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Journal of Iron and Steel Research International 2012年第S1期19卷 305-308页

作者： YAN zhi-ming CHEN Mei-ling YANG Jun YANG Li GAO Hong School of Materials Science and Engineering.Dalian Jiaotong University

The effects of trace amount modified SiC nanoparticles and electromagnetic stirring(EMS)on mierostructures and mechanical properties of 7055 aluminum alloy are investigated *** result shows that the original developed coarse dendrite and columnar with obvious orientation microstructure turns into homogeneous equiaxed microstructure with the application of trace amount modified SiC nanoparticles and EMS.A minimum grain size is 96 μm and has been observed when the addition of modified SiC nanoparticles is 0.05%and the current of EMS is *** ultimate tensile strength is increased by 15.8%and the elongation is improved by 50%compared to those without modified SiC nanoparticles and ***,the compound effects of trace amount modified SiC nanoparticles and EMS is discussed to explain the mechanisms of grain refinement and mechanical properties on 7055 aluminum alloy.

关键词： modified SiC nanoparticles electromagnetic stirring(EMS) 7055 aluminum alloy microstructure mechanical properties

新型鹅源星状病毒广西流行株GoAstV-GXHZ01-2022基因组分子特征分析

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中国预防兽医学报 2024年第7期46卷 683-690页

作者：谢守玉熊陈勇黄张玲谢颖魏园园罗湘尹郑敏韦显凯林斌李军熊毅广西动物疫病预防控制中心广西南宁530001 广西农垦永新畜牧集团西江有限公司广西贵港537104 广西农业职业技术大学广西南宁530007

为研究新型鹅源星状病毒(GoAstV)广西流行株基因组的分子特征,本研究采集广西3只疑似GoAstV感染发病雏鹅的3份组织病料样品(每份样品包括肾脏、肝脏和脾脏),采用荧光定量RT-PCR(RT-qPCR)检测GoAstV,以GoAstV阳性样品的核酸为模板,经RT-... 详细信息

为研究新型鹅源星状病毒(GoAstV)广西流行株基因组的分子特征,本研究采集广西3只疑似GoAstV感染发病雏鹅的3份组织病料样品(每份样品包括肾脏、肝脏和脾脏),采用荧光定量RT-PCR(RT-qPCR)检测GoAstV,以GoAstV阳性样品的核酸为模板,经RT-PCR分段扩增、测序及拼接获得GoAstV广西株的全基因组序列,采用BioEdit软件分析上述获得的GoAstV全基因组序列与该病毒参考株各功能基因(ORF1a、ORF1b及ORF2)的相似性,采用Bepipred及NetNGlyc软件预测该病毒Cap蛋白的抗原表位与N-糖基化位点,通过Mega 7.0软件绘制各功能基因的进化树,通过RDP 5软件分析ORF基因序列的重组事件。结果显示,RT-qPCR检出3份GoAstV阳性样品,并经测序获得1条GoAstV广西流行株GoAstV-GXHZ01-2022全基因组序列,该基因组全长为7 149 bp,其中5'非编码区(5'UTR)长143 bp,ORF全长6 929 bp,3'UTR长77 bp;GoAstV-GXHZ01-2022株与经典GoAstV代表株的ORF1a、ORF1b及ORF2基因序列的相似性分别为53.0%~53.4%、63.2%~63.5%及48.2%~48.4%,与新型GoAstV参考株相应基因序列的相似性分别为97.0%~99.6%、98.1%~99.8%及97.5%~99.8%;Cap蛋白抗原表位预测结果为aa6~aa16、aa20~aa66及aa80~aa86等共29个区域存在抗原表位,N-糖基化位点预测结果为^(81)NSTD^(84)、^(401)NTTG^(404)、^(464)NITF^(467)及^(531)NTST^(534);功能基因的进化树结果显示,GoAstV-GXHZ01-2022株与新型GoAstV参考株均处于同一进化分支,与禽星状病毒3型(AAstV-3)流行株遗传距离较近,与AAstV-1次之,与AAstV-2最远;基因重组分析结果显示,GoAstV-GXHZ01-2022株的ORF1a和ORF2检测到重组信号,主要亲本株为新型GoAstV安徽株AstV/AH01/Goose/0512/18,二者相似性为98.6%,次要亲本株为新型GoAstV河南株AstV/HB02/Goose/0310/19,二者相似性为99.1%。表明GoAstV-GXHZ01-2022株与新型GoAstV参考株相似性最高,进化趋势也一致,并检测到重组现象。本研究为丰富GoAstV基因库中广西流行株全基因组序列信息提供基础数据。

