检索结果-南通市图书馆

China Forex 2024年第2期 44-51页

作者： GAO Zhanjun yin Yanlin 不详

Since the beginning of 2024,the Chinese economy has been gradually recovering and showing an overall positive *** momentum is steadily building in economicactivity,as positive contributors are *** the first quarter,the gross domestic product(GDP)increased by 5.3%year-on-year,the consumerprice index(CPI)showed positive year-onyear growth.

关键词： interview momentum Chairman

Mechanism underlying treatment of diabetic kidney disease using Traditional Chinese Medicine based on theory of yin and Yang balance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2018年第5期38卷 797-802页

作者： Piao Yuanlin yin Dehai Department of Traditional Chinese Medicine Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences

The pathogenic mechanism of diabetic kidney disease(DKD) is complex. The development of DKD cannot be fully explained by a single *** Chinese Medicine(TCM) has been applied extensively for the treatment of DKD in ***, studying the mechanism of DKD using theories and methods that are appropriate for TCM characteristics and searching for theoretical bases for TCM clinical application are topics that still need to be explored and researched. Activation of the transforming growth factor(TGF)-β1/Smad and PI3 K/Akt/mTOR signaling pathways functions as a self-protection mechanism against renal microinflammation in DKD. However, the persistent abnormal overactivation of reactions causes secondary cell dysfunction, cell apoptosis, increased extracellular matrix(ECM) secretion, and eventually renal fibrosis. During this process, the dysregulation of self-balance among a variety of signaling pathways and the loss of self-feedback regulatory mecha-nisms downstream of these signaling pathways are critical causes of the occurrence and development of DKD. TCM may both inhibit the expression or activation of "hyperactive" signaling pathways(NFB, Smad3, and PI3 K/Akt/mTOR) and increase the expression or activation of "deficient" signaling pathways(Smad7 and PTEN) to restore balance to cells with an abnormal pathophysiological status and achieve the goal of DKD treatment.

关键词： Diabetic kidney disease Traditional Chinese Medicine yin and Yang theory

Effects of Chinese herbs capable of replenishing qi,nourishing yin and activating blood circulation and their compatibility on differentially expressed genes of ischemic myocardium

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Chinese herbs capable of replenishing qi,nourishi...

Transcriptional dysregulation in neurodegenerative diseases:who tipped the balance of yin Yang 1 in the brain?

作者： yin HuiJun GUO ChunYu 史大卓 Cardiovascular Center Xiyuan Hospital of China Academy of Chinese Medical Sciences 中国中医科学院西苑医院中国中医科学院西苑医院心血管病中心

This study was conducted to investigate the effects of Chinese herbs capable of replenishing qi,nourishing yin and activating blood circulation and their compatibility on differentially expressed genes of ischemic myocardium which were selected from differential expression profile we had established before,and to explore the underlying *** acute myocardial infarction(AMI) model was established by ligating the left anterior descending(LAD) coronary artery,then the model rats were randomly divided into the model group,the Metoprolol group,the replenishing qi nourishing yin(RN)group,the activating blood circulation(AB) group,and the replenishing qi,nourishing yin and activating blood circulation(RA) *** addition,the normal group and the sham group were set *** rats of medication groups were administered by intragastric gavage with corresponding drugs on the second day after operations,and the rats of the normal group and the sham group were given normal saline as the same *** the ischemic hearts were harvested on the 8th day after *** myocardial pathomorphological changes were observed under a light *** mRNA changes of target genes such as COX5 a and ATP5 e were detected using Real-time fluorescence quantitative PCR(Q-PCR),and the activities of related enzymes were detected by colorimetric *** main results were as follows:the histological changes were observed by HE staining,and cardiocyte swelling,inflammatory cell infiltration and cytolysis were showed in regional ischemic myocardium of the model group,while the pathomorphological changes in all medication groups did not show obvious *** genes related to energy metabolism,COX5 a and ATP5 e,were selected as the target genes which were down-regulated at the mRNA level in the medication *** activities of correlative functional enzymes also decreased in the RA group compared to that in the model group accordingly(P<0.05).The results indicated that the abno

关键词： Ischemic myocardium compatibility of replenishing qi nourishing yin and activating blood circulation differential gene expression energy metabolism

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第7期14卷 1148-1151页

作者： Zhefan Stephen Chen Ho yin Edwin Chan School of Life Sciences Faculty of ScienceThe Chinese University of Hong Kong Gerald Choa Neuroscience Centre The Chinese University of Hong Kong

yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including *** controls neuronal differentiation,as well as neuronal specification and migration during the development of the mammalian nervous ***,YY1 also mediates the transcription of genes that are required for neuronal *** impairment of the transcriptional function of YY1 causes neuronal *** review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative *** expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms,including recruitment to protein aggregates,protein degradation and aberrant nuclear/cytoplasmic *** the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis neurodegeneration protein aggregates recruitment protein degradation subcellular localization transcriptional regulation yin Yang 1

UPLC-ESI-MS analysis of You Gui yin and its pharmacokinetics after oral administration to rats

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

UPLC-ESI-MS analysis of You Gui Yin and its pharmacokinetics...

