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Journal of Analysis and Testing 2022年第4期6卷 401-410页

作者： Li-Zhen Qiao Chun-mei Yu Rui-Ting Sun State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian116023China School of Chemical Engineering Dalian University of TechnologyPanjin124221China

In the present work,a novel amino-functionalized hexaalkylguanidinium chloride ionic liquid was prepared and grafted on the surface of magnetic materials through polyethyleneimine to enrich polycyclic aromatic hydrocarbons in water in combination with HPLC equipped with an ultraviolet *** effect of several parameters on the extraction efficiency was investigated,including the desorption solvent,the amounts of sorbents,the extraction time,the desorption time and the salt *** the optimized conditions,the method validation exhibited good linearity with correlation coefficients above 0.994 in the range of 0.2-300 ng/mL and low limits of detection and quantification of 0.05 and 0.2 ng/mL,***,relative recoveries were in the range of 80-120%,and the intra-day and inter-day repeatability were good with the relative standard deviations of less than 20%.Finally,the guanidinium ionic liquid modified magnetic materials were applied for the extraction of polycyclic aromatic hydrocarbons from real water samples to demonstrate the utility,and the results show that the proposed method has good prospect for effective enrichment and determination of pollutants in water.

关键词： Guanidinium ionic liquid Magnetic solid-phase extraction Amino-functionalized Polycyclic aromatic hydrocarbons

Transplantation of microencapsulated umbilical-cord-blood-derived hepatic-like cells for treatment of hepatic failure

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World Journal of Gastroenterology 2011年第7期17卷 938-945页

作者： Fang-Ting Zhang Hui-Juan Wan Ming-Hua Li Jing Ye mei-Jun yin Chun-Qiao Huang Jie Yu Central Laboratory Peking University Shenzhen Hospital Shenzhen 518036 China

AIM: To investigate intraperitoneal transplantation of microencapsulated hepatic-like cells from human umbilical cord blood for treatment of hepatic failure in rats. METHODS: CD34+ cells in umbilical cord blood cells were isolated by magnetic cell sorting. In the in vitro experiment, sorted CD34+ cells were amplified and induced into hepatic-like cells by culturing with a combination of fibroblast growth factor 4 and hepatocyte growth factor. Cultures without growth factor addition served as controls. mRNA and protein levels for hepatic-like cells were analyzed by reverse transcription-polymerase chain reaction, immunohistochemistry and immunofluorescence. In the in vivo experiment, the hepatic-like cells were encapsulated and transplanted into the abdominal cavity of acute hepatic failure (AHF) rats at 48 h after D-galactosamine induction of acute hepatic failure. Transplantation with PBS and unencapsulated hepatic-like cells served as controls. The mortality rate, hepatic pathological changes and serum biochemical indexes were determined. The morphology and structure of microcapsules in the greater omentum were observed. RESULTS: Human albumin, alpha-fetoprotein and GATA-4 mRNA and albumin protein positive cells were found among cultured cells after 16 d. Albumin level in culture medium was significantly increased after culturing with growth factors in comparison with culturing without growth factor addition (P < 0.01). Compared with the unencapsulated group, the mortality rate of the encapsulated hepatic-like cell-transplanted group was significantly lower (P < 0.05). Serum biochemical parameters, alanine aminotransferase, aspartate aminotransferase and total bilirubin in the encapsulated group were significantly improvement compared with the PBS control group (P < 0.01). Pathological staining further supported these findings. At 1-2 wk post-transplantation, free microcapsules with a round clear structure and a smooth surface were observed in peritoneal lavage fl

关键词： Microencapsulation Hepatic-like cells Umbilical cord blood cells CD34 antigen Alginate Acute hepatic failure

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基于NSCT的SMP立体匹配算法研究

电子学报 2008年第4期36卷 772-776页

作者：丁辉付梦印王美玲北京理工大学信息科学技术学院北京100081

针对区域立体匹配算法中匹配窗口自适应选择的难点,提出一种基于多尺度分析Nonsubsampled Con-tourlet变换(NSCT)的快速区域立体匹配新算法.首先介绍NSCT并对其时移不变性进行讨论.采用由粗到精的匹配策略和快速的SMP匹配代价函数降低... 详细信息

针对区域立体匹配算法中匹配窗口自适应选择的难点,提出一种基于多尺度分析Nonsubsampled Con-tourlet变换(NSCT)的快速区域立体匹配新算法.首先介绍NSCT并对其时移不变性进行讨论.采用由粗到精的匹配策略和快速的SMP匹配代价函数降低运算量.实验结果表明,该算法具有很高准确率.

