检索结果-南通市图书馆

Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2020年第3期18卷 169-177页

作者： yi hong-wei ZHU Xiao-Xiao HUANG Xiao-Li LAI Yu-Zhu TANG Yue Department of Pharmacology School of MedicineSoutheast UniversityNanjing 210009China

The objective of this study was to verify the protective effect of Bifidobacterium longum(BL) and the synergistical effect of Selenium and BL on alcohol plus high fat diet(HFD) induced hepatic injury in mice. We also want to explore the mechanism of Selenium-enriched Bifidobacterium longum(Se BL). C57 BL/6 mice were treated with alcohol plus HFD with or without different dosage of BL or Se BL for 4 weeks. Serum levels of ALT, AST, TC, TG, LDL-C, HDL-C, FFAs, TNF-α, IL-6 and IL-1β, hepatic MDA level, SOD activity, the m RNA levels of AMPK, PPAR-α and SREBP1 were invested. Se BL inhibited lipid accumulation in hepatocytes;reduced serum AST and ALT levels;improved dyslipidemia;decreased serum FFAs, TC, TG and LDL-C levels. Se BL also inhibited alcohol plus HFD-induced hepatocyte oxidative stress through decrease in hepatic MDA levels and increase in SOD activity. Se BL also regulated lipid metabolism related genes such as AMPK, PPAR-α and SREBP1. Although BL had similar effect as Se BL, Se BL is more effective than BL. Se BL protected mice from alcohol plus HFD-induced hepatic injury in mice because of its inhibitory effect on hepatocellular oxidative stress, lipogenesis and inflammation. Selenium enhanced the protective effect of BL.

关键词： Selenium-enriched Bifidobacterium longum Alcoholic liver disease Non-alcoholic fatty liver disease Oxidative stress Inflammation

Cloning and analysis of a new 4CL-like gene in Populus tomentosa

在线全文

学校读者我要写书评

暂无评论

Forestry Studies in China 2013年第2期15卷 98-104页

作者： hong-yi wei Guo-Dong RAO Yu-Kun WANG Lei ZHANG Hai LU College of Life Sciences and Biotechnology Beijing Forestry University

The phenylpropanoid enzyme 4-coumarate： coenzyme A ligase （4CL）, plays a key role in general phenylpropanoid metabolism. Our investigation involves a new 4CL-like gene cloned from Populus tomentosa. This new 4CL- like gene is 1,692 bp and encodes a protein of 552 aa. After analysis of its domain, we found a highly conserved region of a 4CL gene family in this 4CL-like gene. Based on our results, we believe that this gene belongs to the family of 4CL. A recombinant vector, referred to as pET30a-4CL-like, was constructed by connecting this 4CL-like gene fragment to pET30a. After inducing it with IPTG for 3 h, the 4CL-like protein was purified by a Ni-NTA method. This 4CL-like protein has a calculated molecular weight of 60 kDa by SDS-PAGE.

关键词： 4-coumarate coenzyme A tigase (4CL), Populus tomentosa, recombinant vector, purification

Legal Narration in a Global Era： A Survey of the 7^th East Asian Conference on Philosophy of Law

在线全文

学校读者我要写书评

暂无评论

Fudan Journal of the Humanities and Social Sciences 2009年第1期2卷 169-174页

作者： Huang Wen-yi wei hong-fa

The 7^th East Asian Conference on Philosophy of Law was held in Changchun, Jilin from Sept. 21 to 22,2008, devoted to the theme of ＂Law and Social Harmony in East Asia in Globalization. ＂ It was sponsored by the Jurisprudence Division of China Law Society（CLS） and the Center for Jurisprudence Research（JRC）, Jilin University. More than 260 scholars attended. Most attendees came from China's Mainland in addition to those from Japan, South Korea, Mongolia, America, Austria, Italy, Taiwan, hong Kong, and Macao.

关键词：第七届东亚法哲学大会区域主义法律全球化

Ethanol promotes saturated fatty acid-induced hepatoxicity through endoplasmic reticulum(ER) stress response

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2015年第4期13卷 250-256页

作者： yi hong-wei MA Yu-Xiang WANG Xiao-Ning WANG Cui-Fen LU Jian CAO wei WU Xu-Dong Department of Pharmacology Medical School Southeast University State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Center for Diagnostic Nanosystems Marshall University

Serum palmitic acid(PA), a type of saturated fatty acid, causes lipid accumulation and induces toxicity in ***(Et OH) is metabolized by the liver and induces hepatic injury and inflammation. Herein, we analyzed the effects of Et OH on PA-induced lipotoxicity in the liver. Our results indicated that Et OH aggravated PA-induced apoptosis and lipid accumulation in primary rat hepatocytes in dose-dependent manner. Et OH intensified PA-caused endoplasmic reticulum(ER) stress response in vitro and in vivo, and the expressions of CHOP, ATF4, and XBP-1 in nucleus were significantly increased. Et OH also increased PA-caused cleaved caspase-3 in cytoplasm. In wild type and CHOP–/– mice treated with Et OH and high fat diet(HFD), Et OH worsened the HFD-induced liver injury and dyslipidemia, while CHOP knockout blocked toxic effects of Et OH and PA. Our study suggested that targeting UPR-signaling pathways is a promising, novel approach to reducing Et OH and saturated fatty acid-induced metabolic complications.

