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江西建材 2024年第6期 87-89页

作者：顾晓卫徐象林易子浩杭州杭港地铁有限公司杭州新蕴实业发展有限公司浙江工业大学岩土工程研究所

为研究深基坑开挖对周围环境的影响，文中以杭州某软土地区某深基坑工程为例，结合施工现场的监测数据，对基坑开挖全过程中周围环境的变形特性、支护结构变形及支撑轴力变化情况进行分析，以期为同类型基坑的设计和施工提供参考。

关键词：深基坑软土监测分析

Decrement of Sugar Consumption in Rice Young Panicle Under High Temperature Aggravates Spikelet Number Reduction

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Rice science 2020年第1期27卷 44-55页

作者： WANG Yaliang ZHANG yikai SHI Qinghua CHEN Huizhe XIANG Jing HU Guohui CHEN Yanhua WANG Xiaodan WANG Junke yi zihao ZHU Defeng ZHANG Yuping China National Rice Research Institute/State Key Laboratory of Rice Biology Hangzhou 310006China College of Agronomy Jiangxi Agricultural University/Key Laboratory of Crop PhysiologyEcology and Genetics BreedingMinistry of EducationNanchang 330045China

Two rice genotypes Huanghuazhan(HHZ, heat-resistant) and IR36(heat-susceptible) were subjected to high-temperature(HT, 40℃) and normal-temperature(NT, 32℃) treatments at the spikelet differentiation stage. HT treatment inhibited spikelet differentiation, aggravated spikelet degeneration, reduced spikelet size, and disordered carbohydrate allocation. Meanwhile, HT treatment increased nonstructural carbohydrate content in leaves, but decreased that in stems and young panicles, and the same tendencies of sucrose and starch contents were observed in leaves and stem. However, HT treatment significantly increased the sucrose content and sharply decreased the glucose and fructose contents in young panicles. Lower activity levels of soluble acid invertase(EC3.***.1.26) and sucrose synthase(EC2.***.1.13) were observed under HT treatment. Moreover, HT treatment reduced the activities of key enzymes associated with glycolysis and the tricarboxylic acid cycle, which indicated sucrose consumption was inhibited in young panicles under HT treatment. Exogenous glucose and fructose applied under HT treatment increased the spikelet number more than exogenous sucrose. In conclusion, the results demonstrated that the reduction of spikelet number under high temperature was more affected by the decrease in sugar consumption than the blocking of sucrose transport. The impairment of sucrose hydrolysis was the main reason for the inhibition of sugar utilization.

关键词： rice high temperature panicle development spikelet number carbohydrate allocation sugar consumption

Nanocomposite: Keggin-type Co_(4)-polyoxometalate@cobaltporphyrin linked graphdiyne for hydrogen evolution in seawater

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Nano Research 2024年第3期17卷 1281-1287页

作者： Jiejie Ping Danyang He Fei Wang Nan Wang yi-cheng Fu zihao Xing Zhiyu Jia Guo-Yu Yang Key Laboratory of Cluster Science Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Facluty of Chmeistry Northeast Normal UniversityChangchun 130024China Peking University Third Hospital Beijing 100190China

Polyoxometalate-based nanocomposites with electrocatalytic activity have been applied in hydrogen evolution reactions(HER).Seawater as the main water resource on the earth should be developed as the water electrolysis to prepare high-purity *** this paper,we used two synthesis strategies to prepare the nanocomposite Co_(4)-POM@Co-PGDY(Co_(4)-POM:the Kegging-type microcrystals of K_(10)[Co_(4)(PW_(9)O_(3)4)2]and Co-PGDY:cobalt-porphyrin linked graphdiyne)with excellent activity for ***-PGDY as the porous material is applied not only as the protection of microcrystals towards the metal ion in seawater but also as the co-electrocatalyst of Co_(4)-***_(4)-POM@Co-PGDY exhibits excellent HER performance in seawater electrolytes with low overpotential and high stability at high ***,we have observed a key H_(3)O+intermediate emergence on the surface of nanocomposite during hydrogen evolution process in seawater by Raman synchrotron radiation-based Fourier transform infrared(SR-FTIR).The results in this paper provide an effective strategy for preparing polyoxometalate-based electrocatalysts with high-performance toward hydrogen evolution reaction.

关键词： polyoxometalate graphdiyne seawater hydrogen evolution reaction

The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis

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Acta Pharmaceutica Sinica B 2024年第2期14卷 712-728页

作者： Xiaoxuan Zhong Xiang Wei Yan Xu Xuehai Zhu Bo Huo Xian Guo Gaoke Feng zihao Zhang Xin Feng Zemin Fang Yuxuan Luo Xin yi Ding-Sheng Jiang Division of Cardiovascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Key Laboratory of Organ Transplantation Ministry of EducationNHC Key Laboratory of Organ TransplantationChinese Academy of Medical SciencesWuhan 430030China School of Life Science and Technology Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China