关键词：区域匹配 Nonsubsampled Ccontourlet变换时移不变性图像多尺度几何分析

DESIGN OF LOW-DENSITY PARITY CHECK CODES FOR MIMO SYSTEMS WITH DOUBLY-ITERATIVE RECEIVERS

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Journal of Electronics(China) 2010年第4期27卷 553-556页

作者： mei Zhonghui Li Xiaofei College of Telecommunication and Information Engineering Nanjing University of Posts and Telecommunications Nanjing 210003 China

In this paper, the Multiple Input Multiple Output (MIMO) doubly-iterative receiver which consists of the Probabilistic Data Association detector (PDA) and Low-Density Parity-Check Code (LDPC) decoder is developed. The receiver performs two iterative decoding loops. In the outer loop, the soft information is exchanged between the PDA detector and the LDPC decoder. In the inner loop, it is exchanged between variable node and check node decoders inside the LDPC decoder. On the light of the Extrinsic Information Transfer (EXIT) chart technique, an LDPC code degree profile optimization algorithm is developed for the doubly-iterative receiver. Simulation results show the doubly-receiver with optimized irregular LDPC code can have a better performance than the one with the regular one.

关键词： Probabilistic Data Association (PDA) Multiple-Input Multiple-Output (MIMO) Low-Density Parity-Check Code (LDPC) Extrinsic Information Transfer (EXIT) chart

Dynamical economic dispatch using distributed barrier function-based optimization algorithm

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Science China(Technological Sciences) 2019年第12期62卷 2104-2112页

作者： YAO YiYang TIAN FangZheng mei Feng FU JunJie DAI Bo YU WenWu State Grid Zhejiang Electric Power Corporation Information&Telecommunication Branch Hangzhou 310007China School of Mathematics Southeast UniversityNanjing 210096China

In this paper, we study the distributed economic dispatch problem where the supply demand balance, capacity constraints and ramp-rate constraints are considered. In order to accommodate varying power load and power storage in reality, we introduce two variables where each variable is time-varing and has its own dynamics. The renewable power is also considered. Barrier functions are introduced to deal with the local constraints by means of imposing penalty terms into the objective function to ensure that the optimal solution satisfies the corresponding constraints. Based on the Langrange dual theory, the primal optimization problem is transformed into the dual problem, which is solved by the primary-dual algorithm proposed in this paper. Under the assumption that the communication graph is an undirected and connected graph, we analyze the convergence of the proposed algorithm. The simulations on IEEE six-bus test systems are carried out to verify the performance of the algorithm, which shows that the proposed algorithm converges to the optimal solution, while all the constraints are met.

关键词： multi-agent systems distributed optimization barrier function Langrange function

Risk assessment of glacial debris flow on alpine highway under climate change: A case study of Aierkuran Gully along Karakoram Highway

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Journal of Mountain Science 2021年第6期18卷 1458-1475页

作者： LI Ya-mei SU Li-jun ZOU Qiang WEI Xue-li Institute of Tibetan Plateau Research Chinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengduSichuan 610041China China-Pakistan Joint Research Centre on Earth Sciences CAS-HECIslamabad 45320Pakistan University of Chinese Academy of Sciences Beijing 100049China Transportation Planning Survey and Design Institute of Xinjiang Uygur Autonomous Region Urumqi 830006China

