检索结果-南通市图书馆

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao zhenyu yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Efficient Helicopter-Satellite Communication Scheme Based on Check-Hybrid LDPC Coding

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2018年第3期23卷 323-332页

作者： Ping wang Liuguo yin jianhua Lu Department of Electronic Engineering Tsinghua University Beijing 100084 China EDA Laboratory Research Institute of Tsinghua Universityin Shenzhen Shenzhen 518057 China. School of Information Science andTechnology Tsinghua University Beijing 100084 China EDA Laboratory Research Institute ofTsinghua University in Shenzhen Shenzhen 518057 China Department of Electronic Engineering Tsinghua University Beijing 100084 China

When implementing helicopter-satellite communications, periodical interruption of the received signal is a challenging problem because the communication antenna is intermittently blocked by the rotating blades of the helicopter. The helicopter-satellite channel model and the Forward Error Control（FEC） coding countermeasure are presented in this paper. On the basis of this model, Check-Hybrid（CH） Low-Density Parity-Check（LDPC）codes are designed to mitigate the periodical blockage over the helicopter-satellite channels. The CH-LDPC code is derived by replacing part of single parity-check code constraints in a Quasi-Cyclic LDPC（QC-LDPC） code by using more powerful linear block code constraints. In particular, a method of optimizing the CH-LDPC code ensemble by searching the best matching component code among a variety of linear block codes using extrinsic information transfer charts is proposed. Simulation results show that, the CH-LDPC coding scheme designed for the helicopter-satellite channels in this paper achieves more than 25% bandwidth efficiency improvement, compared with the FEC scheme that uses QC-LDPC codes.

关键词： helicopter-satellite communications check-hybrid Low-Density Parity-Check(LDPC) codes Extrinsic Information Transfer(EXIT) iterative decoding

Microstructures andmicrom anics of

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2023年第4期24卷 299-302页

作者： zhenyu yin Pei wang Sheng DAI Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlanta 30332 GAUSA

1Introduction Geomaterials,such as soil,rock,and concrete,have a clearly defined microstructure at the level of individual grains(Sprunt and Brace,1974;Ichikawa et al.,2001).While difficult to observe directly,these microstructures,including their particle size distribution,particle shape,mineralogy,interaction,and bonding behavior,have a strong influence on both microand macroscopic behaviors of geomaterials(Gao and Zhao,2013);He et al.,2018;Alqam et al.,2019;Sun et al.,2020;yin et al.,2020;wang et al.,2022 .In recent years,various kinds of engineered geomaterials,such as fiber-reinforced and bio-reinforced soils,have been shown to have even more sophisticated microstructures(Uygunoglu,2008;Mujah et al.,2019).

关键词： microstructure bonding macroscopic

Tumor therapy by fast moving magnetic nanoparticle under low-frequency alternating magnetic field

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2015年第2期8卷 52-60页

作者： Yangyang Liu Zhiyu Qian jianhua yin Xiao wang Department of Biomedical Engineering Nanjing University of Aeronautics and Astronautics Nanjing P.R.China

Magnetic nanoparticle plays an important role in biomedical engineering,especially in tumor *** this paper,a new technique has been developed by using the rapid moving magnetic nanoparticle under a low-fequency alternating magnetic field(LFAMF)to kill tumor *** LFAMF system which was used to drive magnetic nanoparticles(MNPs)was setup with the magnetic field frequency and power range at心10-100Hz and~10-200 mT,*** the experiment,the LFAMF was adjusted at different frequencies and power *** exper-imental results show that the liver tumnor cells(HepG2)mixed with MNPs(10 pug/mL)becamne partial fragments when exposed in the LFAMF with different frequencies(~10-100Hz)and power(~10200 mT),and the higher the frequency or the power,the more the tumor cells were killed at the same magnetic nanoparticle ***:Tumor oells were effectively damaged by MNPs under LFAMF,which suggests that they had great potential to be applied in tumor therapy.

关键词： Different frequency cells power cancer

A batch microfabrication of a self-cleaning,ultradurable electrochemical sensor employing a BDD film for the online monitoring of free chlorine in tap water

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2022年第2期8卷 85-96页

作者： Jiawen yin Wanlei Gao Weijian Yu Yihua Guan zhenyu wang Qinghui Jin Faculty of Electrical Engineering and Computer Science Ningbo University315211 NingboP.R.China State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of Sciences200050 ShanghaiP.R.China

Free chlorine is one of the key water quality parameters in tap ***,a free chlorine sensor with the characteristics of batch processing,durability,antibiofouling/antiorganic passivation and in situ monitoring of free chlorine in tap water continues to be a challenging *** this paper,a novel silicon-based electrochemical sensor for free chlorine that can self-clean and be mass produced via microfabrication technique/MEMS(Micro-Electro-Mechanical System)is proposed.A liquid-conjugated Ag/AgCI reference electrode is fabricated,and electrochemically stable BDD/Pt is employed as the working/counter electrode to verify the effectiveness of the as-fabricated sensor for free chlorine *** sensor demonstrates an acceptable limit of detection(0.056 mg/L)and desirable linearity(R^(2)=0.998).Particularly,at a potential of+2.5 V,hydroxyl radicals are generated on the BBD electrode by electrolyzing water,which then remove the organic matter attached to the surface of the sensor though an electrochemical digestion *** performance of the fouled sensor recovers from 50.2 to 94.1%compared with the initial state after self-cleaning for 30 *** addition,by employing the MEMS technique,favorable response consistency and high reproducibility(RSD<4.05%)are observed,offering the opportunity to mass produce the proposed sensor in the future.A desirable linear dependency between the pH,temperature,and flow rate and the detection of free chlorine is observed,ensuring the accuracy of the sensor with any hydrologic *** interesting sensing and selfcleaning behavior of the as-proposed sensor indicate that this study of the mass production of free chlorine sensors by MEMS is successful in developing a competitive device for the online monitoring of free chlorine in tap water.

