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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-fang Wu Yi-Sheng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(ye).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while ye had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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Influence of foreign direct investment from China on achieving the 2030 Sustainable Development Goals in African countries

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Chinese Journal of Population,Resources and Environment 2021年第3期19卷 213-220页

作者： ye fang School of Economics and Finance Huaqiao UniversityQuanzhou362000China

The lack of funding is one of the most important challenges in achieving the 2030 Sustainable Development Goals(SDGs)in African *** foreign direct investment(FDI)from China as an important source of external financing help African countries achieve their SDGs?This study used the panel data random effects model to analyze the influence of China’s direct investment on SDG ***,the study conducted the ordered probit model to examine the influence of FDI from China on the trend of achieving each SDG in Africa,with the SDGs being grouped into social,economic,and environmental *** showed that China’s direct investment contributed to the achievement of SDGs in *** from China positively influenced the SDG score in general and some of the 17 SDG scores including SDG 7(Affordable and Clean Energy),SDG 8(Decent Work and Economic Growth),SDG 9(Industry,Innovation,and Infrastructure),SDG 12(Responsible Consumption and Production),SDG 13(Climate Action),and SDG 15(Life on Land).The relationship between FDI from China and the trends for SDG 7,8,9,11(Sustainable Cities and Communities),and 14(Life below Water)was significantly ***,the SDG scores above belonged to the economic and environmental dimensions,whereas FDI from China had no significant influence on the social-dimension SDG scores and *** further expand the scale of China’s direct investment,more investment scopes,particularly those in the social dimension,should be ***,China-Africa cooperation should be deepened to create a good investment environment for the achievement of African countries’SDGs and to facilitate China’s implementation of promoting the development of developing countries as mentioned in the 2030 Agenda of Sustainable Development and building the China-Africa community with a shared future.

关键词： Sustainable Development Goals Africa Foreign direct investment 2030 Agenda of Sustainable Development

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Reconfigurable parallel mechanisms with planar five-bar metamorphic linkages

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Science China(Technological Sciences) 2014年第1期57卷 210-218页

作者： ye Wei fang YueFa GUO Sheng Department of Mechanical Engineering Beijing Jiaotong University

This paper presents the idea of constructing reconfigurable limbs by integrating metamorphic linkages as *** planar five-bar metamorphic linkages that have three phases resulting from locking of motors are *** the assumption that the constraint exerted by the reconfigurable limb can switch between no constraint,a constraint force,and a constraint couple,the output motions of the metamorphic linkage in its two planar four-bar linkage phases are *** adding an appropriate joint to planar four-bar linkages with translational output,four planar five-bar linkages that can be employed in the construction of reconfigurable limbs are *** chains that can provide a constraint couple and a constraint force are synthesized based on screw *** limbs that have three configurations associated with the three distinct phases of the metamorphic linkages are assembled with planar five-bar metamorphic linkages and serial chains with four degrees of freedom.A class of reconfigurable parallel mechanisms are constructed by connecting a moving platform and a base with three identical reconfigurable *** degrees of freedom of the reconfigurable parallel mechanism in different configurations with the metamorphic linkages in different phases are ***,the actuation scheme for this kind of mechanisms is addressed.

关键词： reconfigurable limb planar five-bar metamorphic linkage screw theory reconfigurable parallel mechanism actuation scheme

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East Asian monsoon intensification promoted weathering of the magnesium-rich southern China upper crust and its global significance

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Science China Earth Sciences 2021年第7期64卷 1155-1170页

作者： Yibo yang Albert GALY Xiaomin fang Christian FRANCE-LANORD Shiming WAN Rongsheng yang Jian ZHANG Ran ZHANG Song yang Yunfa MIAO Yudong LIU Chengcheng ye Key Laboratory of Continental Collision and Plateau Uplift Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China Centre de Recherches Pétrographiques et Géochimiques UMR7358CNRS-Universitéde LorraineVandoeuvre les Nancy 54500France University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Climate Change Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

The Oligocene-Miocene boundary Asian climatic reorganization linked to the northward migration of the East Asian monsoon into subtropical China is a potentially important but poorly constrained atmospheric CO_(2) consumption ***,we performed a first-order estimate of the CO_(2) consumption induced by silicate chemical weathering and organic carbon burial in subtropical China related to this climatic *** results show that an increase in long-term CO_(2 )consumption by silicate weathering varies from 0.06×10^(12)to 0.87×10^(12)mol yr^(-1)depending on erosion flux reconstructions,with an~50%contribution of Mg-silicate weathering since the late *** organic carbon burial flux is approximately 25%of the contemporary CO_(2) consumption by silicate *** results highlight the significant role of weathering of the Mg-rich upper continental crust in East China,which would contribute to the rapid decline in atmospheric CO_(2) during the late Oligocene and the Neogene rise in the seawater Mg *** this climatic reorganization was mainly induced by the Tibetan Plateau uplift,our study suggests that the growth of the Himalayan-Tibetan Plateau can lead to indirect modification of the global carbon and magnesium cycles by changing the regional hydrological cycle in areas of East Asia that are tectonically less active.