Glacial debris flows(GDFs) often occur in alpine regions that are subject to rapid climate change, and pose a serious threat to road systems. However, the ways that climate change impacts GDF risks along road systems remain poorly understood. Aierkuran Gully, located in eastern Pamir along Karakoram Highway(KKH), is a hotspot for GDF activity and climate change, and was thus selected to investigate the GDF risk to road systems under climate change conditions. Reg CM4.6 climate data for northwestern China were selected as climate projections during baseline(2011–2020) and future periods(2031–2040) under the Representative Concentration Pathway(RCP) 8.5. To reflect the coupling effect of rainfall and melt water that triggers GDF, a glacial hydrological model DETIM that considers both factors was applied to calculate the peak debris flow discharge. A FLO-2D model was calibrated based on high-quality data collected from a detailed field investigation and historical debris flow event. The FLO-2D model was used to simulate the debris flow depth and velocity during baseline and future periods under RCP8.5. The debris flow hazard was analyzed by integrating the maximum flow depth and momentum. Road structure vulnerability was further determined based on the economic value and susceptibility of hazard-affected objects. The GDF risk along KKH was assessed based on the GDF hazard and vulnerability analysis. Our results show that climate change would lead to amplified peak debris flow discharge, trigger highermagnitude GDF, and induce more severe damage and threats to the road system. Compared with the baseline period, the debris flow damage risk for culverts and bridges would increase and the areas that inundate the road and pavement would expand. Our findings provide valuable insights for the development of mitigation strategies to adapt road systems to climate change, especially in alpine regions with highly active GDFs.

关键词： Glacial debris flow Risk assessment Climate change Alpine area Karakoram Highway

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基于视觉和毫米波雷达的车辆检测(英文)

红外与毫米波学报 2014年第5期33卷 465-471页

作者：靳璐付梦印王美玲杨毅北京理工大学自动化学院北京100081 复杂系统智能控制与决策教育部重点实验室北京100081

根据智能车辆主动驾驶辅助系统中的重要性,提出了一种融合毫米波雷达数据和视觉多特征的车辆检测算法。车辆检测算法通过三个步骤实现,首先,提出一种空间对准算法实现毫米波雷达和视觉的空间对准;其次,根据空间对准结果和搜索策略提取... 详细信息

根据智能车辆主动驾驶辅助系统中的重要性,提出了一种融合毫米波雷达数据和视觉多特征的车辆检测算法。车辆检测算法通过三个步骤实现,首先,提出一种空间对准算法实现毫米波雷达和视觉的空间对准;其次,根据空间对准结果和搜索策略提取目标车辆的感兴趣区域;最后,融合车底阴影、对称轴、左右边缘等车辆特征实现车辆检测,其中,为了准确得到目标车辆的车底阴影,提出一种改进的车底阴影分割算法。算法的性能在不同的场景下得到证实,实验结果表明该车辆检测算法是有效和可靠的。

关键词：主动驾驶辅助系统车辆检测空间对准感兴趣区域车底阴影

Radiomics for predicting perineural invasion status in rectal cancer

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World Journal of Gastroenterology 2021年第33期27卷 5610-5621页

作者： Mou Li Yu-mei Jin Yong-Chang Zhang Ya-Li Zhao Chen-Cui Huang Sheng-mei Liu Bin Song Department of Radiology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology Chengdu Seventh People’s HospitalChengdu 610213Sichuan ProvinceChina Department of Research Collaboration R&D CenterBeijing Deepwise&League of PHD Technology Co.LtdBeijing 100080China

