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Pleomorphic rhabdomyosarcoma of the vagina: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2396-2403页

作者： Pan Xu Shan-Shan Ling E Hu Bi-xia yi Department of Gynecology The Affiliated Jinhua Hospital of Wenzhou Medical UniversityJinhua 321000Zhejiang ProvinceChina Zhejiang University School of Medicine Hangzhou 310006Zhejiang ProvinceChina

BACKGROUND Rhabdomyosarcoma(RMS)of the vagina in postmenopausal women is an extre-mely rare malignant tumor that was originally described as a unique group of soft tissue sarcomas originating from primitive mesenchymal *** was first re-ported in postmenopausal women in 1970,and fewer than 50 postmenopausal patients have been reported to *** SUMMARY A 68-year-old multiparous female was admitted to the hospital on October 11,2023,with the chief complaint of a mass causing vaginal prolapse with incomplete urination that had persisted for 4 *** vaginal mass was approximately the size of a pigeon egg;after lying down,the vaginal mass *** resection was performed,and vaginal pleomorphic RMS was diagnosed based on pathology and immunohistochemical staining *** patient is currently undergoing *** present study also reviewed the clinical,histolo-gical,and immunohistochemical features and latest treatment recommendations for vaginal *** abnormal vaginal mass should be promptly investigated through pelvic examination and appropriate *** current initial treat-ment for vaginal RMS is biopsy and primary *** When surgery is planned for vaginal RMS,an organ-preserving approach should be considered.

关键词： Rhabdomyosarcoma Vagina Postmenopausal woman Pleomorphic Case report

Bortezomib depended on PRDM1 and TP53 to exert therapeutic effect in activated B-cell-like diffuse large B-cell lymphoma

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Genes & Diseases 2024年第2期11卷 550-553页

作者： Jing Tang Yue Li Jiazhu Wu Haorui Shen Hua yin Jinhua Liang Li Wang Jianyong Li yi xia Wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China

PR/SET domain 1(PRDM1)gene is located on chromosome 6q21,encoding the B lymphocyte-induced maturation protein 1(BLIMP1).1 It is reported that loss of PRDM1 function is exacerbated in activated B-cell-like(ABC)-diffuse large B cell lymphoma(DLBCL)and associated with inferior ***,it remains unclear what leads to PRDM1 inactivation and the drug resistance mechanism caused by abnormal inactivation of *** investigated the contribution of PRDM1 gene as a prognosis and potential therapeutic target for ABC-DLBCL patients and further clarified the possible mechanism of PRDM1 abnormal *** first proposed that TP53 could regulate PRDM1 by histone ubiquitination modification at the post-transcriptional level.

关键词： PRDM1 TP53 therapeutic

Genotyping on circulating tumor DNA improves mutation detection rate in high-risk diffuse large B-cell lymphoma

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Genes & Diseases 2024年第4期11卷 116-119页

作者： yi xia Li Wang Jinhua Liang Haorui Shen Jiazhu Wu Hua yin Yue Li Huayuan Zhu Jianyong Li Wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China

Diffuse large B-cell lymphoma(DLBCL)is the most common lymphoma with heterogeneous clinical *** who are primarily refractory to the frontline therapy or relapse less than 12 months after diagnosis have an extremely di... 详细信息

关键词： lymphoma diagnosis clinical

Percutaneous transhepatic cholangioscopy-assisted biliary polypectomy for local palliative treatment of intraductal papillary neoplasm of the bile duct

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1821-1832页

作者： Xu Ren Yong-Ping Qu Chun-Lan Zhu xiao-Hong Xu Hong Jiang yi-xia Lu Hong-Peng Xue Digestive Disease Hospital of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Digestive Endoscopy Center of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Second Department of Gastroenterology Digestive Disease Hospital of Heilongjiang Provincial Hospitaland Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Department of Pathology Heilongjiang Provincial HospitalHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a premalignant biliarytype epithelial neoplasm with intraductal papillary or villous *** reported local palliative therapeutic modalities,including endoscopic nasobiliary drainage,stenting and biliary curettage,endoscopic biliary polypectomy,percutaneous biliary drainage,laser ablation,argon plasma coagulation,photodynamic therapy,and radiofrequency ablation to relieve mechanical obstruction are limited with weaknesses and *** have applied percutaneous transhepatic cholangioscopy(PTCS)-assisted biliary polypectomy(PTCS-BP)technique for the management of IPNB including mucin-hypersecreting cast-like and polypoid type tumors since *** To assess the technical feasibility,efficacy,and safety of PTCS-BP for local palliative treatment of *** Patients with mucin-hypersecreting cast-like or polypoid type IPNB and receiving PTCS-BP between September 2010 and December 2019 were ***-BP was performed by using a half-moon type snare with a soft stainless-steel wire,and the tumor was snared and resected with *** primary outcome was its feasibility,indicated by technical *** secondary outcomes were efficacy,including therapeutic success,curative resection,and clinical success,and *** Five patients(four with mucin-hypersecreting cast-like type and one with polypoid type IPNB)were ***-and high-grade intraepithelial neoplasia(HGIN)and recurrent IPNB with invasive carcinoma were observed in one,two,and two patients,*** cholangitis and/or obstructive jaundice were presented in all four patients with mucin-hypersecreting cast-like type *** five patients achieved technical success of *** patients(three with mucin-hypersecreting cast-like type and one with polypoid type IPNB)obtained therapeutic success;one with mucin-hypersecreting cast-like type tumors in the intrahepatic small bile duct and HGIN h

