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LncRNA pol-lnc78 as a ceRNA regulates antibacterial responses via suppression of pol-miR-n199-3p-mediated SARM down-regulation in Paralichthys olivaceus

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Zoological Research 2024年第1期45卷 25-35页

作者： Xian-Hui Ning bing Han Ye Peng Shao-Wu yin College of Marine Science and Engineering Nanjing Normal UniversityNanjingJiangsu 210023China CAS Key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdaoShandong 266071China Co-Innovation Center for Marine Bio-Industry Technology of Jiangsu Province LianyungangJiangsu 222005China

Long non-coding RNAs(lncRNAs)function as key modulators in mammalian immunity,particularly due to their involvement in lncRNA-mediated competitive endogenous RNA(ceRNA)*** their recognized significance in mammals,research on lncRNAs in lower vertebrates remains *** the present study,we characterized the first immune-related lncRNA(pol-lnc78)in the teleost Japanese flounder(Paralichthys olivaceus).Results indicated that pol-lnc78 acted as a ceRNA for pol-miR-n199-3p to target the sterile alpha and armadillo motif-containing protein(SARM),the fifth discovered member of the Toll/interleukin 1(IL-1)receptor(TIR)adaptor *** ceRNA network regulated the antibacterial responses of flounder via the Toll-like receptor(TLR)signaling ***,SARM acted as a negative regulator and exacerbated bacterial infection by inhibiting the expression of inflammatory cytokines IL-1βand tumor necrosis factor-α(TNF-α).Pol-miR-n199-3p reduced SARM expression by specifically interacting with the 3’untranslated region(UTR),thereby promoting SARM-dependent inflammatory cytokine expression and protecting the host against bacterial ***,pol-lnc78 sponged pol-miR-n199-3p to ameliorate the inhibition of SARM *** infection,the negative regulators pol-lnc78 and SARM were significantly down-regulated,while pol-miR-n199-3p was significantly up-regulated,thus favoring host antibacterial *** findings provide novel insights into the mechanisms underlying fish immunity and open new horizons to better understand ceRNA crosstalk in lower vertebrates.

关键词： LncRNA SARM miRNA ceRNA Antibacterial response

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实时高温下与热处理后砂岩动态拉伸特性研究

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工程爆破 2021年第6期27卷 9-17,51页

作者：王超尹土兵中南大学资源与安全工程学院长沙410083 中南大学深部金属矿产开发与灾害控制湖南省重点实验室长沙410083

为了开展实时高温下及加热冷却后岩石动态力学性质的对比研究,利用自行设计的加热装置结合SHPB系统对两种温度状态砂岩的动态拉伸特性进行试验研究,处理温度为常温(25℃)~600℃共7组。结果表明:砂岩的率效应在两种温度状态下都存在,热... 详细信息

为了开展实时高温下及加热冷却后岩石动态力学性质的对比研究,利用自行设计的加热装置结合SHPB系统对两种温度状态砂岩的动态拉伸特性进行试验研究,处理温度为常温(25℃)~600℃共7组。结果表明:砂岩的率效应在两种温度状态下都存在,热处理后的砂岩拉伸强度除100℃外都比常温状态小,且随着热处理温度的增大,拉伸强度减小,温度会影响试样的破坏形态。高温下砂岩的拉伸强度除600℃外都比常温状态大,且拉伸强度随着温度的升高先增大后减小,加载率对破坏模式起主导作用。高温下的热膨胀作用会抑制裂纹相互连接,使得岩石结构更加密实,导致砂岩在实时高温下的拉伸强度相比加热冷却后有很大的区别。

关键词：砂岩高温 SHPB 拉伸强度破坏模式

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Ultra reliability and massive connectivity provision in integrated internet of military things(IoMT)based on tactical datalink

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Defence Technology（防务技术） 2024年第3期33卷 386-398页

