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Electrochemical Dearomative Spirocyclization of N-Acyl Sulfonamides in a Continuous-Flow Cell

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Chinese Journal of Chemistry 2024年第9期42卷 980-984页

作者： Ting Liu Zhaojiang Shi Yaofeng Yuan Yuqi Lin ke-yin Ye key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University) College of ChemistryFuzhou University FuzhouFujian350108China

The development of efficient and sustainable methods to obtain spirocyclic compounds is of significance as these structures are widely found in pharmaceuticals and ***,we disclose an electrochemical dearomative spirocyclization of N-acyl sulfonamides in a continuous-flow *** reaction is simple and efficient without external catalysts or supporting electrolytes and could be applied in a decagram-scale synthesis.

关键词： Electrochemistry Continuous-flow Dearomatization Spirocyclization Sulfonamides Cyclization Methodology and reactions

A highly sensitive fluorescent probe RN-NA reveals peroxynitrite as a novel biomarker for primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 219-227页

作者： Bo Qin Yuan Lei Luo Bao You-Jia Zhang ke-yin Liu Yu-Hong Chen Department of Ophthalmology&Visual Science Eye&ENT HospitalShanghai Medical CollegeFudan UniversityShanghai 200031China key Laboratory of Myopia NHFPC(Fudan University)Shanghai Key Laboratory of Visual Impairment and Restoration(Fudan University)Shanghai 200031China State key Laboratory of Biobased Material and Green Papermaking Key Laboratory of Pulp&Paper Science and Technology of Shandong Province/Ministry of EducationQilu University of TechnologyShandong Academy of SciencesJinan 250353Shandong ProvinceChina

AIM:To directly quantify peroxynitrite(ONOO-)using a highly sensitive fluorescence resonance energy transfer probe RN-NA,investigate the association between ONOOand primary open angle glaucoma(POAG),and clarify whether RN-NA could be used as a potential tool for POAG ***:Plasma and aqueous humor(AH)samples were collected from POAG patients(n=100,age:59.70±6.87y)and age-related cataract(ARC)patients(n=100,age:61.15±4.60y)admitted to our ***,RN-NA was used to detect ONOO-in plasma and AH samples,and the relationship between ONOO-level and POAG was analyzed using binary logistic ***,Pearson correlation analysis was applied to characterize the correlation of the levels of ONOO-with the patients’age,intraocular pressure(IOP),and mean deviation of visual field *** ONOO-scavenger MnTMPyP was employed to treat the 3-morpholinosyndnomine(SIN-1)-induced ocular hypertension in mice(n=7,6-8wk).Finally,the IOP and ONOO-in both eyes were measured 30min after the last drug ***:ONOO-levels of AH and plasma were significantly higher in the POAG group than in the ARC group(Pker of POAG,especially advanced ***,anti-nitration compounds may be novel ocular hypotens

关键词： peroxynitrite fluorescent probe RN-NA primary open angle glaucoma 3-morpholinosyndnomine

Underestimated Methane Emissions from Solid Waste Disposal Sites Reveal Missed Greenhouse Gas Mitigation Opportunities

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Engineering 2024年第5期36卷 12-15页

作者： Yao Wang Chuanbin Zhou Ziyang Lou Houhu Zhang Abid Hussain Liangtong Zhan ke yin Mingliang Fang Xunchang Fei School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore 639798Singapore State key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Nanjing Institute of Environmental Sciences Ministry of Ecology and EnvironmentNanjing 210042China Department of Civil and Environmental Engineering Carleton UniversityOttawaON K1S 5B6Canada Ministry of Education(MOE)key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhou 310058China Department of Environmental Engineering School of Biology and the EnvironmentNanjing Forestry UniversityNanjing 210037China Department of Environmental Science and Engineering Fudan UniversityShanghai 200433China

*** Cities are responsible for approximately 70%of all anthropogenic greenhouse gas(GHG)emissions and about 60%of all anthropogenic methane(CH4)emissions[1,2].Solid waste disposal sites(including landfills and dumpsites),which are prevalent in global cities,emit CH4 generated from the anaerobic biodegradation of municipal solid waste(MSW).Notably,the proportions of CH4 emissions from disposal sites surpass 50%of the total CH4 emissions in some megalopolises[3].CH4 has a high global warming potential(GWP),being 28 times stronger than carbon dioxide(CO_(2))over a 100-year period and 80 times stronger over a 20-year period[4].Understanding and mitigating CH4 emissions from solid waste disposal sites is particularly pertinent and pressing,considering that the latest Synthesis Report from the Intergovernmental Panel on Climate Change(IPCC)emphasizes that the current pace of mitigation and adaptation policies and measures falls short of restraining global temperature rise to under 1.5℃ within the 21st century[4].More than 150 countries signed the Global Methane Pledge at the United Nations Climate Change Conference in Glasgow(COP26),which aims to reduce global annual CH4 emissions by 30%by 2030,compared with emissions in 2020[5].

