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China Ocean Engineering 2024年第2期38卷 233-246页

作者： DING Xin-dong WANG Shu-qing LIU Wen-cheng ye xiao-han College of Engineering Ocean University of ChinaQingdao 266100China Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China Department of Marine Technology Norwegian University of Science and Technology(NTNU)Trondheim NO-7491Norway

The collapse pressure is a key parameter when RTPs are applied in harsh deep-water *** investigate the collapse of RTPs,numerical simulations and hydrostatic pressure tests are *** the numerical simulations,the eigenvalue analysis and Riks analysis are combined,in which the Hashin failure criterion and fracture energy stiffness degradation model are used to simulate the progressive failure of composites,and the“infinite”boundary conditions are applied to eliminate the boundary *** for the hydrostatic pressure tests,RTP specimens were placed in a hydrostatic chamber after filled with *** has been observed that the cross-section of the middle part collapses when it reaches the maximum *** collapse pressure obtained from the numerical simulations agrees well with that in the ***,the applicability of NASA SP-8007 formula on the collapse pressure prediction was also *** has a relatively greater difference because of the ignorance of the progressive failure of *** the parametric study,it is found that RTPs have much higher first-ply-failure pressure when the winding angles are between 50°and 70°.Besides,the effect of debonding and initial ovality,and the contribution of the liner and coating are also discussed.

关键词： reinforced thermoplastic pipes post-buckling behavior progressive failure of composites debonding initial ovality

Advances of nanoparticles in transmucosal drug delivery

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Nano Research 2024年第4期17卷 2874-2885页

作者： Li Zhang Changwei Yang Yingxiang Song Tao Sheng Junyan Li Jicheng Yu xiaohong Wu xiao ye Geriatric Medicine Center Department of EndocrinologyZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014China Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 311121China Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Key Laboratory for Diagnosis and Treatment of Endocrine Gland Diseases of Zhejiang Province Hangzhou 310014China

Transmucosal drug administration represents a potential strategy for enhancing treatment efficacy and reducing side effects by avoiding the first-pass effect into the systemic circulation and delivering therapeutics directly to the target disease ***,many challenges still remain in its clinical application,including low drug availability and limited retention time in the *** burgeoning advancement of nanotechnologies offers great potential to overcome the above limitations,leveraging their distinct advantages of high drug-loading capacity and strong *** this review,the latest developments of nanoparticles(NPs)in transmucosal drug delivery as well as their clinical applications are discussed.

关键词： nanoparticles(NPs) transmucosal drug delivery mucosal barriers biomaterials

Towards hydrometeorological thresholds of reservoir-induced landslide from subsurface strain observations

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Science China(Technological Sciences) 2024年第6期67卷 1907-1922页

作者： ye xiao ZHU HongHu WANG Jia ZHENG WanJi ZHANG Wei SCHENATO Luca PASUTO Alessandro CATANI Filippo School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China Department of Geosciences University of PadovaPadova35131Italy School of Geosciences and Info-Physics Central South UniversityChangsha410083China Department of Information Engineering University of PadovaPadova35131Italy National Research Council-Research Institute for Geo-Hydrological Protection(CNR-IRPI) Padova35127Italy

Synergistic multi-factor early warning of large-scale landslides is a crucial component of geohazard prevention and mitigation efforts in reservoir *** forecasting and early warning based on surface displacements have been widely ***,the lack of direct subsurface real-time observations limits our ability to predict critical hydrometeorological conditions that trigger landslide *** this paper,we leverage subsurface strain data measured by high-resolution fiber optic sensing nerves that were installed in a giant reservoir landslide in the Three Gorges Reservoir(TGR)region,China,spanning a whole hydrologic year since February *** spatiotemporal strain profile has preliminarily identified the slip zones and potential drivers,indicating that high-intensity short-duration rainstorms controlled the landslide kinematics from an observation *** the time lag effect,we reexamined and quantified potential controls of accelerated movements using a data-driven approach,which reveals immediate response of landslide deformation to extreme rainfall with a zero-day *** identify critical hydrometeorological rules in accelerated movements,accounting for the dual effect of rainfall and reservoir water level variations,we thus construct a landslide prediction model that relies upon the boosting decision tree(BDT)algorithm using a dataset comprising daily rainfall,rainfall intensity,reservoir water level,water level fluctuations,and slip zone strain time *** results indicate that landslide acceleration is most likely to occur under the conditions of mid-low water levels(i.e.,57.9 mm and rainfall intensity>24.4 mm/h).Moreover,this prediction model allows us to update hydrometeorological thresholds by incorporating the latest monitoring *** on the shoulder of this landslide case,our study informs a practical and reliable path

