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胶州湾内外沉积物岩芯中多氯萘的分布特征研究

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环境科学学报 2011年第4期31卷 816-823页

作者：潘静杨永亮杨伟贤路国慧谷保佐知山下信义国家地质实验测试中心中国地质科学院生态地球化学重点开放实验室北京100037 多伦多大学日本综合产业技术研究所

利用13C同位素稀释-高分辨率气相色谱-高分辨率质谱法测定了胶州湾内、外沉积物岩芯中多氯萘(PCNs)异构体的含量,对其同系物分布、可能来源、沉积通量及毒性当量进行了初步探讨,并研究了由各类来源PCNs进入到胶州湾的历史沉积趋势.结果... 详细信息

利用13C同位素稀释-高分辨率气相色谱-高分辨率质谱法测定了胶州湾内、外沉积物岩芯中多氯萘(PCNs)异构体的含量,对其同系物分布、可能来源、沉积通量及毒性当量进行了初步探讨,并研究了由各类来源PCNs进入到胶州湾的历史沉积趋势.结果表明,胶州湾内、外沉积物岩芯中∑PCNs含量范围分别为3.9～56.4pg·g-1和9.9～29.5pg·g-1(以干重计).胶州湾内、外PCNs同系物分布的共同特点是以三氯代和四氯代CNs为主,占∑PCNs的80%以上,这种同系物组成与工业制品Halowax相似.沉积物岩芯中PCNs沉积通量峰值分别出现在20世纪70年代中期(湾外)和20世纪90年代末(湾内).PCNs各异构体在沉积物垂直剖面中的含量变化表明,在20世纪50年代,PCNs主要来自木柴和煤的燃烧,在20世纪70年代至90年代初期间,有Halowax1014的输入,而垃圾焚烧飞灰的指示性单体PCN66/67和PCN52/60在岩芯上部的含量增长则表明来自城市固体废弃物焚烧的贡献越来越重要.所有样品中PCNs毒性当量含量(TEQ)都小于0.1pg·g-1(以干重计).

关键词：多氯萘沉积物岩芯来源胶州湾

A new osteogenic protein isolated from Dioscorea opposita Thunb accelerates bone defect healing through the mTOR signaling axis

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Bioactive Materials 2023年第9期27卷 429-446页

作者： John Akrofi Kubi Augustine Suurinobah Brah Kenneth Man Chee Cheung yin Lau Lee Kai-Fai Lee Stephen Cho Wing Sze Wei Qiao Kelvin wai-Kwok yeung Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)Hong Kong S.A.R.PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma HKU-Shenzhen HospitalShenzhen518053PR China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineHKU21 Sassoon RoadHong Kong S.A.RPR China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterHKU-Shenzhen HospitalShenzhenPR China Department of Biology Faculty of ScienceHong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Golden Meditech Center for NeuroRegeneration Sciences Hong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Applied Oral Sciences and Community Dental Care Faculty of DentistryHong Kong S.A.RPR China

Delayed bone defect repairs lead to severe health and socioeconomic impacts on patients. Hence, there are increasing demands for medical interventions to promote bone defect healing. Recombinant proteins such as BMP-2 have been recognized as one of the powerful osteogenic substances that promote mesenchymal stem cells (MSCs) to osteoblast differentiation and are widely applied clinically for bone defect repairs. However, recent reports show that BMP-2 treatment has been associated with clinical adverse side effects such as ectopic bone formation, osteolysis and stimulation of inflammation. Here, we have identified one new osteogenic protein, named ‘HKUOT-S2’ protein, from Dioscorea opposita Thunb. Using the bone defect model, we have shown that the HKUOT-S2 protein can accelerate bone defect repair by activating the mTOR signaling axis of MSCs-derived osteoblasts and increasing osteoblastic biomineralization. The HKUOT-S2 protein can also modulate the transcriptomic changes of macrophages, stem cells, and osteoblasts, thereby enhancing the crosstalk between the polarized macrophages and MSCs-osteoblast differentiation to facilitate osteogenesis. Furthermore, this protein had no toxic effects in vivo. We have also identified HKUOT-S2 peptide sequence TKSSLPGQTK as a functional osteogenic unit that can promote osteoblast differentiation in vitro. The HKUOT-S2 protein with robust osteogenic activity could be a potential alternative osteoanabolic agent for promoting osteogenesis and bone defect repairs. We believe that the HKUOT-S2 protein may potentially be applied clinically as a new class of osteogenic agent for bone defect healing.

关键词： Dioscorea spp protein Mesenchymal stem cells(MSCs) Osteoblast differentiation Bone mineral density(BMD) Bone defect repair mTOR signaling pathway

Low-molecular-weight estrogenic phytoprotein suppresses osteoporosis development through positive modulation of skeletal estrogen receptors

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Bioactive Materials 2024年第12期42卷 299-315页

作者： John Akrofi Kubi Augustine Suurinobah Brah Kenneth Man Chee Cheung Andy Chun Hang Chen yin Lau Lee Kai-Fai Lee Wei Qiao Yibin Feng Kelvin wai Kwok yeung Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma HKU-Shenzhen HospitalShenzhen518053PR China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineHKU21 Sassoon RoadPR China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterHKU-Shenzhen HospitalShenzhenPR China Applied Oral Sciences and Community Dental Care Faculty of DentistryPR China School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)PR China

Age-related osteoporosis is a metabolic skeletal disorder caused by estrogen deficiency in postmenopausal *** use of anti-osteoporotic drugs such as bisphosphonates and FDA-approved anti-resorptive selective estrogen receptor modulators(SERMs)has been associated with various clinical *** recently discovered a low-molecular-weight biocompatible and osteoanabolic phytoprotein,called HKUOT-S2 protein(32 kDa),from Dioscorea opposita Thunb that can accelerate bone defect ***,we demonstrated that the HKUOT-S2 protein treatment can enhance osteoblasts-induced ossification and suppress osteoporosis development by upregulating skeletal estrogen receptors(ERs)ERα,ERβ,and GPR30 expressions in ***,HKUOT-S2 protein estrogenic activities promoted hMSCs-osteoblasts differentiation and functions by increasing osteogenic markers,ALP,and RUNX2 expressions,ALP activity,and osteoblast biomineralization in *** treatment impaired the HKUOT-S2 protein-induced ERs expressions,osteoblasts differentiation,and ***,we demonstrated that the HKUOT-S2 protein could bind to ERs to exert osteogenic and osteoanabolic *** results showed that the biocompatible HKUOT-S2 protein can exert estrogenic and osteoanabolic properties by positively modulating skeletal estrogen receptor signaling to promote ossification and suppress ***,there is no or limited data if any,on osteoanabolic *** HKUOT-S2 protein can be applied as a new osteoanabolic SERM for osteoporosis treatment.

关键词： Ovariectomy(ovx) Osteoporosis Osteoblast functions Estrogen receptors(ERs) HKUOT-S2 protein

Planar scintigraphy in assessment of mandibular asymmetry: Unilateral condylar hyperplasia vs asymmetric mandibular hyperplasia

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Journal of Biomedical Science and Engineering 2012年第12期5卷 836-844页

作者： Lo John Yau Yat yin yeung wai Chow David Cheung Lim Kwong Department of Diagnostic Imaging Hong Kong Adventist Hospital Hong Kong China Discipline of Oral and Maxillofacial Surgery Faculty of Dentistry the University of Hong Kong Hong Kong China

Objectives: To 1) explore the planar scintigraphic findings in asymmetry patients caused by unilateral condylar hyperplasia (UCH) or asymmetric mandibular hyperplasia (AMH);2) develop a local agecondylar activity reference norm;and 3) check the accuracy of the new norm and compare with other analytical methods. Material and Method: Chinese patients with mandibular asymmetry and scintigraphic findings available were recruited. Clinical, radiographic records and scintigraphic condylar activity ratio (CAR) were studied. Regression analysis was performed to quantify the relationship between age and CAR to develop a new norm. The sensitivity of condylar activity assessment using a) traditional norm;b) new norm;and c) percentile difference was compared. In patients with serial data available, longitudinal analysis of the scintigraphic changes were checked. Result: 109 patients were eligible for the study. Significant difference in CAR was noted between UCH and AMH patients. Linear relationship was observed between age and CAR. A new norm of the age-CAR was established, which showed improved sensitivity in condylar activity prediction in UCH and AMH when compared with traditional norm. Relative to percentile difference, the sensitivity of new norm was lower in AMH but not in UCH patients. Serial analysis revealed gradual decline in CAR with minimal change in percentile difference. Conclusion and Clinical Relevance: There is difference in scintigraphic condylar activity between UCH and AMH patients. A norm of age-CAR relationship was established, which showed improved sensitivity in condylar activity prediction in UCH patients. Further study is required to confirm the role of scintigraphy in AMH.

关键词： cintigraphy Bone Scan Facial Asymmetry Mandibular Asymmetry Unilateral Condylar Hyperplasia

Using recombinant adhesive proteins as durable and green flame-retardant coatings

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Synthetic and Systems Biotechnology 2021年第4期6卷 369-376页

作者： Weng I.leong Owen Lok In Lo Fong Tin Cheng wai Man Cheong leo Chi U.Seak Pui Ching Middle School(Macao) Edificio Pui Ching7A Av.de Horta e CostaMacao SARChina Department of Physiology Development and NeuroscienceUniversity of CambridgeCambridgeCB23DYUnited Kingdom The Centre for Inflammation Research University of Edinburgh47 Little France CrescentEdinburghEH164TJUnited Kingdom

Current fire retardants are known to be toxic to humans and our *** environmental-friendly flame retardants(FRs),protein-based flame retardants have been studied extensively recently,even though they are not *** this study,we designed,synthesized and tested a durable protein-based FR through the fusion of the adhesion domain from either mussel foot protein-5(mfp-5)or cellulose-binding domain(CBD)with flame retardant protein(SR protein and alpha casein).We first verified the expression of the recombinant proteins in Escherichia coli using Western ***,we coated the fusion protein(carrying cell lysates)to cotton fabrics and wood and verified with Infrared(IR)*** a vertical burning test and wood flammability test,we confirmed the flame retardancy of the materials after the protein *** the vertical burning test,the SR protein and alpha casein flame retardant proteins with the CBD adhesion domain showed a 50.0%and 43.3%increase in flame *** data is also consistent in the wood flame retardancy *** imaging experiments also suggested these new fire retardants can be preserved on the materials well even after ***,our results showed that flame-retardant proteins with adhesion domains are high potential candidates of green alternative flame retardants.

关键词： Flame retardant protein Cellulose-binding domain(CBD) Mussel foot protein-5(mfp-5)

Facile and Green Synthesis of α,β-Unsaturated Ketone Catalyzed by Air-Stable Organobismuth Complex

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Advances in Materials Physics and Chemistry 2012年第4期2卷 142-145页

作者： Renhua Qiu Yimiao Qiu Zhengong Meng Xingxing Song Zhenyong Jia Shuangfeng yin Chak- Tong Au wai-yeung Wong Collenge of Chemistry and Chemical Engineering Hunan University Changsha 410082 P.R. China Department of Chemistry Hong Kong Baptist Universtiy Hong Kong China Department of Chemistry Hong Kong Baptist Universtiy Hong Kong China Wong

Air-stable cationic organobismuth complexes (2-5) possessing both acidic and basic characters were synthesized. The catalyst system that comprises an air-stable bifunctional Lewis acidic/basic organobismuth complex and [Bmim]BF4 showed high catalytic activity, diastereoselec-tivity, stability, and reusability in the one-pot synthesis of (E)-α,β-unsaturat-ed ketones through highly selective crossed-condensation of ketones and aldehydes. Through switching the reaction from homogeneous to heterogeneous, the system shows facile separation ability and facile reusability.

关键词： α β-Unsaturated Ketone Catalysis Facile Seperation Catalytic System Organobismuth .Synthesis

Validation of genetic variants associated with metabolic dysfunctionassociated fatty liver disease in an ethnic Chinese population

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World Journal of Hepatology 2020年第12期12卷 1228-1238页

作者： Guan Huei Lee Wah Wah Phyo wai Mun Loo Raymond Kwok Taufique Ahmed Asim Shabbir Jimmy So Calvin Jianyi Koh Juanda leo Hartono Mark Muthiah Kieron Lim Poh Seng Tan yin Mei Lee Seng GeeLim Yock Young Dan Division of Gastroenterology and Hepatology Department of MedicineNational University Health SystemSingapore 119228Singapore Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Medicine Khoo Teck Puat HospitalSingapore 768828Singapore Department of Surgery National University Health SystemSingapore 119228Singapore

BACKGROUND Genetic factors play an important role in the pathogenesis and development of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To study the association of single nucleotide polymorphisms(SNPs),previously identified in Western populations,with the risk of MAFLD in a Singapore Chinese population and their interactions with environmental and medical risk *** A retrospective case-control study was conducted with 72 MAFLD cases and 72 controls with no hepatic steatosis on computed tomography,magnetic resonance imaging,or controlled attenuation parameter *** were recruited from two tertiary *** alleles such as NCAN,GCKR,LYPLAL1,PNPLA3,PPP1R3B,FDFT1,COL13A1,EFCAB4B,PZP,and TM6SF2 were genotyped using the TaqMan®Predesigned SNP Genotyping *** Weight and body mass index(BMI)were 1.2-times higher in patients(70.6 kg,95%confidence interval[CI]:57.1-84.1 vs 60.8 kg,95%CI:48.5-73.1,P<0.001 and 26.9 kg,95%CI:23-40.8 vs 23.3 kg 95%CI:19-27.6,P<0.001 respectively).The prevalence of diabetes mellitus in patients was 40.3%and 20.8%in controls(P=0.011).Patients had higher mean triglycerides than controls(P<0.001).PNPLA3 GG was more likely to be associated with MAFLD(43.4%CC vs 69.7%GG,P=0.017,and 44.8%CG vs 69.7%GG,P=0.022).In multivariable analysis,hypertriglyceridemia(odds ratio[OR]:2.0495%CI:1.3-3.1,P=0.001),BMI(OR:1.295%CI:1.1-1.4,P<0.001)and PNPLA3 GG(OR:3.495%CI:1.3-9.2,P=0.014)were associated with MAFLD(area under the receiver operating characteristic curve of 0.823).CONCLUSION Among the Chinese population of Singapore,PNPLA3 homozygous GG allele is a strong predictor of MAFLD,whereas LYPLAL1,GCKR,FDFT1,COL13A1,PZP,and TM6SF2 are not significantly ***,high BMI,and PNPLA3 GG are independent predictors of MAFLD.

关键词： Single nucleotide polymorphism PNPLA3 Genotyping Metabolic dysfunction-associated fatty liver disease Non-alcoholic steatohepatitis Hypertriglyceridemia Body mass index waist-hip ratio,Screening Hepatic steatosis

国际SCI期刊导航《Environmental Science & Technology》

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岩矿测试 2014年第6期33卷 908-908页

作者：杨伟贤多伦多大学

《Environmental Science＆Technology》（缩写为：ES＆T,印刷版ISSN：0013-936X,网络版ISSN：1520-5851）由美国化学学会出版,现为半月刊,是目前全球公认的环境科学领域权威杂志。《ES＆T》2013年度影响因子为5.481,在环境工程和科学... 详细信息

《Environmental Science＆Technology》（缩写为：ES＆T,印刷版ISSN：0013-936X,网络版ISSN：1520-5851）由美国化学学会出版,现为半月刊,是目前全球公认的环境科学领域权威杂志。《ES＆T》2013年度影响因子为5.481,在环境工程和科学类期刊中居于首位,被引频次为105646次。《ES＆T》现任主编为美国爱荷华大学的Jerald Schnoor教授,该刊亚太地区地区副主编是中国科学院生态研究中心江桂斌院士和香港理工大学李向东教授。

关键词：期刊 SCI 美国化学学会香港理工大学导航国际环境科学中国科学院

Peptidic defective interfering gene nanoparticles against Omicron,Delta SARS-CoV-2 variants and influenza A virus in vivo

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3484-3493页

作者： Hanjun Zhao Chuyuan Zhang Hoiyan Lam Xinjie Meng Zheng Peng Man Lung yeung Jasper Fuk-Woo Chan Kelvin Kai-Wang To Kwok-Yung Yuen State Key Laboratory of Emerging Infectious Diseases Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Department of Microbiology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong Special Administrative RegionChina Department of Infectious Disease and Microbiology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdong ProvinceChina Carol Yu Centre for Infection The University of Hong KongPokfulamHong Kong Special Administrative RegionChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina

Defective interfering genes(DIGs)are short viral genomes and interfere with wild-type viral ***,we demonstrate that the new designed SARS-CoV-2 DIG(CD3600)can significantly inhibit the replication of SARS-CoV-2 including Alpha,Delta,Kappa and Omicron variants in human HK-2 cells and influenza DIG(PAD4)can significantly inhibit influenza virus replication in human A549 *** dose of influenza DIGs prophylactically protects 90%mice from lethal challenge of A(H1N1)pdm09 virus and CD3600 inhibits SARS-CoV-2 replication in hamster lungs when DIGs are administrated to lungs one day before viral *** further investigate the gene delivery vector in the respiratory tract,a peptidic TAT2-P1&LAH4,which can package genes to form small spherical nanoparticles with high endosomal escape ability,is demonstrated to dramatically increase gene expression in the lung ***2-P1&LAH4,with the dual-functional TAT2-P1(gene-delivery and antiviral),can deliver CD3600 to significantly inhibit the replication of Delta and Omicron SARS-CoV-2 in hamster *** peptide-based nanoparticle system can effectively transfect genes in lungs and deliver DIGs to inhibit SARS-CoV-2 variants and influenza virus in vivo,which provides the new insight into the drug delivery system for gene therapy against respiratory viruses.

关键词： influenza vivo Delta