关键词： landfill Solid restrain

北京2022年冬奥会六足冰壶机器人机构设计与运动规划

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Engineering 2024年第4期35卷 15-31页

作者： ke yin Yue Gao Feng Gao Xianbao Chen Yue Zhao Yuguang Xiao Qiao Sun Jing Sun School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China key Laboratory of Mechanical System and Vibration School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

When a curling rock slides on an ice sheet with an initial rotation,a lateral movement occurs,which is known as the curling *** force of friction between the curling rock and the ice sheet changes continually with changes in the environment;thus,the sport of curling requires great skill and *** throwing of the curling rock is a great challenge in robot design and control,and existing curling robots usually adopt a combination scheme of a wheel chassis and gripper that differs significantly from human throwing movements.A hexapod curling robot that imitates human kicking,sliding,pushing,and curling rock rotating was designed and manufactured by our group,and completed a perfect show during the Beijing 2022 Winter Olympics *** switching between the walking and throwing tasks is realized by the robot’s morphology transformation based on leg configuration *** robot’s controlling parameters,which include the kicking velocity v_(k),pushing velocity v_(p),orientation angle θc,and rotation velocityω,are determined by aiming and sliding models according to the estimated equivalent friction coefficientμ_(equ)and ratio e of the front and back *** stable errors between the target and actual stopping points converge to 0.2 and 1.105 m in the simulations and experiments,respectively,and the error shown in the experiments is close to that of a well-trained wheelchair curling *** robot holds promise for helping ice-makers rectify ice sheet friction or assisting in athlete training.

关键词： Legged robot Curling robot Winter Olympics Mechanism design Motion planning

东南亚研究知识生产的本土化与国际化路径——以新加坡东南亚研究所的兴起为例

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东南亚研究 2024年第3期 128-152,158页

作者：尹珂北京大学国际关系学院

东南亚区域作为人文社科研究的试验田,是知识生产的重要场域。20世纪60年代,新加坡与美国、欧洲和澳大利亚东南亚研究知识网络相互连接,使其在知识生产国际化的背景下成为东南亚区域内部知识生产的中心。东南亚研究所(ISEAS)是新加坡独... 详细信息

东南亚区域作为人文社科研究的试验田,是知识生产的重要场域。20世纪60年代,新加坡与美国、欧洲和澳大利亚东南亚研究知识网络相互连接,使其在知识生产国际化的背景下成为东南亚区域内部知识生产的中心。东南亚研究所(ISEAS)是新加坡独立后建立的第一个自主研究机构。在新加坡,东南亚区域研究与其国内政治之间呈现出政治推动—学界领衔、知识输出—政策参考的紧密关系。ISEAS开启的东南亚研究是东南亚地区的一场研究革命。从初期学习欧美的东南亚研究中心项目到吸引域内外流动学者从事在地研究,再到招聘固定学者,创办学术和政策刊物,出版东南亚研究著作,ISEAS稳步建设成为国际化与本土化相互交融的研究单元和网络。从知识生产的路径来看,ISEAS的兴起得益于本土化和国际化的稳步互动。ISEAS搭乘英语世界东南亚研究的“快车道”,迅速推进研究人员的国际化,在东南亚研究去殖民化和本土化的大背景下成为东南亚研究的一面旗帜。

关键词：东南亚研究知识生产本土化国际化新加坡东南亚研究所区域国别研究

Unveiling the secrets of gastrointestinal mucous adenocarcinoma survival after surgery with artificial intelligence:A population-based study

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2404-2418页

作者： Jie Song Xiang-Xiu Yan Fang-Liang Zhang Yong-Yi Lei Zi-yin ke Fang Li Kai Zhang Yu-Qi He Wei Li Chao Li Yuan-Ming Pan Department of Gastroenterology Dongying People’s HospitalDongying Hospital of Shandong Provincial Hospital GroupDongying 257000Shandong ProvinceChina Gastrointestinal Surgery Department Suining Central HospitalSuining 629000Sichuan ProvinceChina Obstetrical Department Suining Central HospitalSuining 629000Sichuan ProvinceChina School of Medicine Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina Department of Pathology Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049China General Department Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Department of Gastroenterology Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Department of Thoracic Surgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Department of Gastroenterology Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049China Cancer Research Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

BACKGROUND Research on gastrointestinal mucosal adenocarcinoma(GMA)is limited and controversial,and there is no reference tool for predicting postoperative *** To investigate the prognosis of GMA and develop predictive *** From the Surveillance,Epidemiology,and End Results database,we collected clinical information on patients with *** random sampling,the patients were divided into the discovery(70%of the total,for model training),validation(20%,for model evaluation),and completely blind test cohorts(10%,for further model evaluation).The main assessment metric was the area under the receiver operating characteristic curve(AUC).All collected clinical features were used for Cox proportional hazard regression analysis to determine factors influencing GMA’s *** This model had an AUC of 0.7433[95% confidence intervals(95%CI):0.7424-0.7442]in the discovery cohort,0.7244(GMA:0.7234-0.7254)in the validation cohort,and 0.7388(95%CI:0.7378-0.7398)in the test *** packaged it into Windows software for doctors’use and uploaded *** gastric adenocarcinoma had the worst prognosis,and these were protective factors of GMA:Regional nodes examined[hazard ratio(HR):0.98,95%CI:0.97-0.98,P<0.001]and chemotherapy(HR:0.62,95%CI:0.58-0.66,P<0.001).CONCLUSION The deep learning-based tool developed can accurately predict the overall survival of patients with GMA *** surgery,chemotherapy,and adequate lymph node dissection during surgery can improve patient outcomes.

