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罗汉果的植物化学成分及其药理作用研究进展

饮料工业 2024年第3期27卷 73-77页

作者：张书泰陈芹芹尹小明吉诺恩(厦门)生物科技有限公司福建厦门361008

罗汉果甜苷是罗汉果甜度的主要来源,其具有抗氧化、降糖、抗过敏、抗癌、抗组织损伤等多种生物活性,是一种低热量天然甜味剂。因此,罗汉果甜苷在食品和药物制剂等方面具有很大的开发潜力,具有广阔的市场前景。本文对近年来罗汉果甜苷的... 详细信息

罗汉果甜苷是罗汉果甜度的主要来源,其具有抗氧化、降糖、抗过敏、抗癌、抗组织损伤等多种生物活性,是一种低热量天然甜味剂。因此,罗汉果甜苷在食品和药物制剂等方面具有很大的开发潜力,具有广阔的市场前景。本文对近年来罗汉果甜苷的化学成分、生物活性、药理作用以及罗汉果甜苷安全性等研究进展进行综述,以期为罗汉果甜苷的开发和综合利用提供参考。

关键词：罗汉果抗氧化剂低血糖甜味剂罗汉果甜苷抗癌

Mechanisms of Enhanced Rice Growth and Nitrogen Uptake by Nitrate

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Pedosphere 2007年第6期17卷 697-705页

作者： DUAN ying-Hua yin xiao-ming ZHANG Ya-Li SHEN Qi-Rong College of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 （China）

Rice is being increasingly cultivated in intermittently irrigated regions and also in aerobic soil in which Nitrate （NO3^- ） plays important role in nutrition of plant. However, there is no information regarding the influence of nitrate on the overall growth and uptake of nitrogen （N） in rice plant. Solution culture experiments were carried out to study the effects of NO^3- on the plant growth, uptake of N, and uptake kinetics of NH4^＋ in four typical rice （Oryza sativa L.） cultivars （conventional indica, conventional japonica, hybrid indica, and hybrid japonica）, and on plasma membrane potential in roots of two conventional rice cultivars （indica and japonica） at the seedling stage. The results obtained indicated that a ratio of 50/50 NH4^＋-N/NO3^--N increased the average biomass of rice shoots and roots by 20% when compared with that of 100/0 NH4^＋-N/NO3^--N. In case of the 50/50 ratio, as compared with the 100/0 ratio, total N accumulated in shoots and roots of rice increased on an average by 42% and 57%, respectively. Conventional indica responds to NO3^- more than any other cultivars that were tested. The NO^3- supply increased the maximum uptake rate （Vmax） of NH4^＋ by rice but did not show any effect on the apparent Michaelis-Menten constant （Km） value, with the average value of Vmax for NH4^＋ among the four cultivars being increased by 31.5% in comparison with those in the absence of NO3^-. This suggested that NO3^- significantly increased the numbers of the ammonium transporters. However, the lack of effect on the Km value also suggested that the presence of NO3^- had no effect on the affinity of the transporters for NH4^＋. The plasma membrane potential in the roots of conventional indica and japonica were greatly increased by the addition of NO3^- , suggesting that NO3^- could improve the uptake of N by roots of the rice plant. In conclusion, the mechanisms by which NO3^- enhances the growth and N uptake of rice plant was found by the increased value of Vm

关键词： ammonium uptake nitrate nutrition nitrogen uptake plasma membrane potential rice

Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways

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Cell Research 2000年第3期10卷 161-167页

作者： yin xiao-ming (Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA) DepartmentofPathology UniversityofPittsburghSchoolofMedicinePA15261USA.xmyin@pitt.edu

Two major apoptosis pathways have been defined in mammalian cells, the Fas/TNF-R1 death receptor pathway and the mitochondria pathway. The Bcl-2 family proteins consist of both anti-apoptosis and pro- apoptosis members that regulate apoptosis, mainly by controlling the release of cytochrome c and other mitochondrial apoptotic events. However, death signals mediated by Fas/TNF-R1 receptors can usually activate caspases directly, bypassing the need for mitochondria and escaping the regulation by Bcl-2 family proteins. Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Activated Bid is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Such a connection between the two apoptosis pathways could be important for induction of apoptosis in certain types of cells and responsible for the pathogenesis of a number of human diseases.

