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Extensive multifocal and pleomorphic pulmonary lesions in Waldenstrom macroglobulinemia: A case report

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World Journal of Clinical Cases 2020年第11期8卷 2305-2311页

作者： De-Feng Zhao Hao-Yong Ning Jian Cen yi Liu Li-Ren Qian zhi-Hai Han Jian-Liang Shen Department of Hematology Beijing Boren HospitalBeijing 100070China Department of Pathology Navy General Hospital of PLABeijing 100048China Department of Hematology Navy General Hospital of PLABeijing 100048China Department of Respiratory Care Navy General Hospital of PLABeijing 100048China

BACKGROUND Waldenstrom macroglobulinemia(WM) is a type of small lymphocytic lymphoma that mainly affects the bone marrow, spleen, and lymph nodes. A subset of patients with WM demonstrates extramedullary involvement(4.4%),and the most frequent extramedullary disease site involved is the lungs(30%).CASE SUMMARY A 60-year-old male patient who experienced intermittent breath-holding for 6 mo was admitted on August 14, 2017. Chest computed tomography indicated multiple pulmonary cavities in the upper lobes of both lungs, with pulmonary consolidation, ground-glass opacities, patchy infiltrates, fibrous bands, large bullae, and enlarged lymph nodes in the mediastinum. The patient was a heavy smoker(20 cigarettes/d for 40 years). Diagnostic fiberoptic bronchoscopy revealed normal findings. Serological examination revealed a remarkable increase in serum immunoglobulin M levels(30.24 g/L;normal: 0.4-2.30 g/L). A computed tomography-guided percutaneous pulmonary biopsy was performed in the left lower lobe of the lung with pulmonary consolidation and indicated that the alveolar structure disappeared and that a large amount of amyloid-like deposition was present along with the infiltration of very few lymphocytes and plasma cells. The patient was treated with the combined treatment of dexamethasone + rituximab + lenalidomide over four courses. Serum immunoglobulin M did not normalize, and he received ibrutinib +*** This patient with WM and lung amyloidosis had a wide range of pulmonary lesions and a variety of morphological features, which was a rare case. Yet, some changes might be ascribed to heavy smoking.

关键词： Waldenström macroglobulinemia Lung Amyloidosis Computed tomography Case report

lingual nerve injury caused by laryngeal mask airway during percutaneous nephrolithotomy:A case report

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World Journal of Clinical Cases 2021年第35期9卷 11095-11101页

作者： Zheng-yi Wang Wan-Zhang Liu Feng-Qi Wang ying-zhi Chen Ting Huang He-Sheng Yuan Yue Cheng Medical College Ningbo UniversityNingbo 315211Zhejiang ProvinceChina Department of Urology Ningbo First HospitalThe Affiliated Hospital of Ningbo UniversityNingbo 315010Zhejiang ProvinceChina

BACKGROUND lingual nerve injury(LNI)is a rare complication following the use of laryngeal mask airway(LMA).The occurrence of this unexpected complication causes uncomfortable symptoms in patients and worsens their quality of *** present an unusual case of LNI caused by the use of an LMA in percutaneous nephrolithotomy(PCNL).CASE SUMMARY A 49-year-old man presented to our hospital with a 3-year history of intermittent left lower back *** computed tomography showed a 25 mm×20 mm stone in the left renal *** surgery using LMA was performed to remove the renal *** patient reported numbness on the tip of his tongue after the operation,but there were no signs of swelling or *** patient was diagnosed with LNI after other possible causes were ruled *** symptom of numbness eventually improved after conservative medical therapy for 1 *** patient completely recovered 3 wk after *** This is the first case report describing LNI with the use of LMA in *** our case,an inappropriate LMA size,intraoperative movement,and a specific surgical position might be potential causes of this rare complication.