关键词： Tibetan Plateau Late Oligocene Silicate weathering Carbon cycle Oceanic Mg cycle

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Revolutionizing immunology with single-cell RNA sequencing

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Cellular & Molecular Immunology 2019年第3期16卷 242-249页

作者： Haide Chen fang ye Guoji Guo Center for Stem Cell and Regenerative Medicine Zhejiang University School of Medicine310058 HangzhouChina Bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of Medicine310009 HangzhouChina Zhejiang Provincial Key Lab for Tissue Engineering and Regenerative Medicine Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine310058 HangzhouChina Institute of Hematology Zhejiang University310058 HangzhouChina Stem Cell Institute Zhejiang University310058 HangzhouChina

The immune system is composed of a complex hierarchy of cell types that protect the organism against disease and maintain *** heterogeneity of immune cells is the key to understanding the immune *** single-cell RNA sequencing(scRNA-seq)technologies are revolutionizing our ability to study *** measuring transcriptomes at the single-cell level,scRNA-seq enables identification of cellular heterogeneity in far greater detail than conventional *** this review,we introduce the existing scRNA-seq technologies and present their strengths and *** also discuss potential applications and future innovations of scRNA-seq in immunology.

关键词： homeostasis immune maintain

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Radar Cross-Section Measurement Using the Near-Field Single-Frequency Angular-Diversity Technique

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Journal of Systems Engineering and Electronics 2000年第1期11卷 1-7页

作者： ye, Xiaodong fang, Dagang Sheng, Weixing Nanjing Univ of Science and Technology Nanjing China

Radar cross-section (RCS) measurement with the near-field electromagnetic wave illumination of a target has been proved to be practical. The existing methods employ the multiplefrequency angular-diversity (MFAD) technique, whereas this paper considers the single-frequency angular-diversity (SFAD) technique. The paper takes into account the scattering center modeling and the limitation of higher sidelobes in reconstructing images in the SFAD technique compared to the MFAD technique. A method of combining the SFAD technique with the RELAX approach is presented for the high-resolution extraction of scattering centers on a target. The proposed method offers an excellent RCS recovery, which is validated by numerical results.

关键词： Electromagnetic wave scattering Image reconstruction Radar imaging Radar target recognition Relaxation processes

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Extreme climate events,migration for cultivation and policies:A case study in the early Qing Dynasty of China

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Science China Earth Sciences 2007年第3期50卷 411-421页

作者： fang XiuQi ye Yu ZENG ZaoZao School of Geography Beijing Normal UniversityBeijing 100875China Institute of Geographical Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China

Based on the historical records of the annual increase in the workforce (men older than 16 years of age), the annual new taxed cropland in the Shengjing area (Northeast China), the extreme climate events in North China, and related management policies in Northeast China during 1661―1680, a case study has been conducted to investigate the relationship between the extreme climate events in North China and the migration to Northeast China for cultivation. This study has found that the migration to Northeast China for cultivation from 1661 to 1680 was a response to the drought events that occurred in North China. The upsurge of migration, which occurred in 1665―1680, was a response to the drought period during 1664―1680 in North China while the fewer disasters period in Northeast China. There were three migratory peaks during the upsurge of migration, which corresponded to the three drought events. The peaks of migration, however, often lagged behind the drought events about 1―2 years. The encourag-ing-migration policy, which was adopted to encourage cultivation in Northeast China, did not produce much migration into the region in the early Qing Dynasty. It did, however, provide a policy background, which ensured more than 10000 migrants per year to Northeast China when North China suffered from drought/flood disasters. As a response to the highest peak of migration induced by the severe droughts in North China during 1664―1667, a prohibiting-migration policy restricted further migration to Northeast China was carried out in 1668. Although the prohibiting-migration policy could not entirely stop the migrants fleeing from famine in North China to Northeast China, the migrants and cultivation were significantly reduced under the policy. The frequent changes of the policy on the years when taxation started after the land was cultivated were also related to climate events. The extreme climate events in North China, migration to Northeast China for cultivation, and the relat

关键词： migration cultivation extreme climate event Northeast China Qing Dynasty

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成熟度和温度对芙蓉李贮藏期间生理生化特性及蜡质结构的影响

