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Isolation and Characterization of an Algicidal Bacterium Indigenous to Lake Taihu with a Red Pigment able to Lyse Microcystis aeruginosa

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Biomedical and Environmental Sciences 2013年第2期26卷 148-154页

作者： YANG Fei WEI Hai Yan li Xiao Qin li Yun Hui li Xiao Bo yin li hong PU Yue Pu Key Laboratory of Environmental Medicine Engineering Ministry of EducationSchool of Public HealthSoutheast University

Objective To isolate and characterize indigenous algicidal bacteria and their algae-lysing compounds active against Microcystis aeruginosa, strains TH1, TH2, and FACHB 905. Methods The bacteria were identified using the Biolog automated microbial identification system and 16S rDNA sequence analysis. The algae-lysing compounds were isolated and purified by silica gel column chromatography and reverse-phase high performance liquid chromatography. Their structures were confirmed by Nuclear Magnetic Resonance （NMR） and Fourier Transform infrared （FT-IR） spectroscopy. Algae-lysing activity was observed using microscopy. Results The algae-lysing bacterium LTH-2 isolated from Lake Taihu was identified as Serratia marcescens. Strain LTH-2 secreted a red pigment identified as prodigiosin （C20H25N30）, which showed strong lytic activity with algal strains M. aeruginoso TH1, TH2, and FACHB 905 in a concentration-dependent manner. The 50% inhibitory concentration （ICs0） of prodigiosin with the algal strains was 4.8 （±0.4）×10^-2 μg/mL, 8.9 （±1.1）×10^-2μg/mL, and 1.7 （±0.1）×10^-1 μg/mL in 24 h, respectively. Conclusion The bacterium LTH-2 and its pigment related to damage of cell membranes. The bacterium for regulating blooms of harmful M. aeruginosa. had strong Microcystis-lysing activity probably LTH-2 and its red pigment are potentially useful

关键词： Algicidal bacteria Microcystis aeruginosa Harmful algal blooms (HABs) Serratiamarcescens Algae-lysing

Association between NFE2L2 Gene Polymorphisms and Noise-induced Hearing Loss in a Chinese Population

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Biomedical and Environmental Sciences 2019年第6期32卷 465-470页

作者： WANG Bo Shen XU Kai ZHANG hong PU Yue Pu yin li hong HAN Lei CHEN lin WANG Ning ZHU Bao li ZHANG Juan Key Laboratory of Environmental Medicine Engineering of Ministry of Education School of Public Health Southeast University Nanjing 210009 Jiangsu China Department of Prevention and Control for Occupational Disease Jiangsu Provincial Center for Disease Prevention and Control Nanjing 210009 Jiangsu China

Occupatio nal n oise is among the most comm on risks associated with the wellbeing of employees. Occupational exposure to noise causes disabling hearing loss in 16% of adults *** has bee n ack no wledged that no ise-induced heari ng loss (NIHL) is a multifactorial disease, having both genetic and environ mental factors. NIHL continues to be permanent as well as irreversible, but NIHL can be preve nted. As dem on strated by the latest research, excessive oxidative stress in the cochlea has a close link with the pathogenesis of NIHL. which highlights the fact that appropriate control of oxidative stress is a productive strategy for preve nting the in crease in prevale nee and progression of NIHL.

关键词： NFE2L2 Gene Polymorphisms Chinese Population

Association of combined CYP2E1 gene polymorphism with the risk for esophageal squamous cell carcinoma in Huai'an population,China

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Chinese Medical Journal 2007年第20期120卷 1797-1802页

作者： liU Ran yin li-hong PU Yue-pu School of Public Health Southeast University Nanjing 210009 China