关键词： lingual nerve injury Laryngeal mask airway Percutaneous nephrolithotomy Case report

City Size Distribution and Its Spatiotemporal Evolution in China

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Chinese Geographical Science 2016年第6期26卷 703-714页

作者： SHI Lifeng ZHANG Zengxiang LIU Fang ZHAO Xiaoli WANG Xiao LIU Bin HU Shunguang WEN Qingke ZUO Lijun yi ling XU Jinyong Institute of Remote Sensing and Digital Earth Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Based on the National Land Use/Cover Database of China(NLUD-C) in the end of the 1980s(the 1980s,hereafter), 1995, 2000, 2005, and 2010, 665 cities were selected to study the size distribution and its changes of urban lands in China. In this study, the spatiotemporal evolutions of urban land size distribution as well as the influence of administrative-level on these cities were explored by combining urban spatial positions and administrative-levels. Results indicate that: 1) City size distribution using urban lands was more practical and reasonable than using non-agricultural population. 2) In the 1980s, cities with ascending urban land rank were centralized in Eastern China, specially the Changjiang(Yangtze) River Delta, the Zhujiang(Pearl) River Delta, and Beijing-Tianjin-Hebei region. Cities in Central, Western, and Northeast China mainly indicated descending urban land rank. 3) The transfer of national development focus resulted in cities with ascending urban land rank becoming evenly distributed nationwide; however, this trend was slightly centralized around Chengdu, Chongqing, and Wuhan in different periods. 4) During the 1980s to 2010, the proportion of cities with ascending urban land rank in provincial capitals, municipalities, and special administrative regions(high-level cities, hereafter) was consistently higher than those in prefecture- and county-level cities except for 2005–2010. The ranks of the majority of the prefecture- and county-level cities were mainly descending, supported by ascending; the proportion of cities with unchanged rank is small. This study breaks through the bottleneck of traditional research in the area of city size distribution by examining urban land replacing the non-agricultural population. The current study also provides scientific explanation for the healthy and reasonable development of urban land as well as the coordinated development of population urbanization and land urbanization.

关键词： Chinese city urban land size distribution spatiotemporal evolution remote sensing

Hypolipidemic effect of SIPI-7623,a derivative of an extract from oriental wormwood,through farnesoid X receptor antagonism

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Chinese Journal of Natural Medicines 2018年第8期16卷 572-579页

作者： DENG yi-Fang HUANG Xiao-ling SU Mei YU Peng-Xia ZHANG Zhen LIU Quan-Hai WANG Guo-Ping LIU Min-Yu Department of Pharmacology Shanghai Institute of Pharmaceutical Industry Jiangsu Carephar Pharmaceutical Co. Ltd.

Farnesoid X receptor(FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription *** a metabolic regulator,FXR plays key roles in bile acid and cholesterol metabolism and lipid and glucose ***,FXR is a potential drug target for several metabolic syndromes,especially those related to lipidemia *** the present study,we identified small molecule SIPI-7623,a derivative of an extract from Oriental wormwood(Artemisia capillaris),and found that it specifically upregulated the expression of cholesterol-7-alpha-hydroxylase(CYP7 A1),downregulated the expression of sterol-regulatory element-binding protein 1 c(SREBP-1 c) in the liver,and inhibited the expression of ileal bile acid binding-protein(IBABP) in the ileum of *** found that inhibition of FXR by SIPI-7623 decreased the level of cholesterol and ***-7623 reduced the levels of cholesterol and triglyceride in in vitro Hep G2 cell models,ameliorated diet-induced atherosclerosis,and decreased the serum lipid content on rats and rabbits model of atherosclerosis in ***,SIPI-7623 decreased the extent of atherosclerotic *** resutls demonstrated that antagonism of the FXR pathway can be employed as a therapeutic strategy to treat metabolic diseases such as hyperlipidemia and *** conclusion,SIPI-7623 could be a promising lead compound for development of drugs to treat hyperlipidemia and atherosclerosis.

