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宫腔粘连中水凝胶促内膜修复的研究与进展

中国组织工程研究 2024年第17期28卷 2774-2781页

作者：邬浩明王瑶陈圆梦朱慧莉李开南熊成东胡旭麟成都大学临床医学院/附属医院四川省成都市610081 四川大学华西第二医院生殖医学科-出生缺陷与相关妇儿疾病教育部重点实验室四川省成都市610041 中国科学院大学北京市100049 四川大学生物治疗国家重点实验室四川省成都市610041

背景:防止宫腔粘连复发的关键是重建具有正常功能的子宫内膜,国内外对于宫腔粘连复发治疗的最新突破在于利用可降解材料制备水凝胶类物质防止粘连复发。目的:综述宫腔粘连中水凝胶促内膜修复的研究进展。方法:系统检索PubMed数据库、Web... 详细信息

背景:防止宫腔粘连复发的关键是重建具有正常功能的子宫内膜,国内外对于宫腔粘连复发治疗的最新突破在于利用可降解材料制备水凝胶类物质防止粘连复发。目的:综述宫腔粘连中水凝胶促内膜修复的研究进展。方法:系统检索PubMed数据库、Web of Science、中国知网、万方数据库,以“宫腔粘连,子宫内膜损伤,子宫内膜再生,水凝胶,Intrauterine adhesions,Endometrial injury,Endometrium regeneration,hydrogel”为关键词,收集各数据库1990年1月至2023年3月发表的相关文献。结果与结论:近年来国内外关于宫腔粘连中水凝胶促内膜修复的研究取得了一定进展,对于宫腔粘连的防治和促进内膜修复具有重要作用:①水凝胶作为组织工程中一大重要载体,它本身具有优秀的生物相容性、生物降解性和三维网状结构,可以更好地应用在宫腔粘连治疗中;②以水凝胶为基础的搭载体系,可以通过运输药物/生物制剂/干细胞来促进子宫内膜上皮细胞的增殖分化,并恢复正常子宫形态,防止粘连复发;③透明质酸类水凝胶在满足良好生物相容性的同时还可以促进内膜上皮细胞的增殖分化,且在子宫内会被相应的酶类物质水解,不会影响机体正常代谢,是目前临床常用的子宫防粘连剂,也是组织工程研究中最常用的一种水凝胶载体;④以温敏特性出众的泊洛沙姆水凝胶可以在进入体内迅速凝胶化,快速形成物理屏障,并可对搭载物质起到缓释作用和提供细胞生长/黏附平台;⑤利用不同特性材料制备治疗性水凝胶的前景广阔,比如温敏特性水凝胶、pH响应性水凝胶以及光敏水凝胶等,但还存在诸多问题需要解决,例如水凝胶体系的安全性以及降解产物是否引起免疫反应、对正常机体经期是否具有影响等问题,还需要大量动物实验及临床试验来验证其安全性和有效性,不断完善治疗策略。

关键词：宫腔粘连水凝胶修复子宫内膜再生生长因子干细胞

Electronic and magnetic structures of chain structured ironselenide compounds

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Frontiers of physics 2014年第4期9卷 465-471页

作者： Wei Li Chandan Setty X. H. Chen Jiangping hu State Key Laboratory of Functional Materials for Informatics and Shanghai Center for Superconductivity Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China Department of Physics and State Key Laboratory of Surface Physics Fudan University Shanghai 200433 China Department of Physics Purdue University West Lafayette IA 47907 USA Hefei National Laboratory for Physical Science at Microscale and Department of Physics University of Science and Technology of China Hefei 230026 China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 China

Electronic and magnetic structures of iron selenide compounds Ce2O2FeSe2 （2212＊） and BaFe2Se3 （123＊） are studied by the first-principles calculations. We find that while all these compounds are composed of one-dimensional （1D） Fe chain （or ladder） structures, their electronic structures are not close to be quasi-lD. The magnetic exchange couplings between two nearest-neighbor （NN） chains in 2212＊ and between two NN two-leg-ladders in 123＊ are both antiferromagnetic （AFM）, which is consistent with the presence of significant third NN AFM coupling, a common feature shared in other iron-chalcogenides, FeTe （11＊） and Kyfe2-xSe2 （122＊）. In magnetic ground states, each Fe chain of 2212＊ is ferromagnetic and each two-leg ladder of 123＊ form a block-AFM structure. We suggest that all magnetic structures in iron-selenide compounds can be unified into an extended J1-J2-J3 model. Spin-wave excitations of the model are calculated and can be tested by future experiments on these two systems.