关键词： slow-moving landslide fiber-optic monitoring subsurface strain hydrometeorological threshold extreme weather

Thermo-hydro-poro-mechanical responses of a reservoir-induced landslide tracked by high-resolution fiber optic sensing nerves

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1018-1032页

作者： xiao ye Hong-Hu Zhu Gang Cheng Hua-Fu Pei Bin Shi Luca Schenato Alessandro Pasuto School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China School of Computer Science North China Institute of Science and Technology(National Safety Training Center of Coal Mines)Beijing101601China State Key Lab of Coastal and Offshore Engineering Department of Geotechnical EngineeringDalian University of TechnologyDalian116024China National Research Council-Research Institute for Geo-Hydrological Protection(CNR-IRPI) Padova35127Italy Department of Information Engineering University of PadovaPadova35131Italy

Thermo-poro-mechanical responses along sliding zone/surface have been extensively ***,it has not been recognized that the potential contribution of other crucial engineering geological interfaces beyond the slip surface to progressive ***,we aim to investigate the subsurface multiphysics of reservoir landslides under two extreme hydrologic conditions(*** and dry),particularly within sliding *** on ultra-weak fiber Bragg grating(UWFBG)technology,we employ specialpurpose fiber optic sensing cables that can be implanted into boreholes as“nerves of the Earth”to collect data on soil temperature,water content,pore water pressure,and *** Xinpu landslide in the middle reach of the Three Gorges Reservoir Area in China was selected as a case study to establish a paradigm for in situ thermo-hydro-poro-mechanical *** UWFBG-based sensing cables were vertically buried in a 31 m-deep borehole at the foot of the landslide,with a resolution of 1 m except for the pressure *** reported field measurements covering the period 2021 and 2022 and produced the spatiotemporal profiles throughout the *** show that wet years are more likely to motivate landslide motions than dry *** annual thermally active layer of the landslide has a critical depth of roughly 9 m and might move downward in warmer *** dynamic groundwater table is located at depths of 9e15 m,where the peaked strain undergoes a periodical response of leap and withdrawal to annual hydrometeorological *** interface behaviors may support the interpretation of the contribution of reservoir regulation to slope stability,allowing us to correlate them to local damage events and potential global *** paper also offers a natural framework for interpreting thermo-hydro-poro-mechanical signatures from creeping reservoir bank slopes,which may form the basis for a landslide monitoring and early warning system.

关键词： Reservoir landslide Thermo-hydro-poro-mechanical response Ultra-weak fiber bragg grating(UWFBG) subsurface evolution Engineering geological interface Geotechnical monitoring

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王恩涌的学术生命路径和学术树

地理学报 2024年第4期79卷 1085-1096页

作者：吴必虎肖晔北京大学城市与环境学院旅游研究与规划中心北京100871

运用学术生命路径方法,研究已故当代中国地理学家、地理教育家王恩涌先生的学术史。在统计了王恩涌1954—2019年192种次学术著述的基础上,在时间维度上建立学术生命路径曲线和学术生命路径表,并系统构建学术树,以分析其学术著述的数量... 详细信息

