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Nanograins on Ti-25Nb-3Mo-2Sn-3Zr alloy facilitate fabricating biological surface through dual-ion implantation to concurrently modulate the osteogenic functions of mesenchymal stem cells and kill bacteria

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Journal of Materials Science & Technology 2021年第14期73卷 31-44页

作者： Run Huang Lei Liu Bo Li Liang Qin Lei Huang Kelvin w.K.yeung Yong Han School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan232001China Department of Orthopaedics and Traumatology The University of Hong KongHong KongChina State-key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi'an710049China Department of Gastrointestinal Surgery Hubei Cancer HospitalWuhan430060China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhen518053China

Surface mechanical attrition treatment(SMAT)method is an effective way to generate nanograined(ng)surface on Ti-25 Nb-3 Mo-2 Sn-3 Zr(wt.%)(named as TLM),a kind ofβ-type titanium alloy,and the achieved nanocrystalline surface was proved to promote positive functions of osteoblastic *** this work,to further endow the ng TLM alloy with both good osteogenic and antibacterial properties,magnesium(Mg),silver(Ag)ion or both were introduced onto the ng TLM surface by ion implantation process,as a comparison,the Mg and Ag ions were also co-implanted onto coarsegrained(CG)TLM *** obtained results show that subsequent ion implantation does not remarkably induce the surface roughness and topography alteration of the SMAT-treated layers,and it also has little impact on the microstructure of the SMAT-derivedβ-Ti *** addition,the implanted Mg and Ag ions are observed to exist as MgO and metallic Ag na noparticles(NPs)embedding tightly in theβ-Ti matrix with grain size of about 15 and 7 nm,*** cell adhesion and functions(including proliferation,osteo-differentiation and extracellular matrix mineralization)of rabbit bone marrow mesenchymal stem cells(rBMMSCs)and the bacterial colonization of Staphylococcus aureus(***)on the different surfaces were *** in-vitro experimental results reveal that the Mg and Ag single-ion implanted ng surface either significantly promotes the rBMMSCs response or inhibits the growth ***,whereas the Mg/Ag coimplanted ng surface could concurrently enhance the rBMMSCs functions as well as inhibit the bacterial growth compared to the ng surface,and this efficacy is more pronounced as compared to the Mg/Ag co-implantation in the CG *** SMAT-achieved nanograins in the TLM surface layer are identified to not only play a leading role in determining the fate of rBMMSCs but also facilitate fabricating dualfunctio nal surface with both good osteogenic and antibacterial activities through co-imp

关键词： β-Type titanium Nanograined surface Ion implantation Stem cells Antibacterial property

Use of biological and chemical molecules in regulating embryo implantation and endometrial receptivity

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Reproductive and Developmental Medicine 2022年第4期6卷 234-242页

作者： Xian Chen Shu-Ya Sun Ernest Hung-Yu ng Raymond Hang-wun Li william Shu-Biu yeung Kai-fai Lee Department of Obstetrics and Gynaecology LKS Faculty of Medicinethe University of Hong KongHong Kong SARChina Shenzhen Key Laboratory of Fertility Regulation the University of Hong Kong-Shenzhen HospitalShenzhen 518053China

This review summarizes the drugs and chemicals that may modulate embryo ***-hormonal molecules,including aspirin,improved endometrial blood flow,while low molecular weight heparin,vitamin E,sildenafil,and atosiban modulated the expression of endometrial *** factors,including human chorionic gonadotropin and growth hormones,can regulate the expression of endometrial receptivity *** immunomodulatory molecules,including granulocyte colony-stimulating factor,peripheral blood mononuclear cells,autologous platelet-rich plasma,and intralipid and intravenous immunoglobulins,may improve implantation rate by modulating endometrial immune *** extracts of the Chinese herbs Paeonia lactiflora and Perilla frutescens increased the expression of leukemia inhibitory factors in endometrial epithelial ***,the use of the commercially available Library of Pharmacologically Active Compounds with a high-throughput screening method has provided an approach to screen for compounds that may potentially enhance or suppress embryo *** these biomedical findings translate into clinical effects that enhance or suppress embryo implantation requires further investigation.

关键词： Embryo implantation Endometrial receptivity fertilization Repeated implantation failure Birth control Emergency contraception

Investigation in Longitudinal Compression of wool Based Suiting Fabrics

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Journal of China Textile University(English Edition) 1999年第4期16卷 95-100页

作者： LeungMei-yi LoT.Y. DhingraR.C. yeung K.w.