作者： Li bing Yating Gu Lanke Hu Li Bowen Yang Lihua Jue Wang Yue yin Northwestern Polytechnical University Xi'an 710072China China Academy of Information and Communications Technology Beijing 100191China China Intelligent and Connected Vehicles(Beijing)Research Institute Co. LtdBeijing 100176China The 20th Research Institute of China Electronic Technology Group Corporation Xi’an 710068China Xidian University Xi'an 710071China

One of the major challenges arising in internet of military things(IoMT)is accommodating massive connectivity while providing guaranteed quality of service(QoS)in terms of ultra-high *** this regard,this paper presents a class of code-domain nonorthogonal multiple accesses(NOMAs)for uplink ultra reliable networking of massive IoMT based on tactical datalink such as Link-16 and joint tactical information distribution system(JTIDS).In the considered scenario,a satellite equipped with Nr antennas servers K devices including vehicles,drones,ships,sensors,handset radios,*** coded modulation,a special form of multiple input multiple output(MIMO)-NOMA is *** discussion starts with evaluating the output signal to interference-plus-noise(SINR)of receiver filter,leading to the unveiling of a closed-form expression for overloading systems as the number of users is significantly larger than the number of devices admitted such that massive connectivity is *** expression allows for the development of simple yet successful interference suppression based on power allocation and phase shaping techniques that maximizes the sum rate since it is equivalent to fixed-point programming as can be *** proposed design is exemplified by nonlinear modulation schemes such as minimum shift keying(MSK)and Gaussian MSK(GMSK),two pivotal modulation formats in IoMT standards such as Link-16 and *** results show that near capacity performance is ***,the performance is obtained using simple forward error corrections(FECs)of higher coding rate than existing schemes do,while the transmit power is reduced by 6 *** proposed design finds wide applications not only in IoMT but also in deep space communications,where ultra reliability and massive connectivity is a keen concern.

关键词： Satellite network Deep space communications Internet of military things Non-orthogonal multiple access MIMO Link-16 JITDS

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Synergistic effect of Zr and Mo on precipitation and high-temperature properties of Al-Si-Cu-Mg alloys

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China Foundry 2024年第1期21卷 71-81页

作者： Chao Gao bing-rong Zhang yin-ming Li Zhi-ming Wang Xiang-bin Meng Faculty of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Hebei Ounai Machinery Mould Co.Ltd. Xingtai 054500HebeiChina

This study focuses on finding a solution to the sharp decline in mechanical properties of Al-Si-Cu-Mg alloys due to rapid coarsening of traditional intermediate phases at high temperature.A new type of modified al oy,to be used in automobile engines at high temperatures,was prepared by adding Zr and Mo into Al-Si-Cu-Mg *** synergistic effects of Zr and Mo on the microstructure evolution and high-temperature mechanical properties were *** show that the addition of Zr and Mo generates a series of intermetallic phases dispersed in the *** can improve the strength of the alloy by hindering dislocation movement and crack *** addition,some nano-strengthened phases show coherent interfaces with the matrix and improve grain *** addition of Mo greatly improves the heat resistance of the *** extremely low diffusivity of Mo enables it to improve the thermal stability of the intermetallic phases,inhibit precipitation during aging,reduce the size of the precipitates,and improve the heat resistance of the alloy.

关键词： Al-Si-Cu-Mg alloy high-temperature properties Zr-Mo-rich intermetallics nano-strengthening phases

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Acute upper gastrointestinal bleeding due to portal hypertension in a patient with primary myelofibrosis:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2621-2626页

作者： Yu Chen bing-bing Kong He yin Hao Liu Sheng Wu Ting Xu Department of Emergency Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Pathology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China