关键词： chlorine batch electrode

Root and xylem ABA changes in response to soil drying in two woody plants

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1999年第24期44卷 2236-2241页

作者： Huafang wang jianhua Zhang Jiansheng Liang Weilun yin Hong Kong Baptist Univ Dept Biol Hong Kong Peoples R China Beijing Forestry Univ Coll Plant Sci Beijing 100083 Peoples R China

Two woody plants, Platycladus orientalise (tolerant to drought) and Acacia auriculi-formis (sensitive to drought), have been subjected to rapid and slow soil drying. ABA levels in their roots and xylem sap have been determined using radioimmunoassay (RIA, sensitivity is 0.4 pmol per assay vial) with a monoclonal antibody against ( + )-ABA. ABA contents of P. orientalise and A. auriculiformis growing in well watered soil are 0.3 and 2.5 nmol-gDW-1 in

关键词： Platycladus orientalise Acacia auriculiformis root xylem sap ABA soil drying.

Seismic Low-Frequency Shadow beneath Gas Hydrate in the Shenhu Area Based on the Stereoscopic Observation System

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2018年第3期29卷 669-678页

作者： Xueqin Liu Huaishan Liu Lei Xing Yanxin yin jianhua wang Key Lab of Submarine Geosciences and Prospecting Techniques Ministry of Education Ocean University of China Evaluation and Detection Technology Laboratory of Marine Mineral Resources Qingdao National Laboratory for Marine Science and Technology National Engineering Laboratory of Offshore Oil Exploration CNOOC Research Institute

Spectral analysis shows a low-frequency shadow under the BSR interface. Traditional low-frequency shadow analysis is based on stacked data. In order to understand the BSR low-frequency shadow more clearly, a frequency division analysis on stereoscopic observation seismic data based on the adaptive optimal-kernel （AOK） frequency analysis method is presented. It includes ocean-bottom seismometer （OBS） data （common receiver point data including vertical and horizontal components）, vertical cable data （common receiver point data） and horizontal cable data （stacked section of different offsets）. The OBS data frequency analysis gets a conclusion that vertical component has a significant effect on the low-frequency shadow, but the horizontal component did not. The vertical cable data shows that the low frequency band of vertical cable is wider than OBS. And then the horizontal cable data frequency analysis points out that the bigger the angle of incidence is, the more obvious the low-frequency shadow will be. The low-frequency shadow feature is shown in the stereoscopic observation field and the visual effect on com- mon reception point data is better. The lateral reservoir distribution characteristics are predicted from low-frequency shadow feature analysis of the hydrate BSR based on stereoscopic observation.

关键词： hydrate BSR stereoscopic observation low-frequency shadow.

Responses of woody plant root and xylem sap ATP to soil drying

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1999年第13期44卷 1172-1178页

作者： Huafang wang jianhua Zhang Jiansheng Liang Weilun yin Beijing Forestry Univ Beijing 100083 Peoples R China Hong Kong Baptist Univ Hong Kong Peoples R China

The ATP in roots and xylem sap of two woody plant species, Platycladus orientalis and Acacia auriculiformis, subjected to rapid and slow soil drying has been determined employing firefly luciferase ATP assay method (sensitivity is at 10-12 mol ATP L-1). The ATP levels in the two species were 1.6 nmol. gDW-1 and 0.6 nmol. gDW-1 in roots, and 5.6 μmol·m-3 and 8 μmol ·m-3 in xylem sap, respectively. When plants of P. orientalis and A. auriculiformis were subjected to rapid soil drying, respectively, as soil water content （SWC） decreased from the normal level ( 0.2.5 g·gDW-1) to 0.02 and 0.06 g·gDW-1, separately, plant water potential （ ψ ）dropped to - 4 and - 3.2 MPa, differently, the ATP in roots decreased 99.7% and 42%, respectively. When the rapidly dried soil was watered for up to 6 d, SWC and ψ, were found to recover to their normal levels, but ATP content in roots of P. orientalis and A. auriculiformis recovered by 10% and 23%, respectively. When plants

关键词： Platycladus orientalis Acacia auriculiformis roots xylem sap ATP soil drought.

社会主义建设实践中的中华民族共同体认同意识——传承弘扬“两路”精神与铸牢中华民族共同体意识学术研讨会综述

在线全文

学校读者我要写书评

暂无评论

四川旅游学院学报 2025年第1期 98-100页

作者：王振宇四川旅游学院四川成都610100

2024年9月21日,传承弘扬“两路”精神与铸牢中华民族共同体意识学术研讨会在四川成都顺利召开。来自中国西藏信息中心、雅安市党史研究室、四川大学、西南交通大学、西华大学、四川师范大学、西藏民族大学、伊犁师范大学、四川旅游学院... 详细信息

2024年9月21日,传承弘扬“两路”精神与铸牢中华民族共同体意识学术研讨会在四川成都顺利召开。来自中国西藏信息中心、雅安市党史研究室、四川大学、西南交通大学、西华大学、四川师范大学、西藏民族大学、伊犁师范大学、四川旅游学院等科研院校的70余名专家学者齐聚蓉城,围绕新时期如何更好地传承和弘扬“两路”精神、深入挖掘“两路”精神对铸牢中华民族共同体意识所具有的独特价值和现实意义等议题展开研讨。会议达成了学术共识,拓宽了“两路”精神和铸牢中华民族共同体意识的研究思路,为推动新时期铸牢中华民族共同体意识提供了有益的指导和借鉴。

关键词： “两路”精神中华民族共同体认同意识