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Time range of Mesozoic tectonic regime inversion in eastern North China Block

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Science China Earth Sciences 2004年第2期47卷 151-159页

作者： ZHAI Mingguo ZHU Rixiang LIU Jianming MENG Qingren HOU Quanlin HU Shengbiao LIU Wei LI Zhong ZHANG hongfu ZHANG Huafeng Key Laboratory of Mineral Resources Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China

An important tectonic inversion took place in eastern North China Block(NCB) during Mesozoic, which caused a great lithosphere thinning, reconstruction of basin-range series, powerful interaction between mantle and crust, a vast granitic intrusion and volcanism, and large-scale metallogenic explosion. The time range of the Mesozoic tectonic regime inversion in the eastern North China Block is one of the key issues to understand mechanism of tectonic regime inversion. Our updated results for recognizing the time range are mainly obtained from the following aspects: structural analyses along northern and southern margins of the NCB and within the NCB for revealing tectonic inversion from compression to extension and structural striking from ~EW to NNE; geothermic analyses of the eastern sedimental basins for a great change of thermal history and regime; basin analysis for basin inversion from compression to extension and basin migration from ~EW to NNE; petrological and geochemical studies of volcanic rocks and lowermost crust xenoliths for recognizing peak period of mantle upwelling and intense interaction between mantle and crust, and main metallogenic epoch. All the studies of the above give the same time range from~150-140 Ma to ~110-100Ma, peaking at ~120 Ma.

关键词： eastern NCB Mesozoic tectonic regime inversion time range

Clinical feature difference between juvenile amyotrophic lateral sclerosis with SPTLC1 and FUS mutations

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Chinese Medical Journal 2023年第2期136卷 176-183页

作者： Peishan Wang Qiao Wei hongfu Li Zhi-ying Wu Department of Neurology Second Affiliated HospitalZhejiang University School of Medicineand Key Laboratory of Medical Neurobiology of Zhejiang ProvinceHangzhouZhejiang 310009China Department of Medical Genetics Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China

Background: Juvenile amyotrophic lateral sclerosis (JALS) is an uncommon form of amyotrophic lateral sclerosis whose age at onset (AAO) is defined as prior to 25 years. FUS mutations are the most common cause of JALS. SPTLC1 was recently identified as a disease-causative gene for JALS, which has rarely been reported in Asian populations. Little is known regarding the difference in clinical features between JALS patients carrying FUS and SPTLC1 mutations. This study aimed to screen mutations in JALS patients and to compare the clinical features between JALS patients with FUS and SPTLC1 mutations. Methods: Sixteen JALS patients were enrolled, including three newly recruited patients between July 2015 and August 2018 from the Second Affiliated Hospital, Zhejiang University School of Medicine. Mutations were screened by whole-exome sequencing. In addition, clinical features such as AAO, onset site and disease duration were extracted and compared between JALS patients carrying FUS and SPTLC1 mutations through a literature review. Results: A novel and de novo SPTLC1 mutation (c.58G>A, p.A20T) was identified in a sporadic patient. Among 16 JALS patients, 7/16 carried FUS mutations and 5/16 carried respective SPTLC1 , SETX , NEFH , DCTN1 , and TARDBP mutations. Compared with FUS mutation patients, those with SPTLC1 mutations had an earlier AAO (7.9 ± 4.6 years vs. 18.1 ± 3.9 years, P < 0.01), much longer disease duration (512.0 [416.7-607.3] months vs. 33.4 [21.6-45.1] months, P < 0.01), and no onset of bulbar. Conclusion: Our findings expand the genetic and phenotypic spectrum of JALS and help to better understand the genotype-phenotype correlation of JALS.

关键词： FUS Juvenile amyotrophic lateral sclerosis Phenotype SPTLC1

Layered Birnessite Cathode with a Displacement/Intercalation Mechanism for High-Performance Aqueous Zinc-Ion Batteries

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Nano-Micro Letters 2020年第4期12卷 137-151页

