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液相超声法制备金属硫化物量子点的研究进展

激光与红外 2024年第6期54卷 843-851页

作者：张泰玮胡坤李国彬夏溢坪杨奥李学铭唐利斌杨培志云南师范大学能源与环境科学学院可再生能源材料先进技术与制备教育部重点实验室云南昆明650500 昆明物理研究所云南昆明650223 云南省先进光电材料与器件重点实验室云南昆明650223

量子点(Quantum Dots,QDs)是一种零维纳米材料,其尺寸小于或接近激子玻尔半径。随着纳米技术的发展,金属硫化物量子点因其独特的光学、电学和磁学性质而受到广泛关注,可将其分为过渡金属硫化物量子点(TMD QDs)、Ⅱ-Ⅵ族量子点及Ⅳ-Ⅵ族... 详细信息

量子点(Quantum Dots,QDs)是一种零维纳米材料,其尺寸小于或接近激子玻尔半径。随着纳米技术的发展,金属硫化物量子点因其独特的光学、电学和磁学性质而受到广泛关注,可将其分为过渡金属硫化物量子点(TMD QDs)、Ⅱ-Ⅵ族量子点及Ⅳ-Ⅵ族量子点等。超声法制备量子点具有高效、环保、易于控制和可扩展性等优点,逐渐成为制备金属硫化物量子点的重要技术之一。金属硫化物量子点有着别于传统体相材料的优异光电特性,在近些年里,其优越而又独特的性能使得在更多的领域中得到了深入的研究和应用,如光电器件、生物成像、光催化等。本文综述了超声法制备不同金属硫化物量子点的研究进展,并对其性质和应用进行了归纳和总结。最后,对超声法制备金属硫化物量子点进行了展望。

关键词：量子点金属硫化物超声法光电特性

Expression of CD44v6 and Livin in gastric cancer tissue

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Chinese Medical Journal 2012年第17期125卷 3161-3165页

作者： LIANG yi-zhi FANG Tai-yong XU Hai-gang ZHUO zhi-qiang Department of Gastroenterology Second Affiliated Hospital Fujian Medical University Quanzhou Fujian 362000 China Department of Pathology Second Affiliated Hospital Fujian Medical University Quanzhou Fujian 362000 China Department of Infectious Diseases Quanzhou Children's Hospital Quanzhou Fujian 362000 China

Background CD44v6 plays an important role in invasion and metastasis of tumor, Livin has anti-apoptotic effects. The present study aimed to explore the expression and clinical significance of CD44v6 and Livin in gastric cancer tissue. Methods Streptavidin-peroxidase linked immunohistochemical method was used to determine the expression of CD44v6 and Livin in gastric cancer tissue and adjacent normal gastric tissues from 59 patients with histopathologically confirmed gastric cancer, and in gastric tissue specimens of 15 patients with gastric polyps, and 15 patients with chronic non-atrophic gastritis. The chi-square test was used for comparison of the relevant factors, Spearman＇s rank correlation test was applied for relationship among positive expression of the proteins. Results The expresion of CD44v6 was positive in 64.4% of the gastric cancer patients; 5.1%, 0 and 13.3% in specimens of normal tissues adjacent to the cancer tissues, in gastric tissue specimens of patients with gastric polyps, and patients with chronic non-atrophic gastritis, respectively. The expression of Livin was positive in 52.5% of the gastric cancer tissues, 6.8%, 0 and 6.7% in the adjacent normal gastric tissue, specimens of patients with gastric polyps and chronic non-atrophic gastritis, respectively. The expression of CD44v6 was significantly correlated with the depth of invasion, the degree of differentiation, and lymphnode metastasis of gastric cancer （P 〈0.05）. The positive expression rate of Livin protein was also significantly correlated with degree of differentiation of gastric cancer cells and metastasis to lymphnodes （P 〈0.05）, but not correlated with the depth of invasion and pathological types （P 〉0.05）. The expression of CD44v6 and Livin in the gastric cancer tissue was positively correlated （rs=0.286, P=0.028）. Conclusions The increased expression of CD44v6 and Livin in gastric cancer tissue may be closely related with development and progression of gastric cancer. CD44v6 and

关键词： gastric cancer CD44v6 Livin expression immunohistochemistry

Transfusion of Plasma Collected at Late Phase after Preconditioning Reduces Myocardial Infarct Size Induced by Ischemia-reperfusion in Rats In vivo

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Chinese Medical Journal 2017年第3期130卷 303-308页

作者： Yang Zhao zhi-Nan Zheng Chi-Wai Cheung zhi-yi Zuo San-Qing Jin Department of Anesthesia The Sixth Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510655 China Department of Anesthesia Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong 999077 China Department of Anesthesia University of Virginia Health System Charlottesville Virginia 22902 USA

