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Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3585-3599页

作者： De-Gang Li Jia-Peng Jiang fan-ye Chen Wei Wu Jun Fu Gong-He Wang Yu-Bo Li Department of Gastrointestinal and Anorectal Surgery The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina

BACKGROUND Gastrointestinal stromal tumors(GISTs)are typical gastrointestinal tract *** is the first-line therapy for GIST *** resistance limits the long-term effectiveness of *** regulatory effect of insulin-like growth factor 2(IGF2)has been confirmed in various cancers and is related to resistance to chemotherapy and a worse *** To further investigate the mechanism of IGF2 specific to *** IGF2 was screened and analyzed using Gene Expression Omnibus(GEO:GSE225819)*** IGF2 knockdown or overexpression by transfection,the phenotypes(proliferation,migration,invasion,apoptosis)of GIST cells were characterized by cell counting kit 8,Transwell,and flow cytometry *** used western blotting to evaluate pathway-associated and epithelial-mesenchymal transition(EMT)-associated *** injected transfected cells into nude mice to establish a tumor xenograft model and observed the occurrence and metastasis of *** Data from the GEO indicated that IGF2 expression is high in GISTs,associated with liver metastasis,and closely related to drug *** cells with high expression of IGF2 had increased proliferation and migration,invasiveness and *** of IGF2 significantly inhibited those *** addition,OEIGF2 promoted GIST metastasis in vivo in nude ***2 activated IGF1R signaling in GIST cells,and IGF2/IGF1R-mediated glycolysis was required for GIST with liver *** cells with IGF2 knockdown were sensitive to imatinib treatment when IGF2 overexpression significantly raised imatinib ***,2-deoxy-D-glucose(a glycolysis inhibitor)treatment reversed IGF2 overexpressionmediated imatinib resistance in *** IGF2 targeting of IGF1R signaling inhibited metastasis and decreased imatinib resistance by driving glycolysis in GISTs.

关键词： Insulin-like growth factor 2 Gastrointestinal stromal tumors IGF1R Glycolysis Imatinib resistance

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The response of Golgi protein 73 to transcatheter arterial chemoembolization in patients with hepatocellular carcinoma may relate to the influence of certain chemotherapeutics

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Hepatobiliary & Pancreatic Diseases International 2015年第4期14卷 406-412页

作者： Jie Pan ye-fan Zhang Hua-Yu Yang Hai-Feng Xu Xin Lu Xin-Ting Sang Shou-Xian Zhong Yi-Lei Mao Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Abdominal Surgery Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND： Golgi protein 73 （GP73） is a promising bio- marker of hepatocellular carcinoma （HCC）. It decreases after surgical resection, and resumes upon recurrence, indicating a potential indicator for the effectiveness of the treatment. But changes of GP73 after transcatheter arterial chemoemboliza- tion （TACE） have not been reported so far. This study was to investigate the dynamic changes of GP73 in HCC patients af- ter TACE treatment, and the possible underlying mechanisms in the cell cultures. METHODS： Blood samples were collected from 72 HCC pa- tients, before TACE, at day I and day 30 after TACE. GP73 lev- els were measured by Western blotting. The dynamic changes of GP73 were analyzed and compared with image changes and clinical data. The effects of chemotherapeutic agents （5-FU and pirarubicin） on GP73 expression were tested in three HCC cell lines （HepG2, HCCLM3 and MHCC97H）. RESULTS： The GP73 level was significantly elevated at day 1 and day 30 after TACE in HCC patients compared with that before the procedure （P〈0.05）. There was no statistical differ- ence between the two time points after TACE, nor correlationbetween GP73 levels and dinicopathological features, tumor metastasis, and patient survival. Pirarubicin, not 5-FU, signifi- cantly increased GP73 expression in three cell lines. CONCLUSIONS： Unlike surgical resection which decreases the GP73 level, TACE significantly increased GP73 expression in patients with HCC. No correlations were observed among GP73 levels, tumor characteristics and prognosis of patients with HCC.