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核农学报 2025年第1期39卷 128-139页

作者：周丹蓉叶新福方智振林炎娟福建省农业科学院果树研究所福建福州350013

为研究成熟度和温度对芙蓉李贮藏期间生理生化特性和果皮蜡质结构的影响,本研究选择2个成熟度(F:约六成熟;S:约八成熟)的芙蓉李,于4、25℃条件下进行试验,分析16个生理生化指标的差异,采用正交偏最小二乘判别法(OPLS-DA)筛选不同成熟度... 详细信息

为研究成熟度和温度对芙蓉李贮藏期间生理生化特性和果皮蜡质结构的影响,本研究选择2个成熟度(F:约六成熟;S:约八成熟)的芙蓉李,于4、25℃条件下进行试验,分析16个生理生化指标的差异,采用正交偏最小二乘判别法(OPLS-DA)筛选不同成熟度芙蓉李在不同温度贮藏期间的主要差异性指标,检测芙蓉李贮藏前后蜡质结构的变化并分析其贮藏效应。结果表明,4℃条件下F与S之间的主要差异性指标为可溶性固形物含量(SS)、果肉硬度(FF)、果皮色度值a^(*)(PC-a^(*))、花色苷(AC)含量、可滴定酸(TA)含量、果皮硬度(PF),25℃时为SS、超氧化物歧化酶(SOD)活性、PC-a^(*)、果皮色度值b*(PC-b*)。不同成熟度果实的SS含量、PC-a^(*)、AC含量均随贮藏天数增加而逐渐上升(S贮藏28 d除外),同一贮藏天数下AC含量在25℃时显著高于4℃时,同一温度同一贮藏天数时S中的SS含量、PC-a^(*)显著高于F;PF、FF和TA含量随贮藏天数的延长而逐渐下降,4℃和F有利于FF和PF的保持,而25℃下TA含量下降更快;SOD活性随贮藏天数的延长先升高后下降,且在25℃和S中下降更显著。芙蓉李蜡质主要以直立片状晶体和颗粒状结晶的形式存在;两种晶体数量和形态的变化可能影响水分的流失,从而影响细胞壁结构的稳定性,进而影响贮藏性。本研究可为芙蓉李的采收和贮藏保鲜提供技术参考。

关键词：芙蓉李成熟度贮藏温度生理生化特性蜡质结构

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Towards gauge unified,supersymmetric hidden strong dynamics

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Chinese Physics C 2021年第1期45卷 16-31页

作者： Cheng-Wei Chiang Sichun Sun fang ye Department of Physics NTUTaipei Department of Physics and Center for Mathematics and Theoretical Physics NCUTaoyuan Institute of Physics Academia SinicaTaipei Physics Division NCTSHsinchu Institute for Advanced Study The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong

We consider a class of models with extra complex scalars that are charged under both the Standard Model and a hidden strongly coupled S U(N)h gauge sector and discuss the seenarios in which the new scalars are identified as the messenger fields that mediate the spontaneously broken supersymmetries from the hidden sector to the visible *** new scalars are embedded into 5-plets and 10-plets of an S(/(5)v gauge group that potentially unifies the Standard Model gauge *** Higgs bosons remain as elementary *** the supersymmetrized version of this class of models,vector-like fermions whose left-handed components are superpartners of the new scalars are *** to the hidden strong force,the new low-energy scalars hadronize before decaying and thus evade the common direct searches of the supersymmetric *** can be seen as a gauge mediation seenario with the scalar messenger fields forming low-energy bound *** also discuss the possibility that in the tower of bound states formed under hidden strong dynamics(of at least the TeV scale),there exist a dark matter candidate and the collider signatures(***,diboson,or dijet)of models that may show up in the near future.

关键词： collider searches beyond the standard model extra complex scalars

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SIMULATION OF SOLUTE TRANSPORT IN A PARALLEL SINGLE FRACTURE WITH LBM/MMP MIXED METHOD

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Journal of Hydrodynamics 2008年第3期20卷 365-372页

作者： TAN ye-fei ZHOU Zhi-fang College of Civil Engineering Hohai University NanJing 210098 China

This article deals with the solute transport in a single fracture with the combination of the Lattice Boltzmann Method （LBM） and Modified Moment Propagation （MMP） method, and this mixed method is proved to have several advantages over the LBM and Moment Propagation （MP） mixed method which leads to negative concentrations under some conditions in computation. The disadvantage of LBM/MP has been overcome to a certain extent. Also, this work presents an LBM solution of modeling single fractures with uniformly or randomly distributed grains, which can provide a new path of applying the LBM in solute transport simulation in fractures.

关键词： Lattice Boltzmann Method (LBM) Modified Moment Propagation (MMP) method LBM/MMP mixed method single fracture solute transport rough fracture

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