关键词： first-principles calculations magnetism spin-wave excitations

Accuracy of predicting metabolizable energy from in vitro digestible energy determined with a computer-controlled simulated digestion system in feed ingredients for ducks

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Animal Nutrition 2022年第1期8卷 52-60页

作者： Yuming Wang Liting Yin hu Zhang Ke Li Dailin Li Feng Zhao The State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China Newhope Liuhe Co.Ltd. Beijing 100102China

Two experiments were conducted to study the accuracy of predicting true metabolizable energy(TME)of ingredients for ducks from in vitro digestible energy(IVDE)determined with a computer-controlled simulated digestion *** 1 was to establish TME prediction models from the IVDE of 9 energy feed ingredients and 12 protein feed ingredients using regression *** 2 was to validate the accuracy of the predicted ME of 10 ingredients randomly selected from *** diets were formulated with 2 to 6 of 10 *** in vivo TME values were compared with calculated values based on the TME predicted in *** Exp.1,the correlation coefficients between TME and IVDE were 0.9339(P<0.05)in 9 energy feed ingredients and 0.8332(P<0.05)in 12 protein feed *** significant difference was observed on the slope and intercept of TME regression models between 9 energy feed ingredients and 12 protein feed ***,the regression model of TME on IVDE for 21 feed ingredients was TME=0.7169×IVDE+1,224(R^(2)=0.7542,P<0.01).Determined and predicted TME differed by less than 100 kcal/kg of DM in 11 ingredients,and the difference ranged from 100 to 200 kcal/kg of DM in 5 ***,the difference between determined and predicted TME varied from 410 to 625 kcal/kg of DM in rice bran,rapeseed meal,corn gluten meal,and citric acid *** Exp.2,the determined and calculated TME were comparable(3,631 vs.3,639 kcal/kg of DM)and highly correlated(r=0.9014;P<0.05)in 10 *** and calculated TME differed by less than 100 kcal/kg of DM in 7 diets and by 106 to 133 kcal/kg of DM in 3 *** results have demonstrated that TME can be accurately predicted from IVDE in most feed ingredients,but it is less accurate for rice bran,rapeseed meal,corn gluten and citric acid meal.

关键词： Duck In vitro digestible energy Prediction model True metabolizable energy

尾静脉注射衰老标志蛋白30对脓毒症小鼠心肌损伤的抑制作用及其机制

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山东医药 2024年第26期64卷 41-46页

作者：胡培静张学丹杜占奎曹彪西安医学院第二附属医院心血管内科西安710005

目的观察尾静脉注射衰老标志蛋白30(SMP30)对脓毒症小鼠心肌损伤的抑制作用,并探讨其作用机制。方法取60只雄性C57BL/6小鼠,随机分为空载对照组、空载模型组、SMP30模型组各20只,空载对照组和空载模型组尾静脉注射空载腺相关病毒载体,SM... 详细信息