关键词： hepatocellular carcinoma transcatheter arterial chemoembolization Golgi protein 73 chemotherapeutics

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Integrated bound-state-in-the-continuum photon-pair source

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Photonics Research 2024年第6期12卷 1322-1327页

作者： fan ye YUE QIN CHENFEI CUI XIANKAI SUN HON KI TSANG Department of Electronic Engineering The Chinese University of Hong KongHong KongChina

Integrated photon-pair sources based on spontaneous parametric down conversion(SPDC)in novel high-χ^((2))materials are used in quantum photonic systems for quantum information processing,quantum metrology,and quantum ***,the need for extensive fabrication process development and optimization of dry-etching processes significantly impedes the rapid exploration of different material platforms for low-loss quantum photonic ***,bound states in the continuum(BICs)have emerged as a promising approach for realizing ultralow-loss integrated photonic circuits without requiring an etching *** realizations of BIC photonic circuits have,however,been limited primarily to the classical ***,we explore the BIC phenomena in the quantum regime and show that the etchless BIC platform is suitable for use in integrated entangled photon-pair sources based on the SPDC process in high-χ^((2))*** lithium niobate as an example,we demonstrate photon-pair generation at telecommunication wavelengths,attaining a maximum internal generation rate of 3.46 MHz,a coincidence-to-accidental ratio of 5773,and an experimental two‐photon interference visibility of 94%.Our results demonstrate that the BIC platform can be used for quantum photonic circuits,and this will enable the rapid exploration of different emergingχ^((2))materials for possible use in integrated quantum photonics in the future.

关键词： process quantum continuum

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Dual-function beam splitter of high contrast gratings

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Chinese Physics B 2021年第4期30卷 252-256页

作者： Wen-Jing fang Xin-ye fan Hui-Juan Niu Xia Zhang Heng-Ying Xu Cheng-Lin Bai Shandong Provincial Key Laboratory of Optical Communication Science and Technology School of Physical Science and Information EngineeringLiaocheng UniversityLiaocheng 252000China Institute of Information Photonics and Optical Communications Beijing University of Posts and Telecommunications(BUPT)State Key Laboratory of Information Photonics and Optical CommunicationsBeijing 100876China

we preset the design and rabrication of a novel auai-iunction hign contrast gratings that can De usea as a polarizationselective beam splitter with transverse magnetic polarization,which performs two independent functions,i.e.,reflection focusing and power equalization at a wavelength of 1550 *** dual-function grating profile is optimized by the rigorous coupled-wave analysis and the finite-element *** analytical expressions of phase and modal guideline for the beam splitter design are *** beam splitter based on the grating structure is experimentally studied at a distance of 160 μm from the reflection plane,the results are consistent with the theoretical results basically.

关键词： beam splitter high contrast gratings polarization-selective focusing phase modulation

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Brainmask:an ultrasoft and moist microelectrocorticography electrode for accurate positioning and long-lasting recordings

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Microsystems & Nanoengineering 2023年第5期9卷 295-307页

作者： Bowen Ji fanqi Sun Jiecheng Guo Yuhao Zhou Xiaoli You ye fan Longchun Wang Mengfei Xu Wen Zeng Jingquan Liu Minghao Wang Huijing Hu Honglong Chang Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Collaborative Innovation Center of Northwestern Polytechnical University Shanghai 201108China Institute of Medical Research Northwestern Polytechnical UniversityXi’an 710072China College of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China National Key Laboratory of Science and Technology on Micro/Nano Fabrication Department of Micro/Nano ElectronicsShanghai Jiao Tong UniversityShanghai 200240China

Bacterial cellulose(BC),a natural biomaterial synthesized by bacteria,has a unique structure of a cellulose nanofiberweaved three-dimensional reticulated *** films can be ultrasoft with sufficient mechanical strength,strong water absorption and moisture retention and have been widely used in facial *** films have the potential to be applied to implantable neural interfaces due to their conformality and moisture,which are two critical issues for traditional polymer or silicone *** this work,we propose a micro-electrocorticography(micro-ECoG)electrode named“Brainmask”,which comprises a BC film as the substrate and separated multichannel parylene-C microelectrodes bonded on the top *** can not only guarantee the precise position of microelectrode sites attached to any nonplanar epidural surface but also improve the long-lasting signal quality during acute implantation with an exposed cranial window for at least one hour,as well as the in vivo recording validated for one *** novel ultrasoft and moist device stands as a next-generation neural interface regardless of complex surface or time of duration.