Background： Plasma transfusion is a common clinical practice. Remote ischemic preconditioning （RIPC） protects organs against ischemia-reperfusion （IR） injury. Whether preconditioned plasma （PP）, collected at late phase after RIPC, could protect organs against IR injury in vivo is unknown. This study explored whether transfusion of PP could reduce myocardial inihrct size （IS） after I R in rat in vivo. Methods： Eighty Lewis rats were randomized to eight groups （n= 10 for each group）. Two groups of plasma donor rats donated plasma at 48 h after transient limb ischemia （PP） or control protocol （nonpreconditioned plasma [NPP]）. Six groups of recipient rats received normal saline （NS; NS-IR 1, and NS-1R 24 groups）, NPP （NPP-IR I and NPP-1R 24 groups）, or PP （PP-IR 1 and PP-IR 24 groups） at one or 24 h before myocardial IR. Myocardial IR consisted of 30-min left anterior descending （LAD） coronary artery occlusion and 180-rain reperIhsion. The area at risk （AAR） and infarct area were determined by double-staining with Evans blue and triphenyltetrazolium chloride. IS was calculated by inihrct area divided by AAR. This was a 3 × 2 factorial design study, and factorial analysis was used to evaluate the data. If an interaction between the fluid and transfusion time existed, one-way analysis of variance with Bonferroni correction lbr multiple comparisons was used to analyze the single effects of fluid type when the transfusion time was fixed. Results： IS in the NPP-IR I and PP-IR1 groups was smaller than in the NS-IR I group （F - 6.838, P = 0.005; NPP-IR I： 57 ± 8% vs. NS-IRI： 68± 6%, t = 2.843, P - 0.020; PP-IR I： 56 ~ 8% vs. NS-IR 1：68 ~ 6%, t - 3.102, P - 0.009）, but no significant difference was detected between the NPP-IR 1 and PP-IR 1 groups （57 ± 8% vs. 56 ± 8%, t 0.069, P = 1.000）. IS in the N PP-IR 24 and PP-IR 24 groups was smaller than in the NS-IR 24 group （F - 24.796, P 〈 0.001： NPP-IR 24： 56% ± 7% vs. NS-IR 24：68 ± 7%, t = 3.102, P =0.026; PP-IR 24：40±9% vs. NS-IR

关键词： Ischemia Ischemic Preconditionina Myocardial Infarction, Myocardial Reperfusion Injury Plasma

Temperature-dependent chloride-mediated access to atom-precise silver thiolate nanoclusters

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Science China Chemistry 2022年第6期65卷 1094-1099页

作者： ling Yang Xin-Yao Wang Xiao-Yan Tang Meng-yi Wang Chun-Yan Ni Hong Yu ying-Lin Song Brendan F.Abrahams Jian-Ping Lang College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China School of Materials Engineering Changshu Institute of TechnologyChangshu215500China School of Physical Science and Technology Soochow UniversitySuzhou215006China School of Chemistry University of MelbourneParkvilleVictoria3010Australia

By using a unique temperature-dependent,chloride-mediated approach,two atom-precise silver nanoclusters[Cl@Ag_(14)(Tab)_(12)-(C_(5)H_(4)NCl)_(12)](PF_(6))_(13)(Cl@Ag_(14))and[Cl_(3)@Ag_(24)(Tab)_(20)(C_(5)H_(4)NCl)_(11)]Cl(PF_(6))_(20)(Cl_(3)@Ag_(24))(Tab=4-(trimethylammonio)benzenethiolate,C_(5)H_(4)NCl=3-chloropyridine)were obtained ***,the number of chloride ions encapsulated inside the Ag-S shell could be regulated by the slow dissolution of almost insoluble KCl at various *** inclusion of additional core chloride ions results in the expansion of the surrounding Ag-S *** article provides a promising synthetic approach for controlling the number of Ag atoms that form a shell around the anionic core,in addition to offering a potential pathway for the introduction of other inorganic anions into silver *** broadly,through the use of related ligands,the synthetic strategy offers scope for generating new families of silver thiolate clusters of varying size and composition.

