信息

以2-巯基苯并噻唑(促进剂M)、二环己胺为原料,乙醇为溶剂,次氯酸钠为氧化剂合成了N,N-二环己基-2-苯并噻唑次磺酰胺(DCBS),探索了乙醇质量分数、原料配比、反应温度、反应时间对产品质量和收率的影响,确定了最佳工艺条件:n(M):n(二环己胺):n(次氯酸钠)=1.00:0.83:2.25,次氯酸钠质量浓度为178 g/L,反应温度为55℃,反应时间为2h,中试结果表明产品质量满足HG/T 4140—2010要求,收率稳定在86%以上。

关键词：橡胶促进剂 DCBS 乙醇溶剂法次氯酸钠

Rapid growth of industrial nitrogen fluxes in China: Driving forces and consequences

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Science China Earth Sciences 2013年第3期56卷 662-670页

作者： GU BaoJing YANG GuoFu LUO WeiDong DU yuanyuan GE ying CHANG Jie College of Economics Zhejiang University College of Life Sciences Zhejiang University Research Center for Sustainable Development Zhejiang University

Human activities are strongly modifying the global nitrogen (N) cycle through increasing input, N species diversity, and pool size of industrial reactive N (Nr). However, the fluxes, fates and environmental consequences of industrial Nr (excluding synthesized N fertilizer) remain poorly understood and quantified. We report here that industrial Nr flux has increased 13.4-fold over the past 30 years in China, reaching 3.7Tg N (1 Tg=10 12g) in 2008, accounting for over 50% of China's food Nr flux. Socioeconomic development (per capita GDP, urbanization and household size) significantly drives the growth of industrial Nr fluxes. This leads to "hotspots" of industrial Nr, mainly in relatively developed Eastern China. Industrial Nr loss rate during production is only 5%, much lower than that of cropland (50%) and livestock (80%). However, industrial Nr loss is point source pollution, and Nr release in concentrated doses produces serious risk in small regions. The contribution of structural N to total industrial Nr with a lifespan longer than one year (e.g., synthetic fiber, plastic) increased from 20% in 1980 to 70% in 2008. There was about 2.6 Tg N structural industrial Nr accumulated in human settlements in 2008, which could be one ex- planation of an unknown Nr sink of anthropogenic Nr input (mainly Haber-Bosch N fixation). Legacy effects caused by structural N accumulation have long-term consequences for environmental and human health, although structural N delays Nr release and reduces short-term Nr pollution. Industrial Nr use generates new features of modern global N biogeochemistry, such as increasing Nr species diversity, reducing Nr turnover rate. Future dynamics simulation of the earth system should involve industrial Nr. Explicit consideration and accounting of the fluxes and environmental consequences of industrial Nr would provide decision-makers a novel view of regional sustainable development.

关键词： legacy effect garbage siege food nitrogen structural nitrogen point source pollution

不同混合比例茅台酒糟与芭蕉叶对其青贮饲料营养品质、发酵品质和微生物群落的影响

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动物营养学报 2024年第2期36卷 1340-1349页

作者：赵圆圆樊雪莹成启明陈超陈玉连李茂雅雷耀王佳楚函何湘江王志军刘鹰昊贵州大学动物科学学院贵阳550025 内蒙古农业大学草原与资源环境学院草地资源教育部重点实验室农业农村部饲草栽培、加工与高效利用重点实验室呼和浩特010021 中国农业科学院草原研究所呼和浩特010010

本试验旨在探究不同混合比例茅台酒糟与芭蕉叶对其青贮饲料营养品质、发酵品质和微生物群落的影响。试验共设置6个茅台酒糟与芭蕉叶的混合比例,分别为:100%芭蕉叶单独青贮(BCK组)、20%茅台酒糟与80%芭蕉叶混合青贮(J20B80组)、40%茅台... 详细信息

