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一锅法合成含两种桥联链的杯[4]双冠醚和双杯[4]冠醚

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有机化学 2012年第1期32卷 189-192页

作者：叶进启杨发福张筱逸焦自玉郭红玉福建师范大学化学与材料学院福州350007 福建师范大学福建省高分子材料重点实验室福州350007

报道了"一锅法"合成含两种桥联链的新型杯[4]双冠醚和双杯[4]冠醚.杯[4]芳烃先与N,N'-乙撑基-二(2-氯乙酰胺)发生"1+1"缩合反应,然后直接加入三甘醇双对甲苯磺酸酯继续进行"2+2"缩合反应,合成了含两种桥联链的新型双杯[4]冠醚4.按照相... 详细信息

报道了"一锅法"合成含两种桥联链的新型杯[4]双冠醚和双杯[4]冠醚.杯[4]芳烃先与N,N'-乙撑基-二(2-氯乙酰胺)发生"1+1"缩合反应,然后直接加入三甘醇双对甲苯磺酸酯继续进行"2+2"缩合反应,合成了含两种桥联链的新型双杯[4]冠醚4.按照相似程序,杯[4]芳烃先后与N,N'-乙撑基-二(2-氯乙酰胺)、溴乙酸乙酯和二乙烯三胺反应,得到含两种桥联链的新型杯[4]双冠醚5.化合物5进一步与异硫氰酸苯酯反应合成带硫脲支链的杯[4]双冠醚6.所有新化合物的结构与构象经元素分析、质谱、核磁共振谱等表征证实.

关键词：杯冠醚双杯芳烃合成一锅法

基于病案首页数据的手术并发症监控模式构建及其效果评价

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中华医院管理杂志 2023年第2期39卷 113-118页

作者：张冠荣梁会营李丹薛允莲叶晋奇杨小红南方医科大学附属广东省人民医院(广东省医学科学院)信息管理处广州510080

目的:探索基于病案首页数据建立手术并发症监控模式,并分析其对手术并发症发生率变化趋势的影响。方法:广州市某三级综合医院以绩效考核中手术并发症发生率数据为核心要素,基于"结构-过程-结果"框架构建手术并发症监控模式。通过全国三... 详细信息

目的:探索基于病案首页数据建立手术并发症监控模式,并分析其对手术并发症发生率变化趋势的影响。方法:广州市某三级综合医院以绩效考核中手术并发症发生率数据为核心要素,基于"结构-过程-结果"框架构建手术并发症监控模式。通过全国三级公立医院绩效考核病案首页采集系统,收集该医院2019年1月至2022年6月的手术并发症发生例数和同期出院手术患者人数。对手术并发症发生率采用描述性分析,采用Joinpoint回归分析手术并发症发生率的变化趋势,并计算月变化百分比(MPC)和平均月变化百分比(AMPC)。结果:医院自2021年5月开始实施手术并发症监控模式,手术并发症发生率从2021年6月的2.55%下降至2022年6月的0.82%,MPC为-5.58%(P=0.024),优于2019年1月至2021年5月的变化情况(MPC=0.18%,P=0.755)。结论:医院构建的手术并发症监控模式可以有效降低手术并发症发生率,为优化医院医疗质量管理流程和决策模式提供参考。

关键词：诊疗工作管理医学手术并发症防控措施病案首页发生率监测体系

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei Xiong Xuan ye Hongzhang Cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： Jian‑En Zhou Yilin Li Xiaoming Lin Jiaye ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template Lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

Netrin-1 signaling pathway mechanisms in neurodegenerative diseases

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Neural Regeneration Research 2025年第4期20卷 960-972页

作者： Kedong Zhu Hualong Wang Keqiang ye Guiqin Chen Zhaohui Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurology The First Hospital of Hebei Medical UniversityBrain Aging and Cognitive Neuroscience Laboratory of Heibei ProvinceShijiazhuangHebei ProvinceChina Faculty of Life and Health Sciences Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal *** profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic *** amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer’s disease and Parkinson’s disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals’susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of *** findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative *** a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.

关键词： Alzheimer’s disease axon guidance colorectal cancer Netrin-1 receptors Netrin-1 signaling pathways Netrin-1 neurodegenerative diseases neuron survival Parkinson’s disease UNC5C

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying Wu Shan ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

The impact of biofuel plantation on biodiversity: a review

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Chinese Science Bulletin 2014年第34期59卷 4639-4651页

作者： ye Liu Yue Xu Fengchun Zhang jinqi Yun Zehao Shen Department of Ecology College of Urban and Environmental Sciences Key Laboratory of the Ministry of Education for Earth Surface Processes Peking University Chinese Research Academy of Environmental Sciences Foreign Economic Cooperation Office Ministry of Environmental Protection

Because plants convert solar energy into chemical energy stored in organisms, biomass production as an energy source can help to reduce the world's reliance on fossil energy and mitigate global warming. Biofuel production is a fast-growing industry that represents a new type of large-scale human disturbance on ecosystems. Thus, the benefits of biofuel production bring environmental risks that include its potential impact on biodiversity, which is still an open question. In this review, we start first with a brief overview of the evolution of biofuel concept; second, we review the state of biofuel production across the continents,with a major emphasis on the main species used and their major feedstock. For which, we found significant differences for land use and environmental cultural management of biofuel plantation between tropical and temperate ***, we summarize the impacts of biofuel plantation on biodiversity at multiple scales, based on the case studied with respect to the corresponding issues. At the genetic level,introgression and contamination by aggressive genotypes are a primary risk. At the species level, habitat pollution, degradation, and disturbance caused by intensive managementof biofuel plantation significantly raise the risk of habitat fragmentation, native extinction, and bio-invasion. At the ecosystem level, the large-scale homogeneous landscape of biofuel plantation results in simplified community and food web that severely damage ecosystem services, including ecosystem diversity. Finally, we compare the current and potential benefits and risks of biofuel plantations for the practical application of a biofuel industry of China. We emphasize the land use constraint from food security and biodiversity conservation, and the need for scientific research and systematic monitoring as a critical support for the sustainable development of biofuel production in China.

关键词：生物多样性保护生物燃料种植环境生态系统服务生态系统多样性燃料生产人为干扰环境风险

An intravascular needle coated by ZnO nanoflowers for in vivo elimination of circulating tumor cells

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Nano Research 2023年第1期16卷 873-881页

作者： jinqi Li Xinlei Li Yangfeng Zhang Kun Jin ye Yuan Ruiqi Ming Yuhua Yang Tongsheng Chen MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China Guangdong Provincial Key Laboratory of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China SCNU Qingyuan Institute of Science and Technology Innovation Co. Ltd.South China Normal UniversityQingyuan 511500China Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China State Key Laboratory of Optoelectronic Materials and Technologies Nanotechnology Research CenterSchool of Materials Science&EngineeringSun Yat-sen UniversityGuangzhou 510275China

Circulating tumor cells(CTCs)are recognized as the main source of tumor recurrence and *** the CTCs in peripheral blood provides a new strategy to reduce the probability of recurrence or ***,we proposed a concept to eliminate CTCs by inserting a needle in the superficial blood *** the property of ZnO and the structure of nanoflowers,we designed a medical needle coated with ZnO nanoflowers(ZNFs),which killed about 90%of captured CTCs in vitro and prevented the injecting CTCs from spreading to lung tissue in BABL/c mouse *** in vitro and in vivo demonstrated that the CTCs not only were captured and killed,but also detached from the needle surface after dead,enabling the ZNFs needle continually eliminate ***,a theoretical model was presented to explain the penetration mechanism of cells by nanostructures,which indicated that nanoflowers structure can puncture CTCs more easily than vertical nanowire *** concept of inserting an intravascular needle provides a potential strategy to lower the concentration of CTCs in blood and reduce the probability of tumor recurrence or metastasis.

关键词： ZnO nanoflowers circulating tumor cells elimination cancer treatment theoretical model

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T2D750/22双摇臂抱杆的研制及应用

电力建设 2011年第7期32卷 92-96页

作者：叶建云方国庆李维波黄超胜金鹤翔叶进其俞宏智王汉炜浙江省送变电工程公司杭州市310016 浙江省建设机械集团有限公司杭州市310014

针对舟山与大陆联网大跨越工程2基370m高塔的组立施工特点,研制了T2D750/22双摇臂抱杆。该抱杆具有以下几个创新技术及其特点,包括海岛高空抗强台风计算、起升绕绳系统、起升和变幅钢丝绳防干扰装置、双侧力矩控制系统、摇臂防撞装置、... 详细信息

针对舟山与大陆联网大跨越工程2基370m高塔的组立施工特点,研制了T2D750/22双摇臂抱杆。该抱杆具有以下几个创新技术及其特点,包括海岛高空抗强台风计算、起升绕绳系统、起升和变幅钢丝绳防干扰装置、双侧力矩控制系统、摇臂防撞装置、井筒吊装系统和SC60变频施工升降机等。

关键词： 370m高塔双摇臂抱杆抗强台风双侧力矩控制