关键词： temperature-dependent chloride-mediated core expansion silver thiolate nanocluster transformation

Preparation of Molecularly Imprinted Composites Initiated by Hemin/Graphene Hybrid Nanosheets and Its Application in Detection of Sulfamethoxazole

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Current Medical Science 2019年第1期39卷 159-165页

作者： Shao-fei GUO Xiao-yu CHEN Peng WANG Cheng CHEN Rui-hua PAN Yue-tao ling yi-zhu TANG Hubei Entry-Exit Inspection and Quarantine Bureau of PRC Wuhan 430022China Hubei Institute of Sport Science Wuhan 430205China

Molecularly imprinted polymers(MIPs)exhibit high selectivity resulting from imprinted cavities and superior performance from functional materials,which have attracted much attention in many ***,the combination of MIPs film and functional materials is a great *** this study,hemin/graphene hybrid nanosheets(H-GNs)were used to initiate the imprinted polymerization by catalyzing the generation of free ***,MIPs using sulfamethoxazole as the template was directly prepared on the surface of H-GNs without any film *** importantly,the template could be absorbed on the H-GNs to enhance the number of imprinted sites per unit surface area,which could improve the selectivity of MIPs ***,the composites could exhibit high adsorption capacity(29.4 mg/g),imprinting factor(4.2)and excellent conductivity,which were modified on the surface of electrode for rapid,selective and sensitive detection of sulfamethoxazole in food and serum *** linear range was changed from 5μg/kg to 1 mg/g and the limit of detection was 1.2μg/*** sensor was free from interference caused by analogues of sulfamethoxazole,which provides a novel insight for the preparation of MIPs-based sensor and its application in food safety monitoring and human exposure study.

关键词： MIP/H-GNs composites sulfamethoxazole nano enzyme-mediated polymerization sensor dietary exposure

Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia

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Chinese Journal of Cancer Research 2017年第5期29卷 463-470页

作者： Jiaxiong Tan Shaohua Chen Yuhong Lu Danlin Yao ling Xu yikai Zhang Lijian Yang Jie Chen Jing Lai zhi Yu Kanger Zhu Yangqiu Li Institute of Hematology School of Medicine Jinan University Department of Hematology the First Affiliated Hospital Jinan University Key Laboratory for Regenerative Medicine of Ministry of Education Jinan University

Objective： To investigate the association between the T cell inhibitory receptor programmed death 1（PD-1）and T cell exhaustion status in T cells from patients with de novo acute myeloid leukemia（AML） and AML in complete remission（CR）.Methods：Surface expression of PD-1 and the exhaustion and immunosenescence markers CD244 and CD57 on CD3＋,CD4＋ and CD8＋ T cells from peripheral blood samples from 20 newly diagnosed,untreated AML patients and 10 cases with AML in CR was analyzed by flow ***-three healthy individuals served as ***：A significantly higher percentage of PD-1＋ cells were found for CD3＋ T cells in the de novo AML group compared with healthy *** addition,an increased level of PD-1＋ CD8＋ T cells,but not PD-1＋ CD4＋,was found for CD3＋ T cells in the de novo AML and AML-CR samples.A higher percentage of CD244＋ CD4＋,CD244＋ CD8＋,CD57＋ CD4＋ and CD57＋ CD8＋ T cells was found in CD3＋ T cells in samples from those with de novo AML compared with those from healthy *** increased PD-1＋ CD244＋ and PD-1＋ CD57＋ coexpression was found for CD4＋ and CD8＋ T cells in the de novo AML group compared with healthy ***：We characterized the major T cell defects,including co-expression of PD-1 and CD244,CD57-exhausted T cells in patients with de novo AML,and found a particular influence on CD8＋ T cells,suggesting a poor anti-leukemia immune response in these patients.

关键词： Acute myeloid leukemia PD-1 T cell exhaustion

1990—2019年江苏省人群伤害疾病负担及其变化特征

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江苏预防医学 2024年第1期35卷 7-11页

作者：韩颖颖蔡波徐红林玲李鑫林周金意南通市疾病预防控制中心江苏南通226007 江苏省疾病预防控制中心

目的了解1990—2019年江苏省人群伤害的疾病负担及其变化趋势。方法利用2019年全球疾病负担研究资料,对1990—2019年江苏省人群伤害疾病负担进行分析,使用GBD 2019世界标准人口年龄构成对伤害发病率、死亡率和伤残调整寿命年(DALYs)率... 详细信息

目的了解1990—2019年江苏省人群伤害的疾病负担及其变化趋势。方法利用2019年全球疾病负担研究资料,对1990—2019年江苏省人群伤害疾病负担进行分析,使用GBD 2019世界标准人口年龄构成对伤害发病率、死亡率和伤残调整寿命年(DALYs)率进行标化,应用Joinpoint 4.***.1.0软件计算年度平均变化百分比(AAPC),应用人群归因危险百分比(PAF)估计归因于职业性风险、饮酒和低骨密度所致伤害的疾病负担变化情况。结果2019年,江苏省全人群伤害标化发病率、标化死亡率和标化DALYs率分别为7688.1/10万(95%UI:7141.0/10万~8287.0/10万)、40.0/10万(95%UI:28.8/10万~49.8/10万)和2135.3/10万(95%UI:1788.2/10万~2502.5/10万),男性伤害标化发病率、标化死亡率和标化DALYs率均高于女性。1990—2019年,伤害标化发病率呈上升趋势(AAPC=0.41%,t=7.82,P<0.05),标化死亡率和标化DALYs率均呈下降趋势(AAPC为-1.89%和-2.19%,t值为-20.23和-23.16,P值均<0.05),伤害归因于职业性危害的PAF呈下降趋势(AAPC=-1.28%,t=-8.91,P<0.05),归因于饮酒和低骨密度的PAF呈上升趋势(AAPC为1.88%和2.46%,t值为16.73和30.69,P值均<0.05)。结论江苏省人群伤害疾病负担呈下降趋势,男性伤害疾病负担高于女性,应针对重点人群开展减少酒精使用、预防职业性危害和低骨密度预防等工作。