BACKGROUND Perineural invasion(PNI),as a key pathological feature of tumor spread,has emerged as an independent prognostic factor in patients with rectal cancer(RC).The preoperative stratification of RC patients according to PNI status is beneficial for individualized treatment and improved ***,the preoperative evaluation of PNI status is still *** To establish a radiomics model for evaluating PNI status preoperatively in RC *** This retrospective study enrolled 303 RC patients in a single institution from March 2018 to October *** patients were classified as the training cohort(n=242)and validation cohort(n=61)at a ratio of 8:2.A large number of intraand peritumoral radiomics features were extracted from portal venous phase images of computed tomography(CT).After deleting redundant features,we tested different feature selection(n=6)and machine-learning(n=14)methods to form 84 *** best performing classifier was then selected to establish ***,the clinicoradiological model(combined model)was developed by combining Rad-score with clinical *** models for predicting PNI were compared using receiver operating characteristic curve(ROC)analysis and area under the ROC curve(AUC).RESULTS One hundred and forty-four of the 303 patients were eventually found to be *** factors including CT-reported T stage(cT),N stage(cN),and carcinoembryonic antigen(CEA)level were independent risk factors for predicting PNI *** established Rad-score by logistic regression analysis after selecting features with the L1-based *** combined model was developed by combining Rad-score with cT,cN,and *** combined model showed good performance to predict PNI status,with an AUC of 0.828[95%confidence interval(CI):0.774-0.873]in the training cohort and 0.801(95%CI:0.679-0.892)in the validation *** comparison of the models,the combined model achieved a higher AUC than the clinic

关键词： Radiomics Perineural invasion Rectal cancer Computed tomography Preoperative prediction Model building

Antitumor activity of nervosine Ⅶ,and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells

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Chinese Journal of Natural Medicines 2020年第2期18卷 81-89页

作者： HUANG Shuai ZHAO Shuang-mei SHAN Lian-Hai ZHOU Xian-Li School of Life Science and Engineering Southwest Jiaotong UniversityChengdu 610031China

Nervosine Ⅶ is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis *** is first study to investigate the antitumor activity of nervosine Ⅶ in vitro,and the results indicated that nervosine Ⅶ induced autophagy and apoptosis in HCT116 human colorectal cancer *** studies showed that nervosine Ⅶ-induced apoptosis was associated with the intrinsic pathway by the activation of caspase-9,-3 *** induced by nervosine Ⅶ was characteristic with the regulation of autophagic markers including the increase of LC3-Ⅱ and beclin 1 proteins,and the decrease of p62 *** Ⅶ simultaneously induced autophagy and apoptosis by activated MAPKs signaling pathway including JNK,ERK1/2 and p38,suppressing the p53 signaling pathway.

关键词： Liparis nervosa Pyrrolizidine alkaloids NervosineⅦ Autophagy Apoptosis HCT116 cells

Cellular senescence in musculoskeletal homeostasis,diseases,and regeneration

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Bone Research 2021年第4期9卷 444-455页

作者： mei Wan Elise F.Gray-Gaillard Jennifer H.Elisseeff Department of Orthopaedic Surgery The Johns Hopkins University School of MedicineBaltimoreMDUSA Translational Tissue Engineering Center Wilmer Eye Institute and the Department of Biomedical EngineeringThe Johns Hopkins UniversityBaltimoreMDUSA

Emerging insights into cellular senescence highlight the relevance of senescence in musculoskeletal disorders,which represent the leading global cause of *** senescence was initially described by Hayflick et *** 1961 as an irreversible nondividing state in in vitro cell culture *** now know that cellular senescence can occur in vivo in response to various stressors as a heterogeneous and tissue-specific cell state with a secretome phenotype acquired after the initial growth *** the past two decades,compelling evidence from preclinical models and human data show an accumulation of senescent cells in many components of the musculoskeletal *** senescence is therefore a defining feature of age-related musculoskeletal disorders,and targeted elimination of these cells has emerged recently as a promising therapeutic approach to ameliorate tissue damage and promote repair and regeneration of the skeleton and skeletal *** this review,we summarize evidence of the role of senescent cells in the maintenance of bone homeostasis during childhood and their contribution to the pathogenesis of chronic musculoskeletal disorders,including osteoporosis,osteoarthritis,and *** highlight the diversity of the senescent cells in the microenvironment of bone,joint,and skeletal muscle tissue,as well as the mechanisms by which these senescent cells are involved in musculoskeletal *** addition,we discuss how identifying and targeting senescent cells might positively affect pathologic progression and musculoskeletal system regeneration.

关键词： skeletal homeostasis dividing