This paper describes an investigation in the fabric longi-tudinal compressibility of thirty-one suiting and trouse-ring materials using a newly developed device attached to the advanced Instron extensometer *** at-tachment was designed mainly to ensure a correct align-meat of fabric plane at the start of *** newly developed testing method,fabric longitudinalcompression curve was obtained and the results of longi-tudinal compressibility measured by two different com-pression load ranges(from 0 to 0.5 N/m width and 0 to1 N/m width)were *** addition,their rela-tionships with the fabric low-stress mechanical proper-ties measured by the KES-F system were investigatedusing statistical *** results clearly indicatedthat significant differences existed when substituting fab-ric longitudinal compressibility with fabric extensibilitymeasured using the KES-F system under a *** infiuence of yarn rotational movement in fab-ric on the longitudinal

关键词： longitudinal compressibility extensibility shear rigidity formability and bending rigidity

Structural equation modeling analysis of factors influencing architects' trust in project design teams

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Journal of Chongqing University 2009年第1期8卷 32-36页

作者：丁志坤 ng Fung-fai College of Civil Engineering Shenzhen University Faculty of Architecture The University of Hong Kong

This paper describes a structural equation modeling （SEM） analysis of factors influencing architects＇ trust in project design teams. we undertook a survey of architects, during which we distributed 193 questionnaires in 29 A-level architectural design institutes selected radomly from the altogether 59 ones in Shenzhen, P. R. China, and received 130 valid questionnaires. we used Amos 6.0 for SEM to identify significant personal construct based factors affecting interpersonal trust. The results show that only social interaction between architects significantly affects their interpersonal trust. The explained variance of trus~ is not very high in the model. Therefore, future research should add more factors into the current model. The practical implication is that team managers should promote the social interactions between team members such that the interpersonal trust level between team members can be improved.

关键词： architect trust project design team cluster sampling structural equation modeling

Effect of stimulated IVF cycles on global endometrial gene expression and receptivity

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Effect of stimulated IVF cycles on global endometrial gene e...

Rare case of intussusception in an adult with acute myeloid leukemia

第一届中华医学会生殖医学分会、中国动物学会生殖生物学分会联合年会

作者： Kai-fai Lee Pak-Yiu ng Ernest H.Y.ng Pak-Chung Ho william S.B.yeung Department of Obstetrics and Gynaecology The University of Hong KongPokfulam Hong Kong CHINA

In human, the development of endometrium is regulated by steroid hormones and the endometrial lining undergoes cyclical morphological changes every 28 days. Soon after fertilization, the developing embryo transverses to the fallopian tube and implants onto the endometriumn on days 19-24 of the menstrual cycle. This narrow period of time is commonly known as "receptive window".

关键词： IVF Effect of stimulated IVF cycles on global endometrial gene expression and receptivity

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world Journal of Gastroenterology 2015年第2期21卷 688-693页

作者： Man fai Law Cheuk Kei w.ng Chun Yin Pang Hay Nun Chan Ho Kei Lai Chung Yin Ha Celia ng Yiu Ming yeung Sze fai Yip Department of Medicine Tuen Mun Hospital Department of Medicine and Therapeutics Prince of Wales Hospital Department of Radiology Kwong Wah Hospital Department of Pathology Tuen Mun Hospital

Intussusception is rarely reported in adult patients with acute leukemia. we report a case of intussusception in a 29-year-old woman with acute myeloid leukemia(AML). She developed right lower quadrant pain, fever, and vomiting on day 16 of induction *** examination showed tenderness and guarding at the right lower quadrant of the abdomen. Abdominal computed tomography(CT) showed distension of the cecum and ascending colon, which were filled with loops of small bowel, and herniation of the ileocecal valve into the cecum. we proceeded to laparotomy and revealed ileocecal intussusception with the ileocecal valve as the leading point. The terminal ileum was thickened and invaginated into the cecum, which showed gangrenous changes. Right hemicolectomy was performed and microscopic examination of the colonic tissue showed infiltration of leukemic cells. The patient recovered after the operation and was subsequently able to continue treatment for AML. This case demonstrates that the diagnosis of intussusception is difficult because the presenting symptoms can be non-specific, but abdominal CT can be informative for preoperative diagnosis. Resection of the involved bowel is recommended when malignancy is suspected or confirmed. Intussusception should be considered in any leukemia patients presenting with acute abdomen. A high index of clinical suspicion is important for early diagnosis.