关键词： Apoptosis Bcl-2 family proteins Bid Fas TNF.

Dynamic manipulation of multimodal emission in Er^(3+)-activated non-core-shell structure for optical thermometry and information security

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Rare Metals 2024年第4期43卷 1702-1712页

作者： Xuan Liu Zi-Xia Lin yin-Biao Shi xiao-Yan Wang ming-Ye Ding xiao-Fei Yang College of Science Nanjing Forestry UniversityNanjing210037China Testing Center Yangzhou UniversityYangzhou225009China

Regulating luminescent dynamics of lanthanide-based luminescent materials via external stimuli is of great significance in the fields of optical thermometry and high-level ***,it is still a huge challenge to realize multimodal emissions with tunable color outputs from a single activator in simple structures via smart dynamic control of photon transition ***,we present a mechanistic strategy to achieve multimodal luminescence of Er^(3+)activators with color-switchable outputs in a non-core-shell *** the control of excitation dynamics(λ_(ex)=980,808,1532,377 nm),the population among the intermediate en ergy levels of Er^(3+)and the interaction between Er^(3+)and Yb^(3+)could be precisely modulated through energy transfer and migration processes,leading to the generation of colortunable multimodal luminescence upon diverse excitation modes(non-steady-state,single-/dual-wavelength steady,thermal activation).Inspired by its special luminescent performance,the as-obtained material exhibits great potential in noncontact thermometry,multimodal anticounterfeiting,and high-capacity information encryption by performing a series of proof-of-concept *** findings might provide a conceptual model to modulate the luminescent dynamics in a simple-structured system for the generation of color-adjustable multimodal emissions,which is convenient for the development of advanced luminescent materials toward versatile cuttingedge applications.

关键词： Lanthanide ions Multimodal emission Upconversion Downshifting Anti-counterfeiting Luminescent thermometry

Distribution of Mineral Nutrients and Active Ingredients in Aloe vera Irrigated with Diluted Seawater

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Pedosphere 2014年第6期24卷 722-730页

作者： JIANG Chao-Qiang QUAN Ling-Tong SHI Feng YANG Na WANG Chang-Hai yin xiao-ming ZHENG Qing-Song College of Resources and Environmental Science Key Laboratory of Marine BiologyNanjing Agricultural University Tobacco Research Institute Anhui Academy of Agricultural Science College of Life Science Nanjing Agricultural University

With increasing demand for irrigation water, agricultural scientists and planners pay more attention to the utilization of diluted seawater as an alternative source for irrigation of crops. A greenhouse pot experiment was conducted to study how seawater stress(SS) affects growth, water content, cationic accumulation, and active ingredients in leaves of Aloe vera after 30 d of growth in nutrient media with 0%(control), 22%(22% SS), and 42%(42% SS) seawater stress. Results indicated the SS did not change dry biomass of leaves and stems, but gradually decreased biomass allocation to roots with increasing seawater stress. Na+and Cl-in A. vera plant did not increase obviously with a big increase in seawater percentage due to low transpiration of Aloe vera. 42% SS decreased N concentration in most plant organs, but did not change or increased P concentration. Seawater stress tended to decrease concentrations of K+and Ca2+in A. vera. However, seawater salinity tended to increase the concentrations of aloin concentration in top(young) and middle leaves, and there was no significant effect of both stresses on aloin concentration in base(old) leaves. The 42% SS treatment decreased polysaccharide concentrations only in the base leaves, but not in top and middle leaves. In summary, supplying suitably diluted seawater for 30 d could increase the qualities and value of A. vera, without substantial effects on shoot dry biomass production.

