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GABPB1-AS1 acts as a tumor suppressor and inhibits non-small cell lung cancer progression by targeting miRNA-566/F-box protein 47

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Oncology Research 2021年第6期29卷 401-409页

作者： HUALIANG LV CHANGCHUN LAI WENQU ZHAO yibo song Department of Pulmonary and Critical Care Medicine Maoming People’s HospitalMaomingChina Department of Clinical Laboratory Maoming People’s HospitalMaomingChina Department of Pulmonary and Critical Care Medicine Nanfang Hospital Affiliated to Southern Medical UniversityGuangzhouChina

It has been certiﬁed that GABPB1-AS1 is aberrantly expressed and plays as a vital role in some kinds of ***,its expression pattern and functions in non-small cell lung cancer(NSCLC)are still largely *** study aims to assess GABPB1-AS1 expression and biological roles in *** expression of GABPB1-AS1 was detected in NSCLC specimens and adjacent normal ***8 and Transwell assays were performed to evaluate the effects of GABPB1-AS1 on NSCLC cell proliferation,migration and *** tools and luciferase reporter assays were applied to predict and verify GABPB1-AS1’s direct *** results revealed that GABPB1-AS1 is sharply reduced in NSCLC specimens and cell ***8 assays indicated that overexpression of GABPB1-AS1 dramatically reduced NSCLC cell growth,and Transwell assays proved that NSCLC cell migration and invasion were distinctly inhibited by *** of the mechanism uncovered that miRNA-566(miR-566)/F-box protein 47(FBXO47)is directly targeted by GABPB1-AS1 in *** study demonstrated that GABPB1-AS1 inhibited NSCLC cell proliferation,migration and invasion by targeting miR-566/FBXO47.

关键词： GABPB1-AS1 NSCLC Progression miRNA-566 FBXO47

鸟嘌呤核苷酸交换因子1与厚体1在胃癌发生发展及转移过程中的作用研究

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当代医学 2024年第3期30卷 35-39页

作者：白力嘎王家宏宋一波内蒙古科技大学包头医学院研究生院内蒙古包头014040 内蒙古科技大学包头医学院第一附属医院肝胆二科内蒙古包头014040

目的检测鸟嘌呤核苷酸交换因子1(Vav1)、厚体1(Dkk1)在胃癌及癌旁组织中的表达水平,探讨Vav1和Dkk1在胃癌发生发展及转移过程中的作用及临床价值。方法选取2020年6月至2022年6月于内蒙古科技大学包头医学院第一附属医院外科行胃癌根治... 详细信息

目的检测鸟嘌呤核苷酸交换因子1(Vav1)、厚体1(Dkk1)在胃癌及癌旁组织中的表达水平,探讨Vav1和Dkk1在胃癌发生发展及转移过程中的作用及临床价值。方法选取2020年6月至2022年6月于内蒙古科技大学包头医学院第一附属医院外科行胃癌根治术且经过病理确诊的57例胃癌患者作为研究对象,收集患者胃癌组织、癌旁组织(癌组织边缘5 cm)各57份。应用免疫组化法检测Vav1和Dkk1在胃癌及癌旁组织中的表达,分析胃癌中Vav1与Dkk1阳性表达率的相关性,不同临床病理特征与Vav1和Dkk1表达情况的关系,ROC曲线分析Vav1和Dkk1在胃癌中的诊断价值。结果胃癌组织中Vav1和Dkk1的阳性表达均高于癌旁组织,差异有统计学意义(P0,P<0.05)。Vav1和Dkk1的AUC分别为0.952和0.857,对胃癌的诊断效能均较理想。结论Vav1、Dkk1在胃癌中的表达呈正相关。Vav1和Dkk1在胃癌发生发展及转移过程中起重要作用,Vav1、Dkk1特异性靶向药物有望为胃癌有效治疗提供新思路。

关键词：胃癌鸟嘌呤核苷酸交换因子1 厚体1 免疫组化法

Synthesis of Hyperbranched Polymer for 3D Printing

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Chinese Journal of Chemistry 2021年第11期39卷 3064-3070页