关键词： Intraductal papillary neoplasm of the bile duct Percutaneous transhepatic cholangioscopy Biliary polypectomy Feasibility Efficacy

Feasibility of compacted attapulgite/diatomite amended clayey soils as gas barrier materials

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3707-3717页

作者： Heng Zhuang Wei-yi xia Jia-Ming Wen Min Wang ying-Zhen Li Ning-Jun Jiang Konstantin S.Rodygin Yan-Jun Du Jiangsu Key Laboratory of Low Carbon and Sustainable Geotechnical Engineering Institute of Geotechnical EngineeringSoutheast UniversityNanjing211189China Jiangsu Province Ecology and Environment Protection Engineering Research Center of Groundwater Pollution Prevention and Control Jiangsu Environmental Engineering Technology Co.Ltd.Nanjing210036China Zijin(Changsha)Engineering Technology Co. Ltd.Changsha410006China Institute of Chemistry Saint Petersburg State UniversityStary Petergof198504Russia

Compacted clay liners are extensively used as barriers to control the upward diffusion of vapors of volatile or semi-volatile organic contaminants released from unsaturated contaminated soils at industrycontaminated *** study aimed to investigate the gas diffusion barrier performance of compacted clayey soils amended with three agents including attapulgite and diatomite individually,and attapulgite/diatomite *** properties including water retention,volumetric shrinkage,gas diffusion,and unconfined compressive strength were evaluated through a series of laboratory tests of amended compacted clayey *** results demonstrate that the decrease in volume proportions of interaggregate pores leads to an increase in unconfined compressive strength(qu).Both hydrophilic groups and microstructures of attapulgite and diatomite result in an increase in water retention percent(Wt)of compacted clayey soil specimens after amendment regardless of the type of agent or initial water content(w0).Furthermore,the ratio of the gas diffusion coefficient(De)to the gas diffusion coefficient in the air(Da)was significantly reduced owing to a decrease in volume proportions of inter-aggregate pores,hydrophilic group,and microstructures of attapulgite and *** electron microscope analyses revealed that rod-shaped attapulgite filled the inter-aggregate pores formed by clay particles,whereas the disc-shaped diatomite particles,characterized by micropores,failed to obstruct the interaggregate pores due to their larger particle *** intrusion porosimetry(MIP)analyses showed a reduction in pore volume in the inter-aggregate pores,leading to a reduction in the total pore volume for both the attapulgite and attapulgite/diatomite mixture amended clays,which is in accordance with the scanning electron microscope(SEM)*** findings are pertinent to the practical application of compacted clay liners as gas barriers against the upward migration of volatile or s

关键词： Compacted clay liner Attapulgite/diatomite mixture Diffusion barrier Water retention

众包制造环境下协同产品族设计与延迟决策的主从关联优化

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计算机集成制造系统 2024年第2期30卷 695-707页

作者：吴军夏一浙江财经大学管理学院浙江杭州310018 天津大学管理与经济学部天津300072

针对众包制造环境下产品族设计与延迟决策之间的协同优化问题,建立了以产品族设计为主、延迟决策为从的混合整数非线性双层规划模型。模型上层由制造商设计产品族架构以最大化自身的期望利润,下层由多个分销商优化延迟产品模块的类型以... 详细信息

针对众包制造环境下产品族设计与延迟决策之间的协同优化问题,建立了以产品族设计为主、延迟决策为从的混合整数非线性双层规划模型。模型上层由制造商设计产品族架构以最大化自身的期望利润,下层由多个分销商优化延迟产品模块的类型以最大化各自的期望利润,且各分销商之间的决策具有相互独立性。考虑到延迟产品模块事先不确定,提出虚拟延迟结构将该优化问题具体化,并证明需要被延迟的产品模块。开发了一个双层嵌套遗传算法对模型进行求解。用智能冰箱产品族延迟案例验证了所提模型和算法的有效性,并对所提延迟偏好参数进行了灵敏度分析。

