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Sporadic somatic mutation of c-kit gene in a family with gastrointestinal stromal tumors without cutaneous hyperpigmentation

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World Journal of Gastroenterology 2006年第11期12卷 1813-1815页

作者： Chun-Nan yeh tsung-Wen Chen Department of Surgery Chang Gung Memorial Hospital Chang Gung University 5Fu-Hsing StreetKwei-ShanTaoyuanTaiwanChina

We described two members in a family with gastrointestinal stromal tumors （GISTs） without cutaneous hyperpigmentation. The patients were father and son who did not have cutaneous hyperpigmentation. Histological examination showed that these tumors were GISTs expressing CD34 and CD117. Tumor DNA extracted from paraffin-embedded specimens revealed somatic mutation with a deletion mutation at different codons in exon 11 of c-kit gene after direct sequencing analysis. No germline mutation was detected in DNA extracted from peripheral leukocytes obtained from the father and son. We propose that GISTs could be caused by sporadic somatic mutation in a family without germline mutation and hyperpigmentation.

关键词： Sporadic GIST Somatic c-kit mutation

Intense blue-emitting Ca_2PO_4Cl:Eu^(2+) phosphor for near-ultraviolet converting white light-emitting diodes

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Journal of Rare Earths 2010年第S1期28卷 250-253页

作者： Yi-Chen Chiu Chun-Kuei Chang Yao-tsung yeh Shyue-Ming Jang Material and Chemical Research Laboratories Industrial Technology Research Institute Phosphors Research Laboratory and Department of Applied Chemistry National Chiao Tung University

A blue phosphor Ca2PO4Cl:Eu2+(CAP:Eu2+) was synthesized by solid state *** Ca2PO4Cl:Eu2+ exhibited high quantum efficiency and excellent thermal *** luminescent intensity of Ca2PO4Cl:Eu2+ was found to be 128% under excitation at 380 nm,149% under 400 nm,and 247% under 420 nm as high as that of BaMgAl10O17:Eu2+.The optimal doping concentration was observed to 11 mol.% of CAP:Eu2+.The energy transfer between Eu2+ ions in CAP were occurred via electric multipolar interaction,and the critical transfer distance was estimated to be 1.26 nm.A mixture of blue-emitting Ca2PO4Cl:Eu2+,green-emitting(Ba,Sr)2SiO4:Eu2+ and red-emitting CaAlSiN3:Eu2+ phosphors were selected in conjunction with 400 nm chip to fabricate white LED *** average color-rendering index Ra and correlated color temperature(Tc) of the white LEDs were found to be 93.4 and 4590 K,*** results indicated that it was a promising candidate as a blue-emitting phosphor for the near-UV white light-emitting diodes.

关键词： Ca2PO4Cl:Eu2+ phosphors luminscense rare earths

Advanced gastrointestinal stromal tumor patients with complete response after treatment with imatinib mesylate

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World Journal of Gastroenterology 2006年第13期12卷 2060-2064页

作者： Kun-Chun Chiang tsung-Wen Chen Chun-Nan yeh Hsiang-Lin Lee Department of Surgery and Nuclear Medicine Chang Gung Memorial Hospital Chang Gung UniversityTaoyuanTaiwanChina

AIM： Most gastrointestinal stromal tumors （GISTs） express constitutively activated mutant isoforms of kit kinase or platelet-derived growth factor receptor alpha （PDGFRA）, which are potential therapeutic targets for imatinib mesylate （Glivec）. Partial response occurred in almost two thirds of GIST patients treated with Glivec. However, complete response （CR） after Glivec therapy was sporadically reported. here we illustrated advanced GIST patients with CR after Glivec treatment. METHODS： Between January 2001 and June 2005, 42 advanced GIST patients were treated with Glivec. Patients were administered 400 mg of Glivec in 100-mg capsules, taken orally daily with food. The response of the tumor to Glivec was evaluated after one month, three months, and every three months thereafter or whenever medical need was indicated. Each tumor of patients was investigated for mutations of kit or PDGFRA. RESULTS： The median follow-up time of the 42 ad-vanced GIST patients treated with Glivec was 16.9 months （range, 1.0- 47.0 months）. Overall, 3 patients had complete response CR （7.1%）, 26 partial response （67.8%）, 5 stationary disease （11.9%）, and 3 progressive disease （11.9%）. The median duration of Glivec administration for the three patients was 36 months （range, 23-36 months）. The median time to CR after Glivec treatment was 20 months （range, 9-26 months）. Deletion and insertion mutations of c-kit exon 11 and insertion mutation of c-kit exon 9 were found in two cases and one case, respectively. CONCLUSION： Complete response （CR） can be achieved in selected advanced GIST patients treated with Glivec. The median time to CR after Glivec treatment was 20 months. Deletion and insertion mutations of kit exon 11 and insertion mutation of kit exon 9 contribute to the genetic features in these selected cases.