作者： yibo song Fahu Yang Zhenwei Zheng Pingping Wu Lixia Huo Jinshan Guo Jingxia Wang Institute of Polymer Science and Engineering College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhouGansu730000 China CAS Key Laboratory of Bio-inspired Materials and Interfacial Sciences Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190 China

3D printing has been developing rapidly in recent years owing to its application in academic and industry areas,but the poor mechanical property of printing materials limits its ***,a photocurable resin with good mechanical property was obtained based on hyperbranched polymer synthesized through the reaction of carboxylic acids with isocyanates catalyzed by magnesium *** kinds of hyperbranched polymers with different molecular weight were fabricated by modulating the content of *** mixing hyperbranched polymer with acryloylmorpholine,polyethylene glycol diacrylate 400 and photoinitiator of 819,the photocurable resin was *** influence of various factors on mechanical properties of samples was investigated such as molecular weight of hyperbranched polymer and the light exposure *** with the commercial resin,the flexural strength(116.06 MPa)and impact strength(34.59 kJ/m^(2))of the resultant resin increased by 21.2%and 20.8%,respectively.

关键词： Polymerization Carboxylic acids reacting with isocyanates Photochemistry Mechanical properties 3D printing

Utilization of waste vanadium-bearing resources in the preparation of rare-earth vanadate catalysts for semi-hydrogenation of α,β-unsaturated aldehydes

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Frontiers of Chemical Science and Engineering 2022年第12期16卷 1793-1806页

作者： Yang Zhang Guowu Zhan yibo song Yiping Liu Jiale Huang Shu-Feng Zhou Kok Bing Tan Qingbiao Li College of Chemical Engineering Integrated Nanocatalysts Institute(INCI)Huaqiao UniversityXiamen 361021China College of Food and Biology Engineering Jimei UniversityXiamen 361021China College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China

Recycling industrial solid waste not only saves resources but also eliminates environmental concerns of toxic ***,we proposed a new strategy for the utilization of petrochemical-derived carbon black waste,a waste vanadium-bearing resource(V>30000 ppm(10−6)).Chemical leaching was employed to extract metallic vanadium from the waste and the leachate containing V was used as an alternative raw material for the fabrication of vanadate *** the screening of various metal cations,it was found that the contaminated Na^(+)during the leaching process showed strong competitive coordination with the vanadium ***,by adding foreign Ce^(3+)and Y^(3+)cations,two rare-earth vanadates,viz.,flower-like CeVO_(4)and spherical YVO_(4)nanomaterials,were successfully *** techniques such as scanning electron microscopy,transmission electron microscopy,X-ray diffraction,energy-dispersive X-ray spectroscopy,Fourier-transform infrared,and N2 physisorption were applied to analyze the physicochemical properties of the waste-derived ***,we found that rare-earth vanadate catalysts exhibited good activities toward the semi-hydrogenation ofα,β-unsaturated *** conversion of cinnamaldehyde and cinnamic alcohol selectivity were even higher than those of the common CeVO_(4)prepared using pure chemicals(67.2%vs.27.7%and 88.4%vs.53.5%).Our work provides a valuable new reference for preparing vanadate catalysts by the use of abundant vanadium-bearing waste resources.

关键词： petrochemical solid wastes vanadium recovery resource utilization nanomaterials semi-hydrogenation

The Os14-3-3 family genes regulate grain size in rice

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Journal of Genetics and Genomics 2024年第4期51卷 454-457页

作者： Yingying song Huaizhou Yang Wenran Zhu Huili Wang Juncheng Zhang yibo Li National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research(Wuhan) Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

Rice is one of the most important cereal crops in the world,providing food for more than half of the global population;therefore,increasing grain yield is a major goal of rice *** grain yield is largely dependent on grain size,which is specified by its three dimensions(grain length,width,and thickness)and by the degree of grain filling(Xing and Zhang,2010;Fan and Li,2019).Grain size is an important agronomic trait for stable yield,appearance,milling quality,and domestication in rice that is controlled by multiple ***,discovering more genes regulating grain size for understanding the regulatory mechanisms underlying natural variations is important in crop molecular breeding(Zuo and Li,2014).

