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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-yian Guo Jian-Gang Shen Su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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西藏多龙矿集区遥感异常提取与成矿预测

桂林理工大学学报 2013年第2期33卷 252-258页

作者：别小娟张廷斌孙传敏易桂花郭娜徐志忠成都理工大学旅游与城乡规划学院成都610059 成都理工大学地球科学学院成都610059 成都理工大学管理科学学院成都610059 西藏地勘局第五地质大队青海格尔木816000

以西藏多龙斑岩型铜矿区为例,根据已知矿床,分别利用比值法和主成分分析法对ETM+和ASTER数据提取铁染与羟基异常信息,分析研究已知矿体遥感异常特征;通过波谱特征拟合的方法,对研究区进行波谱分类。利用两方面的成果来对多龙矿集区作成... 详细信息

以西藏多龙斑岩型铜矿区为例,根据已知矿床,分别利用比值法和主成分分析法对ETM+和ASTER数据提取铁染与羟基异常信息,分析研究已知矿体遥感异常特征;通过波谱特征拟合的方法,对研究区进行波谱分类。利用两方面的成果来对多龙矿集区作成矿预测,划定远景成矿区,其中一级预测区6个,二级预测区12个。多种异常对比组合,能够发现更好的指示成矿线索的信息。

关键词：遥感异常波谱特征拟合成矿预测多龙矿集区西藏

气候变化背景下横断山区植被叶面积指数时空变化特征分析

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长江流域资源与环境 2021年第11期30卷 2670-2681页

作者：杨正兰张廷斌易桂花秦岩宾李景吉王国严姚明月成都理工大学地球科学学院四川成都610059 重庆城市职业学院建筑工程学院重庆402160 成都理工大学国家环境保护水土污染协同控制与联合修复重点实验室四川成都610059 成都理工大学旅游与城乡规划学院四川成都610059 蒙大拿大学蒙大拿科技分校比尤特蒙大拿州美国59701 成都理工大学生态环境学院四川成都610059

叶面积指数作为陆地生态过程的重要参数,对生态系统碳循环和区域水土保持具有重要意义。基于MOD15A2H/LAI遥感数据集,利用Theil-Sen media斜率分析、Mann-Kendall趋势检验法以及相关分析法,研究了2001~2018年横断山区植被LAI时空分布格... 详细信息

叶面积指数作为陆地生态过程的重要参数,对生态系统碳循环和区域水土保持具有重要意义。基于MOD15A2H/LAI遥感数据集,利用Theil-Sen media斜率分析、Mann-Kendall趋势检验法以及相关分析法,研究了2001~2018年横断山区植被LAI时空分布格局及变化趋势,根据气象数据、土地覆盖数据和DEM数据,重点分析了横断山区植被LAI对气候变化的响应。结果表明:(1)2001~2018年横断山区植被LAI均值为1.22,空间上呈由北向南逐渐递增的分布特征;(2)横断山区植被LAI受地形影响明显,植被LAI值随海拔升高表现为“升高-降低-稳定”的特征,随坡度增加植被LAI值呈上升趋势;(3)近18a横断山区植被LAI整体以0.07·(10a)^(-1)的速率增加,其中68.92%的区域呈增加趋势,31.08%的区域呈退化趋势;(4)横断山区植被LAI与气温和日照时长呈正相关关系,与降水呈负相关关系。在P<0.05显著性水平下,植被LAI与气温、降水和日照时长的显著相关面积比例依次为22.7%、33.58%和31.80%,表明植被LAI受降水和日照时长影响较大,气温的影响相对较弱。

关键词： LAI 趋势分析相关性分析气候因子横断山区

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驻舰艇军人心理状况与人格特征的相关研究

临床精神医学杂志 2012年第1期22卷 48-49页

作者：衣桂花王心蕊毕海玲青岛大学医学院 2660211 青岛市精神卫生中心

目的:探讨驻舰艇军人心理健康状态及相关因素。方法:采用症状自评量表(SCL-90)、艾森克人格问卷(EPQ)评估海军某水面舰艇200名驻舰航行(长航)前后的心理健康状况。结果:长航前,除人际关系因子外,驻舰军人SCL-90总分及其他因子分均较男... 详细信息

目的:探讨驻舰艇军人心理健康状态及相关因素。方法:采用症状自评量表(SCL-90)、艾森克人格问卷(EPQ)评估海军某水面舰艇200名驻舰航行(长航)前后的心理健康状况。结果:长航前,除人际关系因子外,驻舰军人SCL-90总分及其他因子分均较男性军人常模显著低(P0.05)。SCL-90各因子分与EPQ精神质、神经质呈显著正相关(P<0.01),与掩饰性呈显著负相关(P<0.01);而人际关系、抑郁、恐惧因子分与内外向呈负相关(P<0.05或P<0.01)。结论:驻舰军人心理健康水平较好。人格特征与应激状态下心理健康水平关系密切。

关键词：驻舰艇军人症状自评量表艾森克人格问卷

Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-yi Wang Yao Hao Zi-Jian Wang Xiu-Liang Xu Jiang-hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

近35a若尔盖高原泥炭沼泽变化趋势与驱动力分析

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干旱区研究 2017年第2期34卷 403-410页

作者：王云川易桂花张廷斌别小娟王继斌孙姣姣成都理工大学地球科学学院四川成都610059 成都理工大学管理科学学院四川成都610059 中国科学院水利部成都山地灾害与环境研究所四川成都610041 地学空间信息技术国土资源部重点实验室四川成都610059 成都理工大学工程技术学院四川乐山614000