目的观察尾静脉注射衰老标志蛋白30(SMP30)对脓毒症小鼠心肌损伤的抑制作用,并探讨其作用机制。方法取60只雄性C57BL/6小鼠,随机分为空载对照组、空载模型组、SMP30模型组各20只,空载对照组和空载模型组尾静脉注射空载腺相关病毒载体,SMP30模型组尾静脉注射SMP30腺相关病毒载体。注射2周后,空载模型组和SMP30模型组通过一次性腹腔注射脂多糖(LPS)建立脓毒症模型,空载对照组腹腔注射同等体积生理盐水。于LPS注射24 h后,使用超声心动图仪检测小鼠心功能指标左心室射血分数(LVEF)和左心室缩短分数(LVFS);处死小鼠,收集血清及心脏标本,ELISA法检测血清肌酸激酶同工酶MB(CK-MB)、乳酸脱氢酶(LDH)、心肌肌钙蛋白I(cTnI)水平以及心肌组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性、丙二醛(MDA)含量;TUNEL染色法检测心肌细胞凋亡情况;免疫荧光染色法检测心肌组织巨噬细胞浸润情况;二氢乙锭荧光探针检测心肌组织活性氧自由基(ROS)生成量;qRT-PCR法观察心肌组织白细胞介素(IL)-1β、IL-6、肿瘤坏死因子α(TNF-α)mRNA;Western blotting法观察心肌组织SMP30和沉默信息调节因子1(SIRT1)通路相关蛋白SIRT1、乙酰化核因子κB p65(Ac-NF-κB p65)、乙酰化叉头框蛋白O1(Ac-FOXO1)。结果与空载对照组比较,空载模型组LVEF、LVFS降低,血清CK-MB、LDH、cTnI水平升高,心肌细胞凋亡率增加;心肌组织巨噬细胞浸润明显,IL-1β、IL-6、TNF-αmRNA表达升高;心肌组织ROS及MDA生成增加,SOD和GSH-Px活性减弱;心肌组织SIRT1表达下降,Ac-NF-κB p65和Ac-FOXO1表达升高(P均<0.01)。与空载模型组比较,SMP30模型组LVEF、LVFS升高,血清CK-MB、LDH、cTnI水平降低,心肌细胞凋亡率降低;心肌组织巨噬细胞浸润减少,IL-1β、IL-6、TNF-αmRNA表达降低;心肌组织ROS及MDA生成减少,SOD和GSH-Px活性增强;心肌组织SIRT1表达升高,Ac-NF-κB p65和Ac-FOXO1表达下降(P均<0.01)。结论尾静脉注射SMP30可上调脓毒症小鼠心肌组织SMP30表达,抑制心肌炎症反应和氧化应激水平,从而减轻心肌损伤,其机制可能是通过激活SIRT1信号通路来发挥作用。

关键词：脓毒症衰老标志蛋白30 心肌损伤氧化应激炎症沉默信息调节因子1

Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw(MRONJ)

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International Journal of Oral Science 2022年第3期14卷 245-258页

作者： Ran Yan Ruixue Jiang Longwei hu Yuwei Deng Jin Wen Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina College of Stomatology Shanghai Jiao Tong UniversityShanghaiChina National Center for Stomatology National Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghaiChina d 4Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Medication-related osteonecrosis of the jaw(MRONJ)is primarily associated with administering antiresorptive or antiangiogenic *** significant research on MRONJ,its pathogenesis and effective treatments are still not fully *** models can be used to simulate the pathophysiological features of MRONJ,serving as standardized in vivo experimental platforms to explore the pathogenesis and therapies of *** models exhibit excellent effectiveness and high reproducibility in mimicking human MRONJ,but classical methods cannot achieve a complete replica of the pathogenesis of *** rodent models have been reported with improvements for better mimicking of MRONJ onset in *** review summarizes representative classical and modified rodent models of MRONJ created through various combinations of systemic drug induction and local stimulation and discusses their effectiveness and ***,there is a lack of a unified assessment system for MRONJ models,which hinders a standard definition of MRONJ-like lesions in ***,this review comprehensively summarizes assessment systems based on published peer-review articles,including new approaches in gross observation,histological assessments,radiographic assessments,and serological *** review can serve as a reference for model establishment and evaluation in future preclinical studies on MRONJ.

