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Specific metabolic impairments indicate loss of sustained liver improvements in metabolic dysfunction-associated steatotic liver disease treatment

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 632-649,I0025-I0035页

作者： Ling Luo Junzhao ye Shuyu Zhuo Bo Ma Weiyi Mai Xiaopei Cao Liuqin Liang Wei Wang Shiting Feng Zhi Dong Bihui zhong Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Nutrition The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Gastroenterology The East Division of the First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Cardiology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Endocrinology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Rheumatology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Ultrasound The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Radiology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina

Background:High liver fat content(LFC)induces increased risks of both hepatic and extrahepatic progression in metabolic dysfunction-associated steatotic liver disease(MASLD),while maintaining a significant decline in magnetic resonance imaging-based proton density fat fraction(MRI-PDFF)(≥30%decline relative to baseline)without worsening fibrosis results in improved histological severity and ***,the factors associated with the loss of sustained responses to treatment remain unclear,and we aim to identify ***:Consecutive treatment-naïve MASLD patients between January 2015 and February 2022,with follow-up until April 2023,were included in this prospective cohort *** quantified by MRI-PDFF and liver stiffness measurements(LSM)determined by two-dimensional shear wave elastography(2D-SWE)were evaluated at weeks 0,24 and ***-PDFF response was defined as a≥30%relative decline in PDFF values,and LSM response was defined as a≥1 stage decline from ***:A total of 602 MASLD patients were *** the 303 patients with a 24-week MRI-PDFF response and complete follow-up of 48 weeks,the rate of loss of MRI-PDFF response was 29.4%,and multivariable logistic regression analyses showed that 24-week insulin resistance(IR),still regular exercise and caloric restriction after 24 weeks,and the relative decline in LFC were risk factors for loss of MRI-PDFF *** of LSM response at 48 weeks occurred in 15.9%of patients,and multivariable analysis confirmed 24-week serum total bile acid(TBA)levels and the relative decline in TBA from baseline as independent *** significant association was found at 48 weeks between loss of MRI-PDFF response and loss of LSM ***:MASLD patients with IR and high TBA levels are at higher risks of subsequent diminished sustained improvements of steatosis and fibrosis,respectively.

关键词： Metabolic dysfunction-associated steatotic liver disease(MASLD) loss of response magnetic resonance imaging-based proton density fat fraction response(MRI-PDFF response) liver stiffness measurements response(LSM response)

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佛冈县近50年来降雨特征浅析

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人民珠江 2012年第1期33卷 24-28页

作者：童宏福叶爱中广东省水文局清远水文测报中心广东清远511510 北京师范大学全球变化与地球系统科学研究院北京100875

针对全球气温升高、气候变化导致降雨发生变化、极端事件频发问题,选用珠江流域中佛冈县作为研究区域,统计了1960—2009年佛冈县50年逐日降雨资料,发现佛冈县年总降雨近50年有所减小,尤其是5月和10月降雨量存在减少趋势,日最大降雨量也... 详细信息

针对全球气温升高、气候变化导致降雨发生变化、极端事件频发问题,选用珠江流域中佛冈县作为研究区域,统计了1960—2009年佛冈县50年逐日降雨资料,发现佛冈县年总降雨近50年有所减小,尤其是5月和10月降雨量存在减少趋势,日最大降雨量也存在减小趋势,说明降雨减小的原因主要是暴雨量减小。由于降雨的减少主要是暴雨的减少所致,说明气候变化有可能降低佛冈县发生洪涝灾害的概率。

关键词：气候变化降雨特征趋势佛冈

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跨流域调水的大尺度分布式水文模型研究与应用

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南水北调与水利科技 2011年第1期9卷 1-7,95页

作者：夏军叶爱中王蕊王中根中国科学院地理科学与资源研究所陆地水循环及地表过程重点实验室北京100101 北京师范大学全球变化与地球系统科学研究院北京100875

变化环境下区域分布式水循环模拟研究,是地球系统科学中的重大科学问题,也是区域水安全和水资源风险管理需求的重要应用基础。本文开展了以南水北调中线工程联系的跨汉江、黄河和海河多个流域的区域水循环模拟、环境变化影响与水安全研... 详细信息

变化环境下区域分布式水循环模拟研究,是地球系统科学中的重大科学问题,也是区域水安全和水资源风险管理需求的重要应用基础。本文开展了以南水北调中线工程联系的跨汉江、黄河和海河多个流域的区域水循环模拟、环境变化影响与水安全研究。重点论述了跨流域调水的大尺度分布式水文模型(LDTVGM)的研究与展望。目的是探讨变化环境下跨流域调水的分布式水循环模型的建立,发展区域水循环动力学-非线性系统-多源不确定性分析与综合的理论与影响评估方法,为分析应对气候变化和高强度人类活动影响的区域水资源安全及应对措施的风险管理,提供科学依据。