关键词： Farnesoid X receptor antagonist Hypolipidemic Bile acid enterohepatic circulation Cholesterol-7-alpha-hydroxylase Sterol-regulatory element-binding protein 1c

NHC-Boryl Radical Catalysis for Cycloisomerization With C–C Triple Bond Reorganization

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CCS Chemistry 2019年第5期1卷 504-512页

作者： Ai-Qing Xu Feng-Lian Zhang Tian Ye zhi-Xiang Yu yi-Feng Wang Hefei National Laboratory for Physical Sciences at the Microscale Center for Excellence in Molecular Synthesis of CASDepartment of ChemistryUniversity of Science and Technology of ChinaHefeiAnhui 230026China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Our present study unveils a new and efficient N-heterocyclic carbene(NHC)-boryl radical-catalyzed cycloisomerization of N-(2-ethynylaryl)*** catalytic process is triggered by the addition of an NHC-boryl radical to the alkynyl moiety,followed by a radical cascade comprising of an intramolecular cyclization,successive 1,5-and 1,2-aryl migrations,and the reorganization of a C–C triple bond.

关键词： radical catalysis NHC-boryl radical cycloisomerization C-C triple bond reorganization aryl migration DFT calculation

Anti-inflammatory effect of extracts of Dendropanax dentige and Lycopodiastrum casuarinoides on rheumatoid arthritis and their underlying mechanism in rats

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中国药理学与毒理学杂志 2016年第10期30卷 1036-1037页

作者： CHEN Gang LIU zhi-kai HAN Chen-yun LI Jia-shuang ZOU yi-ping Key Laboratory of Natural Active Pharmaceutical Constituents of Jiangxi Province Yichun University

OBJECTIVE To investigate the anit-inflammatory effect of extracts of Dendropanax dentiger(Harms)Merr and Lycopodiastrum casuarinoides(Spring)Holub on rheumatoid arthritis(RA)using adjuvant arthritis(AA)rat model and possible *** The AA rat model of RA was induced in adult SparagueDawley(SD)rats by injecting of the adjuvant at base ***-week-old male SD rats were randomly divided into the following groups:normal saline group(blank control),*** decoction group(80g·kg-1·d-1),*** decoction group(80 g·kg·d-1),the total of glucoside Tripterygium(GTT)group(positive control,2 mg·kg-1·d-1).They were administered orally for *** of tissues arthritis rats was observed by H.E *** volume of paw swelling was measured and the arthritis inflammation index was *** expressions of tumor necrosis factor-α(TNF-α)and interlukin-1β(IL-1β)were detected by the ELISA *** addition,previous study has reported that plant-derived mi RNAs play a role for cross kingdom regulatory ***,we also performed RNA-seq technique to identify bioactive mi RNAs via comparative transcriptome analysis between *** and *** Comparing with AA model group,the volume of paw swelling and the arthritis index were increased significantly in the AA rat model group(Pling of *** decoction group,*** decoction group was decreased by 25.2%and 10.3%,respectively,and the arthritis index was decreased by 27.2%and 18.3%,*** with AA model group,TNF-αprotein expression of *** decoction group and *** decoction groups were decreased by 16.3%and 14.7%,and IL-1βprotein expression was decreased by 23.6%,18.9%(P<0.05,P<0.01),***,we found that some plant-derived homologous mi RNAs(such as mi RNA192 and mi RNA30a)associated with cell

关键词： rheumatoid arthrits aqueous extracts of D.dentiger and L.Cauarinoides anti-inflammatory effect miRNA cross-kingdom regulation

Research of detonation products of RDX/Al from the perspective of composition

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Defence Technology（防务技术） 2023年第6期24卷 31-45页

作者： Xing-han Li zhi-cong yi Qi-jun Liu Fu-sheng Liu Ze-teng Zhang Shen-yuan Hou Xian-xu Zheng Xu Zhang Hong-bo Pei School of Physical Science and Technology Southwest Jiaotong UniversityChengdu610031China National Key Laboratory for Shock Wave and Detonation Physics Mianyang621900China

