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Microbiota-mediated shaping of mouse spleen structure and immune function characterized by scRNA-seq and Stereo-seq

Journal of Genetics and Genomics 2023年第9期50卷 688-701页

作者： yin Zhang Juan Shen Wei Cheng Bhaskar Roy Ruizhen Zhao Tailiang Chai Yifei Sheng Zhao Zhang Xueting Chen Weiming Liang Weining Hu Qijun Liao Shanshan Pan Wen Zhuang Yangrui Zhang Rouxi Chen Junpu mei Hong Wei Xiaodong Fang College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China BGI-Shenzhen ShenzhenGuangdong 518083China College of Animal Sciences and Technology Huazhong Agricultural UniversityWuhanHubei 430070China BGI-Qingdao BGI-ShenzhenQingdaoShandong 266555China BGI-Sanya BGI-ShenzhenSanyaHainan 572025China Precision Medicine Institute The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China

Gut microbes exhibit complex interactions with their hosts and shape an organism's immune system throughout its *** the largest secondary lymphoid organ,the spleen has a wide range of immunological *** explore the role of microbiota in regulating and shaping the spleen,we employ scRNA-seq and Stereo-seq technologies based on germ-free(GF)mice to detect differences in tissue size,anatomical structure,cell types,functions,and spatial molecular *** identify 18 cell types,9 subtypes of T cells,and 7 subtypes of B *** differential expression analysis reveals that the absence of microorganisms results in alterations in erythropoiesis within the red pulp region and congenital immune deficiency in the white pulp ***-seq results demonstrate a clear hierarchy of immune cells in the spleen,including marginal zone(MZ)macrophages,MZ B cells,follicular B cells and T cells,distributed in a well-defined pattern from outside to ***,this hierarchical structure is disturbed in GF ***7 and Cxcl13 chemokines are specifically expressed in the spatial locations of T cells and B cells,*** speculate that the microbiota may mediate the structural composition or partitioning of spleen immune cells by modulating the expression levels of chemokines.

关键词： ScRNA-seq Spatial transcriptome GF mouse Spleen structure Microbiota Immune function

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Synthesis,Structure and Biological Activities of 2-(1H- 1,2,3-Benzotriazol-1-yl)-1-(4-methylphenyl)-2- (1H-1,2,4-triazol-1-yl)-1-ethanone

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Chemical Research in Chinese Universities 2006年第4期22卷 465-467页

作者： WAN Jun LI Chun-li LI Xue-mei ZHANG Shu-sheng College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China

The title compound was synthesized and characterized by IR, ^1H NMR, elemental analysis and single crystal X-ray diffraction analysis. Its biological activities were also tested. The results show that the title compound reveals inhibiting activities towards wheat gibberellin, apple ringspot, tomato early blight, peanut cercospora arachidicola and stem wilt of asparagus.

关键词： Triazole derivative Biological activity Crystal structure

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Recent progress towards fluorinated copolymers for efficient photovoltaic applications

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Chinese Chemical Letters 2016年第8期27卷 1241-1249,1467页

作者： Xiao-Peng Xu ying Li mei-Ming Luo Qiang Peng Key Laboratory of Green Chemistry and Technology of Ministry of Education College of Chemistryand State Key Laboratory of Polymer Materials EngineeringSichuan University

This review paper summarizes the recent progress of highly efficient copolymers with the fluorination strategy for photovoltaic *** first present a brief introduction of the fundamental principles of polymer solar cells,and then the functions of fluorine atoms on the polymer donor ***,we review the research progress of the reported copolymers by classification of the fluorinated acceptor units and donor units,*** resulting structure-property correlations of these copolymers are also discussed which shall certainly facilitate widespread utilization of this strategy for constructing high-performance photovoltaic copolymers in the future.

关键词： Polymer solar cells Fluorination Acceptor units Donor units High efficiency

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Application of sewage sludge and intermittent aeration strategy to the bioremediation of DDT- and HCH-contaminated soil

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Journal of Environmental Sciences 2014年第8期26卷 1673-1680页

作者： Qi Liang mei Lei Tongbin Chen Jun Yang Xiaoming Wan Sucai Yang Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences

Adding organic amendments to stimulate the biodegradation of pesticides is a subject of ongoing interest. The effect of sewage sludge on the bioremediation of dichlorodiphenyltrichloroethane（DDT） and hexachlorocyclohexane（HCH） contaminated soil was investigated in bench scale experiments,and intermittent aeration strategy was also used in this study to form an anaerobic–aerobic cycle. Bioremediation of DDT and HCH was enhanced with the addition of sewage sludge and the intermittent aeration. The removal rates of HCH and DDT were raised by 16.8%–80.8% in 10 days. Sewage sludge increased the organic carbon content from 6.2 to218 g/kg,and it could also introduce efficient degradation microbes to soil,including Pseudomonas sp.,Bacillus sp. and Sphingomonas sp. The unaerated phase enhanced the anaerobic dechlorination of DDT and HCH,and anaerobic removal rates of β-HCH,o,p′-DDT and p,p′-DDT accounted for more than 50% of the total removal rates,but the content of α-HCH declined more in the aerobic phase.