关键词：跨流域调水分布式水文模型地下水影响

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Liu-Jun-Zi decoction alleviates chemotherapy-induced anorexia by regulating gut microbiota and TLR4/MyD88/NF-κB p65 signaling pathway

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Traditional Medicine Research 2024年第8期9卷 47-58页

作者： Yu-Jie Gao Xi-Pei Wu Bin-Bin ye Yong-Zhao Dai Yao-zhong Zhao Xiu-Xiu Liao Ke Nie School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China

Background:Liu-Jun-Zi decoction(LJZD),a classical nourishing formula in China,has been proven to be effective in treating chemotherapy-induced *** this study,the mechanism of LJZD in alleviating chemotherapy-induced anorexia was discussed from the aspects of regulating gut microbiota,repairing intestinal barrier injury and inhibiting inflammatory ***:A rat model of chemotherapy-induced anorexia was established using *** study evaluated the therapeutic effects of LJZD by observing the weight,food intake,and intestinal pathology of *** impact of LJZD on gut microbiota and metabolites,specifically short-chain fatty acids,was investigated through gut microbiota analysis and targeted *** anti-inflammatory and intestinal protective effects of LJZD were assessed by examining the expression of intestinal tight junction proteins associated with the inflammatory ***:LJZD alleviated cisplatin-induced inflammation and intestinal barrier disruption,as evidenced by upregulated expression of tight junction protein 1(TJ-1)and occludin,along with reduced serum levels of interleukin 6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and ***,LJZD alleviated microbiota imbalance and regulated the levels of short-chain fatty acids,especially increased the relative abundance of Coriobacteriales Incertae Sedis,Lactabacillus johnsonii F19785,Parasutterella,and reduced the *** the hypothalamus,LJZD exerts suppressive effects on the toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB)p65 signaling pathway,leading to a downregulation in the transcriptional activity of IL-6 and IL-1β,as well as Interleukin 6 receptors(IL-6R)and Interleukin-1βreceptors(IL-1R1)mRNA expression ***:In summary,LJZD alleviate chemotherapy-induced anorexia by modulating the gut microbiota,repairing the intestinal mechanical barriers,and suppressing the TLR4

关键词： Liu-Jun-Zi decoction chemotherapy-induced anorexia cisplatin TLR4/MyD818/NF-κB p65 gut microbiota rat

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Paradoxical herniation associated with hyperbaric oxygen therapy after decompressive craniectomy: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1793-1798页

作者： zhong-Xing ye Xin-Xin Fu Yang-Zong Wu Ling Lin Liang-Qi Xie Yu-Ling Hu Yi Zhou Zhu-Gui You Hai Lin Department of Neurosurgery The Second People's Hospital of Fujian Province(The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine)Fuzhou 350001Fujian ProvinceChina Department of Neurosurgery The Second Hospital of LongyanLongyan 364000Fujian ProvinceChina Department of Neurosurgery Zhangping City HospitalLongyan 364400Fujian ProvinceChina

BACKGROUND Whether hyperbaric oxygen therapy(HBOT)can cause paradoxical herniation is still *** SUMMARY A 65-year-old patient who was comatose due to brain trauma underwent decompressive craniotomy and gradually regained consciousness after *** was administered 22 d after surgery due to speech *** herniation appeared on the second day after treatment,and the patient’s condition worsened after receiving mannitol treatment at the rehabilitation *** timely skull repair,the paradoxical herniation was resolved,and the patient regained consciousness and had a good recovery as observed at the follow-up *** Paradoxical herniation is rare and may be caused by ***,the underlying mechanism is unknown,and the understanding of this phenomenon is *** use of mannitol may worsen this *** skull repair can treat paradoxical herniation and prevent serious complications.

关键词： Decompressive craniectomy Hyperbaric oxygen therapy Mannitol Paradoxical herniation Case report

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Modulated noble metal/2D MOF heterostructures for improved hydrogen storage of MgH_(2)

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Rare Metals 2024年第4期43卷 1672-1685页

作者： Zeng-Yi Li Li-Xian Sun Fen Xu Yu-Mei Luo Yong-Peng Xia Sheng Wei Chen-Chen Zhang Ri-Guang Cheng Chao-Feng ye Meng-Yuan Liu Ju-Lan Zeng zhong Cao Hong-Ge Pan School of Material Science and Engineering Guilin University of Electronic TechnologyGuilin541004China School of Chemistry and Chemical Engineering Changsha University of Science and TechnologyChangsha410114China Institute of Science and Technology for New Energy Xi’an Technological UniversityXi’an710021China