Background Cytochrome P450 2E1 （CYP2E1） has an important role in the metabolic activation of precarcinogens such as N-nitrosoamines and other low relative molecular mass, organic compounds. This study examined whether CYP2E1 Rsal and Dral polymorphism are associated with susceptibility to esophageal squamous cell carcinoma and the correlation between the genotypes and expression levels of CYP2E1 mRNA.Methods Seventy-seven patients with newly diagnosed, untreated esophageal squamous cell carcinoma and 79 healthy controls matched in age, gender and residence were recruited for the control study. An Rsal polymorphism in the 5＇-flanking region and a Dral polymorphism in the sixth intron of the CYP2E1 gene, which could possibly affect its transcription, were determined in this study by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） and mRNA level of CYP2E1 was measured by quantitative real-time reverse transcription PCR.Results No significant association of Rsal or Dral polymorphism of CYP2E1 with susceptibility of esophageal squamous cell carcinoma were demonstrated （OR=1.67, 95%CI： 0.89-3.15, P=0.11; OR=1.11, 95%CI： 0.59-2.09, P=0.74, respectively）. With SHEsis software, no linkage disequilibrium was detected between Rsal and Dral polymorphism （D＇=0.528, r^2=0.27）. When combined Rsal polymorphism with Dral polymorphism, the association between that carrying c2 allele and DD genotype and the risk for esophageal squamous cell carcinoma were found （OR=5.77, 95%CI： 1.65-20.22）. Compared with the normal controls, the mRNA levels with Rsal polymorphism, Dral polymorphism, or any combined genotypes in cases showed no statistical difference.Conclusions This study suggests that carrying c2 allele and DD genotype conferreded an elevated risk for esophageal squamous cell carcinoma. There was no significant statistical relationship between the genotypes c1/c2, D/C, or the combined allele and mRNA expression.

关键词： esophageal neoplasms cytochrome P450 2E1 polymorphism, single nucleotide

Impact of Enterprise Ownership and Size on Registered Hematotoxicity in Benzene-exposed Workers

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Biomedical and Environmental Sciences 2018年第12期31卷 917-921页

作者： WANG Bo Shen HAN Lei YANG Dan Dan ZHANG Juan yin li hong ZHANG Meng ying XU Kai XING Cai hong ZHU Bao li PU Yue Pu Key Laboratory of Environmental Medicine Engineering of Ministry of Education School of Public Health Southeast University Nanjing 210009 Jiangsu China Jiangsu Provincial Center for Disease Prevention and Control Nanjing 210000 Jiangsu China National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and Prevention Beijing 100050 China Center for Global Health School of Public Health Nanjing Medical University Nanjing 210000 Jiangsu China

Benzene is a classified as ahuman carcinogen that can cause myelodysplastic syndrome and acute myelogenousleukemia;.This compound is also a potent toxin suppressing the bone ***,benzene causes serious hematological ad... 详细信息

关键词： SOE Impact of Enterprise Ownership and Size on Registered Hematotoxicity in Benzene-exposed Workers TWA

An EliSA Based on a Truncated Soluble ORF2 Protein for the Detection of PCV2 Antibodies in Domestic Pigs

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Virologica Sinica 2010年第3期25卷 191-198页

作者： Shuang-hui yin Shun-li YANG hong TIAN Jin-yan WU You-jun SHANG Xue-peng CAI Xiang-tao liU Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Animal Virology of Ministry of Agriculture Lanzhou 730046China

Postweaning multisystemic wasting syndrome (PMWS) is an important swine disease that is closely associated with porcine circovirus type 2 (PCV2). The capsid protein (Cap protein) is a major structural protein that has at least three immunoreactive regions, and it can be a suitable candidate antigen for detecting the specific antibodies of a PCV2 infection. In the present study, an indirect enzyme-linked immunosorbent assay (TcEliSA) based on a truncated soluble Cap protein produced in Escherichia coli (***) was established and validated for the diagnostic PCV2 antibodies in swine. The TcEliSA was validated by comparison with an indirect immunofluorescence assay (IIFA). The diagnostic sensitivity (DSN), specificity (DSP), and accuracy of the TcEliSA were 88.6%, 90.7% and 89.4%, respectively. The agreement rate was 89.38% between results obtained with TcEliSA and IIFA on 113 field sera. A cross-reactivity assay showed that the method was PCV2-specific by comparison with other sera of viral disease. Therefore ,the TcEliSA will be helpful for the development of a reliable serology diagnostic test for large scale detection of PCV2 antibodies and for the evaluation of vaccine against PCV2 in swine.