关键词： Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw MRONJ

m6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3379-3381页

作者： Beijian Zhang Hao Jiang Jian Wu Yun Cai Zhen Dong Yongchao Zhao Qinfeng hu Kai hu Aijun Sun Junbo Ge Department of Cardiology Zhongshan HospitalFudan UniversityShanghaiChina Shanghai Institute of Cardiovascular Diseases ShanghaiChina Key Laboratory of Viral Heart Diseases National Health CommissionShanghaiChina Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina

Dear Editor,N6-methyladenosine(m6A)is the most common posttranscriptional mammalian mRNA modification involved in multiple biological processes and diseases.1 However,its role in cardiac energy metabolism changes during heart failure(HF)remains *** we explored the role of m6A demethylase fat mass and obesity-associated protein(FTO)in glucose metabolism during pressure overload-induced *** RNA immunoprecipitation sequencing(MeRIP-seq)was performed to map transcriptome-wide m6A modifications in transverse aortic constriction(TAC)and sham *** number of identified m6A peaks was higher in the TAC than in the sham hearts(Fig.1a).Consistent with previous reports,the m6A peaks were enriched in 3’-untranslated regions in both the TAC and sham hearts(Fig.1b).2 The m6A peaks were characterized by the canonical RGAAR(R=A or G)motif(Fig.1c).

关键词： metabolism cardiac m6A

human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor

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Protein & Cell 2023年第6期14卷 416-432页

作者： Yinghui Wei Meiling Zhang Jing hu Yingsi Zhou Mingxing Xue Jianhang Yin Yuanhua Liu hu Feng Ling Zhou Zhifang Li Dongshuang Wang Zhiguo Zhang Yin Zhou Hongbin Liu Ning Yao Erwei Zuo Jiazhi hu Yanzhi Du Wen Li Chunlong Xu hui Yang Center for Reproductive Medicine International Peace Maternity and Child Health HospitalInnovative Research Team of High-level Local Universities in ShanghaiSchool of MedicineShanghai Jiao Tong UniversityShanghai 2000301.Center for Reproductive MedicineInternational Peace Maternity and Child Health HospitalInnovative Research Team of High-level Local Universities in ShanghaiSchool of MedicineShanghai Jiao Tong UniversityShanghai 200030China Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China Lingang Laboratory Shanghai Research Center for Brain Science and Brain-Inspired Intelligence TechnologyShanghai 200031China Center for Reproductive Medicine Ren Ji HospitalSchool of MedicineShanghai Key Laboratory for Assisted Reproduction and Reproductive GeneticsShanghai Jiao Tong UniversityShanghai 200127China The MOE Key Laboratory of Cell Proliferation and Differentiation School of Life SciencesGenome Editing Research CenterPeking UniversityBeijing 100871China Center for Reproductive Medicine Shandong UniversityJinan 250012China Center for Reproductive Medicine Anhui Provincial Maternal and Child Health HospitalHefei 230001China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China

Approximately 140 million people worldwide are homozygous carriers of APOE4(ε4),a strong genetic risk factor for late onset familial and sporadic Alzheimer’s disease(AD),91%of whom will develop AD at earlier age than heterozygous carriers and *** to AD could be reduced by targeted editing of APOE4,but a technical basis for controlling the off-target effects of base editors is necessary to develop low-risk personalized gene ***,we first screened eight cytosine base editor variants at four injection stages(from 1-to 8-cell stage),and found that FNLS-YE1 variant in 8-cell embryos achieved the comparable base conversion rate(up to 100%)with the lowest bystander *** particular,80%of AD-susceptibleε4 allele copies were converted to the AD-neutralε3 allele in humanε4-carrying *** control measures combined with targeted deep sequencing,whole genome sequencing,and RNA sequencing showed no DNA or RNA off-target events in FNLS-YE1-treated human embryos or their derived stem ***,base editing with FNLS-YE1 showed no effects on embryo development to the blastocyst ***,we also demonstrated FNLS-YE1 could introduce known protective variants in human embryos to potentially reduce human susceptivity to systemic lupus erythematosus and familial *** study therefore suggests that base editing with FNLS-YE1 can efficiently and safely introduce known preventive variants in 8-cell human embryos,a potential approach for reducing human susceptibility to AD or other genetic diseases.