关键词： breeding crops grain

A stamp based exploration framework for numerical weather forecast

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Computer Aided Drafting,Design and Manufacturing 2017年第2期27卷 7-15页

作者： song yibo Chen Li Liao Hongsen Yong Junhai School of Software Tsinghua University

Numerical weather simulation data usually comprises various meteorological variables, such as precipitation, temperature and pressure. In practical applications, data generated with several different numerical simulation models are usually used together by forecasters to generate the final forecast. However, it is difficult for forecasters to obtain a clear view of all the data due to its complexity. This has been a great limitation for domain experts to take advantage of all the data in their routine work. In order to help explore the multi-variate and multi-model data, we propose a stamp based exploration framework to assist domain experts in analyzing the data. The framework is used to assist domain experts in detecting the bias patterns between numerical simulation data and observation data. The exploration pipeline originates from a single meteorological variable and extends to multiple variables under the guidance of a designed stamp board. Regional data patterns can be detected by analyzing distinctive stamps on the board or generating extending stamps using the Boolean set operations. Experiment results show that some meteorological phenomena and regional data patterns can be easily detected through the exploration. These can help domain experts conduct the data analysis efficiently and further guide forecasters in producing reliable weather forecast.

关键词： multivariate data visualization numerical weather model ensemble weather forecast

Expansion and improvement of ChinaMu by MuT-seq and chromosome-level assembly of the Mu-starter genome

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Journal of Integrative Plant Biology 2024年第4期66卷 645-659页

作者： Lei Liang Yuancong Wang Yanbin Han Yicong Chen Mengfei Li yibo Wu Zeyang Ma Han Zhao Rentao song State Key Laboratory of Maize Bio-breeding Frontiers Science Center for Molecular Design BreedingJoint International Research Laboratory of Crop Molecular BreedingNational Maize Improvement CenterCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100091China Institute of Crop Germplasm and Biotechnology Jiangsu Provincial Key Laboratory of AgrobiologyJiangsu Academy of Agricultural SciencesNanjing 210014China Sanya Institute of China Agricultural University Sanya 572025China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

ChinaMu is the largest sequence-indexed Mutator(Mu)transposon insertional library in maize(Zea mays).In this study,we made significant improvements to the size and quality of the ChinaMu *** developed a new Mu-tag isolation method Mu-Tn5-seq(MuT-seq).Compared to the previous method used by ChinaMu,MuT-seq recovered 1/3 more germinal insertions,while requiring only about 1/14 of the sequencing volume and 1/5 of the experimental *** MuT-seq,we identified 113,879 germinal insertions from 3,168 Mu-active F1 *** also assembled a high-quality genome for the Mu-active line Mu-starter,which harbors the initial active MuDR element and was used as the pollen donor for the mutation *** the Mu-starter genome,we recovered 33,662(15.6%)additional germinal insertions in 3,244(7.4%)genes in the Mu-starter *** Mu-starter genome also improved the assignment of 117,689(54.5%)germinal *** newly upgraded ChinaMu dataset currently contains 215,889 high-quality germinal *** insertions cover 32,224 pan-genes in the Mu-starter and B73Ref5 genomes,including 23,006(80.4%)core genes shared by the two *** a test model,we investigated Mu insertions in the pentatricopeptide repeat(PPR)superfamily,discovering insertions for 92%(449/487)of PPR genes in ChinaMu,demonstrating the usefulness of ChinaMu as a functional genomics resource for maize.

