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Exploring the optimal operation time for patients with hypertensive intracerebral hemorrhage： tracking the expression and progress of cell apoptosis of prehematomal brain tissues

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Chinese Medical Journal 2010年第10期123卷 1246-1250页

作者： ZHANG Xin-qing ZHANG Zhi-min yin xiao-liang ZHANG Kun CAI Hui LING Feng Department of Neurosurgery Xuanwu Hospital Capital Medical University Beijing 100053 China Department of Neurosurgery Beijing Chui Yang Liu Hospital Beijing 100022 China Department of Pathology Beijing Chui Yang Liu Hospital Beijing 100022 China

Background Hypertensive intracerebral hemorrhage （HICH） is a severe disease with high morbidity and mortality. Timely removal of the hematoma through surgical procedures may effectively reduce secondary injuries. However, there has long been a debate over the proper timing of such surgery. In this study, we explored the optimal operation time for HICH patients by observing the pathological changes in perihematomal brain regions during different stages of onset. Methods Twenty-five specimens of brain tissue, obtained from perihematomal region of HICH patients in different phases, were subjected to haematoxylin-eosin （HE） staining, terminal deoxynucleotidyl transferase-mediated deoxyuridine 5-triphosphate nick-end labeling （TUNEL） staining and Caspase-3, matrix metalloproteinases-9 （MMP-9） immunohistochemical staining. The changing roles of necrosis and apoptosis and the expression of MMP-9 and Caspase-3 positive cells were all observed using image analysis. Results The obvious expression of TUNEL positive cells was recognized within 6 hours of ICH onset, reaching its peak between 6 hours and 24 hours in the early phase. Results were highly consistent with Caspase-3 and MMP-9 positive cell counts. Necrosis was found 6 hours after ICH onset and aggravated after 12 hours. Conclusions In the early phase, apoptosis was seen as a major modality of injury in the brain tissue of the perihematomal region and was strongly correlated with the expression of MMP-9 and Caspase-3. The results of the present study suggest that an operation performed as soon as possible after ICH onset may be optimal for preserving the nervous system function.

关键词： cerebral hemorrhage apoptosis caspase-3 matrix metalloproteinases operations

日本对能源危机的应急管理——以第一次石油危机为例

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东北亚论坛 2010年第1期19卷 123-128,F0003页

作者：尹晓亮南开大学日本研究院天津30071

日本面对战后第一次国家危机,先是组建应急管理机构,以此为基础,从行政号召、政府指导和法律管制等层面制定了诸多措施,并很快形成了具有"防火墙"作用的应急管理体系。该体系为调整危机状态下的国家权力、公民权利以及国家权力与公民权... 详细信息

日本面对战后第一次国家危机,先是组建应急管理机构,以此为基础,从行政号召、政府指导和法律管制等层面制定了诸多措施,并很快形成了具有"防火墙"作用的应急管理体系。该体系为调整危机状态下的国家权力、公民权利以及国家权力与公民权利之间的各种能源经济关系,充分发挥行政、法律对社会无序状态、紧急状态的防范和矫正功能起到了关键性的作用。在应急危机管理中,日本政府所发挥的6大能效,也为日本从无预防性的应急管理向未雨绸缪的预防管理转型提供了极为宝贵的心理储备、经验借鉴和制度遗产。

关键词：日本能源石油危机应急管理措施政府效能

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构建国际环境秩序中的共识认知与政治议价

河北大学学报（哲学社会科学版） 2012年第6期37卷 122-128页

作者：尹晓亮南开大学日本研究院天津300192

在构建环境秩序中,科学层面的共识认知并未有效对"集体行动"进行快速、必要的逻辑引导,更未成为普通民众中的文化认知。这就客观上需要通过"政治杠杆"着力驱动从"科学认知"向"文化认知"方向上加速转化与渗透。然而,由于"局中人"之间存... 详细信息

在构建环境秩序中,科学层面的共识认知并未有效对"集体行动"进行快速、必要的逻辑引导,更未成为普通民众中的文化认知。这就客观上需要通过"政治杠杆"着力驱动从"科学认知"向"文化认知"方向上加速转化与渗透。然而,由于"局中人"之间存在利益结构差异,导致相关国家间在构建环境秩序的规范、规制等问题上形成了复杂的"议价博弈"。对此,中国作为世界上最大的发展中国家,在构建全球环境秩序的过程中,亟需结合国情谋划合理的对应方略。

关键词：气候变暖环境秩序共识认知政治议价

能源环境双约束下日本能源结构转型探研——以两次石油危机时期为例

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河北大学学报（哲学社会科学版） 2010年第6期35卷 42-49页