关键词：鹅星状病毒基因组分子特征

Engineering property test of kaolin clay contaminated by diesel oil

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Journal of Central South University 2015年第12期22卷 4837-4843页

作者：刘志彬刘松玉蔡奕 Institute of Geotechnical Engineering School of Transportation Southeast University Jiangsu Key Laboratory of Urban Underground Engineering & Environmental Safety Department of Hydraulic Engineering Tongji University

Engineering property of kaolin clay contaminated by diesel oil was studied through a series of laboratory *** contents(mass fraction) of 4%,8%,12%,16% and 20% were selected to represent different contamination degrees,and the soil specimens were manually prepared through mixing and static compaction *** water content and dry density of the test kaolin clay were controlled at 10% and 1.58 g/cm^3,*** results indicate that since part of the diesel oil will be released from soil by evaporation,the real water content should be derived through calibration of the quasi water content obtained by traditional test *** contamination degree of the kaolin clay increases,both liquid limit and plastic limit decrease,but there's only a slight increase for plasticity *** pressure of contaminated kaolin clay under confined condition will be lowered when oil-content gets *** compressive strength(UCS) of the oil-contaminated kaolin clay is influenced by not only oil content but also curing *** of contamination degree will continually lower UCS of the kaolin clay *** addition,electrical resistivity of the contaminated kaolin clay with given water content decreases with the increase of oil ***,soil resistivity is in good relationship with oil content and ***,oil content of 8% is found to be a critical value for engineering property of kaolin clay to transit from water-dominated towards oil-dominated characteristics.

关键词： engineering property kaolin clay diesel oil contaminated soil electrical resistivity

Digenic heterozygous mutations in EYS/LRP5 in a Chinese family with retinitis pigmentosa

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 325-328页

作者： Feng-Juan Gao Sheng-Hai Zhang Jun-yi Chen Ge-zhi Xu Ji-Hong Wu Eye&ENT Hospital State Key Laboratory of Medical NeurobiologyInstitutes of Brain Science and Collaborative Innovation Center for Brain ScienceShanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Key Laboratory of Visual Impairment and Restoration Shanghai 200032China Key Laboratory of Myopia Ministry of HealthFudan UniversityShanghai 200032China

Dear Editor,I am ***-Hong Wu,from the Department of Ophthalmology,Eye＆ENT Hospital of Fudan University,China.I write to present a case report of retinitis pigmentosa（RP）caused by novel digenic heterozygous mutation... 详细信息

关键词： LRP gene Digenic heterozygous mutations in EYS/LRP5 in a Chinese family with retinitis pigmentosa

Resource allocation based on genetic algorithm for multi-hop OFDM system with non-regenerative relaying

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The Journal of China Universities of Posts and Telecommunications 2009年第5期16卷 25-32页

作者： SHI Jie , XU Wen-jun, HE zhi-qiang, NIU Kai, WU Wei-ling School of Information and Telecommunication Engineering, Beijing University of Posts and Telecommunications, Beijing 100876, China [a]School of Information and Telecommunication Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

This article investigates resource allocation in multi-hop orthogonal frequency division multiplexing （OFDM） system with amplifying-and-forwarding relaying to maximize the end-to-end capacity, Most existing methods for multi-hop system focus on power allocation or subcarrier selection separately, but joint resource allocation is rarely considered due to the absence of effective interaction schemes. In this work, a novel joint resource allocation methodology is proposed based on Partheno genetic algorithm （PGA）, which produces excellent subcarrier allocation set （referred to as individual in PGA） with higher capacity by evolution operator generation by generation. In addition, an adaptive power allocation is also designed to evaluate the fitness of PGA and further enhance the system capacity. Both theoretical analysis and simulated results show the effectiveness of the proposed joint strategy. It outperforms the traditional method by as much as 40% capacity improvement for 3-hop relaying system when system power is high, and obtains much more capacity enhancement percent under conditions of low system power.

关键词： multi-hop OFDM system non-regenerative relaying genetic algorithm power allocation subcarrier selection resource allocation

不仕后梁——从王审知墓志看韩偓的隐居地选择与其晚年作品心态

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福建教育学院学报 2024年第1期25卷 115-118页

作者：王云一陕西师范大学文学院陕西西安710119

韩偓是晚唐五代名臣、诗人,“南安四贤”之一,其于天复三年(903)被贬出朝廷,仕宦几于唐末历史相始终,唐亡后不仕后梁朝廷而甘于隐居。韩偓晚年“挈其族南依王审知而卒”,故王审知在其晚年为一重要人物。通过考察王审知生平可以更清晰地... 详细信息