作者： Xian‑Zhi Zhai Jin Qu Shu‑Meng Hao Ya‑Qiong Jing Wei Chang Juan Wang Wei Li Yasmine Abdelkrim hongfu Yuan Zhong‑Zhen Yu State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Mn-based rechargeable aqueous zinc-ion batteries(ZIBs)are highly promising because of their high operating voltages,attractive energy densities,and ***,the electrochemical performances of Mn-based cathodes usually suffer from their serious structure transformation upon charge/discharge ***,we report a layered sodium-ion/crystal water co-intercalated Birnessite cathode with the formula of Na0.55Mn2O4·0.57H2O(NMOH)for high-performance aqueous ZIBs.A displacement/intercalation electrochemical mechanism was confirmed in the Mn-based cathode for the first ***+and crystal water enlarge the interlayer distance to enhance the insertion of Zn^2+,and some sodium ions are replaced with Zn^2+ in the first cycle to further stabilize the layered structure for subsequent reversible Zn^2+/H^+ insertion/extraction,resulting in exceptional specific capacities and satisfactory structural ***,a pseudo-capacitance derived from the surface-adsorbed Na^+ also contributes to the electrochemical *** NMOH cathode not only delivers high reversible capacities of 389.8 and 87.1 mA h g^−1 at current densities of 200 and 1500 mA g^−1,respectively,but also maintains a good long-cycling performance of 201.6 mA h g^−1 at a high current density of 500 mA g^−1 after 400 cycles,which makes the NMOH cathode competitive for practical applications.

关键词： Zinc-ion batteries Birnessite Sodium ions Layered structure Crystal water

Dietary ferulic acid and vanillic acid on inflammation,gut barrier function and growth performance in lipopolysaccharide-challenged piglets

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Animal Nutrition 2022年第1期8卷 144-152页

作者： Ruizhi Hu Shusong Wu Baizhen Li Jijun Tan Jiahao Yan ying Wang Zhiyi Tang Ming Liu Chenxing Fu hongfu Zhang Jianhua He Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients College of Animal Science and TechnologyHunan Agricultural UniversityChangsha410128China Beijing China-Agri HongKe Bio-Technology Co. Ltd.Beijing102206China State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing100193China

Ferulic acid(FA)and vanillic acid(VA)are considered as major phenolic metabolites of cyanidin 3-glucoside,a polyphenol that widely exists in plants that possess a protective effect against oxidative stress and inflammation in our previous *** study aimed to investigate the effect of FA and VA on inflammation,gut barrier function,and growth performance in a weaned piglet model challenged with lipopolysaccharide(LPS).Thirty-six piglets(PIC 337×C48,28 d of age)were randomly allocated into 3 treatments with 6 replicate pens(2 piglets per pen).They were fed with a basal diet or a diet containing 4,000 mg/kg of FA or *** supplementation of VA significantly increased average daily gain(ADG)(P<0.05).Both FA and VA decreased serum levels of thiobarbituric acid reactive substances(TBARS),interlukin(IL)-1β,IL-2,IL-6,and tumor necrosis factor(TNF)-α(P<0.05),and enhanced the expression of tight junction protein oclaudin(P<0.05).Analysis of gut microbiota indicated that both FA and VA increased the Firmicutes/Bacteroidetes ratio alongside reducing the relative abundance of the Prevotellaceae family including Prevotella 9 and Prevotella 2 genera,but enriched the Lachoiraceaea family including the Lachnospiraceae FCS020 group(P<0.05).Moreover,VA reduced the relative abundance of Prevotella 7 and Prevotella 1 but enriched Lachnospira,Eubacterium eligens group,and Eubacterium xylanophilum group(P<0.05),while FA showed a limited effect on these *** results demonstrated that both VA and FA could alleviate inflammation and oxidative stress,but only VA has a significant positive effect on the growth performance of LPS-challenged piglets potentially through modulating gut microbiota.

关键词： Ferulic acid Vanillic acid Inflammation Gut barrier function Growth performance Piglet

Neuroprotective effects of salvianolic acid B on secondary spinal cord damage

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Neural Regeneration Research 2011年第3期6卷 188-192页

作者： Ye, Zhizhong Deng, Yubin Wu, hongfu Gan, Danhui Sun Yat Sen Univ Dept Pathophysiol Zhongshan Sch Med Guangzhou 510080 Guangdong Peoples R China Guangdong Med Coll Dept Physiol Dongguan 523808 Guangdong Peoples R China Guangdong Med Coll Futian Affiliated Hosp Shenzhen 518040 Guangdong Peoples R China

Salvianolic acid B （Sal B）, an effective ingredient of Danshen （salvia miltiorrhiza root）, has been shown to exhibit anti-oxidative and anti-inflammatory effects. The present study investigated whether Sal B has a neuroprotective effect on secondary spinal cord injury when administrated alone. In addition, the effects of Sal B on attenuating expression of tumor necrosis factor-α （TNF-α） following acute spinal cord injury were analyzed, as well as the effects of combined treatment of Sal B and etanercept. Immunohistochemical staining demonstrated that Sal B significantly reduced matrix metalloproteinase-1 and c-Fos expression at 24 hours after spinal cord injury, and decreased tissue edema was detected using the dry-wet weight method at 3 days after injury. In addition, Sal B significantly promoted recovery of motor function in rats. These effects were most significant at a dose of 20 mg/kg Sal B. At 24 hours after spinal cord injury, reverse transcription-polymerase chain reaction and western blot assay results showed that Sal B, etanercept, or the combination significantly suppressed increased TNF-α mRNA and protein expression, although the combination resulted in more significant outcomes. These results suggested that Sal B exerted neuroprotective effects against secondary spinal cord injury by reducing expression of matrix metalloproteinase-1, c-Fos, and TNF-α. Moreover, Sal B combined with etanercept resulted in more significant anti-inflammatory effects.