关键词：伤害疾病负担伤残调整寿命年江苏省

淡水系统中4种塑料颗粒的老化过程及DOC产物分析

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环境科学 2021年第8期42卷 3829-3836页

作者：李婉逸刘智临苗令占侯俊河海大学浅水湖泊综合治理与资源开发教育部重点实验室南京210098 河海大学环境学院南京210098

淡水系统中的微塑料污染及其生态效应已经引起国内外学者的广泛关注,但关于不同类型微塑料在自然环境中的老化研究较少.为探究不同类型微塑料的老化过程,分析老化产物,以4种水体中常见的微塑料聚丙乙烯(polystyrene,PS)、低密度聚乙烯(l... 详细信息

淡水系统中的微塑料污染及其生态效应已经引起国内外学者的广泛关注,但关于不同类型微塑料在自然环境中的老化研究较少.为探究不同类型微塑料的老化过程,分析老化产物,以4种水体中常见的微塑料聚丙乙烯(polystyrene,PS)、低密度聚乙烯(low-density polyethylene,LDPE)、聚丙烯(polypropylene,PP)和聚羟基丁酸(polyhydroxybutyrate,PHB)为研究对象,进行了40 d的自然光老化实验.结果表明:(1)在老化过程中,4种不同类型塑料老化析出液水质指标pH、ORP、EC和DO均产生不同程度的上升或下降趋势.(2)经扫描电镜(scanning electron microscope,SEM)观测发现LDPE表面形态变化最大,已经形成裂纹和孔洞.傅立叶红外检测发现,实验中LDPE的羰基指数增加程度最大,增加了31.48%.(3)微塑料老化会产生溶解态产物,即溶解性有机碳(dissolved organic carbon,DOC),DOC质量浓度随老化时间增加而增加,与本底值相比,老化40 d的PHB、PP和LDPE微塑料析出液中DOC质量浓度增加显著,分别增加了61.29%、69.49%和89.15%.以上结果表明经自然光照射,塑料会在自然水体中出现明显的老化,并释放出有机物,由此带来的生态效应应受到更多的关注和研究.

关键词：淡水系统微塑料老化老化程度溶解性有机碳(DOC)

Downregulation of ceramide synthase 1 promotes oral cancer through endoplasmic reticulum stress

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International Journal of Oral Science 2021年第1期13卷 108-116页

作者： Wen Chen Chenzhou Wu Yafei Chen Yuhao Guo ling Qiu Zhe Liu Haibin Sun Siyu Chen Zijian An Zhuoyuan Zhang yi Li Longjiang Li State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Head and Neck Oncology West China Hospital of StomatologySichuan UniversityChengduChina Department of Oral and Maxillofacial-Head and Neck Oncology Capital Medical University School of StomatologyBeijingChina

C18 ceramide plays an important role in the occurrence and development of oral squamous cell ***,the function of ceramide synthase 1,a key enzyme in C18 ceramide synthesis,in oral squamous cell carcinoma is still *** aim of our study was to investigate the relationship between ceramide synthase 1 and oral *** this study,we found that the expression of ceramide synthase 1 was downregulated in oral cancer tissues and cell *** a mouse oral squamous cell carcinoma model induced by 4-nitroquinolin-1-oxide,ceramide synthase 1 knockout was associated with the severity of oral malignant *** studies showed significant upregulation of PCNA,MMP2,MMP9,and BCL2 expression and downregulation of BAX expression in the pathological hyperplastic *** addition,ceramide synthase 1 knockdown promoted cell proliferation,migration,and invasion in *** of CERS1 obtained the opposite *** synthase 1 knockdown caused endoplasmic reticulum stress and induced the VEGFA *** transcription factor 4 is responsible for ceramide synthase 1 knockdown caused VEGFA transcriptional *** addition,mild endoplasmic reticulum stress caused by ceramide synthase 1 knockdown could induce cisplatin *** together,our study suggests that ceramide synthase 1 is downregulated in oral cancer and promotes the aggressiveness of oral squamous cell carcinoma and chemotherapeutic drug resistance.

关键词： endoplasmic cancer reticulum