韩偓是晚唐五代名臣、诗人,“南安四贤”之一,其于天复三年(903)被贬出朝廷,仕宦几于唐末历史相始终,唐亡后不仕后梁朝廷而甘于隐居。韩偓晚年“挈其族南依王审知而卒”,故王审知在其晚年为一重要人物。通过考察王审知生平可以更清晰地了解韩偓的晚年经历。文章通过考证王审知墓志进一步了解韩偓晚年的隐居地选择,同时分析韩偓隐居之后的行迹与晚年诗作心态,明晰其诗作发展变化,进而了解在晚唐五代背景下大部分诗人作品的创作心态。

关键词：晚唐王审知墓志韩偓行迹创作心态

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基于代谢组学的六神曲降血脂作用机制研究

中国中药杂志 2024年第3期49卷 770-778页

作者：刘金辉田颖颖赵新月李依林吕英楠刘闯林兆洲王子健左泽平王志斌北京中医药大学中药学院北京100029 北京同仁堂股份有限公司科学研究所北京100079

研究六神曲对高脂血症模型大鼠的治疗作用,并借助非靶向代谢组学探究六神曲降血脂的作用机制。通过给予高脂饲料构建混合型高脂血症模型大鼠,造模成功后分为模型组、普伐他汀钠组(4.4 mg·kg^(-1))、血脂康组(0.1 g·kg^(-1))、六神曲... 详细信息

研究六神曲对高脂血症模型大鼠的治疗作用,并借助非靶向代谢组学探究六神曲降血脂的作用机制。通过给予高脂饲料构建混合型高脂血症模型大鼠,造模成功后分为模型组、普伐他汀钠组(4.4 mg·kg^(-1))、血脂康组(0.1 g·kg^(-1))、六神曲高剂量组(2.4 g·kg^(-1))、六神曲中剂量组(1.2 g·kg^(-1))、六神曲低剂量组(0.6 g·kg^(-1)),给药周期4周,每日1次,空白组和模型组给予等体积超纯水。以血清脂质水平、肝脏苏木精-伊红(hematoxylin-eosin,HE)染色作为考察指标,研究六神曲对混合型高脂血症的干预作用,并通过非靶向代谢组学技术分析六神曲对混合型高脂血症模型大鼠血浆内代谢物变化的影响,而后通过代谢物通路富集,分析六神曲发挥降血脂作用的机制。结果显示,与模型组相比,六神曲尤其是高剂量可显著降低总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-c)含量(P<0.05或P<0.01);肝脏HE染色发现高剂量组脂肪细胞数量有一定程度的减少。通过非靶向代谢组学技术筛选得到的潜在生物标志物有3-磷酸甘油、鞘氨醇、1-磷酸鞘氨醇、脱氧尿苷等,主要涉及鞘脂代谢过程、甘油磷脂代谢过程、甘油酯代谢途径、嘧啶代谢途径共4条可能与脂质代谢相关的代谢通路。该研究为深入探究六神曲降血脂机制提供借鉴,对进一步推广六神曲的临床应用及增加适应症具有重要意义。

关键词：代谢组学高脂血症六神曲脂质代谢 1-磷酸鞘氨醇

四川省16家大型禽类养殖场抗生素残留调查和细菌耐药性分析

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四川动物 2024年第1期43卷 1-9页

作者：吕华刘玲宋涛林家富褚以文刘蒙沙菁洲周雅靓程涛吴怡张力杨嵩马兴换成都大学抗生素研究与再评价四川省重点实验室成都610106 四川省固体废物与化学品管理中心成都610032 四川大学华西医院成都610041 四川省生态环境科学研究院成都610041 四川省农业生态资源保护中心成都610041 微山县第三人民医院山东微山277600

为评估禽类养殖场粪便中抗生素的残留及细菌耐药性情况,本研究以四川省16家大型规模化禽类养殖场为监测点,重点分析粪便中抗生素残留特征和肠杆菌耐药特征,并对粪便中抗生素的选择性耐药风险熵进行评估。16份粪便样品中共检出18种抗生素... 详细信息

为评估禽类养殖场粪便中抗生素的残留及细菌耐药性情况,本研究以四川省16家大型规模化禽类养殖场为监测点,重点分析粪便中抗生素残留特征和肠杆菌耐药特征,并对粪便中抗生素的选择性耐药风险熵进行评估。16份粪便样品中共检出18种抗生素,抗生素检出浓度0.54~2780.00μg·kg^(−1),其中,ZJZX中多西环素检出浓度最高,达到2780.00μg·kg^(−1);抗生素的选择性耐药风险熵为0.0040~10561.13,呈现出高选择性耐药风险;其次,从粪便中共筛选鉴定出14株肠杆菌科Enterobacteriaceae细菌,均表现出多重耐药性,且有33种耐药基因被不同程度检出。畜禽粪便中磺胺类、四环素类、氯霉素类和喹诺酮类抗生素残留较为严重,且养殖环境中肠杆菌科细菌表现出多重耐药性,建议有关部门加强畜禽养殖中多西环素、氟苯尼考和恩诺沙星等抗生素的管控,同时应加强对畜禽养殖企业中肠杆菌耐药性的监控。