关键词： GIST Complete response Imatinib mesylate

Mucosal patterns of Helicobacter pylori-related gastritis without atrophy in the gastric corpus using standard endoscopy

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World Journal of Gastroenterology 2010年第4期16卷 496-500页

作者： Shwu-Tzy Wu Chien-Hua Chen yeh-Huang Hung tsung-Hsun Yang Vun-Siew Pang Yung-Hsiang yeh Department and Graduate Program of Bioindustrial Technology Dayeh UniversityChanghua County 51591TaiwanChina Division of Gastroenterology Department of Internal MedicineShow-Chwan Memorial HospitalChanghuaCity 500TaiwanChina Division of Gastroenterology Department of Internal MedicineChang Bing Show-Chwan Memorial HospitalChanghua County 505TaiwanChina

AIM:To identify the mucosal patterns of Helicobacter pylori(*** )-related gastritis in the gastric corpus using standard endoscopy and to evaluate their ***:A total of 112 consecutive patients underwent upper gastrointestinal *** endoscopists classified the endoscopic findings into 4 *** the second part of the study,90 images were shown to 3 endoscopists in order to evaluate the inter-observer and intra-observer variability in image ***:The mucosal patterns of the gastric bodywere categorized into 4 *** 1 pattern was defined as cleft-like appearance,type 2 as regular arrangement of red dots,type 3 pattern as the mosaic mucosal pattern and type 4 pattern as the mosaic pattern with a focal area of *** 1 and type 2 mucosal patterns were statistically significant in predicting *** status as compared with other mucosal types(χ 2 = 12.79 and 61.25 respectively,P her mucosal types(χ 2 = 21.22 and 11.02 respectively,P hermore,the sensitivity,specificity,positive and negative predictive values of type 3 plus type 4 patterns for predicting ***-positive gastric mucosa were 100%,86%,94%,and 100%,*** mean κ values for inter-and intra-observer agreement in assessing the various endoscopic patterns were 0.808(95% CI,0.678-0.938) and 0.826(95% CI,0.727-0.925) ***:Our study suggests that mucosal patterns in ***-infected gastric mucosa without atrophy can be reliably identified using standard endoscopy in the gastric corpus.

关键词： Gastric mucosa Helicobacter pylori Gastritis Digestive system diagnostic techniques Endoscopy

Treatment of patients with advanced gastrointestinal stromal tumor of small bowel: Implications of imatinib mesylate

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World Journal of Gastroenterology 2006年第23期12卷 3760-3765页

作者： Chun-Nan yeh tsung-Wen Chen Ting-Jung Wu Swei Hsueh Yi-Yin Jan Department of Surgery Chang Gung Memorial HospitalChang Gung University5 Fu-Hsing StreetKwei-ShanTaoyuanTaiwanChina Department of Pathology Chang Gung Memorial HospitalChang Gung University5 Fu-Hsing StreetKwei-ShanTaoyuanTaiwan China

AIM： To examine the impact of imatinib mesylate （Glivec） on patient survival and response and its safety, and the correlation of the response rate with the kit gene mutation status. METHODS： Thirty-three of 74 （44.6%） small bowel gastrointestinal stromal tumor （GIST） patients who developed recurrence after curative resection and not treated with Glivec were classified as group A patients. Twenty-two advanced small bowel GIST patients treated with Glivec were classified as group B patients. Clinicopathological features, post-recurrence and overall survival rates were compared. Each tumor in group B patients was investigated for mutations of kit or plateletderived growth factor alpha （PDGFRA）. The mutation type was correlated with clinical outcomes. The antitumor effect and safety of Glivec in group B patients were also assessed. RESULTS： Advanced small bowel GIST patients treated with Glivec had substatntially longer post-recurrence survival and higher overall survival rates than those not treated with Glivec. A total of 15 patients had a partial response （PR）（67.8%）. Activated mutations of c-kit were found in 16 of 19 tested patients and no PDGFRA mutant was identified. In 13 patients with GISTs harboring exon 11 kit mutations, the partial response rate （PR） was 69.3%, whereas two of three patients with tumors containing an exon 9 kit mutation had an overall response rate （ORR） of 66.7% （not significant）. CONCLUSION： Glivec significantly prolongs the postrecurrence and overall survival of Asian patients with advanced GISTs. Glivec induces a sustained objective response in more than half of Asian patients withadvanced small bowel GISTs. Activated mutations of kit exon 11 are detectable in the vast majority of GISTs. There is no difference in the PR rate for patients whose GISTs have kit exon 9 and exon 11 mutations.