关键词： ChinaMu Mutator MuT-seq PPR gene Zea mays

Large contributions of emission reductions and meteorological conditions to the abatement of PM_(2.5)in Beijing during the 24th Winter Olympic Games in 2022

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Journal of Environmental Sciences 2024年第2期136卷 172-188页

作者： Yaping Jiang Shaocai Yu Xue Chen yibo Zhang Mengying Li Zhen Li Zhe song Pengfei Li Xiaoye Zhang Eric Lichtfouse Daniel Rosenfeld Key Laboratory of Environmental Remediation and Ecological Health Ministry of EducationResearch Center for Air Pollution and HealthCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China College of Science and Technology Hebei Agricultural UniversityBaoding 071000China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China Aix-Marseille Univ CNRSColl FranceCNRSIRDINRAEEuropole Mediterraneen de l’ArboisAvenue Louis Philibert13100 Aix en ProvenceFrance Xi’an Jiaotong University State Key Laboratory of Multiphase Flow in Power EngineeringXi’an 710049China Institute of Earth Sciences The Hebrew University of JerusalemJerusalemIsrael

To guarantee the blue skies for the 2022 Winter Olympics held in Beijing and Zhangjiakou from February 4 to 20,Beijing and its surrounding areas adopted a series of emission control *** provides an opportunity to determine the impacts of large-scale temporary control measures on the air quality in Beijing during this special ***,we applied the WRF-CMAQ model to quantify the contributions of emission reduction measures and meteorological *** show that meteorological conditions in 2022 decreased PM_(2.5)in Beijing by 6.9 and 11.8μg/m^(3)relative to 2021 under the scenarios with and without emission reductions,*** emission reduction measures implemented in Beijing and seven neighboring provinces resulted in an average decrease of 13.0μg/m^(3)(-41.2%)in PM_(2.5)in *** the entire period,local emission reductions contributed more to good air quality in Beijing than nonlocal emission *** the emission reduction scenario,local,controlled regions,other regions,and boundary conditions contributed 47.7%,42.0%,5.3%,and 5.0%to the PM_(2.5)concentrations in Beijing,*** results indicate that during the cleaning period with the air masses from the northwest,the abatements of PM_(2.5)were mainly caused by local emission ***,during the potential pollution period with the air masses from the east-northeast and west-southwest,the abatements of PM_(2.5)were caused by both local and nonlocal emission reductions almost *** implies that regional coordinated prevention and control strategies need to be arranged scientifically and rationally when heavy pollution events are forecasted.

关键词： PM_(2.5) WRF-CMAQ Meteorological conditions Emission reductions Winter Olympic games

Pseudomonas aeruginosa regulator PvrA binds simultaneously to multiple pseudo-palindromic sites for efficient transcription activation

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Science China(Life Sciences) 2024年第5期67卷 900-912页

作者： yibo Zhu Bingnan Luo Xingyu Mou Yingjie song Yonghong Zhou Yongbo Luo Bo Sun Youfu Luo Hong Tang Zhaoming Su Rui Bao Center of Infectious Diseases Division of Infectious Diseases in State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of Geriatrics and National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengdu 610041China Key Laboratory of Biodiversity and Environment on the Qinghai-Tibetan Plateau Ministry of EducationSchool of Ecology and EnvironmentTibet UniversityLhasa 850000China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China College of Life Science Sichuan Normal UniversityChengdu 610101China Accurate Biotechnology(Hunan)Co. LtdChangsha 410006China

Tetracycline repressor(TetR)family regulators(TFRs)are the largest group of DNA-binding transcription factors and are widely distributed in bacteria and *** play vital roles in controlling the expression of various genes and regulating diverse physiological ***,a TFR protein Pseudomonas virulence regulator A(PvrA),was identified from Pseudomonas aeruginosa as the transcriptional activator of genes involved in fatty acid utilization and bacterial ***,we show that PvrA can simultaneously bind to multiple pseudo-palindromic sites and upregulate the expression levels of target ***-electron microscopy(cryo-EM)analysis indicates the simultaneous DNA recognition mechanism of PvrA and suggests that the bound DNA fragments consist of a distorted B-DNA double *** crystal structure and functional analysis of PvrA reveal a hinge region that secures the correct domain motion for recognition of the promiscuous ***,our results showed that mutations disrupting the regulatory hinge region have differential effects on biofilm formation and pyocyanin biosynthesis,resulting in attenuated bacterial ***,these findings will improve the understanding of the relationship between the structure and function of the TetR family and provide new insights into the mechanism of regulation of *** virulence.

关键词： Pseudomonas aeruginosa transcription regulator TetR protein-structure virulence