BACKGROUND Acute upper gastrointestinal bleeding is a common medical emergency that has a 10%hospital mortality *** to the etiology,this disease can be divided into acute varicose veins and nonvaricose *** from esophageal varices is a life-threatening complication of portal *** hypertension is a clinical syndrome defined as a portal venous pressure that exceeds 10 *** is the most common cause of portal hypertension,and thrombosis of the portal system not associated with liver cirrhosis is the second most common cause of portal hypertension in the Western *** myeloproliferative disorders are the main cause of portal venous thrombosis,and somatic mutations in the Janus kinase 2 gene(JAK2 V617F)can be found in approximately 90% of polycythemia vera,50% of essential thrombocyrosis and 50% of primary *** SUMMARY We present a rare case of primary myelofibrosis with gastrointestinal bleeding as the primary manifestation that presented as portal-superior-splenic mesenteric vein *** blood tests revealed the presence of the JAK2 V617F *** marrow biopsy ultimately confirmed the diagnosis of myelofibrosis(MF-2 grade).CONCLUSION In patients with acute esophageal variceal bleeding due to portal hypertension and vein thrombosis without cirrhosis,the possibility of myeloproliferative neoplasms should be considered,and the JAK2 mutation test should be performed.

关键词： Acute esophageal variceal bleeding Portal hypertension Myelofibrosis JAK2 V617F mutation Case report

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Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy

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Chinese Chemical Letters 2024年第8期35卷 205-210页

作者： Zhe Li Ping-Zhao Liang Li Xu Fei-Yu Yang Tian-bing Ren Lin Yuan Xia yin Xiao-bing Zhang State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Photodynamic therapy(PDT)has emerged as a significant cancer therapy ***,cation-based organic small molecule aggregation-induced emission(AIE)photosensitizers(PSs)attract the wide atten-tion of many scientists,due to improved reactive oxygen species(ROS)production after ***,such PSs tend to localize only the mitochondria,limiting the death way of tumor cells(usu-ally apoptosis)during PDT process,which may affect the therapeutic effect under some ***,we designed a novel water-soluble three positive charge PS,TPAN-18F,which could be distributed uniformly in cell cytoplasm and had distribution in different sub-organelles(mitochondria,endoplasmic reticulum,lysosome).The experimental results showed that TPAN-18F-based PDT process can not only disrupt mitochondrial functions(reducing ATP production and destroying mitochondrial membrane po-tential),but also elevate the intracellular lipid peroxides(LPOs)level,which evoke the non-apoptotic death manner of tumor ***,in vivo studies showed that TPAN-18F-based PDT could effectively inhibit tumor ***,we believe that the construction of TPAN-18F is suggestive for tumor non-apoptotic therapy.

关键词： Water-soluble Three positive charge Photosensitizer Nonapoptotic tumor therapy

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Seismic and geological evidence of hidden faults in the yinpan Reservoir area based on a dense seismic array

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Science China Earth Sciences 2024年第7期67卷 2401-2407页

作者： Guangyao yin Huai ZHANG Liwen GONG Q ipeng BAI Yicun GUO bing ZHANG Yaolin SHI Key Laboratoryof Earth System Numerical Modeling and Application(Chinese Academyof Sciences) College of Earth and Planetary SciencesUniversity of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Computational Geodynamics Chinese Academy of SciencesBeijing 100049China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China Beijing Yanshan Critical Zone National Field Scientific Observation and Research Station Beijing 101408China Chongqing Earthquake Agency Chongqing 401147 China Institute of Earthquake Forecasting China Earthquake AdministrationBeijing 100036China Hangzhou Applied Acoustics Research Institute Hangzhou 311100China State Key Laboratory of Geodesy and Earths Dynamics Innovation Academy for Precision Measurement Science and TechnologyCASWuhan 430077China

*** November 23,2017,an M_(S)5.0 earthquake occurred in Wulong,Chongqing,China,resulting in tens of casualties and considerable economic ***,the epicenter of this earthquake was located in the transition zone from the... 详细信息

关键词： earthquake southeast seismic

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三轴压缩岩石动静组合强度及变形特征的研究

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岩土力学 2009年第7期30卷 1981-1986页

作者：叶洲元李夕兵周子龙尹土兵刘希灵中南大学资源与安全工程学院长沙410083

为研究深部地下资源开发过程中矿岩的力学行为,利用自行研制的岩石动静组合加载试验机,对细砂岩进行了两个系列的三维动静组合加载试验,即固定围压改变轴向静压和固定轴向静压改变围压的试验,并对实验数据整理分析。试验结果表明:围压... 详细信息