运用学术生命路径方法,研究已故当代中国地理学家、地理教育家王恩涌先生的学术史。在统计了王恩涌1954—2019年192种次学术著述的基础上,在时间维度上建立学术生命路径曲线和学术生命路径表,并系统构建学术树,以分析其学术著述的数量变化和内容变迁,进而构筑个人学术体系。研究发现:①学术生命路径曲线展示的王恩涌学术著述数量在时间轴上的分布呈现出波峰右偏的特征,不仅反映了个人的生命成长路径,也折射出中国当代政治、经济、文化等领域发展的脉动;②根据学术生命路径表展现出的王恩涌研究学科领域在时间轴上的分布变化,进一步划分为4个时期:苏联影响下的自然地理学时期,研究停滞与探索时期,以文化、政治地理为主的多领域探索时期,地理学科社会化推广时期,反映出王恩涌的个人学术偏好迁徙和中国地理学70年间的整体变化轨迹;③综合构筑的学术树勾勒出王恩涌一生经营的学术群落整体景观,连同进而构建的核心学术图谱凝练了其厚重深远的学术影响。

关键词：王恩涌学术生命路径学术树地理学思想史

Population size estimates based on GPS telemetry

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Zoological Research 2024年第1期45卷 36-38页

作者： Yu-Xuan Fan Pu-Zheng Xie Chi Ma Ting Chen xiao ye Hua-Lin Xu Qiong Yang Peng-Fei Fan School of Life Sciences Sun Yat-sen UniversityGuangzhouGuangdong 510275China College of Agriculture and Biological Sciences DaliYunnan 671003China Neilingding-Futian National Nature Reserve of Guangdong ShenzhenGuangdong 518040China

DEAR EDITOR,Accurate estimation of population size is a crucial issue in wildlife population ecology and *** Global Positioning System(GPS)collars are well recognized as an effective method for monitoring wildlife behavior,their application in direct wildlife population size estimation remains *** this study,GPS telemetry was employed to survey a rhesus macaque(Macaca mulatta)population on Neilingding Island in Guangdong,*** May 2021 to April 2022,32 macaques across nine groups were fitted with GPS collars,producing a dataset of 109739 location *** data from all tracked individuals revealed the annual home ranges of the nine groups.

关键词： China Island size

Comment on “A novel antibiotic class targeting the lipopolysaccharide transporter”

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Pharmacology Discovery 2024年第2期4卷 52-53页

作者： Ruo-Yi Lv xiao-ye Liu Beijing Key Laboratory of Traditional Chinese Veterinary Medicine Beijing University of AgricultureBeijing 102206China Beijing Traditional Chinese Veterinary Engineering Center Beijing University of AgricultureBeijing 102206China

Crisis of antibiotic resistant has become a global threat to public health in recent decades[1–4].Carbapenem antibiotics are a class of atypicalβ-lactam antibiotics with the broadest antibacterial spectrum and the strongest antibacterial ***,carbapenem-resistant Acinetobacter baumannii(CRAB)is stilly emerging,which is a gram-negative bacterium with lipopolysaccharide(LPS),which makes it resistant to several antibiotics and thus difficult to eliminate[5,6].As the number one pathogen of nosocomial infection,CRAB can cause severe pneumonia and bloodstream infection,*** mortality rate of patients infected with invasive CRAB can be as high as 40%to 60%,and it has been listed as the key pathogen of Class 1 by the World Health *** to the lack of feasible antibiotic strategies,phage combination therapy has been used in some patients,while the efficacy is limited[7].Therefore,new discovery and development of antibiotic that targeting CRAB is urgently ***,Kenneth A.