本试验旨在探究不同混合比例茅台酒糟与芭蕉叶对其青贮饲料营养品质、发酵品质和微生物群落的影响。试验共设置6个茅台酒糟与芭蕉叶的混合比例,分别为:100%芭蕉叶单独青贮(BCK组)、20%茅台酒糟与80%芭蕉叶混合青贮(J20B80组)、40%茅台酒糟与60%芭蕉叶混合青贮(J40B60组)、60%茅台酒糟与40%芭蕉叶混合青贮(J60B40组)、80%茅台酒糟与20%芭蕉叶混合青贮(J80B20组)以及100%茅台酒糟单独青贮(JCK组);每个处理设置3个重复。青贮60 d后,对各组青贮饲料的养分含量、发酵品质和微生物群落进行测定。结果表明:1)与BCK组相比,各混合青贮组青贮饲料粗蛋白质(CP)含量显著提高(P<0.05);其中,J60B40组CP含量最高,显著高于J20B80组和J40B60组(P<0.05)。随着茅台酒糟添加比例的提高,青贮饲料中性洗涤纤维含量呈现逐渐降低的趋势。2)与BCK组相比,各混合青贮组青贮饲料pH均显著降低(P<0.05);J60B40组氨态氮含量最低,显著低于除JCK组外的其他组(P<0.05);J60B40组和J80B20组乳酸含量显著高于其他组(P<0.05);J40B60组和J80B20组丙酸(PA)含量较高,显著高于其他组(P<0.05);J60B40组PA含量显著高于J20B80组、JCK组和BCK组(P<0.05);所有组青贮饲料中均未检测到丁酸。3)在细菌门水平上,仅JCK组青贮饲料的优势菌门为变形菌门(Proteobacteria),其余各组的优势菌门均为厚壁菌门(Firmicutes),其次是变形菌门;在细菌属水平上,J60B40组和J80B20组的优势菌属为乳杆菌属(Lactobacillus),相对丰度分别为72.76%和50.92%。在真菌门水平上,除J40B60组外,其余各组的优势菌门均为子囊菌门(Ascomycota);在真菌属水平上,所有组的优势菌属均为其他,其次是毕赤酵母属(Pichia),且均含有少量的裂殖酵母属(Schizosaccharomyces)。综合分析得出,茅台酒糟与芭蕉叶混合青贮可以改善青贮饲料品质,其混合比例为60%茅台酒糟+40%芭蕉叶时青贮品质较好。

关键词：芭蕉叶茅台酒糟微生物群落混合青贮

Monolithic integrated micro-supercapacitors with ultra-high systemic volumetric performance and areal output voltage

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National Science Review 2023年第3期10卷 169-177页

作者： Sen Wang Linmei Li Shuanghao Zheng Pratteek Das Xiaoyu Shi Jiaxin Ma Yu Liu yuanyuan Zhu Yao Lu Zhong-Shuai Wu Hui-Ming Cheng State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Department of Biotechnology Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian National Laboratory for Clean Energy Chinese Academy of Sciences University of Chinese Academy of Sciences Faculty of Materials Science and Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of Sciences Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Advanced Technology Institute University of Surrey

Monolithic integrated micro-supercapacitors(MIMSCs) with high systemic performance and cell-number density are important for miniaturized electronics to empower the Internet of ***,fabrication of customizable MIMSCs in an extremely small space remains a huge challenge considering key factors such as materials selection,electrolyte confinement,microfabrication and device-performance ***,we develop a universal and large-throughput microfabrication strategy to address all these issues by combining multistep lithographic patterning,spray printing of MXene micro electrodes and controllable 3D printing of gel *** achieve the monolithic integration of electrochemically isolated micro-supercapacitors in close proximity by leveraging high-resolution micropatterning techniques for micro electrode deposition and 3D printing for precise electrolyte ***,the MIMSCs obtained demonstrate a high areal-number density of 28 cells cm-2(340 cells on 3.5 × 3.5 cm2),a record areal output voltage of 75.6 V cm-2,an acceptable systemic volumetric energy density of 9.8 mWh cm-3and an unprecedentedly high capacitance retention of 92% after 4000 cycles at an extremely high output voltage of 162 *** work paves the way for monolithic integrated and microscopic energy-storage assemblies for powering future microele ctronics.

关键词： monolithic integrated micro-supercapacitors areal output voltage lithography MXene

贵阳地区市售菜籽油中18种塑化剂含量及风险评估

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中国食品添加剂 2024年第1期35卷 16-23页

作者：范金旭王媛媛李林竹罗廷武王忠奎李韬贵州省分析测试研究院贵阳550000 贵州省检测技术研究应用中心贵阳550000 贵阳市妇幼保健院贵阳550000

为了解贵阳地区菜籽油中邻苯二甲酸脂类(PAEs)塑化剂污染水平,选择贵阳商场、超市、农贸市场、小作坊的市售不同质量等级塑料包装菜籽油65个,依据GB5009.271-2016《食品安全国家标准食品中邻苯二甲酸酯的测定》,利用SPE-GC-MS联用法对DB... 详细信息