关键词： Ethanol(Et OH) Palmitic acid(PA) ER stress CHOP knockout Liver toxicity

Value of 99mTc-MIBI scanning in SPECT/CT fusion imaging of malignant and benign tumor in parotid gland

在线全文

学校读者我要写书评

暂无评论

中国口腔颌面外科杂志 2008年第B5期6卷 182-183页

作者： Ning yi Li hong wei Liu Shu Yao Zuo Department of Oral and MaxiUofacial Surgery NuclearMedicine The Affiliated Hospital of Qingdoo University MedicalCollege Qingdao 266003 China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

半李普希兹算子方程的逼近可解性

应用数学 2007年第4期20卷 671-674页

作者：伊宏伟铁岭师范高等专科学校理工系辽宁铁岭112001

本文先在(π)1空间的闭集上证明了凝聚映射必为A-proper映射,运用此性质证明了型如f(x)-λx=0方程当f为弱内向、半李普希兹映射时是弱逼近可解的,若f为李普希兹型映射,方程还是强逼近可解的.

关键词： (π)1空间 A-proper映射弱内向映射 k-集-压缩映射凝聚映射半李普希兹映射方程强(弱)逼近可解性

Risk factors for prostatic inflammation extent and infection in benign prostatic hyperplasia

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2006年第5期8卷 621-627页

作者： Fa-Xian yi Qiang wei hong Li Xiang Li Ming Shi Qiang Dong Yu-Ru Yang Department of Urology West China Hospital West China Medical School Sichuan University Chengdu Sichuan 610041 China

Aim： To investigate the risk factors for prostatic inflammation extent and infection in patients with benign prostatic hyperplasia （BPH） so as to manage prostatic inflammation more efficiently. Methods： Sixty patients with BPH undergoing TURP between September 2005 and December 2005 in West China Hospital of Sichuan University were studied. Prostate fluid （PF） was collected for the measurement of secretory IgA （SIgA） and complement 3 （C3）. Prostate tissue were collected for testing bacterial 16S rDNA by real-time PCR, examining SIgA in the tissue and examining the inflammation. The possible clinical and immune risk factors for prostatic inflammation or infection were analyzed by using the logistic regression method. Results： Abnormal white blood cell count in urinalysis, prostatic infection and a high concentration of C3 in PF are the risk factors for prostatic inflammation extent （P = 0.025, 0.034 and 0.035, respectively and odds ratio [OR] = 18.269, 8.284 and 1.508, respectively）. Risk factors for prostatic infection include the C3 concentration and the concentration of SIgA in PF （P = 0.003 and 0.013, respectively, and OR=1.645 and 0.993, respectively）. Conclusion： The present study suggests that prostatic inflammation is associated with urinary tract infection, prostatic infection and the activated complement and that prostatic infection is associated with the activated complement and downregulated mucosal immunity in prostates of the patients with BPH. It is also suggested that individual immune regulation should be considered in the treatment of prostatic inflammation and infection of patients with BPH.

关键词： inflammation infection logistic regression benign prostatic hyperplasia prostate

Global epidemiology of mental disorder in atrial fibrillation between 1998-2021:A systematic review and meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第1期14卷 179-193页

作者： Shuai Zhang Na Zhang Liu Liu Wang Zheng Zi-Lin Ma Si-Yu Qiao ying-Li Zhao yi-hong wei Gang Wu Qiu-Ting Yu Bing Deng Lin Shen Department of Cardiology LongHua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

BACKGROUND As the burden of mental disorders among patients with atrial fibrillation(AF)increases,researchers are beginning to pay close attention to the risk and prevalence of these *** studies have independently analyzed the risk of comorbidity with depression and anxiety in patients with AF,no study has systematically focused on the global epidemiology of these two mental *** To explore the prevalence of depression and anxiety in patients with *** Five databases were searched from their date of establishment until January *** studies reporting the comorbidity of AF with depression and anxiety,were included in this *** information,such as the first author/publication year,study year,study type,and prevalence of depression and anxiety,were *** SE 15.1 was used to analyze the ***,meta-regression,and sensitivity analyses were performed to estimate study *** After a thorough search,26 studies were identified and included in this *** prevalence rates of depression and anxiety in adults with AF were 24.3%and 14.5%,*** adult males with AF,the prevalence was 11.7%and 8.7%,respectively,whereas in females it was 19.8%and 10.1%,*** older adults with AF,the prevalence rates of depression and anxiety were 40.3%and 33.6%,*** highest regional prevalence of depression and anxiety was observed in European(30.2%)and North American(19.8%)patients with *** In this study,we found that the prevalence of depression and anxiety among patients with AF varies with sex,region,and evaluation scales,suggesting the need for psychological interventions for patients with AF in clinical practice.

关键词： Atrial fibrillation Depression Anxiety Prevalence

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

改进的多曝光图像金字塔融合方法

光子学报 2019年第8期48卷 100-110页

作者：刘鑫龙易红伟中国科学院西安光学精密机械研究所西安710119 陕西师范大学物理与信息工程学院西安710062

针对多曝光的拉普拉斯金字塔融合算法存在部分过曝光以及暗部细节丢失问题,用相位一致性滤波函数替换原算法融合系数中的对比度函数,改进算法在提取边缘时可以忽略光照和对比度变化对图像的影响,使得融合结果更自然,细节更丰富.通过多... 详细信息

针对多曝光的拉普拉斯金字塔融合算法存在部分过曝光以及暗部细节丢失问题,用相位一致性滤波函数替换原算法融合系数中的对比度函数,改进算法在提取边缘时可以忽略光照和对比度变化对图像的影响,使得融合结果更自然,细节更丰富.通过多组序列图像验证了算法的优点,并与原算法进行比较.结果表明,主观评价方面,该改进算法的融合结果自然,在强光背景下能较好地保留暗部细节,减少光源处的光晕;客观评价方面,该算法融合的高动态范围图像的方差和直方图结果明显优于原算法,所保留的信息多于原算法.

关键词：高动态范围图像融合图像增强相位一致性图像金字塔