Coronary restenosis is an important cause of poor long-term prognosis in patients with coronary heart ***,we show that lysine methyltransferase SMYD2 expression in the nucleus is significantly elevated in serum-and PDGF-BB-induced vascular smooth muscle cells(VSMCs),and in tissues of carotid artery injury-induced neointimal ***2 overexpression in VSMCs(Smyd2-vTg)facilitates,but treatment with its specific inhibitor LLY-507 or SMYD2 knockdown significantly inhibits VSMC phenotypic switching and carotid artery injury-induced neointima formation in *** sequencing revealed that SMYD2 knockdown represses the expression of serum response factor(SRF)target genes and that SRF overexpression largely reverses the inhibitory effect of SMYD2 knockdown on VSMC ***3 directly interacts with and deacetylates SRF,which enhances SRF transcriptional activity in ***,SMYD2 promotes HDAC3 expression via tri-methylation of H3K36 at its ***966,a specific inhibitor of HDAC3,not only counteracts the pro-proliferation effect of SMYD2 overexpression on VSMCs,but also inhibits carotid artery injury-induced neointima formation in ***3 partially abolishes the inhibitory effect of SMYD2 knockdown on VSMC proliferation in a deacetylase activity-dependent *** results reveal that the SMYD2-HDAC3-SRF axis constitutes a novel and critical epigenetic mechanism that regulates VSMC phenotypic switching and neointimal hyperplasia.

关键词： Neointimaformation Histonemethylation Histoneacetylation SRFacetylation SMYD2 HDAC3 LLY-507 RGFP966

深基坑开挖对邻近双线地铁隧道变形影响实测分析

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岩土工程学报 2023年第S2期45卷 214-219页

作者：顾晓卫易子浩王哲苌宽杭州杭港地铁有限公司浙江杭州310017 浙江工业大学岩土工程研究所浙江杭州310023

基坑开挖卸载会导致周围土体以及邻近地铁隧道产生变形,过大的变形会严重危害地铁隧道的安全运营。为研究深基坑开挖对邻近双线地铁隧道变形的影响,以杭州某邻近已运营隧道的基坑工程为依托,结合施工现场的监测数据,对基坑开挖全过程中... 详细信息

基坑开挖卸载会导致周围土体以及邻近地铁隧道产生变形,过大的变形会严重危害地铁隧道的安全运营。为研究深基坑开挖对邻近双线地铁隧道变形的影响,以杭州某邻近已运营隧道的基坑工程为依托,结合施工现场的监测数据,对基坑开挖全过程中的基坑变形及隧道变形进行实测分析,探究基坑变形与旁侧地铁隧道变形数据的联系。

关键词：基坑运营隧道实测分析开挖变形

A pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2679-2693页

作者： Junzhi yi Hui Zhang Fangyuan Bao Zhichu Chen Yuliang Zhong Tianning Ye Xuri Chen Jingyi Qian Mengya Tian Min Zhu Zhi Peng Zongyou Pan Jianyou Li zihao Hu Weiliang Shen Jiaqi Xu Xianzhu Zhang Youzhi Cai Mengjie Wu Hua Liu Jing Zhou Hongwei Ouyang Department of Sports Medicine of the Second Affiliated Hospital and Liangzhu LaboratoryZhejiang University School of MedicineHangzhouChina Dr.Li Dak Sum&yip yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of MedicineHangzhouChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesHangzhouChina The MOE Key Laboratory of Biosystems Homeostasis&Protection The Key Laboratory of Cancer Molecular Cell Biology of Zhejiang ProvinceLife Sciences InstituteZhejiang UniversityHangzhouChina Department of Orthopedics Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhouChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

The knee joint has long been considered a closed *** pathological effects of joint diseases on distant organs have not been ***,our clinical data showed that post-traumatic joint damage,combined with joint bleeding(hemarthrosis),exhibits a worse liver function compared with healthy *** mouse model,hemarthrosis induces both cartilage degeneration and remote liver ***,we found that hemarthrosis induces the upregulation in ratio and differentiation towards Th17 cells of CD4^(+)T cells in peripheral blood and *** of CD4^(+)T cells reverses hemarthrosis-induced liver *** of cartilage matrix induced by hemarthrosis upregulates serological type Ⅱ collagen(COL Ⅱ),which activates CD4^(+)T *** application of a COL Ⅱ antibody blocks the ***,bulk RNAseq and single-cell qPCR analysis revealed that the cartilage Akt pathway is inhibited by blood ***-articular application of Akt activator blocks the cartilage degeneration and thus protects against the liver impairment in mouse and pig *** together,our study revealed a pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells,which refreshes the organ-crosstalk axis and provides a new treatment target for hemarthrosis-related disease.