Application of the Zhe yin’s Gene Inherits Law

中华中医药学会第七次中药分析学术交流会

作者： WANG Ling yin Hua ZHU Xi ZHANG Jian-Hua WANG Xuan Standardization of Chinese medicine research laboratory Zhejiang Chinese Medical University The First Affiliated Hospital of Zhejiang Chinese Medical University

Objective:To develop a sensitive,specific and accurate ultra performance liquid chromatography-electronic spray ion-mass spectrometry(UPLC-ESI-MS)method and apply it for simultaneous quantitation and pharmacokinetics of six Aconitum alkaloids,***(AC),hypaconitine(HA),mesaconitine(MA),benzoylaconine(BAC),benzoylhypaconine(BHA),benzoylmesaconine(BMA)in the plasma of rat after oral administration ***:An ACQUITY UPLCBEH C18 column(2.1×100 mm,1.7 μm)was used to separate the six compounds and internal standard(IS)by gradient mode with mobile phase consisting of water containing 0.1% formic acid and 2mmol/L ammonium formate and methanol containing 0.1%formic acid,at a flow rate of 0.20 mL/min with a column temperature of40℃.UPLC-ESI-MS system coupled was performed in positive ***:For the method validation,the calibration curves were linear(r>0.992) and the limit of quantification was all less than 0.1 ng/*** within day precisions(RSD) were all <15%,accuracies(RE) were within the range of ± 15%,and recoveries ranged from 70.379.3%.Conclusion:The validated method was applied to simultaneous quantitation and successfully used for the first time for the pharmacokinetic evaluation of the six Aconitum alkaloids in plasma of rat after oral administration *** method has high sensitivity and specificity,it could be beneficial for the application of clinical therapy.

关键词： UPLC-ESI-MS Aconitum alkaloids Pharmacokinetic You-Gui-yin

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Open Journal of Genetics 2014年第6期4卷 434-438页

作者： Zhe yin Yunfei Guo Mathematics Department Yanbian University Yanji China Department of Information Management Peking University Beijing China

Several results are provided using gene inherits law in another article [1], making use of the theory of algebra in mathematics, according to which we derive, which will give some reference value to genetics.

关键词： Inherits Law Memory Inheritance Memory Copy

Assessment of Ankylosing Spondylitis Based on the Theory of yin and Yang in Traditional Chinese Medicine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Nursing Research 2021年第5期5卷 33-36页

作者： Yuan Cheng Jichao yin Xinglv Hu Penggang Xu yingchun Liu Chengxiang Lei Shaanxi University of Traditional Chinese Medicine Xianyang 712046Shaanxi ProvinceChina Xi'an Health School Xi'an 710000Shaanxi ProvinceChina Xi'an Hospital of Traditional Chinese Medicine Xi'an 710000Shaanxi ProvinceChina The Fifth Hospital of Xi'an Xi'an 710000Shaanxi ProvinceChina Baoji High-tech Hospital Baoji 721013Shaanxi ProvinceChina

The theory of yin and yang in Chinese medicine signifies everything and can be used to divide everything in the *** diagnosis and assessment of ankylosing spondylitis in Western medicine can also be divided by yin and *** current technologies used in Western medicine for detecting ankylosing spondylitis is summarized,divided,and reasoned with the philosophical views of yin and yang in traditional Chinese medicine.

关键词： Traditional Chinese medicine Ankylosing spondylitis yin and yang theory

Can yin-Chai-Xiao-Du decoction be useful of COVID-19?the mechanism research based on network pharmacology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2020年第4期5卷 188-200页

作者： Lu Yang Ning Li Hai-Bo Hu Bin yin Guo-Jing Zhao Feng-Chan Wang Xu-Hui Wang Hong-Wu Wang Xue-Chao Lu Huan-Tian Cui Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China First Clinical Hospital Shandong University of Traditional Chinese MedicineJinan 250000China Department of Pulmonary Disease in Qingdao Hospital of Traditional Chinese Medicine Qingdao 266700China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan 250000China College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Shandong Provincial Key Laboratory of Animal Cell and Developmental Biology School of Life SciencesShandong UniversityQingdao 250100China