作者：尹晓亮南开大学日本研究院天津300071

能源结构转型是提升能源效率、减少能源消费、改变增长方式的路径选择和关键环节。日本在能源环境双约束下,通过能源结构转型,渐趋走上"能源安全、经济发展和环境保护"三者协调平衡发展之路。拟从转型背景、转型动力、转型内容、转型手... 详细信息

能源结构转型是提升能源效率、减少能源消费、改变增长方式的路径选择和关键环节。日本在能源环境双约束下,通过能源结构转型,渐趋走上"能源安全、经济发展和环境保护"三者协调平衡发展之路。拟从转型背景、转型动力、转型内容、转型手段和转型效果等方面,探研日本能源结构转型过程中规避和舒缓能源环境双约束的践行路径,并以此为基础总结日本政府在主导能源转型过程中的功能定位、转型方式及审议论证。

关键词：日本双约束能源转型

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日本规避石油价格风险的数字化解读

现代日本经济 2010年第1期29卷 24-30页

作者：尹晓亮南开大学日本研究院天津300071

21世纪初油价攀升并未给日本造成像石油危机时期那样的严重冲击,其主要原因是日本在石油的"量"和"质"等方面有了很大变化。"量"分为"减量"和"增量"两个层面。"减量"是指日本通过调整能源消费结构等措施,相应"弱化"和"缓冲"油价上涨风险;... 详细信息

21世纪初油价攀升并未给日本造成像石油危机时期那样的严重冲击,其主要原因是日本在石油的"量"和"质"等方面有了很大变化。"量"分为"减量"和"增量"两个层面。"减量"是指日本通过调整能源消费结构等措施,相应"弱化"和"缓冲"油价上涨风险;"增量"是指日本通过海外能源投资以及加大石油自主开发等措施部分"对冲"和"转嫁"油价上涨风险。"质"是指日本通过诸措施提升石油利用率,从而相应"舒缓"和"稀释"油价上涨风险。

关键词：日本石油价格上涨风险规避

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世界能源形势与日本新国家能源战略

东北亚论坛 2007年第5期16卷 104-109页

作者：尹晓亮南开大学日本研究院天津300071

为应对世界能源形势的新特点和新变化,日本颁布了以"安全"为核心的新国家能源战略。毋庸置疑,此战略的实施过程、运行路径必将波及影响到比邻而居且同为能源进口、消耗大国的中国。因此,有必要从深层次剖析并解读其战略衍生的触发机制... 详细信息

为应对世界能源形势的新特点和新变化,日本颁布了以"安全"为核心的新国家能源战略。毋庸置疑,此战略的实施过程、运行路径必将波及影响到比邻而居且同为能源进口、消耗大国的中国。因此,有必要从深层次剖析并解读其战略衍生的触发机制及其内容,并在此基础上,须探讨如何弱化和规避日本新国家能源战略给中国带来的影响。

关键词：能源日本战略措施影响

Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

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Nano-Micro Letters 2025年第2期17卷 432-446页

作者： Hao yin Yanting Li Zhiying Tian Qichao Li Chenhui Jiang Enfu liang Yiping Guo State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum Electronics Research Institute Beijing 100015People’s Republic of China Fundamental Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also ***,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic *** as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse *** ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filaments Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong yin Yuankai Gu Wendanqi liang Wenbo Ji Jianhua Zhuang Yan Liu Jie Gao You yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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地铁隧道新型二次衬砌结构参数优化分析

建筑机械化 2022年第5期43卷 88-92页

作者：殷小亮中铁二局第二工程有限公司福建三明365399

依托青岛市地铁6号线朝阳山CBD站~华山一路站工程,提出了一种新型二次衬砌结构,为研究其波纹钢板的稳定性,针对锚杆间距、波纹形状、波纹钢板厚度3种主要因素,研究其对二次衬砌混凝土浇筑模板变形的影响程度,利用正交法设计实验,并结合... 详细信息

依托青岛市地铁6号线朝阳山CBD站~华山一路站工程,提出了一种新型二次衬砌结构,为研究其波纹钢板的稳定性,针对锚杆间距、波纹形状、波纹钢板厚度3种主要因素,研究其对二次衬砌混凝土浇筑模板变形的影响程度,利用正交法设计实验,并结合有限元模拟进行参数分析,设计了九种试验方案,对实验结果进行了极差优化分析,得到最佳的波纹钢模板的设计方案。

关键词：隧道施工波纹钢板隧道二次衬砌参数优化数值模拟