选取Landsat系列陆地卫星遥感数据作为数据源,采用主成分变换技术提取了1977年、1994年、2007年和2013年4期若尔盖高原泥炭沼泽的分布状况,分析了近35 a若尔盖高原泥炭沼泽的分布与变化趋势。结果显示:近35 a泥炭沼泽分布面积整体呈减... 详细信息

选取Landsat系列陆地卫星遥感数据作为数据源,采用主成分变换技术提取了1977年、1994年、2007年和2013年4期若尔盖高原泥炭沼泽的分布状况,分析了近35 a若尔盖高原泥炭沼泽的分布与变化趋势。结果显示:近35 a泥炭沼泽分布面积整体呈减少趋势,从1977年的1 997.08 km^2减少到2013年的1 358.66 km^2,减少幅度达到31.97%。该区泥炭沼泽的退化经历了由慢到快,然后逐渐向好的过程,其中1994—2007年是退化高峰期,退化速率为29.1 km^2·a^(-1)。同时,区内泥炭沼泽的退化方式也表现出一定的地域差异,西北部以沙化为主,而东南部退化则主要表现为草甸化。

关键词：泥炭沼泽时空变化变化趋势驱动力若尔盖高原

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青藏高原气候变化对草地碳汇/源格局的影响

自然资源学报 2024年第5期39卷 1208-1221页

作者：耿垭鑫易桂花张廷斌别小娟李景吉王国严林梦男成都理工大学地理与规划学院成都610059 成都理工大学地球与行星科学学院成都610059 国家环境保护水土污染协同控制与联合修复重点实验室(成都理工大学) 成都610059 成都理工大学生态环境学院成都610059

草地碳汇/源是植被生态系统中碳收支和碳平衡的一个重要内容,区分碳汇和碳源对气候变化的响应可为减源增汇提供科学依据。基于MODIS NPP数据和土壤呼吸模型量化了2001—2019年青藏高原草地净生态系统生产力(NEP)的时空变化和碳汇/源格局... 详细信息

草地碳汇/源是植被生态系统中碳收支和碳平衡的一个重要内容,区分碳汇和碳源对气候变化的响应可为减源增汇提供科学依据。基于MODIS NPP数据和土壤呼吸模型量化了2001—2019年青藏高原草地净生态系统生产力(NEP)的时空变化和碳汇/源格局,利用通径分析方法分析了青藏高原气候变化对草地碳汇/源的影响。结果表明:青藏高原草地NEP呈现东高西低的分布格局,年平均值为54.41 g C m^(-2)。草地整体上以碳汇功能为主。碳汇区面积约为72.26万km^(2),碳源区面积约为47.82万km^(2),净碳汇总量65.35 Tg C a^(-1)。近19年青藏高原草地NEP以增加趋势为主,青藏高原气候暖湿化趋势有利于草地NEP的增加,增强碳汇;而暖干化趋势对NEP的影响在不同生态地理区差异较大。

关键词： NEP 碳汇/源气候变化通径分析青藏高原

Facile synthesis of the dodecahydridododecaborate (B12H122-) from borane Lewis base adducts

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Science China Chemistry 2025年

作者： yi Jing Xin-Ran Liu Xing-hua Wang Hui Han Sha-Sha Liang Xi-Meng Chen Dong-Hui Wei Lai-Sheng Wang Xue-Nian Chen College of Chemistry Zhengzhou University School of Chemistry and Chemical Engineering Henan Key Laboratory of Boron Chemistry and Advanced MaterialsHenan Normal University Department of Chemistry Brown University

Polyhedral boranes are a class of well-known boron molecular clusters widely used in energy,chemistry,medicine,and materials science because of their unique physical and chemical *** efforts have been made in the past decades to find more effective synthetic methods for this important class of boron ***,existing synthetic methods suffer from low efficiency and low ***,we report a facile one-pot synthesis of[（CH3）3S]2B12H12with moderate yields at mild *** mechanisms for the multi-step chemoselective synthesis of B12H122-without other by-products are elucidated based on theoretical results and our previous *** Lewis base used in B–H bond condensation reaction,which acts as a hydrogen or to balance the newly generated polyhedral borane charges,is proposed and studied in *** current study has led to a more effective and selective synthetic method for B12H122-and has also implicated the syntheses of other new polyhedral boranes.

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Effects of insertion device on SSRF storage ring

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Nuclear Science and Techniques 2006年第1期17卷 1-6页

作者： ZHANG Li-hua LIAO yi LIU gui-Min Shanghai Institute of Applied Physics the Chinese Academy of Sciences Shanghai 201800 China

Shanghai Synchrotron Radiation Facility (SSRF), one of the third generation light sources, aims to pro-duce high brightness and/or high flux X-ray source for users; therefore insertion devices (IDs) are important magnetic elements for SSRF. In this paper, the linear perturbations due to IDs toward its storage ring lattice, such as beta func-tion distortions, tune shifts, emittance growths, and energy spreads are estimated by using analytical formulae, and the nonlinear effects from IDs, especially dynamic aperture, are simulated by using Racetrack code. The results show that (a) the reduction of dynamic aperture from single undulator is negligible, since electron beam energy of 3.5 GeV is high and ID’s magnetic field is low, and the beta functions in the middle of straight sections, where ID is located, are well optimized; (b) however, the reduction from single wigglers, especially super-conducting wiggler, is visible, be-cause of its higher magnetic field; (c) effects of each ID on emittance growths and energy spreads are less than 7%.

关键词： SSRF 储存环插入装置第三代光源同步加速器