关键词： recording electrode moisture

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TGW3, a Major QTL that Negatively Modulates Grain Length and Weight in Rice

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Molecular Plant 2018年第5期11卷 750-753页

作者： Jie-Zheng Ying Ming Ma Chen Bai Xue-Hui Huang Jian-Li Liu ye- Yang fan Xian-Jun Song National Key Laboratory of Rice Biology and Chinese Center of RiceImprovement China National Rice Research Institute Hangzhou 310006 China Key Laboratory of Plant Molecular Physiology Institute of Botany the Chinese Academy of Sciences No.20 Nanxincun Xiangshan Beijing 100093 China College of Life and Environment Sciences Shanghai Normal University Shanghai 200234 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

Dear Editor, Grain length （size） and weight are essential components of crop yield. To date, many QTLs/genes for these traits have been identified. GS3 encodes a putative transmembrane protein and functions as a negative regulator, and its larger-grain allele contains a nonsense mutation causing a 178-aa truncation （fan et al., 2006）. GL3.1/qGL3 encodes a putative protein phosphatase and also acts as a negative regulator of grain size （Qi et al., 2012; Zhang et al., 2012）. Another negative regulator of grain size and weight is TGW6, which hydrolyzes indole-3-acetic acid （IAA）-glucose into IAA and glucose （Ishimaru et al., 2013）.

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COVID-19 pandemic amplified mortality rates among adolescents with bipolar disorder through family-related factors

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World Journal of Clinical Cases 2024年第11期12卷 1929-1935页

作者： Zhuo-fan ye Yi-Han Hong Jian-Lin Yang Meng-Qing Tan Ju-Min Xie Zu-Cai Xu Department of Neurology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003Hubei ProvinceChina Psychological Children's Ward Mental Health Center of HuangshiHuangshi 435111Hubei ProvinceChina The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Recently,a growing number of adolescents have been afflicted with mental disorders,with annual morbidity rates on the *** trend has been exacerbated by the global coronavirus disease 2019(COVID-19)pandemic,leading to a surge in suicide and self-harm rates among this *** To investigate the impact of the COVID-19 pandemic on adolescent bipolar disorder(BD),along with the underlying factors contributing to heightened rates of suicide and self-harm among *** A comprehensive statistical analysis was conducted utilizing clinical interviews and self-reports obtained from patients or their *** criteria for BDs were based on the Diagnostic and statistical manual of mental disorders,international classification of diseases-11,and the National institute of mental health research domain *** analyses were performed using SPSS 26.0 software,with significance set at Pyears *** factors contributing to adolescent BDs included familial influences,academic stress,genetic predisposition and exposure to school-related ***,a significant increase in suicide attempts and self-harm incidents was observed among adolescents with BD during the COVID-19 *** analysis indicated that the pandemic exacerbated familial discord and heightened academic stress,thereby amplifying the prevalence of suicidal behavior and self-harm among *** The COVID-19 pandemic has exacerbated familial tensions and intensified the incidence of suicide and self-harm among adolescents diagnosed with *** study underscores the urgent need for societal,familial and educational support systems to prioritize the well-being of adolescents and offers valuable insights and guidelines

关键词： Adolescents Bipolar disorder COVID-19 Suicide Self-harm

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pH非敏感型自交联共轭亚油酸囊泡的构建和表征

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高等学校化学学报 2014年第8期35卷 1746-1752页

作者：樊晔方云高迪江南大学化学与材料工程学院食品胶体与生物技术教育部重点实验室无锡214122

以共轭亚油酸（ Conjugated linoleic acid, CLA）为构造pH非敏感型脂肪酸囊泡（ Fatty acid vesicle, FAV）的分子砌块,通过碱异构化法从亚油酸半合成CLA,然后采用pH刺激响应自组装法获得CLA的不饱和脂肪酸囊泡（ Ufasome）,采用紫外... 详细信息