关键词： Intussusception Acute leukemia Abdominal pain Colo

Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma

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Cellular & Molecular Immunology 2010年第1期7卷 61-68页

作者： Kin Chiu Sze-Chun yeung Kwok-fai So Raymond Chuen-Chung Chang Laboratory of Neurodegenerative Diseases Department of AnatomyUniversity of Hong KongPokfulamHong KongChina State Key Laboratory of Brain and Cognitive Sciences University of HongKongPokfulamHongKongChina Research Centre of Heart BrainHormone and Healthy AgingLiKa Shing Faculty of MedicineUniversity of Hong KongPokfulamHong KongChina

Monocyte chemoattractant protein-1(MCP-1)/CCL2 is a C–C chemokine involved in the activation and recruitment of monocytic cells to injury ***-1/CCL2 can induce either neuroprotection or neurodestruction in vitro,depending on the experimental *** aim to use MCP-1/CCL2 as an experimental tool to investigate the morphological changes of microglia when loss of healthy retinal ganglion cells(RGCs)is exacerbated or attenuated in an experimental glaucoma *** a high concentration(1000 ng)of MCP-1/CCL2 and lipopolysaccharide(LPS)-exacerbated RGC loss,100 ng MCP-1/CCL2 provided neuroprotection towards *** MCP-1/CCL2(100 ng)also upregulated insulin-like growth factor-1(IGF-1)immunoreactivity in the *** neuroprotective effect of MCP-1/CCL2 was not due to the massiveinfiltration of microglia/*** together,this is the first report show.ng that an appropriate amount of MCP-1/CCL2 can protect RGCs in experimental glaucoma.

关键词： glaucoma IGF-1 MCP-1/CCL2 microglia neuroprotection

Polymetallaynes and Molecular Metallaynes Containing Platinum,Mercury and Gold for Optoelectronic and Magnetic Applications

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Chinese Journal of Chemistry 2023年第17期41卷 2159-2178页

作者： Chen Zhang Linli Xu wai-yeung w.ng Departmentof Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomHong Kongchina

omprehensive Summary,Polymetallaynes are a promising branch of metallopolymers,in which the introduction of metal building blocks to organic conjugated backbones leads to their unique skeletons and versatile ***,the chemical structures,geometric configurations and functional properties in these organometallic systems can be adjusted flexibly by the appropriate selection of metal centers,auxiliary ligands,or bridging *** recent years,both one-dimensional and two-dimensional polymetallaynes have attracted considerable attention ow.ng to their excellent electronic,optical and magnetic ***,the studies on molecular metallaynes provide substantial insights for the exploration of the structure-property-activity relationships in these organometallic acetylide-containing *** recent research progress of polymeric and molecular metallaynes containing platinum,mercury and gold is discussed in this article.A series of functional properties have been realized in these acetylide-containing compounds by the rational structural design and refined synthetic strategies,leading to their emerging applications including energy conversion,nonlinear optics,data storage and memory,as well as chemo/biosensing.

关键词： Polymetallayne Molecular metallayne Metallated graphyne Platinum Mercury Gold

Dietary exposure to di-isobutyl phthalate increases urinary 5-methyl-2′-deoxycytidine level and affects reproductive function in adult male mice

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Journal of Environmental Sciences 2017年第11期29卷 14-23页

作者： Yitao Pan Xiaoyang w.ng Leo w.Y.yeung Nan Sheng Qianqian Cui Ruina Cui Hongxia Zhang Jiayin Dai Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Man-Technology-Environment Research Centre (MTM) School of Science and Technology Orebro University Orebro SE -70182 Sweden

Phthalates are a large family of ubiquitous environmental pollutants suspected of being endocrine disruptors. Epidemiological studies have associated phthalate metabolites with decreased reproductive parameters and linked phthalate exposure with the level of urinary 5-methyl-2′-deoxycytidine（5mdC, a product of methylated DNA）. In this study, adult male mice were exposed to 450 mg di-isobutyl phthalate（DiBP）/（kg·day） via dietary exposure for 28 days. Mono-isobutyl phthalate（Mi BP, the urinary metabolite） and reproductive function parameters were determined. The levels of 5mdC and 5-hydroxymethyl-2′-deoxycytidine（5hmdC） were measured in urine to evaluate if their contents were also altered by DiBP exposure in this animal model. Results showed that DiBP exposure led to a significant increase in the urinary 5mdC level and significant decreases in sperm concentration and motility in the epididymis, accompanied with reduced testosterone levels and downregulation of the P450 cholesterol side-chain cleavage enzyme（P450scc） gene in the mice testes. Our findings indicated that exposure to DiBP increased the urinary 5mdC levels,which supported our recent epidemiological study about the associations of urinary 5mdC with phthalate exposure in the male human population. In addition, DiBP exposure impaired male reproductive function, possibly by disturbing testosterone levels; P450scc might be a major steroidogenic enzyme targeted by DiBP or other phthalates.

关键词： Di-isobutyl phthalate(DiBP) 'Reproductive function' 5-Methyl-2′-deoxycytidine(5mdC) 'Testosterone 'Deoxyribonucleic acid(DNA) methylation