关键词： Bioremediation Dichlorodiphenyltrichloroethane(DDT) Hexachlorocyclohexane(HCH) Sewage sludge Aeration strategy

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Metal-free reduction of tertiary phosphine oxides with Hantzsch ester

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Chinese Chemical Letters 2014年第1期25卷 176-178页

作者： Tong-Xin Zhang Wei-Xi Zhang mei-Ming Luo Key Laboratory of Green Chemistry & Technology of Ministry of Education College of ChemistrySichuan University

The （COCl）2/Hantzsch ester is found to be an effective system for the metal-free reduction of tertiary phosphine oxides. The reaction proceeds under mild conditions, and is applicable to triarylphosphine oxides and alkyldiarylphosphine oxides to produce the corresponding tertiary phosphines in good to excellent yields. This new finding provides a practical, convenient and metal-free method for the reduction of tertiary phosphine oxides to tertiary phosphines, and shows potential application in organic synthesis.

关键词： Metal-free reduction Tertiary phosphine oxides Tertiary phosphines Hantzsch ester

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Xi UOS: an open-source ubiquitous operating system for industrial Internet of Things

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Science China(Information Sciences) 2022年第1期65卷 262-263页

作者： Donggang CAO Dongliang XUE Zhiyi MA Hong mei Advanced Institute of Information Technology Peking University Computer Science Department Peking University Computer Science Department Shanghai Jiao Tong University

On May 4, 2021, a Chinese research team with members from AIIT（PKU Advanced Institute of Information Technology）, PKU（Peking University）, and SJTU（Shanghai Jiao Tong University）, openly released the source code of Xi UOS, a UOS（ubiquitous operating system） [1] for the industrial Internet of Things（IIo T）, under the open-source license of Mulan PSL v2 on Trustie1)and Mulan OS2).

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HIGH ORDER LAGRANGIAN VELOCITY STATISTICS IN A TURBULENT CHANNEL FLOW WITH Re_τ=80

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Journal of Hydrodynamics 2012年第2期24卷 287-291页

作者： LUO Jian-ping QIU Xiang LI Dong-mei LIU Yu-lu School of Mechanical Engineering Shanghai Institute of Technology Shanghai 200235 China School of Science Shanghai Institute of Technology Shanghai 200235 China Shanghai Institute of Technology Shanghai 200235 China

The scaling properties of high-order Lagrangian velocity structure functions are investigated numerically for a turbulent flow with a friction-velocity based Reynolds number Re_τ=*** Lagrangian particles are released from locations of different distances to the *** relative scaling exponents of the longitudinal velocity component are found to increase with the released distance to the wall and to approach asymptotically to theoretical ***,the scaling exponents of the transverse velocity component are smaller than ,indicating a more intermittent *** for the release locations in the center region,the relative scaling exponents agree very well with theoretical predictions.

关键词： Lagrangian scaling exponents intermittency turbulent channel flow

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A tightly bonded reduced graphene oxide coating on magnesium alloy with photothermal effect for tumor therapy

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Journal of Magnesium and Alloys 2022年第11期10卷 3031-3040页

作者： Lidan Liu Feng Peng Dongdong Zhang mei Li Jian Huang Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Orthopedics Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou 310024China

Photothermal therapy becomes a hotspot in the treatment of bone tumors. Magnesium and its alloys are regarded as potential bone implants for their favorable mechanical property and biodegradable in vivo. However, there is few research devoted to fabricating a photothermal coating on Mg alloy. In the present study, reduced graphene oxide coating with a strong photothermal effect was prepared on the surface of AZ31via two steps. Firstly, graphene oxide coating was deposited on the surface via electrophoresis deposited(GO#), followed by a reduction process of the graphene oxide coating in ultrapure water(rGO#). GO# and rGO# coatings were characterized by SEM, Raman, XRD, FTIR,and XPS. The results revealed that, compared with GO# coating, the content of oxygen-containing(C-O/C-O-C, C=O, O-C=O) groups on rGO# coating was significantly decreased. rGO# coating was found tightly adhered to AZ31 substrate. According to the first-principles calculations, the well-bonded heterostructure between MgO and rGO is the main reason for the strong bonding force. Moreover, the prepared rGO# coating showed a superior photothermal effect, which brings a new strategy to the treatment of bone tumors with Mg-based implants.