Background:In this study,we preliminarily investigated the mechanism of yin-Chai-Xiao-Du decoction for the treatment of COVID-19 by the method of network ***:The potential targets and pathways of yin-Chai-Xiao-Du decoction for the treatment of COVID-19 were examined using network pharmacology;the ingredient and active targets of yin-Chai-Xiao-Du decoction were collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and PharmMapper databases;the COVID-19-related targets were obtained from the online Mendelian inheritance in man,GeneCards,and GeneMANIA databases;the STRING database and Cytoscape were used to build a protein-protein interaction network,and a Network Analyzer tool was used to perform topology analysis to screen for the key ingredients and targets;the ClueGO and KOBAS 3.0 databases were for the enrichment analysis of gene function(Gene Oncology)and gene pathway(Kyoto Encyclopedia of Genes and Genomes);the herb-ingredient-target-pathway network diagram was constructed by ***:The core herbs screened by the network pharmacological analysis were Jinyinhua(Lonicerae japonicae flos),Lianqiao(Forsythia suspensa),Chaihu(Bupleuri radix),Huangqin(Scutellariae radix),yinchen(Herba Artemisiae Scopariae),Guanghuoxiang(Pogostemonis herba),Roudoukou(Semen myristicae)and Qinghao(Artemisiae annuae herba).A total of 293 active ingredients were screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,and the key ingredients were quercetin,kaempferol,isorhamnetin,stigmasterol,beta-sitosterol,and ***-Chai-Xiao-Du decoction has 138 COVID-19-related targets,and the key targets were mitogen-activated protein kinase 3,interleukin-6,tumor necrosis factor,vascular endothelial growth factor A,and CC motif ligand *** Encyclopedia of Genes and Genomes analysis revealed 120 enriched gene pathways,and the key pathways were signaling by interleukins,immune system,c

关键词： Coronavirus disease 2019 Bupleuri radix Scutellariae radix Artemisiae annuae herba Cytokine Storm Tumor necrosis factor Interleukin-6

根系土壤假丝酵母菌Candida sp. yin9对大丽轮枝菌和全齿复活线虫的抑制作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生物安全学报 2022年第1期31卷 56-63页

作者：尹晓燕王羽牛秋红南阳师范学院生命科学与农业工程学院河南南阳473000

【目的】研究黄萎病抗性棉(海7124)根际土壤中酵母菌株对棉花黄萎病病原真菌大丽轮枝菌和全齿复活线虫的拮抗效果,为生物防治棉花黄萎病和全齿复活线虫提供理论依据。【方法】通过镜检、糖发酵实验、碳源同化实验、26S rRNA测序对菌株... 详细信息

【目的】研究黄萎病抗性棉(海7124)根际土壤中酵母菌株对棉花黄萎病病原真菌大丽轮枝菌和全齿复活线虫的拮抗效果,为生物防治棉花黄萎病和全齿复活线虫提供理论依据。【方法】通过镜检、糖发酵实验、碳源同化实验、26S rRNA测序对菌株的形态、生理生化特征及其系统发育关系进行鉴定,并利用七叶苷筛选、刚果红染色、平皿对峙实验、盆栽实验、平板生测实验测试其产酶活性以及抑制大丽轮枝菌和杀线虫活性。【结果】从大批黄萎病抗性棉(海7124)根际土壤中筛选出编号为yin9的酵母菌菌株,分类鉴定结果表明:yin9菌株属于假丝酵母属Candida。平皿对峙实验结果表明:菌株yin9对大丽轮枝菌的抑菌率达59%;将菌株yin9的无菌发酵滤液与大丽轮枝菌孢子共培养12 h后镜检发现,用菌株yin9处理的实验组,大部分棉花黄萎病病菌孢子不能正常萌发。盆栽实验结果表明:菌株yin9对棉花黄萎病的平均防治效果为60.02%,可以显著降低感病棉棉花黄萎病的发病率和病情指数。此外,与从黄萎病抗性棉根际土壤中筛选获得的其他酵母菌株相比,菌株yin9具备较高的杀线虫活性:菌株作用全齿复活线虫48和60 h后,线虫死亡率分别为90%和100%。将菌株yin9发酵液煮沸后,其抑制大丽轮枝菌和杀线虫活性均急剧下降,进一步测试发现,该菌株拥有较高的蛋白酶和纤维素酶活性。【结论】yin9中的生防因子可能是热不稳定性物质,具备较高的杀线虫活性,可以显著提高感病棉对黄萎病的抗性。

关键词：假丝酵母菌大丽轮枝菌线虫蛋白酶纤维素酶

yin He: Dream of a Wilderness Comes True in Tibet

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论