关键词：禽类养殖场抗生素残留风险评估肠杆菌科

Salvianolic acid B protects hepatocytes from H2O2 injury by stabilizing the lysosomal membrane

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World Journal of Gastroenterology 2017年第29期23卷 5333-5344页

作者： Xiao-Feng Yan Pei Zhao Dong-Yan Ma yi-Lu Jiang Jiao-Jiao Luo Liu Liu Xiao-ling Wang Department of Biology School of Basic Medical Science Shanghai University of Traditional Chinese Medicine Women and Infant Hospital of Zhengzhou Shanghai University of Traditional Chinese Medicine

AIM To investigate the capability of salvianolic acid B(Sal B) to protect hepatocytes from hydrogen peroxide(H_2O_2)/carbon tetrachloride(CCl_4)-induced lysosomal membrane permeabilization. METHODS Cell Counting Kit-8 assay was used to measure cell viability. Apoptosis and death were assayed through flow cytometry. Brd U incorporation was used to detect cell proliferation. Serum alanine aminotransferase activity and liver malondialdehyde(MDA) content were measured. Liver histopathological changes were evaluated using hematoxylin-eosin staining. Lysosomal membrane permeability was detected with Lyso Tracker Green-labeled probes and acridine orange staining. The levels of protein carbonyl content(PCC), cathepsins(Cat)B/D, and lysosome-associated membrane protein 1(LAMP1) were evaluated through western blotting. Cytosol Cat B activity analysis was performed with chemiluminescence detection. The m RNA level ofLAMP1 was evaluated through quantitative real-time polymerase chain reaction. RESULTS Results indicated that H_2O_2 induced cell injury/death. Sal B attenuated H_2O_2-induced cell apoptosis and death, restored the inhibition of proliferation, decreased the amount of PCC, and stabilized the lysosome membrane by increasing the LAMP1 protein level and antagonizing Cat B/D leakage into the cytosol. CCl_4 also triggered hepatocyte death. Furthermore, Sal B effectively rescued hepatocytes by increasing LAMP1 expression and by reducing lysosomal enzyme translocation to the *** Sal B protected mouse embryonic hepatocytes from H_2O_2/CCl_4-induced injury/death by stabilizing the lysosomal membrane.

关键词： Lysosomal membrane permeabilization Injury Salvianolic acid B Hepatocyte

一种DeepLabv3+结构改进的高分遥感影像红树林边界识别方法

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广州大学学报（自然科学版） 2024年第3期23卷 93-104页

作者：吴耀炜龚建周陈智勇袁海威林颖怡广州大学地理科学与遥感学院广东广州510006

针对红树林自动监测与保护的迫切需求,文章提出一种DeepLabv3+改进模型的高分辨率遥感影像红树林的识别方案。改进方案主要包括在DeepLabv3+的ASPP(Atrous Spatial Pyramid Pooling)结构中,引入深度可分离卷积和SE(Squeeze and Excitati... 详细信息

针对红树林自动监测与保护的迫切需求,文章提出一种DeepLabv3+改进模型的高分辨率遥感影像红树林的识别方案。改进方案主要包括在DeepLabv3+的ASPP(Atrous Spatial Pyramid Pooling)结构中,引入深度可分离卷积和SE(Squeeze and Excitation)注意力机制,以及在解码端加入CBAM(Convolutional Block Attention Module)注意力机制和多尺度融合技术,以提高模型对红树林关键特征的捕捉和表征能力,从而减少漏检和误检现象。经过严格的精度评价,改进后的DeepLabv3+模型在总体精度上达到了99.60%,在召回率、红树林类交并比(Mangrove-IoU)和类F1-score上也分别达96.05%、95.31%和97.60%。与原始DeepLabv3+、HRNet和PSPNet模型相比,改进模型在所有主要评价指标上表现更优,红树林的识别准确性和边界提取能力明显提升。应用分析也进一步验证了模型的泛化能力和应用潜力。研究成果可优化红树林的实时监测技术。

关键词：红树林边界识别 DeepLabv3+ 注意力机制多尺度特征融合语义分割高分遥感影像