为了解贵阳地区菜籽油中邻苯二甲酸脂类(PAEs)塑化剂污染水平,选择贵阳商场、超市、农贸市场、小作坊的市售不同质量等级塑料包装菜籽油65个,依据GB5009.271-2016《食品安全国家标准食品中邻苯二甲酸酯的测定》,利用SPE-GC-MS联用法对DBP、DEHP等18种邻苯二甲酸类物质进行检测和膳食摄入风险研究。结果表明:65个样品中除DAP、BMPP、DPP、DPhP、DINP、DNP外,其余12种PAEs均有不同程度的检出,DBP、DEHP、DBEP存在超出国家标准限量情况,三种塑化剂超标率和测定浓度范围分别为16.92%(0.006〜4.872 mg/kg)、10.77%(0.085〜3.785 mg/kg)、1.54%(0.088〜0.56 mg/kg),小作坊生产的菜籽油风险较大,超标率较高,达33.33%,应引起政府相关部门和消费者重视;18种塑化剂摄入风险均可接受,但应从生产、加工、储存等环节控制贵阳地区菜籽油质量安全风险。

关键词：贵阳菜籽油塑化剂摄入风险

Thermophysical Properties of a New Environment FriendlyAlternative - Trifluoroiodomethane

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Journal of Thermal Science 1999年第2期8卷 73-78页

作者： Duan yuanyuan Shi Lin Zhu Mingshan Han Lizhong(Department of Thermal Engineering, Tsinghua University, Beijing 100084, China) Department of Thermal Engineering Tsinghua University Beijing China

Trifluoroiodomethane (CF3l) is consider as a Promising refrigerant alternative, especially as a component inmixtures, to replare CFC-12. But reliable thermophysical propelty data for CF3I are still limited. The investigationson thermophysical Propelties of CF3I developed by us are summarized in this paper. Experimental data of criticalParamethe, and the condations of saturated liquid and vapor density, enthaipy of vaporization, vapor pressurs,PVT prowtes, second vinal coefficient ideal-gas heat capacity, surface tension, viscosity and thermalconduchvity are given in the Present paper.

关键词： trifluoreiodomethane CF3I thermodynamic properties transport properties refrigerant alternative

The regulation effect of iNKT cells on the differentiation and function of Th lymphocyte subsets in rheumatoid arthritis

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The regulation effect of iNKT cells on the differentiation a...

Application of high-throughput sequencing technology in HIV drug resistance detection

第十二届全国免疫学学术大会

作者： Wang yuanyuan Liu Huifang yin Xiaolin Zhao Huijuan Xu Minghua Hou Minghui Meng Ming Chen Dongzhi School of Medicine Hebei University Affiliated Hospital of Hebei University

Background:The imbalance of Th1/Th2,Th17/Tregs is the key to the pathogenesis of ***,to inhibit inflammation and restoring immune balance are the core of RA ***:Investigate the regulation effect of iNKT cells on the differentiation and function of Th lymphocyte subsets in RA Methods:First,the peripheral blood of 100 RA patients(70 with active and 30 with inactive RA) and 40 healthy controls were *** in PBMCs were expanded and the frequency was detected dynamically by ***,the highly purified iNKTs were isolated and *** levels of IL-4,IL-10,TNF-α,IFN-γ,IL-17 A,IL-2 and IL-6 were detected in serum and culture *** expression of T-bet,GATA-3,IFN-γ mRNA and IL-4 mRNA were detected in ***,arthritis was induced in DBA/1 mice with GPI peptide,and detect the frequency of iNKTs in the peripheral blood,the levels of the cytokines in serum and the Th1/Th2/Th17 subsets in the ***:The changing trends of cytokines in RA patients and RA model mice were similar,and the levels of Th1,Th2 and Th17 subsets were disordered both in RA patients and RA model *** frequency of iNKTs in the active phase of RA patients and mice were significantly reduced,the proliferation of iNKTs was significantly decreased and iNKTs’ frequency was inversely correlated to IFN-γ/IL-4 and the levels of TNF-α,IL-6 and Th1 ***:The oncome and development of RA may be related to iNKTs’ frequency decline and functional *** play an important role in the development of RA,it may serve as an upstream regulator of the differentiation and function of Th1/Th2/Th17 cell *** suggests that improving the status of iNKTs may become a new therapeutic target for the treatment of RA.

关键词： rheumatoid arthritis(RA) invariant NKT cells(iNKTs) Th1/Th2/Th17 cytokine correlatio

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Biosafety and Health 2021年第5期3卷 276-280页

作者： yuanyuan Zhang Liying Ma State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesChinese Center for Disease Control and PreventionBeijing 102206China Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Drug resistance via drug-resistant mutations in the human immunodeficiency virus(HIV)genome is the primary cause of antiviral therapy ***,HIV drug resistance genotyping has become a critical approach in HIV prevention and *** to the Sanger sequencing technology,high-throughput sequencing(HTS)technology has superior sensitivity and timeliness,with strong detection capabilities for low-frequency *** the continued advancement of HTS technologies,their prominence in HIV drug resistance detection techniques has increased *** article will review the latest developments in HTS technology and its applications in HIV drug resistance testing.

关键词： HIV Drug resistence High-throughput sequencing technology