为研究深部地下资源开发过程中矿岩的力学行为,利用自行研制的岩石动静组合加载试验机,对细砂岩进行了两个系列的三维动静组合加载试验,即固定围压改变轴向静压和固定轴向静压改变围压的试验,并对实验数据整理分析。试验结果表明:围压不变时,细砂岩动静组合强度、弹性模量随轴向静压增大先升高(弹性阶段)后降低(损伤阶段);最大应变率和平均应变率则先下降后升高,并且当轴向静压在其静态三轴抗压强度80%左右时,动静组合强度最大;轴向静压不变时,增大围压,细砂岩动静组合强度、弹性模量升高,平均应变率下降,而最大应变率的变化趋势无明显规律。

关键词：动静组合加载三轴压缩 SHPB

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冲击载荷下脆性岩板损伤断裂演化的实验模拟研究

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四川大学学报（工程科学版） 2011年第6期43卷 85-90页

作者：汪亦显曹平尹土兵中南大学资源与安全工程学院湖南长沙410083

在矿山运输系统中,井壁围岩冲击损伤破坏对经济和安全效益的影响是至关重要的,因为动态冲击载荷对井壁围岩和支护结构会产生严重的削弱破坏作用,室内研究表明,岩石样品如岩板在动态载荷的冲击作用下会失效。为研究在低速冲击载荷作用下... 详细信息

在矿山运输系统中,井壁围岩冲击损伤破坏对经济和安全效益的影响是至关重要的,因为动态冲击载荷对井壁围岩和支护结构会产生严重的削弱破坏作用,室内研究表明,岩石样品如岩板在动态载荷的冲击作用下会失效。为研究在低速冲击载荷作用下,脆性岩石损伤断裂的演化过程,利用分离式霍普金森压杆(SHPB)装置中压缩气体发射球体子弹对脆性岩板进行变角度冲击损伤实验,岩板受到冲击后,边缘出现凹坑,表面裂纹从撞击凹坑直达岩板边缘,实验中样品的表面裂纹能有效代表试样内部的开裂状况,能有效反映冲击能量的耗散、破裂区面积与裂纹表面积随入射能量呈非线性增长趋势,同时与入射角度相关,但当破裂区面积急剧下降时,裂纹表面积反而急剧上升,表明裂纹的发生发展有明显的孕育期,在入射能量达到临界值前,主要表现为裂纹孕育增长,在达到临界值后,发生宏观断裂破坏,裂纹面积呈负增长,破裂区面积增大。实验结果分析表明在实际工程中,围岩和支护结构的抗冲击的最优化设计角度范围在15°～30°。

关键词：冲击载荷岩板实验模拟损伤断裂

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Beating the Fault-Tolerance Bound and Security Loopholes for Byzantine Agreement with a Quantum Solution

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Research 2024年第3期2023卷 445-455页

作者： Chen-Xun Weng Rui-Qi Gao Yu Bao bing-Hong Li Wen-Bo Liu Yuan-Mei Xie Yu-Shuo Lu Hua-Lei yin Zeng-bing Chen National Laboratory of Solid State Microstructures and School of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education)Renmin University of ChinaBeijing 100872China.

Byzantine agreement,the underlying core of blockchain,aims to make every node in a decentralized network reach *** Byzantine agreements unavoidably face two major *** is 1/3 fault-tolerance bound,which means that the system to tolerate f malicious players requires at least 3f+1 *** other is the security loopholes from its classical cryptography ***,we propose a Byzantine agreement framework with unconditional security to break this bound with nearly 1/2 fault tolerance due to multiparty correlation provided by quantum digital *** is intriguing that quantum entanglement is not necessary to break the 1/3 fault-tolerance bound,and we show that weaker correlation,such as asymmetric relationship of quantum digital signature,can also *** work strictly obeys two Byzantine conditions and can be extended to any number of players without requirements for multiparticle *** experimentally demonstrate three-party and five-party consensus for a digital *** work indicates the quantum advantage in terms of consensus problems and suggests an important avenue for quantum blockchain and quantum consensus networks.

关键词： methods. quantum signature

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