关键词： Porcine circovirus type 2 (PCV2) Soluble ORF2 protein EliSA Antibody detection

miR-93-5p Transferred by Exosomes Promotes the Proliferation of Esophageal Cancer Cells via Intercellular Communication by Targeting PTEN

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Biomedical and Environmental Sciences 2018年第3期31卷 171-185页

作者： liU Meng Xin liAO Juan XIE Ming GAO Zhi Kui WANG Xiang Hu ZHANG ying SHANG Mu He yin li hong PU Yue Pu liU Ran Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Nanjing 210009 Jiangsu China Hangzhou First People's Hospital Hangzhou 310000 Zhejiang China North China Petroleum Bureau General Hospital Renqiu 062552 Hebei China

Objective To investigate the relationship between plasma miR-93-5p and the risk of esophageal cancer, as well as the influence of miR-93-5p on the biological function of esophageal cancer cells,exerted through *** The expression of plasma miR-93-5p in esophageal cancer patients and healthy controls was analysed by real-time quantitative PCR. The influence of miR-93-5p on the risk and prognosis of esophageal carcinoma was analyzed by conditional logistic regression and survival analysis. The effect of miR-93-5p on the biological function of recipient cells was investigated by establishing an in vitro donor cell co-culture model. The target gene of miR-93-5p was validated by luciferase reporter assay and Western *** Upregulation of plasma miR-93-5p expression significantly increases the risk of esophageal cancer and is associated with poor prognosis. miR-93-5p transferred by exosomes promotes the proliferation of recipient esophageal cancer cells and affects the expression of PTEN and its downstream proteins p21 and cyclin *** Our study provides a reference for the identification of biomarkers for the diagnosis and prognosis of esophageal cancer.

关键词： Exosomes miR-93-5p Esophageal cancer Plasma biomarker

国家“八七扶贫攻坚计划”实施以来图书馆文化扶贫研究综述

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图书馆论坛 2017年第1期37卷 19-25页

作者：尹莉刘洪长安大学图书馆广东省立中山图书馆

文章综合运用文献计量分析、共词分析、聚类分析和社会网络分析等方法和工具,对国家"八七扶贫攻坚计划"实施以来学术界,特别是图书馆学术界有关文化扶贫的研究进行系统梳理和多维分析。研究表明:图书馆文化扶贫研究与人文社会科学领域... 详细信息

文章综合运用文献计量分析、共词分析、聚类分析和社会网络分析等方法和工具,对国家"八七扶贫攻坚计划"实施以来学术界,特别是图书馆学术界有关文化扶贫的研究进行系统梳理和多维分析。研究表明:图书馆文化扶贫研究与人文社会科学领域该主题研究的文献数量变化趋势基本一致,有着鲜明的阶段性特征;CSSCI来源期刊刊发的图书馆文化扶贫研究成果占到人文社会科学相关研究成果60%左右;形成重点研究团队和研究主题,折射出图书馆学者在文化扶贫研究上的重要地位。

关键词：图书馆文化扶贫贫困地区文化建设文献计量学扶贫计划

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu hong-Wei li Jian-hong Shi Tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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贴报-P3系统、器官及分子毒理学

中国药理学与毒理学杂志 2006年第3期20卷 247-280页

作者： ZHANG Juan ZHU Fang-Yan PU Yue-Pu yin li-hong Department of Occupational and EnvironmentalHealth School of Public Health Southeast UniversityNanjing 210009 China

Myeloperoxidase （MPO） is an important metabolizing enzyme involved in oxidative stress response with some environmental carcinogens including benzene which is associated with bone marrow toxicity and leukemia after ... 详细信息

关键词： POSTERS-P3 Systemic Organic Molecular Toxicology