关键词： Magnesium alloy Reduced graphene oxide Photothermal effect

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2005年中国十五家教学医院院内获得革兰阴性病原菌耐药性分析

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中华医学杂志 2007年第39期87卷 2753-2758页

作者：杨启文徐英春陈民钧胡云建倪语星孙景勇俞云松孔海深何林吴伟元叶惠芬杨银梅朱莲娜郭世辉季萍朱震宏任健康张利侠孙自镛朱旭慧童明庆赵旺胜梅亚宁刘勇张智洁段琼李丹刘蓬蓬王晶韩丽霞王辉谢秀丽中国医学科学院中国协和医科大学北京协和医院风湿免疫科 100730 卫生部北京医院细菌室上海交通大学附属瑞金医院临床微生物科浙江大学医学院附属第一医院细菌室深圳市人民医院检验科广州市第一人民医院细菌室广西医科大学第一附属医院细菌室新疆医科大学附属第一医院细菌室陕西省人民医院检验科华中科技大学同济医学院附属同济医院检验科江苏省人民医院检验科中国医科大学附属第二医院检验科吉林省人民医院细菌室青岛大学医学院附属医院检验科大连医科大学第一附属医院

目的监测2005年我国不同地区15家教学医院分离的医院获得革兰阴性病原菌的耐药性。方法按设计方案收集非重复的1927株院内获得革兰阴性病原菌。菌株经中心实验室复核后,采用琼脂稀释法测定6类18种抗菌药物的最低抑菌浓度(MIC),数据输入 ... 详细信息

目的监测2005年我国不同地区15家教学医院分离的医院获得革兰阴性病原菌的耐药性。方法按设计方案收集非重复的1927株院内获得革兰阴性病原菌。菌株经中心实验室复核后,采用琼脂稀释法测定6类18种抗菌药物的最低抑菌浓度(MIC),数据输入 WHONET 5.4软件进行耐药性分析。结果不产超广谱β内酰胺酶(ESBEs)的大肠埃希菌、肺炎克雷伯菌和奇异变形杆菌对被测β内酰胺类药物的敏感性均较高,而对于产 ESBLs 的大肠杆菌和肺炎克雷伯菌,敏感率大于80%的药物只有美罗培南、亚胺培南和哌拉西林-三唑巴坦。不产 ESBLs 大肠埃希菌对氟喹诺酮类药物的敏感性很低(34.8%～36.1%),产 ESBLs 大肠埃希菌的敏感性则更低(13.4%～17.1%)。对于易产头孢菌素酶(AmpC)的菌株(包括阴沟肠杆菌、产气肠杆菌、枸橼酸杆菌属、沙雷菌属、普通变形杆菌),敏感率均大于80%的抗生素有美罗培南、亚胺培南、哌拉西林-三唑巴坦,另外,敏感性较高的抗菌药物还包括头孢吡肟(67.3%～100%)、阿米卡星(67.3%～95.2%)、头孢他啶(52.9%～100%)和头孢哌酮-舒巴坦(51.9%～100%),氟喹诺酮类药物的敏感率为52.5%～86.2%。铜绿假单胞菌对多黏菌素 B 的敏感性最高(95.6%),敏感率在70%～80%之间的药物有美罗培南、亚胺培南、阿米卡星和哌拉西林-三唑巴坦。鲍曼不动杆菌对多黏菌素 B 的敏感率达98.3%,继之为亚胺培南(80.8%)、美罗培南(76.2%)和米诺环素(67.4%),其他药物的敏感率低于60%。对嗜麦芽窄食单胞菌,敏感性较高的抗菌药物有米诺环素(85.0%)、左氧氟沙星(82.5%)和甲氧苄啶-磺胺甲噁唑(77.5%)。对洋葱伯克霍尔德菌,敏感性相对较高的抗菌药物有米诺环素(77.2%)和美罗培南(61.4%)。结论碳青酶烯类、哌拉西林-三唑巴坦、阿米卡星和头孢吡肟对医院分离的肠杆菌科菌保持了较高的抗菌活性,而非发酵革兰阴性杆菌对临床常用药物的敏感性较以往监测有所降低。

关键词：抗药性微生物肠杆菌科假单胞菌铜绿不动杆菌属耐药性监测

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A Convolutional Autoencoder Based Fault Detection Method for Metro Railway Turnout

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Computer Modeling in Engineering & Sciences 2023年第7期136卷 471-485页

作者： Chen Chen Xingqiu Li Kai Huang Zhongwei Xu Meng mei School of Electronic and Information Engineering Tongji UniversityShanghai201804China School of Engineering City University of Hong KongHong Kong200433China School of Civil Aviation Northwestern Polytechnical UniversityXi’an710072China School of Computer Engineering Jimei UniversityXiamen361021China

Railway turnout is one of the critical equipment of Switch&Crossing(S&C)Systems in railway,related to the train’s safety and operation *** the advancement of intelligent sensors,data-driven fault detection technology for railway turnout has become an important research ***,little research in the literature has investigated the capability of data-driven fault detection technology for metro railway *** paper presents a convolutional autoencoder-based fault detection method for the metro railway turnout considering human field inspection ***,the one-dimensional original time-series signal is converted into a twodimensional image by data pre-processing and 2D ***,a binary classification model based on the convolutional autoencoder is developed to implement fault *** profile and structure information can be captured by processing data as *** performance of our method is evaluated and tested on real-world operational current data in themetro *** results show that the proposedmethod achieves better performance,especially in terms of error rate and specificity,and is robust in practical engineering applications.

关键词： Convolutional autoencoder fault detection metro railway turnout

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