关键词： mortality listed eliminate

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戏曲现代戏时空观表现初探

四川戏剧 2024年第4期 38-41,45页

作者：叶皛上海戏剧学院舞台美术系

戏曲现代戏是文艺创作中的重要艺术表现形式之一。近些年在国家艺术基金等众多基金资助项目中,戏曲现代戏演出剧目的比例不容小觑。面对大量的资金、人力的注入,如何创作好戏曲现代戏已是不容回避的话题,而对其时空表现特征的探究是艺... 详细信息

戏曲现代戏是文艺创作中的重要艺术表现形式之一。近些年在国家艺术基金等众多基金资助项目中,戏曲现代戏演出剧目的比例不容小觑。面对大量的资金、人力的注入,如何创作好戏曲现代戏已是不容回避的话题,而对其时空表现特征的探究是艺术创作继承与发展的基石。

关键词：戏曲现代戏时空观舞台美术

Probing multi-physical process and deformation mechanism of a largescale landslide using integrated dual-source monitoring

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Geoscience Frontiers 2024年第2期15卷 417-432页

作者： Hong-Hu Zhu xiao ye Hua-Fu Pei Wei Zhang Gang Cheng Zi-Li Li School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China Department of Geotechnical Engineering Dalian University of TechnologyDalian 116024China Civil Structural&Environmental EngineeringSchool of Engineering and ArchitectureUniversity College CorkCorkIreland Department of Civil&Environmental Engineering Massachusetts Institute of TechnologyCambridgeMA 02139-4307United States

The implementation of isolated heterologous monitoring systems for spatially distant borehole deployments often comes with substantial equipment costs,which can limit the effectiveness of geohazard mitigation and georisk management *** address this,we have developed a novel monitoring system that integrates fiber Bragg grating(FBG)and microelectromechanical system(MEMS)techniques to capture soil moisture,temperature,sliding resistance,strain,surface tilt,and deep-seated *** system enables real-time,simultaneous data acquisition and cross-validation analyses,offering a costeffective solution for monitoring critical parameters in geohazard-prone *** successfully applied this integrated monitoring system to the Xinpu landslide,an active super-large landslide located in the Three Gorges Reservoir Area(TGRA)of *** resulting strain profile confirmed the presence of two shallow secondary sliding surfaces at depths of approximately 7 m and 12 m,respectively,in addition to the deep-seated sliding surface at a depth of28 *** lower secondary sliding surface was activated by extreme precipitation,while the upper one was primarily driven by significant changes in reservoir water levels and secondarily triggered by concentrated ***-slide piles have remarkably reinforced the upper moving masses but failed to control the lower *** gap between the pile heads and the soil amplified the rainwater erosion effect,creating a preferential channel for rainwater ***-physical measurements revealed a mixture of seepage-driven and buoyancy-driven behaviors within the *** study offers an integrated dual-source multi-physical monitoring paradigm that enables collaborative management of multiple crucial boreholes on a large-scale landslide,and contributes to the evaluation and improvement of engineering measures in similar geological settings.

关键词： Reservoir landslide Multi-physical process Integrated dual-source monitoring Fiber optic Extreme weather

共建“一带一路”国家制造业增加值贸易网络的演化分析

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亚太经济 2024年第1期 73-81页

作者：方慧张潇叶山东财经大学国际经贸学院济南250014 山东财经大学“一带一路”经济发展研究中心济南250014

“一带一路”贸易网络的形成与演进,为中国制造业迈向全球价值链中高端带来新的契机。为深入剖析“一带一路”国家制造业增加值贸易网络的结构特征、空间溢出路径及中国的行业地位演变,构建“一带一路”国家制造业总体及14个细分行业的... 详细信息

“一带一路”贸易网络的形成与演进,为中国制造业迈向全球价值链中高端带来新的契机。为深入剖析“一带一路”国家制造业增加值贸易网络的结构特征、空间溢出路径及中国的行业地位演变,构建“一带一路”国家制造业总体及14个细分行业的增加值贸易网络,研究发现:上述网络呈现联系紧密的“小世界”格局,并具有空间溢出效应;地理邻近与经济发展水平相似的国家更易形成集聚板块,板块间的贸易溢出路径逐渐趋向“联强扶弱”;中国稳居网络核心位置,但在行业层面存在结构性差异:劳动密集型制造业的网络中心地位与贸易强度逐步下降,资本、知识密集型制造业增加值贸易网络中新的比较优势逐渐形成。

关键词： “一带一路” 制造业增加值贸易网络行业地位