关键词： Gastrointestinal stromal tumor Glivec Patient survival Kit gene mutation

A novel method of supporting gold nanoparticles on MWCNTs: Synchrotron X-ray reduction

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China Particuology 2007年第3期5卷 237-241页

作者： Kuan-Nan Lin tsung-yeh Yang Hong-Ming Lin Yeu-Kuang Hwu She-Huang Wu Chung-Kwei Lin Department of Materials Engineering Tatung University Taipei 104 Taiwan China Institute of Physics Academia Sinica 128 Academia Road Nankang Taipei 115 Taiwan China Department of Materials Science and Engineering Feng Chia University 407 Taichung Taiwan China

Gold nanoparticles decorating the surface of multiwalled carbon nanotubes （MWCNTs） are prepared by photochemical reduction. The gold clusters form different interesting geometrical faceted shapes in accordance to time duration of synchrotron X-ray irradiation. The shape of nanogold could be spherical, rod-like, or triangular. Carbon nanotubes serve as optimal templates for the heterogeneous nucleation of gold nanocrystals. These nanocrystal structures are characterized by transmission electron microscope （TEM） and element analysis by energy dispersive spectroscopy （EDS）. 2007 Chinese Society of Particuology and Institute of Process Engineering,Chinese Academy of Sciences. Published by Elsevier B.V.

关键词： Gold MWCNT Heterogeneous nucleation Synchrotron X-ray irradiation

Innovative chest wall reconstruction with a locking plate and cement spacer after radical resection of chondrosarcoma in the sternum: A case report

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World Journal of Clinical Cases 2021年第10期9卷 2302-2311页

作者： Chung-Wei Lin tsung-Yu Ho Chen-Wei yeh Hsien-Te Chen I-Ping Chiang Yi-Chin Fong Department of Orthopedic Surgery China Medical University HospitalChina Medical UniversityTaichung City 40454Taiwan Department of Education China Medical University HospitalChina Medical UniversityTaichung City 40447Taiwan Department of Sports Medicine College of Health CareChina Medical UniversityTaichung City 40402Taiwan Spine Center China Medical University HospitalChina Medical UniversityTaichung City 40454Taiwan Department of Pathology China Medical University HospitalChina Medical UniversityTaichung 40454Taiwan Department of Orthopedic Surgery China Medical University Beigang HospitalYunlin County 65152Taiwan

BACKGROUND Chondrosarcoma,a cartilage matrix producing tumor,is the second most commonly observed primary bone tumor after osteosarcoma,accounting for 15%of all chest wall *** herein report the case of a patient with chondrosarcoma of the sternum and our management of the chest wall defects that presented following radical tumor *** SUMMARY A 31-year-old patient presented to our hospital with dull pain and a protruding mass overlying the chest for 3 *** presence of nocturnal pain and mass size progression was reported,as were overhead arm elevation-related *** tomography showed a focal osteoblastic mass in the sternum with bony exostosis and adjacent soft tissue *** emission tomography-computed tomography revealed hypermetabolic activity with a mass located over the upper *** resonance imaging showed a focal illdefined bony mass of the sternum with cortical destruction and periosteal *** biopsy showed a consistent result with chondrosarcoma with immunohistochemical positivity for S100 and focal positivity for *** grade II chondrosarcoma diagnosis was confirmed by postoperative *** patient underwent radical tumor resection and chest wall reconstruction with a locking plate and cement *** patient was discharged 1 wk after surgery without any *** the 1-year follow-up,there was no local recurrence on *** functional scores,including Constant Score,Nottingham Clavicle Score,and Oxford Shoulder Score,showed the absence of pain in the performance of daily activities or substantial functional *** The diagnosis of chondrosarcoma must be considered when chest wall tumors are *** surgical reconstructive materials,with a locking plate and cement spacer,used in our study are cost-effective and readily-available for the sternum defect.