关键词：众包制造产品族设计延迟决策主从关联优化嵌套遗传算法

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双元驱动的中小企业数字化转型协同机制探析

软科学 2024年第3期38卷 99-106页

作者：夏轶群孟夏上海应用技术大学经济与管理学院上海201418

通过解析中小企业数字化转型三重困局,探究政府与数字化服务商双元驱动的系统协同原理,并构建中小企业、政府和数字化服务商三方主体协同参与的演化博弈模型,进而借助仿真和参数敏感性分析探讨系统演化策略稳定性以及关键变量对策略演... 详细信息

通过解析中小企业数字化转型三重困局,探究政府与数字化服务商双元驱动的系统协同原理,并构建中小企业、政府和数字化服务商三方主体协同参与的演化博弈模型,进而借助仿真和参数敏感性分析探讨系统演化策略稳定性以及关键变量对策略演化和稳定结果的影响,结果表明:政府补贴与服务商技术保证策略均能够有效驱动中小企业数字化转型,且主体策略互相呈正反馈关系;中小企业、服务商和政府的初始参与意愿提高有利于主体更快决策参与;政府制定适当小的补贴比例依然能够调动中小企业参与转型的积极性;相对来说,政府补贴前期涨幅对服务商技术保证策略的影响较大;仅补贴单方时政府对服务商的补贴效用更显著。

关键词：数字化转型中小企业数字化服务商协同机制

Successful rescue of disseminated Nocardia infection with multiple abscesses in a patient with membranous nephropathy after cardiopulmonary resuscitation:A three-year follow-up

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Journal of Biomedical Research 2024年第2期38卷 189-194,I0019,I0020页

作者： yili Xu Hanyang Qian Wen Qian Li Dong Weiying Liu Yan Zhu Yaning Mei yi Xu Ling Wang yi xia Xu Qi Huanping Mei Xueqiang Xu Huijuan Mao Changying Xing Ningning Wang Department of Nephrology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Nephrology Nanjing Tongren HospitalNanjingJiangsu 211102China Department of Image the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Infectious Disease the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Nephrology the Second Hospital of NanjingNanjingJiangsu 210029China Department of Microorganism the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Hematology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Rheumatology and Immunology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China

Nocardiosis manifests as an opportunistic infection,primarily affecting individuals who are immunocompromised and susceptible to the *** present a case study of one patient with nephrotic syndrome and membranous nephropathy,who underwent treatment with prednisone and cyclosporine in *** early 2017,the patient was diagnosed with a"fungal infection"and discontinued the use of *** one month of anti-infection therapy,a cranial magnetic resonance imaging scan showed multiple abscesses in the right temporal *** diagnosis of nocardiosis was confirmed based on the presence of metastatic abscess masses,multiple lung and brain lesions,and a positive culture of Nocardia in the *** changed the anti-infection therapy to a combination of trimethoprim-sulfamethoxazole(TMP-SMX),minocycline,and ***,the patient experienced a sudden cardiac arrest and subsequently recovered after cardiopulmonary *** the five-month follow-up period following the discharge,the patient displayed an enhanced nutritional status and stable renal *** focal infection ultimately resolved during the subsequent three ***-infection caused by Nocardia should be considered in immunocompromised patients,and TMP-SMX is the preferred initial therapy;however,because of the high mortality rate,a long-term combination therapy with imipenem,cefotaxime,amikacin,and TMP-SMX is suggested.

关键词： Nocardia infection glomerulonephritis membranous nephrology cardiopulmonary resuscitation

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高质量建设老年友好型社区的新路径

中南民族大学学报（人文社会科学版） 2024年第6期44卷 174-180,188页

作者：夏屹中南财经政法大学公共管理学院湖北武汉430074

近年来,我国迅速的人口老龄化,使养老问题成为了社会持续关注的焦点。高质量发展老年友好型社区建设,已然成为解决我国老年积极变老的有效途径。在我国老年友好型社区建设取得了巨大成就的基础上,政府出台政策制定了符合中国实际的老年... 详细信息

近年来,我国迅速的人口老龄化,使养老问题成为了社会持续关注的焦点。高质量发展老年友好型社区建设,已然成为解决我国老年积极变老的有效途径。在我国老年友好型社区建设取得了巨大成就的基础上,政府出台政策制定了符合中国实际的老年友好型社区建设的标准,建立了示范性城乡老年友好型社区来解决部分老年人社区养老问题,制定了科学的老年友好型社区评价机制并对已经建立的示范性友好社区进行了评价。其中,仍存在顶层设计不够到位、各地区之间发展不平衡、城乡差别巨大、对乡村老年友好型社区建设投入严重不足、老年服务队伍力量不强等问题。政府应建立健全规划机制、执行机制,完善优化人才机制和智慧机制,构建反馈机制来建立长效与可行的普惠性老年友好型社区,以服务于所有老龄人口而非少数老龄人口。

关键词：养老问题老年友好型社区高质量建设评价机制机制优化

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