The conjugation of external species with twodimensional(2D)materials has broad application *** this study,we have explored the potential of noble metal/2D MOF heterostructures in hydrogen ***,the MgH_(2)-Ni-MOF@Pd system has shown remarkable hydrogen desorption/sorption performances,starting to liberate hydrogen at 1810C,which is 2300C lower than that of pristine *** the catalytic effect of Ni-MOF@Pd,the dehydrogenation apparent activation energy of MgH2 is noticeably decreased from(133.5±17.5)to(34.58±1.87)kJ·moL^(-1),and the hydrogenation apparent activation energy is reduced from(70.41±7.43)to(25.78±4.64)kJ·moL^(-1),which is lowered by 63.4%.The fully-dehydrogenated MgH2-NiMOF@Pd composite rapidly uptakes hydrogen,with 2.62wt%at 100℃and 6.06 wt%at 150℃within 300 s,*** mechanism analysis of MgH2 catalyzed by Ni-MOF@Pd has revealed that the transformation of Mg_2Ni and Mg_2NiH_4 could act as a"hydrogen pump",providing numerous channels for fast diffusion and transport of hydrogen ***,in the dehydrogenation process,the element Pd reacts with MgH_(2)to form the MgPd alloy phase,which makes MgH_(2)take precedence to decompose through the Mg-Pd alloy rather than self-decomposition,further reducing thermal stability and improving de/hydrogenation *** synergistic effect of Mg-Pd,Mg_2Ni,and the special ultra-thin 2D sheet structure of the additive is the main reason for the good hydrogen storage property of MgH_(2)-Ni-MOF@*** findings provide inspiration for designing efficient multifunctional additives with unique morphologies to optimize the hydrogen desorption/sorption behaviors of hydrogen storage materials.

关键词： Hydrogen storage Magnesium hydride 2D metal-organic framework nanosheets Ni/Pd Synergistic catalysis

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Abnormal function of EPHA2/p.R957P mutant in congenital cataract

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1007-1017页

作者： Jing-Jin Zhang Zong-Fu Cao Bi-Ting Zhou Ju-Hua Yang zhong Li Shuang Lin Xiao-Le Chen Nan-Wen Zhang Qin ye Xu Ma Yi-Hua Zhu Department of Ophthalmology the First Affiliated Hospital of Fujian Medical UniversityFujian Institute of OphthalmologyFujian Provincial Clinical Medical Research Center of Eye Diseases and OptometryFuzhou 350005Fujian ProvinceChina Department of Ophthalmology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100000China National Human Genetic Resources Center National Research Institute for Family PlanningBeijing 100081China Department of Bioengineering and Biopharmaceutics School of PharmacyFujian Medical UniversityFuzhou 350004Fujian ProvinceChina

aiM:To identify genetic defects in a Chinese family with congenital posterior polar cataracts and assess the ***:A four-generation Chinese family affected with autosomal dominant congenital cataract was *** individuals took part in this study including 5 affected and 14 unaffected *** sequencing targeted hot-spot regions of 27 congenital cataract-causing genes for variant *** pathogenicity of the variant was evaluated by the guidelines of American College of Medical Genetics and InterVar *** microscopy was applied to detect the subcellular localization of fluorescence-labeled ephrin type-A receptor 2(EPHA2).Co-immunoprecipitation assay was implemented to estimate the interaction between EphA2 and other lens membrane *** mRNA and protein expression were analyzed by reverse transcription-polymerase chain reaction(qRT-PCR)and Western blotting assay,*** cell migration was analyzed by wound healing *** model was generated by ectopic expression of human EPHA2/p.R957P mutant to demonstrate whether the mutant could cause lens opacity in ***:A novel missense and pathogenic variant c.2870G>C was identified in the sterile alpha motif(SAM)domain of *** studies demonstrated the variant’s impact:reduced EPHA2 protein expression,altered subcellular localization,and disrupted interactions with other lens membrane *** mutant notably enhanced human lens epithelial cell migration,and induced a central cloudy region and roughness in zebrafish lenses with ectopic expression of human EPHA2/p.R957P mutant under differential interference contrast(DIC)***:Novel pathogenic c.2870G>C variant of EPHA2 in a Chinese congenital cataract family contributes to disease pathogenesis.