Aluminized explosives exhibit excellent performance because the oxidation of aluminum(Al)powders enhances the pressure and temperature of detonation ***,the equation of state(EOS)of detonation products has not been understood *** the present study,we conducted long-time tests(approximately 1 ms)of a metal rod driven by detonation products of RDX,RDX/Li F,and RDX/*** addition,we used laser velocimetry(PDV)to measure the freesurface velocity of the *** code DLCHEQ was successfully applied to the hydrodynamic program SSS to perform the roddriven test,and a novel method was established to study the EOS of detonation products from the perspective of *** reliability of DLCEHQ was validated by a small deviation(<10%)between the experimental rod free-surface velocity of RDX and the calculated results;the deviation was considerably less than that from the results obtained using the JWL EOS and ideal-gas *** endothermic process and the reaction of Al powders(Al+H_(2)O+NO+CO_(2)→CO+H_(2)+N_(2)+Al_(2)O_(3))were analyzed by calculating the rod free-surface velocity of RDX/Li F and RDX/Al,*** results of the present study demonstrated that the thermodynamic state of Al powders has notable influence on the EOS of aluminized detonation products,and the findings were compared with those of previous ***,the temperature equilibrium between Al powders and CHNO products is not always achieved,and the disequilibrium is more obvious when the reaction of Al powders is ***,the reaction rate of Al powders depends on pressure and Al ***,the endothermic process of Al powders has a high contribution to the decrease in the work ability of RDX/Al instead of the gasconsumption mechanism of the Al *** than half of the reaction heat of Al powders is used to heat itself,whereas the gas consumption during the reaction is negligible.

关键词： Aluminized explosive Detonation products EOS Rod-driven test Compositional evolution

ELIMINATING SPEED PENALTIES IN ECC PROTECTED MEMORY DESIGNS USING “BIT BYPASSING” TECHNIQUES

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Journal of Electronics(China) 2014年第4期31卷 290-297页

作者： zhi Tian Yang Haigang Cai Gang Qiu Xiaoqiang Shu yi Li Yue Cheng Xiaoyan Institute of Electronics Chinese Academy of Sciences University of Chinese Academy of Sciences

In deep sub-micron ICs, growing amounts of on-die memory and scaling effects make embedded memories more vulnerable to reliability problems, such as soft errors induced by radiation. Error Correction Code(ECC) along with scrubbing is an efficient method for protecting memories against these errors. However, the latency of coding circuits brings speed penalties in high performance applications. This paper proposed a "bit bypassing" ECC protected memory by buffering the encoded data and adding an identifying address for the input data. The proposed memory design has been fabricated on a 130 nm CMOS process. According to the measurement, the proposed scheme only gives the minimum delay overhead of 22.6%, compared with other corresponding memories. Furthermore, heavy ion testing demonstrated the single event effects performance of the proposed memory achieves error rate reductions by 42.9 to 63.3 times.

关键词： Error Correction Code (ECC) Memory PerformanceCLC number:TN432

Novel Cellulase Profile of Trichoderma reesei Strains Constructed by cbh1 Gene Replacement with eg3 Gene Expression Cassette

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Acta Biochimica et Biophysica Sinica 2004年第10期36卷 667-672页

作者： Tian-Hong WANG*, Ti LIU, zhi-Hong WU, Shi-Li LIU, yi LU, and yin-Bo QU The State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China The State Key Laboratory of Microbial Technology Shandong University

To construct strains of the filamentous fungus Trichoderma reesei with low cellobiohydrolases while high endoglucanase activity, the Pcbh1-eg3-Tcbh1 cassette was constructed and the coding sequence of the cellobiohydrolase I (CBHI) gene was replaced with the coding sequence of the eg3 gene by homologous recombination. Disruption of the cbh1 gene was confirmed by PCR, Southern dot blot and Western hybri- dization analysis in two transformants denoted as L13 and L29. The filter paper-hydrolyzing activity of strain L29 was 60% of the parent strain Rut C30, and the CMCase activity was increased by 33%. This relatively modest increase suggested that the eg3 cDNA under the control of the cbh1 promoter was not efficiently transcribed as the wild type cbhl gene. However our results confirmed that homologous recombination could be used to construct strains of the filamentous fungus Trichoderma reesei with novel cellulase profile. Such strains are of interest from the basic science perspective and also have potential industrial applications.

关键词： Trichoderma reesei gene replacement gene disruption cbh1 eg3