以共轭亚油酸（ Conjugated linoleic acid, CLA）为构造pH非敏感型脂肪酸囊泡（ Fatty acid vesicle, FAV）的分子砌块,通过碱异构化法从亚油酸半合成CLA,然后采用pH刺激响应自组装法获得CLA的不饱和脂肪酸囊泡（ Ufasome）,采用紫外辐照诱导方式对CLA-ufasome实施囊泡内化学绑定,获得一种新的pH非敏感型FAV.通过酸碱滴定和表面张力实验确定CLA-ufasome形成的适宜pH范围和浓度,利用透射电子显微镜（ TEM）表征了自交联CLA的FAV的形貌,并通过动态光散射（ DLS）法测定了自交联CLA的FAV的稳定性.结果表明,以CLA为分子砌块,当浓度为3 mmol/L时在pH=8.6条件下构建CLA-ufasome,紫外辐照2.5 h后得到粒径为10-20 nm,壁厚为2.0 nm的自交联CLA的FAV,并具有pH非敏感的特性.以抗癌药物五氟尿嘧啶为目标包覆药物,体外释放实验结果表明,自交联CLA的FAV对五氟尿嘧啶具有良好的缓释效果.

关键词：共轭亚油酸不饱和酸囊泡脂肪酸囊泡 pH非敏感性自组装自交联

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基于高精度运动信息的ISAR分辨率评估方法

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电子与信息学报 2021年第9期43卷 2728-2734页

作者：刘也叶钒马岩赵华北京跟踪与通信技术研究所北京100094 空军研究院战略预警研究所北京100000

ISAR分辨率评估是空间目标成像雷达精度鉴定的重要内容。该文针对ISAR分辨率评估中的基准计算与方法设计两个关键问题进行了详细分析,进而提出了基于空间目标高精度轨道与遥测姿态等运动信息的ISAR方位向定标方法。在此基础上,建立了一... 详细信息

ISAR分辨率评估是空间目标成像雷达精度鉴定的重要内容。该文针对ISAR分辨率评估中的基准计算与方法设计两个关键问题进行了详细分析,进而提出了基于空间目标高精度轨道与遥测姿态等运动信息的ISAR方位向定标方法。在此基础上,建立了一种新的ISAR分辨率评估方法。利用某雷达精度鉴定试验中对不同空间目标的实测成像数据,验证了该文方法的合理性与有效性。

关键词：逆合成孔径雷达成像分辨率评估方位向定标

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Super Hybrid Rice Breeding in China：Achievements and Prospects

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Journal of Integrative Plant Biology 2007年第6期49卷 805-810页

作者： Shi-Hua Cheng Li-Yong Cao Jie-Yun Zhuang Shen-Guang Chen Xiao-Deng Zhan ye-Yang fan De-Feng Zhu Shao-Kai Min State Key Laboratory of Rice Biology/National Center for Rice Improvement China National Rice Research Institute Hangzhou 310006 China

Hybrid rice has contributed greatly to the self-sufficiency of food supply In China. To meet the future demand for rice production, a national program on super rice breeding was established In China In 1996. The corresponding targets, breeding strategies and most significant advances are reviewed In this paper. New plant type models have been modified to adjust to various rice growing regions. In recognition of the Importance of applying parents with Intermediate subspecies differentiation In Increasing F1 yield, medium type parental lines were selected from populations derived from Inter-subspecies crosses with the assistance of DNA markers for subspecies differentiation. Results also indicate that a substantial increase of blomass Is the basis for further enhancement of the grain yield potential, and amelioration of leaf characteristics Is helpful In Increasing the photosynthetic rate. Thirty-four super hybrid rice varieties have been released commercially, growing In a total area of 13.5 million hm2 and producing 6.7 thousand million kg more rice In 1998-2005. Although remarkable progress has been made In super hybrid rice breeding In China, selections on the root system and Integration of more blotechnologlcal tools remain a great challenge.

关键词： biomass DNA marker harmonious plant type medium type parents super hybrid rice.

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