关键词： human embryo APOE4 disease-preventive mutations base editor

Trimetallic synergistic optimization of 0D NiCoFe-P QDs anchoring on 2D porous carbon for efficient electrocatalysis and high-energy supercapacitor

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Journal of Energy Chemistry 2022年第11期31卷 149-158,I0006页

作者： Ruiqi Liu Xue-Rong Shi Yi Wen Xiaoxuan Shao Chen Su Jing hu Shusheng Xu School of Materials Engineering Shanghai University of Engineering ScienceShanghai 201620China School of Advanced Materials and Nanotechnology Xidian UniversityXi’an 710071ShaanxiChina School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009JiangsuChina

Developing multi-functional and low-cost noble-metal-free catalysts such as transition metal phosphides(TMPs)to replace noble-metal is of practical significance for energy conversion and ***,the low-durability and the agglomeration phenomenon during the electrochemical process limit their practical ***,using metal–organic frameworks(MOFs)as the precursor and a combined strategy of gradient temperature calcination and thermal phosphorization,a 0D/2D heterostructure of NiCoFe-P quantum dots(QDs)anchored on porous carbon was successfully developed as highly efficient electrode materials for overall water splitting and *** to this distinctive 0D/2D heterostructure and the synergistic effect of multi-metallic TMPs,the NiCoFe-P/C exhibits excellent electrocatalytic activity and durability of HER(87 mV at 10 mA cm^(-2))and OER(257 mV at 100 mA cm^(-2))in the KOH *** NiCoFe-P/C is used as the two electrodes of electrolyzed water,only 1.55 V can drive the current density to 10 m A cm^(-2).At the same time,our NiCoFe-P/C possessed extraordinary property for charge *** particular,an ultra-high energy density of 100.8 Wh kg^(-1) was achieved at a power density of 900.0 W kg^(-1) for our assembled hybrid supercapacitor device NiCoFe-P/C(2:1)//activated carbon(AC).This work may open a potential way for the design of 0D/2D hybrid multifunctional nanomaterials based on TMPs QDs.

关键词： Metal-organic frameworks Transition metal phosphide quantum dots 0D/2D heterostructure Overall water splitting Supercapacitor First-principle calculations

泡沫镍上生长的具有三明治纳米结构的MnCo_(2)O_(4)@NiCoMnS_(4)用于高性能水系非对称超级电容器

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Science China Materials 2024年第3期67卷 816-823页

作者：陈勇超李亚丽董云霞李东昊沈思锦胡继东付玉军贺德衍栗军帅 LONGi Institute of Future Technology and School of Materials&EnergyLanzhou UniversityLanzhou 730000China

本文介绍了一种由水热生长的MnCo_(2)O_(4)(MCO)纳米线以及随后电沉积的NiCoMnS_(4)(NCMS)纳米片组成的高性能超级电容器电极材料,即泡沫镍上生长的MCO@NCMS.由于其多孔和互联的纳米结构以及MCO和NCMS的协同效应,在1 mA cm^(-2)处实现了... 详细信息

本文介绍了一种由水热生长的MnCo_(2)O_(4)(MCO)纳米线以及随后电沉积的NiCoMnS_(4)(NCMS)纳米片组成的高性能超级电容器电极材料,即泡沫镍上生长的MCO@NCMS.由于其多孔和互联的纳米结构以及MCO和NCMS的协同效应,在1 mA cm^(-2)处实现了12,020.8 mF cm^(-2)的高电容,并展现出良好的倍率性能以及循环稳定性.电化学测试表明,组装成的水性非对称超级电容器在0.800 mW cm^(-2)的功率密度下,达到0.611 mW h cm^(-2)的高能量密度并具有良好的循环稳定性,即在15,000次充放电循环后,容量保持率可达90%,且保持100%的库仑效率.

关键词： sandwich structure high energy density transition metal sulfides aqueous asymmetric supercapacitor transition metal oxides