关键词： degeneration damage inhibited

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一种高侧功率开关的输出短路保护电路

微电子学 2021年第1期51卷 10-15,21页

作者：梁怀天方舟罗攀易子皓甄少伟乔明张波电子科技大学电子薄膜与集成器件国家重点实验室成都610054

提出了一种智能高侧功率开关的短路保护电路,包括输出短路检测电路、延时信号产生电路和栅源电压限制电路。采用NMOS管用作功率管,使电路短路时仍处于安全工作区内,提升了高侧功率开关的可靠性。采用0.6μm HV SOI工艺对该短路保护电路... 详细信息

提出了一种智能高侧功率开关的短路保护电路,包括输出短路检测电路、延时信号产生电路和栅源电压限制电路。采用NMOS管用作功率管,使电路短路时仍处于安全工作区内,提升了高侧功率开关的可靠性。采用0.6μm HV SOI工艺对该短路保护电路进行了仿真验证。仿真结果表明,在硬开关故障和负载短路两种情况下,功率管保持处于安全工作区内。

关键词：智能高侧功率开关短路保护安全工作区

带自适应斜坡补偿的COT控制Buck变换器

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微电子学 2021年第6期51卷 866-871页

作者：罗攀甄少伟易子皓方舟杨明宇罗萍张波电子科技大学电子薄膜与集成器件国家重点实验室成都610054

提出了一种采用自适应斜坡补偿(ARC)的恒定导通时间控制Buck变换器。引入了两个斜坡电压,实现对电感电流下降斜率的检测;通过负反馈环路调节斜坡斜率,使斜坡斜率跟随电感电流下降斜率的变化。最终斜坡补偿带来的额外极点被固定下来,以... 详细信息

提出了一种采用自适应斜坡补偿(ARC)的恒定导通时间控制Buck变换器。引入了两个斜坡电压,实现对电感电流下降斜率的检测;通过负反馈环路调节斜坡斜率,使斜坡斜率跟随电感电流下降斜率的变化。最终斜坡补偿带来的额外极点被固定下来,以便于补偿设计。在此基础上,引入瞬态增强电路,提高了负载阶跃响应速度。在5 V输出电压下,负载从3 A到100 mA阶跃时,输出上冲电压减小了150 mV,恢复时间缩短了10μs。负载从100 mA到3 A阶跃时,输出下冲电压减小了130 mV,恢复时间缩短了12μs。

关键词：自适应斜坡补偿电流模恒定导通时间 Buck变换器

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用于Buck变换器的开关电流型误差放大器

微电子学 2021年第6期51卷 849-853页

作者：易子皓甄少伟罗攀方舟程雨凡罗萍张波电子科技大学电子薄膜与集成器件国家重点实验室成都610054

提出了一种用于Buck变换器的开关电流型误差放大器(SC-EA)。在Buck结构中,无需片外补偿即可使系统保持稳定,节省了芯片面积,功率密度更高。误差放大器的带宽随开关频率改变而自适应变化,在高频时仍具有较好稳定性和瞬态响应速度。使用... 详细信息

提出了一种用于Buck变换器的开关电流型误差放大器(SC-EA)。在Buck结构中,无需片外补偿即可使系统保持稳定,节省了芯片面积,功率密度更高。误差放大器的带宽随开关频率改变而自适应变化,在高频时仍具有较好稳定性和瞬态响应速度。使用开关电流型误差放大器的谷值电流模COT结构实现了片上频率补偿,省掉了片外元件,可实现多路并联均流,具有较快的瞬态响应速度。采用0.18μm BCD工艺进行了电路设计。仿真结果表明,在6 MHz、1 MHz开关频率下,选用10μF、70μF输出电容即可达到环路稳定,实现自适应带宽。在6 MHz开关频率下,上、下阶跃瞬态响应时间分别为6.3μs、5.5μs;在1 MHz开关频率下,上、下阶跃瞬态响应时间分别为27.7μs、28.4μs。

关键词：谷值电流模COT控制 Buck变换器开关电流型误差放大器

Optical design of a novel near-infrared phase contrast imaging(NI-PCI)diagnostic on the HL-2A tokamak

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Plasma Science and Technology 2024年第3期26卷 31-37页

作者：徐皓龚少博余羿许敏兰涛王志斌石中兵聂林赵光义刘灏周艺轩袁子豪肖晨雨陈坚 Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082People's Republic of China Southwestern Institute of Physics Chengdu 610041People's Republic of China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026People's Republic of China

The optical design of near-infrared phase contrast imaging(NI-PCI)diagnosis on HL-2A is introduced in this *** scheme benefits from the great progress of near-infrared laser technology and is a broadening of traditional phase contrast *** diagnostic can work as a keen tool to measure plasma wavenumber spectra by inferring string-integrated plasma density *** of both the front optical path which is the path before the laser transmitting into the tokamak plasma and the rear optics which is the path after the laser passing through the plasma is *** 1550 nm laser is chosen as the probe beam and highprecision optical components are designed to fit the laser beam,in which a phase plate with a 194-nm-deep silver groove is the *** with the conventional 10.6μm laser-based PCI system on HL-2A,NI-PCI significantly overcomes the unwanted phase scintillation effect and promotes the measurement capability of high-wavenumber turbulence with an increased maximal measurable wavenumber from 15 cm^(-1)to 32.6 cm^(-1).

关键词： phase contrast imaging near infrared laser plasma laser diagnostic