关键词： cytoprotection salvianolic acid B spinal cord injury tumor necrosis factor-α antagonist neural regeneration

Opening Market in Light of WTO Commitment

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China's Foreign Trade 2004年第1期 42-43页

作者： Xiao Xie and Liang hongfu

China's entry into the WTO and its commitment to market opening is providing a better environment for our growth.

关键词：中国 WTO 对外贸易市场开放经济环境

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基于静电监测和神经网络的航发典型故障诊断

计算机集成制造系统 2019年第11期25卷 2852-2862页

作者：付宇殷逸冰冒慧杰左洪福冯正兴中国民航大学航空工程学院天津300300 南京航空航天大学民航学院江苏南京211106

为解决航空发动机中典型气路机械故障模式的诊断问题,开展了故障模拟静电监测实验。利用经典特征参数分析了4类典型故障模式下的静电信号,在此基础上进一步提出几类新特征指标和初始故障判别逻辑理论,并利用Fisher准则方法对所提新特征... 详细信息

为解决航空发动机中典型气路机械故障模式的诊断问题,开展了故障模拟静电监测实验。利用经典特征参数分析了4类典型故障模式下的静电信号,在此基础上进一步提出几类新特征指标和初始故障判别逻辑理论,并利用Fisher准则方法对所提新特征指标的有效性进行验证。提出一种基于自组织映射神经网络的气路故障诊断工程化应用方法,并对故障诊断算法进行实例验证,结果表明,基于静电信号和自组织映射神经网络的气路故障诊断方法能够很好地识别不同故障模式并具备良好的可视化表达效果,为气路故障诊断提供了一种很好的工程化研究方法。

关键词：航空发动机静电监测传感器故障诊断 Fisher准则自组织映射神经网络

Study on Prediction of the Total Power of Agricultural Machinery Based on Fuzzy BP Network

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Study on Prediction of the Total Power of Agricultural Machi...

航空发动机吸入颗粒物静电感应特性的模拟实验及分析

2015年中国智能自动化学术会议

作者： hongfu Ai The Information of Teaching and Management Center Jilin Agricultural University

It made full use of agriculture-related data, self-learning, and prediction ability of BP neural network which is in the field of artificial intelligence is applied,and combined with fuzzy set theory, in-depth study of the related algorithm, using C++ language programming, established the agriculture machinery corresponding to the total dynamic forecasting model, digging the potential of total power of agriculture machinery in this paper. The author hopes that a reasonable forecast of the development trend of the total power of agricultural machinery in China can be realized and reasonable targets for the development of agricultural mechanization in China.

关键词： The total power of agricultural mechanization BP neural network Fuzzy set Prediction model

来源： cnki会议评论

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航空学报 2015年第2期36卷 691-702页

作者：殷逸冰左洪福文振华蔡景付宇南京航空航天大学民航学院南京210016 郑州航空工业管理学院机电工程学院郑州450015

利用静电传感器和SC-010型环境试验箱等硬件搭建了吸入颗粒物静电监测模拟实验平台,并在此实验平台上展开了针对航空发动机吸入颗粒物静电感应特性的模拟实验研究,成功获取相应静电监测信号。实验设置颗粒材料、管道流速、颗粒粒径和颗... 详细信息

利用静电传感器和SC-010型环境试验箱等硬件搭建了吸入颗粒物静电监测模拟实验平台,并在此实验平台上展开了针对航空发动机吸入颗粒物静电感应特性的模拟实验研究,成功获取相应静电监测信号。实验设置颗粒材料、管道流速、颗粒粒径和颗粒投入质量4种变量作为变量条件,分别进行4组单一变量的对比实验,采集在不同颗粒材料、不同管道流速、不同颗粒粒径以及不同颗粒质量浓度环境下带电颗粒所产生的静电感应信号,对每组实验信号的活动率水平(AL)、正/负事件率(PER/NER)和绝对平均幅值等特征参数进行相应的数据分析和对比,并得到了一些有用的结论。实验发现,上述4种变量条件分别对静电感应信号的绝对时域平均幅值、AL参数、PER/NER参数有不同程度的影响。

关键词：航空发动机进气道静电传感器吸入颗粒物模拟实验