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神经损伤与功能重建 2008年第5期3卷 342-351,356页

作者： WEI-LIN LIU yi-hsuan lee SHIH-yiNG TSAI CHUNG yi HSU YU-YO SUN LIANG-YO YANG SHING-HAN TSAI AND WEI-CHUNG VIVIAN YANG Graduate Institute of Biomedical Materials and Engineering Taipei Medical University Taipei Taiwan Graduate Institute of Neuroscience College of Medicine Taipei Medical Uni- versity Taipei Taiwan Division of Physiology and Neuroscience Graduate Institute of Medi- cal Sciences College of Medicine Taipei Medical University Taipei Taiwan Department of Physiology School of Medicine College of Medicine Taipei Medical University Taipei Tai- wan Graduate Institute of Injury Prevention and Control Taipei Medical University Taipei Taiwan Department of Neurosurgery Taipei Municipal WanFang Hospital Taipei Taiwan

创伤后的神经胶质增生导致硫酸软骨素蛋白聚糖(CSPG)的显著表达,从而抑制轴突生长和再生。甲基强地松龙(MP),一种合成的糖皮质激素,在急性脊髓损伤(SCI)的治疗中有神经保护作用和抗炎效应。但是,MP对于CSPG在活性胶质细胞中的表达的作... 详细信息

创伤后的神经胶质增生导致硫酸软骨素蛋白聚糖(CSPG)的显著表达,从而抑制轴突生长和再生。甲基强地松龙(MP),一种合成的糖皮质激素,在急性脊髓损伤(SCI)的治疗中有神经保护作用和抗炎效应。但是,MP对于CSPG在活性胶质细胞中的表达的作用尚不清楚。本文用a-氨基-3-羟基-5-甲基-4-异恶唑丙酸酯(AM-PA)诱导星形胶质细胞再活化,用环噻嗪模拟SCI的兴奋性中毒刺激。AMPA治疗后,星形胶质细胞再活化的标志物-胶质纤维酸性蛋白(GFAP)、CSPG神经聚糖和磷酸盐的表达都显著上调。AMPA治疗星形胶质细胞的条件培养液强烈抑制大鼠背根神经节中神经元的轴突生长,但这种作用能被MP的预处理所逆转。此外,MP下调成年SCI大鼠中GFAP和CSPG的表达,对抗RU486的糖皮质激素受体(GR)和GR si RNA能逆转MP对GFAP和神经聚糖表达的抑制作用。这些结果提示,MP能在兴奋性中毒损伤后通过GR介导的星形胶质细胞再活化下调和GSPG表达抑制来改善神经修复,促进轴突生长。

关键词：中枢神经系统硫酸软骨素蛋白聚糖神经胶质增生糖皮质激素脊髓损伤

Carbonyl compounds in dining areas,kitchens and exhaust streams in restaurants with varying cooking methods in Kaohsiung,Taiwan

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Journal of Environmental Sciences 2016年第3期28卷 218-226页

作者： Jen-hsuan Cheng yi-Shiun lee Kang-Shin Chen Institute of Environmental Engineering "National" Sun Yat-Sen University

Eighteen carbonyl species in C_1-C_（10） were measured in the dining areas,kitchens and exhaust streams of six different restaurant types in Kaohsiung,southern *** results in the dining areas show that Japanese barbecue（45.06 ppb） had the highest total carbonyl concentrations（sum of 18 compounds）,followed by Chinese hotpot（38.21 ppb）,Chinese stir-frying（8.99 ppb）,Western fast-food（8.22 ppb）,Chinese-Western mixed style（7.38 ppb）,and Chinese buffet（3.08 ppb）,due to their different arrangements for dining and cooking spaces and different cooking *** average,low carbon-containing species（C_1-C_4）,e.g.,formaldehyde,acetaldehyde,acetone and butyraldehyde were dominant and contributed 55.01%-94.52%of total carbonyls in the dining areas of all ***,Chinese-Western mixed restaurants（45.48 ppb） had high total carbonyl concentrations in kitchens mainly because of its small kitchen and poor ***,high carbon-containing species（C_5-C_（10）） such as hexaldehyde,heptaldehyde and nonanaldehyde（16.62%-77.00%of total carbonyls） contributed comparatively with low carbon-containing compounds（23.01%-83.39%of total carbonyls） in ***,Chinese stir-frying（132.10 ppb）,Japanese barbecue（125.62 ppb）,Western fast-food（122.67 ppb）,and Chinese buffet（119.96 ppb） were the four restaurant types with the highest total carbonyl concentrations in exhaust streams,indicating that stir-frying and grilling are inclined to produce polluted *** risk assessments indicate that Chinese hotpot and Japanese barbecue exceeded the limits of cancer risk（10^（-6）） and hazard index（=1）,mainly due to high concentrations of *** other four restaurants were below both limits.