关键词： congenital cataract EPHA2 missense variant function analysis

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Electrical structure identification of deep shale gas reservoir in complex structural area using wide field electromagnetic method

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Applied Geophysics 2024年第3期21卷 564-578,619,620页

作者： Gu Zhi-Wen Li Yue-Gang Yu Chang-Heng Zou zhong-Ping Hu ai-Guo Yin Xue-Bo Wang Qinag ye Heng Tan Zhang-Kun Sichuan Natural Resources Investment Group Geophysical Exploration Institute Co. LtdSi Chuan Cheng Du 610072 PetroChina Southwest Oil and Gas Field Company Si Chuan Cheng Du 610056 Petroleum Engineering Technology Research Institute of Sinopec North China Oil and Gas Company Zheng Zhou 450007

To fully exploit the technical advantages of the large-depth and high-precision artificial source electromagnetic method in the complex structure area of southern Sichuan and compensate for the shortcomings of the conventional electromagnetic method in exploration depth,precision,and accuracy,the large-depth and high-precision wide field electromagnetic method is applied to the complex structure test area of the Luochang syncline and Yuhe nose anticline in the southern *** advantages of the wide field electromagnetic method in detecting deep,low-resistivity thin layers are ***,on the basis of the analysis of physical property data,a geological–geoelectric model is established in the test area,and the wide field electromagnetic method is numerically simulated to analyze and evaluate the response characteristics of deep thin shale gas layers on wide field electromagnetic ***,a wide field electromagnetic test is conducted in the complex structure area of southern *** data processing and inversion imaging,apparent resistivity logging data are used for calibration to develop an apparent resistivity interpretation model suitable for the test *** the basis of the results,the characteristics of the electrical structure change in the shallow longitudinal formation of 6 km are implemented,and the transverse electrical distribution characteristics of the deep shale gas layer are *** the prediction area near the well,the subsequent data verification shows that the apparent resistivity obtained using the inversion of the wide field electromagnetic method is consistent with the trend of apparent resistivity revealed by logging,which proves that this method can effectively identify the weak response characteristics of deep shale gas formations in complex structural *** experiment,it is shown shows that the wide field electromagnetic method with a large depth and high precision can effectively characterize the electric

关键词： complex tectonic area in southern Sichuan wide field electromagnetic method deep exploration shale gas reservoir electrical structure

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High-yield and rapid isolation of extracellular vesicles by flocculation via orbital acoustic trapping:FLOAT

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Microsystems & Nanoengineering 2024年第1期10卷 313-323页

作者： Joseph Rufo Peiran Zhang Zeyu Wang Yuyang Gu Kaichun Yang Joseph Rich Chuyi Chen Ruoyu zhong Ke Jin ye He Jianping Xia Ke Li Jiarong Wu Yingshi Ouyang Yoel Sadovsky Luke P.Lee Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNCUSA Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Obstetrics Gynecologyand Reproductive SciencesMagee-Womens Research InstituteUniversity of PittsburghPittsburghPAUSA Department of Microbiology and Molecular Genetics School of MedicineUniversity of PittsburghPittsburghPAUSA Renal Division and Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Bioengineering Department of Electrical Engineering and Computer ScienceUniversity of CaliforniaBerkeleyBerkeleyCAUSA Department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwonKorea

Extracellular vesicles(EVs)have been identified as promising biomarkers for the noninvasive diagnosis of various ***,challenges in separating EVs from soluble proteins have resulted in variable EV recovery rates and low ***,we report a high-yield(>90%)and rapid(<10 min)EV isolation method called FLocculation via Orbital Acoustic Trapping(FLOAT).The FLOAT approach utilizes an acoustofluidic droplet centrifuge to rotate and controllably heat liquid *** adding a thermoresponsive polymer flocculant,nanoparticles as small as 20 nm can be rapidly and selectively concentrated at the center of the *** demonstrate the ability of FLOAT to separate urinary EVs from the highly abundant Tamm-Horsfall protein,addressing a significant obstacle in the development of EV-based liquid *** to its high-yield nature,FLOAT reduces biofluid starting volume requirements by a factor of 100(from 20 mL to 200µL),demonstrating its promising potential in point-of-care diagnostics.

关键词： trapping utilize separating

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中高职衔接教育中职业素养课程的审视和探索——以会计和电子商务专业为例

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教育教学论坛 2018年第21期 235-237页

作者：叶艾仲蒙友英广西经贸高级技工学校广西苍梧543199

职业素养课程归属公共课程范畴,在中高职衔接教育中审视职业素养课程建设,是构建延续递进、纵横衔接职业素养课程的前提和依据。当前学校对学生职业素养的培养教育呈碎片状,不利于毕业生职业生涯的发展,也不能满足社会不断发展对人才的... 详细信息

职业素养课程归属公共课程范畴,在中高职衔接教育中审视职业素养课程建设,是构建延续递进、纵横衔接职业素养课程的前提和依据。当前学校对学生职业素养的培养教育呈碎片状,不利于毕业生职业生涯的发展,也不能满足社会不断发展对人才的需求。中高职衔接教育中的职业素养课程建设,要体现中等职业学校的教育基础,突出高等职业院校人才培养水平的系统化提升。

关键词：中高职衔接职业素养课程探索

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