关键词： Chondrosarcoma Sternum Chest wall Cement Reconstruction Case report

Predictors of rebleeding after initial hemostasis with epinephrine injection in high-risk ulcers

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World Journal of Gastroenterology 2010年第43期16卷 5490-5495页

作者： Ming-Luen Hu King-Wah Chiu Yi-Chun Chiu yeh-Pin Chou tsung-Hui Hu Shue-Shian Chiou Seng-Kee Chuah Division of Hepatogastroenterology Department of Internal Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Chang Gung University College of Medicine

AIM: To identify the predictors of rebleeding after initial hemostasis with epinephrine injection (EI) in patients with high-risk ulcers. METHODS: Recent studies have revealed that endoscopic thermocoagulation, or clips alone or combined with EI are superior to EI alone to arrest ulcer bleeding. However, the reality is that EI monotherapy is still common in clinical practice. From October 2006 to April 2008, high-risk ulcer patients in whom hemorrhage was stopped after EI monotherapy were studied using clinical, laboratory and endoscopic variables. The patients were divided into 2 groups: sustained hemostasis and rebleeding. RESULTS: A total of 175 patients (144, sustainedhemostasis; 31, rebleeding) were enrolled. Univariate analysis revealed that older age (≥ 60 years), advanced American Society of Anesthesiology (ASA) status (category Ⅲ , Ⅳ and Ⅴ ), shock, severe anemia (hemoglobin herapy in patients with high-risk ulcers should be avoided. Initial hemostasis with thermocoagulation, clips or additional hemostasis after EI is mandatory for such patients to ensure better hemostatic status and to prevent subsequent rebleeding, surgery, morbidity and mortality.

关键词： Epinephrine injection High-risk ulcers Initial hemostasis Predictors Rebleeding

Sunitinib for Taiwan Residents patients with gastrointestinal stromal tumor after imatinib treatment failure or intolerance

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World Journal of Gastroenterology 2011年第16期17卷 2113-2119页

作者： Yen-Yang Chen Chun-Nan yeh Chi-Tung Cheng tsung-Wen Chen Kun-Ming Rau Yi-Yin Jan Miin-Fu Chen Division of Hematology-Oncology Department of Internal MedicineChang Gung Memorial HospitalKaohsiung Medical Center GIST team Department of SurgeryChang Gung Memorial Hospital and University

AIM:To report preliminary results of the efficacy and safety of sunitinib in the management of Taiwan Residents gastrointestinal stromal tumors (GIST) patients facing imatinib mesylate (IM) intolerance or ***:Between 2001 and May 2010,199 Taiwan Residents patients with metastatic GIST were treated at Chang Gung Memorial *** them,23 (11.6%) patients receiving sunitinib were ***:Sixteen male and 7 female patients with a median age of 59 years (range:24-83 years) received ***-two GIST patients changed to sunitinib because of IM failure and 1 because of *** median duration of sunitinib administration was 6.0 mo (range:2-29 mo).The clinical benefit was 65.2% [2 complete response (CR),4 partial response (PR),and 9 stationary disease (SD);15/23].In 12 patients harboring mutations of the kit gene at exon 11,the clinical benefit rate (CR,PR,and SD) was 75.0% and 6 patients with tumors containing kit exon 9 mutations had a clinical benefit of 50.0% (not significant,P=0.344).The progression free survival (PFS) and overall survival (OS) did not differ between patients whose GISTs had wild type,KIT exon 9,or KIT exon 11 ***-foot syndrome was the most common cause of grade Ⅲ adverse effect (26.1%),followed by anemia (17.4%),and neutropenia (13.0%).During the median 7.5-mo follow-up after sunitinib use,the median PFS and OS of these 23 GIST patients after sunitinib treatment were 8.4 and 14.1 mo,***:Sunitinib appears to be an effective treatment for Taiwan Residents with IM-resistant/intolerant GISTs and induced a sustained clinical benefit in more than 50% of Taiwan Residents advanced GIST patients.

关键词： Suintinib Gastrointestinal stromal tumors Imaitinib Failure or intolerance