关键词： Carbonyl compounds Restaurant Exhaust stream Health effect

FACTORS OF 3GWC SYSTEMS FOR DRAWING UP CUSTOMIZED STRATEGIES OF PROMOTION

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Journal of Systems Science and Systems Engineering 2011年第3期20卷 365-381页

作者： Hsin-Pin FU Hwan-Yann SU Fang-Hua WANG Ching-yi CHANG Hung-hsuan lee Department of Marketing and Distribution Management National Kaohsiung First University of Science and Technology Kaohsiung Taiwan China Department of Asia-Pacific Industrial and Business Management National University of Kaohsiung Taiwan China Antai College of Economics ＆ Management Shanghai Jiao Tong University Shanghai China Antai College of Economics ＆ Management Shanghai Jiao Tong University Shanghai China Institute of Management National Kaohsiung First University of Science and Technology Taiwan China

This study utilizes fuzzy analytic hierarchy process （FAHP） to analyze decision-making pattems with regard to third-generation wireless communications （3GWC） service adoption, and to provide customized strategic recommendations to suppliers of 3GWC services regarding marketing and resource allocation in the context of the Chinese 3GWC market. First of all, a three-layer hierarchy of 3GWC adoption factors is developed by referring to the relevant literature and industry reports. A questionnaire of pairwise comparisons in the fuzzy AHP format is then designed and distributed to experts familiar with the handset market in Shanghai, China. These surveys are then analyzed using fuzzy AHP to establish an understanding of the weights and impacts of the various factors. The results show that the four most important factors for the adoption of 3GWC systems are：（i） handset price and voice and data-transmission fees; （ii） handset aesthetics; （iii） personalization; and （iv） network coverage. These findings suggest that providers of such services should customize and diversify the content/applications they offer and ensure the speed and reliability of network access. In addition, handset designs should be in accordance with consumer demands. If these steps can be achieved, then consumers will adopt 3GWC services more rapidly.

关键词： 3GWC (third generation mobile) adoption factors FAHP

GPS Vector Tracking Receivers with Rate Detector for Integrity Monitoring

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Computers, Materials & Continua 2021年第11期69卷 2387-2403页

作者： Dah-Jing Jwo Ming-hsuan lee Department of Communications Navigation and Control EngineeringTaiwan Ocean UniversityKeelung202301TaiwanChina

In this paper,the integrity monitoring algorithm based on a Kalman filter(KF)based rate detector is employed in the vector tracking loop(VTL)of the Global Positioning System(GPS)*** the VTL approach,the extended Kalman filter(EKF)simultaneously tracks the received signals and estimates the receiver’s position,velocity,*** contrast to the scalar tracking loop(STL)that uses the independent parallel tracking loop approach,the VTL technique uses the correlation of each satellite signal and user dynamics and thus reduces the risk of loss lock of *** the VTL scheme provides several important advantages,the failure of tracking in one channel may affect the entire system and lead to loss of lock on all *** integrity monitoring algorithm can be adopted for robustness *** general,the standard integrity monitoring algorithm can timely detect the step type erroneous ***,in the presence of ramp type slowly growing erroneous signals,detection of such type of error takes much more time since the error cannot be detected until the cumulative exceeds the specified *** integrity monitoring based on the rate detector possesses good potential for resolving such *** test statistic based on the pseudorange residual in association with the EKF is applied for determination of whether the test statistic exceeds the allowable threshold *** fault detection and exclusion(FDE)mechanism can then be employed to exclude the hazardous erroneous signals for the abnormal satellites to assure normal operation of GPS *** of the integrity monitoring algorithm based on the EKF based rate detector will be *** assessment and evaluation will be presented.

关键词： Global positioning system vector tracking loop integrity monitoring rate detector slowly growing errors

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Tailoring Light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao Li Hong Zhou Zhihao Ren Cheng Xu Chengkuo lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas Light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

User-guided line abstraction using coherence and structure analysis

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Computational Visual Media 2017年第2期3卷 177-188页

作者： Hui-Chi Tsai Ya-hsuan lee Ruen-Rone lee Hung-Kuo Chu Department of Computer Science "National Tsing Hua University" Information and Communications Research Laboratories Industrial Technology Research Institute

Line drawing is a style of image abstraction where the perceptual content of the image is conveyed using distinct straight or curved lines. However,extracting semantically salient lines is not trivial and mastered only by skilled artists. While many parametric filters have successfully extracted accurate and coherent lines, their results are sensitive to parameter choice and easily lead to either an excessive or insufficient number of lines. In this work, we present an interactive system to generate concise line abstractions of arbitrary images via a few user specified strokes. Specifically, the user simply has to provide a few intuitive strokes on the input images, including tracing roughly along edges and scribbling on the region of interest, through a sketching interface. The system then automatically extracts lines that are long,coherent and share similar textural structures to form a corresponding highly detailed line drawing. We have tested our system with a wide variety of images. Our experimental results show that our system outperforms state-of-the-art techniques in terms of quality and efficiency.

关键词： line abstraction interactive drawing coherence strokes structure strokes stroke matching

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily lee William J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated