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MicroRNAs in colorectal cancer as markers and targets:Recent advances

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World Journal of Gastroenterology 2014年第15期20卷 4288-4299页

作者： Jing-jia ye jiang Cao Clinical Research Center The Second Affiliated HospitalZhejiang University School of Medicine

MicroRNAs are evolutionarily conserved small noncoding RNA molecules encoded by eukaryotic genomic DNA,and function in post-transcriptional regulation of gene expression via base-pairing with complementary sequences in target mRNAs,resulting in translational repression or degradation of target *** represent one of the major types of epigenetic modification and play important roles in all aspects of cellular *** expression of microRNAs has been found in various human diseases including *** efforts have been made to discover the characteristic microRNA expression profiles,to understand the roles of aberrantly expressed microRNAs and underlying mechanisms in different *** the application of DNA microarray,real-time quantitative polymerase chain reaction and other molecular biology techniques,increasing evidence has been accumulated which reveal that aberrant microRNAs can be detected not only intracellularly within the cancer cells,but also extracellularly in plasma of patients,postulating the potential of aberrant microRNAs as promising diagnostic/prognostic markers and attracting therapeutic *** review is intended to provide the most recent advances in microRNA studies in one of the most common cancers,colorectal cancer,especially the identification of those specifically altered microRNAs in colorectal cancer,validation for their relevance to clinical pathological parameters of patients,functional analyses and potential applications of these microRNAs.

关键词： MicroRNA Epigenetic modification Colorectal cancer Marker Therapy

Effects of different courses of moxibustion treatment on intestinal flora and inflammation of a rat model of knee osteoarthritis

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Journal of Integrative Medicine 2022年第2期20卷 173-181页

作者： ye-juan jia Tian-yu Li Peng Han Yu Chen Li-jia Pan Chun-sheng jia School of Acupuncture Moxibustion and TuinaHebei University of Chinese MedicineShijiazhuang 050200Hebei ProvinceChina

Objective:This study was done to determine the effects of different courses of moxibustion on a rat knee osteoarthritis(KOA)model,and explore the dose–effect relationship of moxibustion on KOA from the perspectives of intestinal flora and inflammatory ***:Wistar rats were randomly divided into five groups:normal,model,moxibustion for 2 weeks,moxibustion for 4 weeks and moxibustion for 6 weeks groups(n=5 each group).A KOA rat model was induced by monosodium iodoacetate,and moxibustion intervention was performed at the acupoints“Dubi”(ST35)and“Zusanli”(ST36),once every other *** changes in the cartilage of rat knee joints were assessed after intervention,and fecal samples were subjected to 16 S r RNA high-throughput sequencing for microbial diversity ***:Damage to the knee articular cartilage was obvious in the model group,which also had increased levels of pro-inflammatory factors,decreased levels of anti-inflammatory factors,and intestinal flora disorders with decreased *** degree of cartilage damage in the 4 and 6 weeks of moxibustion groups was significantly improved compared with the model *** 4 and 6 weeks of moxibustion groups also demonstrated reduced levels of interleukin-1βand tumor necrosis factor-a and increased levels of interleukin-10(P<0.05).Both the abundance and diversity of the intestinal flora were increased,approaching those of the normal *** of probiotics Eubacterium coprostanoligenes group and Ruminococcaceae UCG-014 increased,while that of the pathogenic bacteria Lachnospiraceae NK4 A136 group decreased(P<0.05).Although the abundance of Lachnospiraceae NK4 A136 group decreased in the 2 weeks of moxibustion group compared with the model group(P<0.05),there was no statistically significant difference in serum inflammatory factors,flora species diversity or degree of pathological damage compared with the model ***:Moxibustion treatment led to significant improvements in t

关键词： Knee osteoarthritis Different courses Moxibustion treatment Intestinal flora Inflammatory cytokines

Ultrafine SnO_(2)in situ modified graphite felt derived from metal-organic framework as a superior electrode for vanadium redox flow battery

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Rare Metals 2023年第4期42卷 1214-1226页

作者： Qing-Chun jiang Jin Li Yu-Jie Yang Yu-Jie Ren Lei Dai jia-Yi Gao Ling Wang jia-ye ye Zhang-Xing He School of Chemical Engineering North China University of Science and TechnologyTangshan063009China Hebei Province Key Laboratory of Photocatalytic and Electrocatalytic Materials for Environment North China University of Science and TechnologyTangshan063009China Faculty of Science School of Chemistry and PhysicsQueensland University of TechnologyBrisbaneQLD4001Australia Center for Materials Science Queensland University of TechnologyBrisbaneQLD4001Australia

Metal-organic framework(MOF)and its derivatives have low-cost,controllable structure,and good catalytic performance,which are often used in the electrochemical *** this work,SnO_(2)in situ modified graphite felt(SnO_(2)/GF)is prepared by hydrothermal method then simple thermal treatment using Sn-based MOF(Sn-MOF)as ***_(2)is uniformly and firmly distributed on the GF surface rather than the common agglomeration and poor bonding of metal oxides on carbon-based electrodes,providing stable active centers for the VO^(2+)/VO_(2)^(+)and V^(2+)/V^(3+)redox ***250 mA·cm^(-2),the energy efficiency of the battery with SnO_(2)/GF remains at 63.2%,while the blank one has *** former battery,at 100 mA·cm^(-2),has higher energy efficiency and good cycle stability(over 200 cycles).The battery performance of this study is better than that of most previous report in metal oxide-related *** work obtains high-performance composite electrode by simple treatment of MOF,which provides a reference for the application of MOF in vanadium redox flow battery.

关键词： Vanadium redox flow battery(VRFB) Composite electrode Metal-organic framework(MOF) In situ SnO_(2)

Behavior analysis and formative assessments in online oral medicine education during the COVID-19 pandemic

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World Journal of Clinical Cases 2023年第21期11卷 5063-5072页

作者： jia-jia ye ye-Ke Zhao Zhi-Sheng Teng Hui-Wu ye Qin Yuan Xin Nie Department of Stomatology School and Hospital of StomatologyWenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina College of Arts and Humanities Arkansas Tech UniversityRussellvilleAS 72801United States

BACKGROUND During the coronavirus disease 2019(COVID-19)pandemic,traditional teaching methods were disrupted and online teaching became a new topic in education reform and *** this context,it is important to investigate the necessity and effectiveness of online teaching methods for medical *** study explored stomatology education in China to evaluate the development and challenges facing the field using massive open online courses(MOOCs)for oral medicine education during the *** To investigate the current situation and challenges facing stomatology education in China,and to assess the necessity and effectiveness of online teaching methods among medical *** Online courses were developed and offered on personal computers and mobile *** analysis and formative assessments were conducted to evaluate the learning status of *** The results showed that most learners had already completed MOOCs and achieved better *** behavior analysis and student surveys indicated that students enjoyed the learning ***,the development of oral MOOCs during the COVID-19 pandemic faced significant *** This study provides insights into the potential of using MOOCs to support online professional learning and future teaching innovation,but emphasizes the need for careful design and positive feedback to ensure their success.

关键词： Oral medicine COVID-19 Epidemic prevention and control Online education Behavior analysis Formative assessments

Retinal nerve fiber layer thickness changes in obstructive sleep apnea syndrome:a systematic review and Metaanalysis

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1651-1656页

作者： jia-Song Wang Hua-Tao Xie ye jia Ming-Chang Zhang Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

AIM： To evaluate the retinal nerve fiber layer（RNFL）thickness changes in patients with obstructive sleep apnoea syndrome（OSAS）, and detect possible prevalence of glaucoma in this ***： Comprehensive studies were conducted on the Cochrane Library, Pub Med and Embase through March, 2015. Only studies that fit the selection criteria about RNFL and OSAS would be included. For the measures, we calculated the 95% confidence interval（CI）and weighted mean differences（WMD）. The systematic review and Meta-analysis was performed by Rev Man ***： Nine case-control studies were analyzed containing a total of 1086 cases and 580 *** RNFL thickness in OSAS was reduced significantly compared with healthy controls in random effects model（WMD =-2.56, 95% CI：-4.82 to-0.31, P =0.003, I2=57%）. A significant RNFL thickness reduction were found between the two groups in inferior quadrant（WMD =-3.11, 95% CI：-5.53 to-0.69, P =0.01）, superior quadrant（WMD =-2.37, 95% CI：-4.7 to 0.04, P =0.05）. In nasal quadrant（WMD =-2.54, 95% CI：-6.53 to 1.45, P =0.21） and temporal quadrant（WMD=-1.26, 95% CI：-2.19 to 0.47, P =0.15） there was no difference of RNFL thickness between the two ***： The results show that RNFL thickness is lower in patients with moderate or severe OSAS than in normal subjects or patients with mild OSAS according to the nine homogeneity studies.

关键词： retinal nerve fiber layer thickness obstructive sleep apnea syndrome Meta-analysis

ADSORPTION OF SHORT TWO-DIMENSIONAL COMPACT CHAINS

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Chinese Journal of Polymer Science 2006年第3期24卷 237-244页

作者： jia-ye Su Jin Chen Zhao-yun Zhang 章林溪 Department of Physics Zhejiang University Hangzhou 310027 China Yangming Hospital Ningbo University

Short two-dimensional compact chains adsorbed on the attractive surface at different temperatures were investigated by using the enumeration calculation method. First we investigate the chain size and shape of adsorbed chains, such as characteristic ratios of mean-square radii of gyration 〈S^2〉x/N and 〈S^2〉y/N, shape factor 〈δ〉, and the orientation of chain bonds 〈cos^2 θ〉 to illuminate how the size and shape of adsorbed compact chains change with increasing temperatures. There are some special behaviors for the chain size and shape at low temperature, especially for strong attraction interaction. In the meantime, adsorbed compact chains have different behaviors from general adsorbed polymer chains. Some thermodynamics properties are also discussed here. Heat capacity changes non-monotonously, first increases and then reduces. The transition temperature Tc is nearly 1.0, 1.4, 2.0 and 4.2 （in the unit of To） for the case of ε = 0, -1, -2 and -4 （in the unit of kTo）, respectively. Average energy per bond increases while average Helmholtz free energy per bond decreases with increasing temperatures. From these two thermodynamics parameters we can also get another transition temperature Tc＇, and it is close to 0.7, 1.1, 1.5 and 3.4 for ε= 0, -1, -2, and -4, respectively. Therefore, Tc is greater than Tc＇ under the same condition. These investigations may provide some insights into the thermodynamics behaviors of adsorbed protein-like chains.

关键词： Adsorption of compact chain Enumeration calculation method.

Small-incision lenticule extraction versus femtosecond lenticule extraction for myopic:a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 115-121页

作者： jia-Song Wang Hua-Tao Xie ye jia Ming-Chang Zhang Department of Ophthalmology Union HospitalTongji MedicalCollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

AIM： To examine differences in efficacy, accuracy, safety, aberrations and corneal biomechanical between Small incision lenticule extraction （SMILE） and femtosecond lenticule extraction （FLEx） for myopia. METHODS： Comprehensive studies were conducted on the PubMed, MEDLINE, EMBASE, and Cochrane Controlled Trials Register before 31 July, 2015. Meta-analyses were performed on the primary outcomes [loss of ≥2 lines of corrected distance visual acuity （CDVA）, uncorrected distance visual acuity （UDVA） ≥20/20, spherical equivalent （SE） within ±0.50 diopters （D）, final refractive SE], secondary outcomes were high-order aberrations （HOAs） and corneal biomechanical [central corneal thickness （CCT）, corneal hysteresis （CH） and corneal resistance factor （CRF）]. RESULTS： Seven trials describing a total of 320 eyes with myopia were included in this Meta-analysis. No significant differences were found in the efficacy [UDVA weighted mean difference （WMD） -0.01; 95%CI： -0.04 to 0.01; P=0.37, UDVA ≥20/20, OR 1.49; 95%CI： 0.78 to 2.86; P=0.23], accuracy （SE WMD -0.03; 95%CI： -0.12 to 0.07; P=0.58 , SE within ±0.5 D OR 1.25; 95%CI： 0.34 to 4.65; P=0.74）, HOAs （WMD -0.04; 95%CI： -0.09 to 0.01; P=0.14） and CCT WMD 1.83; 95%CI： -7.07 to 10.72; P=0.69, CH WMD -0.01; 95%CI： -0.42 to 0.40; P=0.97, CRF WMD 0.17; 95%CI： -0.33 to 0.67; P=0.50） in the last fellow-up. But for safety, FLEx may achieve fewer CDVA lost two or more two lines （OR 11.11; 95%CI： 1.27 to 96.86; P=0.03） than SMILE, however CDVA （WMD 0.00; 95%CI： -0.03 to 0.02; P=0.77） is similar. CONCLUSION： SMILE and FLEx are comparable in terms of both efficacy, accuracy, aberrations and corneal biomechanical measures in the follow-up,but FLEx seems to be better in safety measures. The results should be interpreted cautiously since relevant evidence is still limited, although it is accumulating. Further large-scale, well-designed randomized controlled trials are urgently needed.

关键词： myopia small-incision lenticule extraction femtosecond lenticule extraction Meta-analysis

Single Molecule Imaging with Liquid Phase Electron Microscopy

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Chinese Journal of Chemistry 2023年第6期41卷 679-684页

作者： jia-ye Li De-Yi Zhang Sheng Mao Huan Wang College of Chemistry and Molecular Engineering Bejing National Laboratory for Molecular SciencesCenter for SpectroscopyBejing Key Laboratory of Polymer Chemistry&Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringNational Biomedical Imaging CenterPeking UniversityBeijing 100871China Department of Mechanics and Engineering Sciences College of EngineeringPeking UniversityBejing 100871China

Few single-molecule experiments have enabled the direct imaging of functional biomacromolecules in real-time in their native liquid environments,resolving their conformational adaptations,transient interactions,and intermediate *** phase electron microscopy(LP-EM),due to its unique combination of spatial and temporal resolution,has shown to be a promising *** experiments have enabled successful imaging of intact structures of organic molecules and biological systems with an ordinary electron *** image processing methods and quantitative data analysis from single particle experiments based on the optical microscope,quantifying motion and relaxation of these interacting molecules allows the experimental observations of pathways,to test theoretical predictions,and discovery of new *** LP-EM with tomography,fluorescence,and mass spectroscopy allows for probing multi-dimensional structural and dynamic *** remain in obtaining high-quality data in large quantities,which can be improved by developing new liquid cell platforms and machine learning-based data analysis.

关键词： Single-molecule studies Direct Imaging Liquid-phase electron microscopy Analytical methods Image analysis

Detection of food source by PCR analysis of the gut contents of Aldrichina grahami （Aldrich）（Diptera： Calliphoridae） during post-feeding period

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Insect Science 2007年第1期14卷 47-52页

作者： KAI LI GONG-YIN ye jia-YING ZHU CUI HU Institute of Insect Sciences College of Agriculture and Biotechnology Zhejiang University Hangzhou China

The last meal of sarcophagous maggots may be useful in identifying the species on whose flesh they have fed （the＂host＂species）. The DNA profile of the host species may indeed be detectable in the＂last meal＂. In this paper, mitochondrial DNA analysis of gut contents was used to identify the prior host of post-feeding larvae of Aldrichina grahami （Aldrich）（Diptera： Calliphoridae）. A modified logistic equation was fitted to estimate the probability of identifying the host under five different constant temperatures （16, 20, 24, 28 and 32 ℃）. Our results shows that the detected time ranged from a maximum of 24 h at 32℃ to 42 h at 16℃ and a minimum of 12 h at 32~C to 30 h at 16℃. Furthermore, the host detection time was also calculated to give the maximal time after larval hatching from the egg. These results indicate that, in criminal cases where the maggots stray from the corpse, the last meal of the larvae should not be overlooked as potentially critical evidence.

关键词： Cytochrome b gene detectable time forensic entomology gut post-feeding