关键词： aloin growth nutrition distribution polysaccharide seawater irrigation

Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： JIANG Yu-xia ZHAO Yan-na YU xiao-ling yin Li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(p<0.05).GRd treatment induced leukemia cell differentiation,showing increased expressions of peroxidase and specific proteins concerning erythrogenic or granulocytic differentiation(p<0.05).GRd treatment elicited upregulation of p-ERK,p-GSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(P<0.05).After GRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

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带式输送系统节能优化调度研究

制造业自动化 2024年第5期46卷 114-119页

作者：岑梁尹小明黄海棠胡文博张世荣国网浙江长兴县供电有限公司浙江湖州313100 国网电力科学研究院武汉能效测评有限公司湖北武汉430074 武汉大学电气与自动化学院湖北武汉430072

带式输送系统具有运输量大、单位耗能低等优点,在水泥熟料输送中获得了应用。以带速和运输量控制为手段,研究水泥熟料带式输送系统的优化调度策略,旨在提升系统能源效率并抑制带速波动;还深入研究了优化时域宽度对调度策略性能的影响。... 详细信息

带式输送系统具有运输量大、单位耗能低等优点,在水泥熟料输送中获得了应用。以带速和运输量控制为手段,研究水泥熟料带式输送系统的优化调度策略,旨在提升系统能源效率并抑制带速波动;还深入研究了优化时域宽度对调度策略性能的影响。选取某水泥熟料带式输送系统为例,分别在入库量波动、满负荷及低负荷3种工况下对优化调度策略进行了研究,结果表明:优化调度策略在3种工况下均取得了可观的节费率和节能率;当预测宽度大于等于4h,提出的调度策略即可获得较大收益,有效缩短了预测宽度。

关键词：分时电价优化调度带式输送机能耗模型水泥熟料

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3种生干虾皮制品营养成分分析与评价

食品安全质量检测学报 2024年第4期15卷 106-113页

作者：尹明晓李翔宇邵瑶佳水珊珊涂传海张宾浙江海洋大学比萨海洋研究生学院舟山316022 浙江海洋大学食品与药学学院舟山316022

目的探究不同海域生干虾皮制品的营养成分组成及其差异性。方法采用化学测定结合仪器分析法,对黄海、东海和南海海域产生干虾皮样品的基本营养成分、蛋白质消化率、氨基酸种类及含量、脂肪酸组成及含量、矿物元素种类及含量等进行测定... 详细信息

目的探究不同海域生干虾皮制品的营养成分组成及其差异性。方法采用化学测定结合仪器分析法,对黄海、东海和南海海域产生干虾皮样品的基本营养成分、蛋白质消化率、氨基酸种类及含量、脂肪酸组成及含量、矿物元素种类及含量等进行测定。结果3种生干虾皮样品中水分含量和粗蛋白含量较高,且盐分含量较低(均小于5.00%),其中以东海海域生干虾皮样品中粗蛋白含量高达69.56%;3种生干虾皮样品中总糖含量(以葡萄糖计)分别为0.34 g/100 g(黄海)、1.89 g/100 g(东海)和0.73 g/100 g(南海);东海海域生干虾皮中检测出17种游离氨基酸,黄海和南海海域虾皮样品中未检出苯丙氨酸;东海生干虾皮中检出了23种脂肪酸,而黄海和南海海域虾皮中分布检出21种和22种脂肪酸,其中均含有10种饱和脂肪酸(saturated fatty acid,SFA),4种单不饱和脂肪酸(monounsaturated fatty acid,MUFA),且均含有人体所必需的脂肪酸(以棕榈酸含量最多);3种生干虾皮中矿物质成分均含有14种常量及微量元素,其中Ca、Na、K、P元素含量丰富。结论3种不同海域生干虾皮在理化指标、营养成分及氨基酸、脂肪酸和矿物质含量方面存在较大差异,可为虾皮营养价值评价、消费者食用消费提供参考。

关键词：生干虾皮营养成分氨基酸脂肪酸消化率

Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第6期42卷 826-837页

作者： Feng-ming yin Li-Li Wu Shu-Sheng Li xiao-Na Pan xiao-Li Zhu Xu-Bao Jiang Xiang Zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China Shandong Institute for Product Quality Inspection Jinan250102China College of Chemical Engineering Tianjin UniversityTianjin300072China

Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent ***,the underlying interaction between their fluorescent properties and phase transition remains *** this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as ***,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence *** further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous ***,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of *** study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词： Polyethyleneimine Multi-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release