关键词： Deep learning Gastrointestinal mucous adenocarcinoma Overall survival Surgery Clinical tool

基于InVEST模型和PLUS模型的三峡库区(重庆段)碳储量时空变化及预测

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长江科学院院报 2024年第9期41卷 60-69页

作者：尹珂廖思雨重庆师范大学地理与旅游学院重庆401331

分析三峡库区(重庆段)近10 a的土地利用类型及碳储量的空间格局,并模拟未来10 a不同情景下土地变化趋势、预测碳储量变化,有利于促进区域土地利用格局的优化、合理生态政策的制定。利用InVEST模型,选取13个驱动因子,分析三峡库区(重庆段... 详细信息

分析三峡库区(重庆段)近10 a的土地利用类型及碳储量的空间格局,并模拟未来10 a不同情景下土地变化趋势、预测碳储量变化,有利于促进区域土地利用格局的优化、合理生态政策的制定。利用InVEST模型,选取13个驱动因子,分析三峡库区(重庆段)在2010—2020年及不同发展情景下2030年的土地利用变化趋势,并结合PLUS模型评估其碳储量状况。结果表明:①2010—2020年三峡库区(重庆段)土地利用变化主要表现为耕地、草地和湿地向林地、建设用地及水域的快速转移;2010年、2020年碳储量分别为426.89×10^(6)、425.51×10^(6) t,呈下降趋势,总量减少了1.38×10^(6) t;②碳储量分布具有空间分异性,总体表现为西低东高、南低北高、库首>库尾,碳储量空间变化与地类变化具有较高的一致性;土地利用空间格局演变的贡献度最高的驱动因素是社会经济因子,其中人口、GDP最为突出;③到2030年,自然发展情景和城镇发展情景下碳储量分别减少了0.76×10^(6)、8.98×10^(6) t,生态保护情景下增加了3.72×10^(6) t。高碳密度的地类向低碳密度地类转移是导致碳储量减少的主要原因,因此,未来应形成平衡、协调、低碳的土地利用空间格局,规划城市增长边界,重点保障巫山山系、大巴山系、武陵山系等林草高碳储量区,推行尾库区复林复草,保障库区碳汇功能。

关键词：碳储量三峡库区 PLUS模型 InVEST模型土地利用变化

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跨学科科研合作:内涵、现实意义及实践模式

科教文汇 2024年第3期 9-13页

作者：柯崟江苏卫生健康职业学院江苏南京211800

跨学科科研合作是以解决科研问题为导向,由具备不同学科背景的个体、团队或组织通过合作形式进行学科知识共享和融合,旨在取得有价值的科研成果,推动知识整合创新、促进科研生产力发展和国家科技创新。目前存在三种实践模式:个体情境下... 详细信息

跨学科科研合作是以解决科研问题为导向,由具备不同学科背景的个体、团队或组织通过合作形式进行学科知识共享和融合,旨在取得有价值的科研成果,推动知识整合创新、促进科研生产力发展和国家科技创新。目前存在三种实践模式:个体情境下的跨学科科研合作模式、团队情境下的跨学科科研合作模式和组织情境下的跨学科科研合作模式。这三种模式在跨学科科研合作过程中呈现出各自特点,并表现为从个体到团队再到组织逐渐发展演变的过程。

关键词：跨学科科研合作实践模式

体育强国建设助推中国式现代化:内涵、逻辑与路径

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体育文化导刊 2024年第2期 28-34页

作者：郎永超沈克印武汉体育学院经济与管理学院武汉430079 湖北体育产业研究中心武汉430079

运用文献资料、逻辑分析等方法,探寻体育强国建设助推中国式现代化的内涵释义、逻辑理路,并提出实践路径。内涵:在中国共产党的领导下,体育强国建设通过实现体育各领域的协调发展来助推国家富强、民族复兴、人民幸福,呈现出人民性、发... 详细信息

运用文献资料、逻辑分析等方法,探寻体育强国建设助推中国式现代化的内涵释义、逻辑理路,并提出实践路径。内涵:在中国共产党的领导下,体育强国建设通过实现体育各领域的协调发展来助推国家富强、民族复兴、人民幸福,呈现出人民性、发展性、系统性的现代化特征。逻辑理路是由历史逻辑、理论逻辑、现实逻辑三部分组成。路径:加强党的全面领导,推进治理能力现代化;构建对外交流合作新格局,扩大国际影响力;解决关键短板问题,助力体育领域均衡化发展。

关键词：体育管理中国式现代化体育强国体育现代化