检索结果-南通市图书馆

Growth hormone improves insulin resistance in visceral adipose tissue after duodenal-jejunal bypass by regulating adiponectin secretion

引用

World Journal of Diabetes 2024年第6期15卷 1340-1352页

作者： Zi-Tian Liu guang-Wei yang Xiang Zhao Shuo-Hui Dong yang Jiao Zheng Ge Ao yu Xi-Qiang Zhang Xin-Zhen Xu Zhi-Qiang Cheng Xiang Zhang Ke-Xin Wang Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of General Surgery Shandong University of Qilu Hospital(Qingdao)Qingdao 266000Shandong ProvinceChina

BACKGROUND The mechanism of improvement of type 2 diabetes after duodenal-jejunal bypass(DJB)surgery is not *** To study the morphological and functional changes in adipose tissue after DJB and explore the potential mechanisms contributing to postoperative insulin sensitivity improvement of adipose tissue in a diabetic male rat *** DJB and sham surgery was performed in a-high-fat-diet/streptozotocin-induced diabetic rat *** adipose tissue was weighed and observed under *** inguinal fat to represent subcutaneous adipose tissue(SAT)and mesangial fat to represent visceral adipose ***-sequencing was utilized to evaluate gene expression alterations *** hematoxylin and eosin staining,reverse transcription-quantitative polymerase chain reaction,western blot,and enzyme-linked immunosorbent assay were used to study the *** resistance was evaluated by *** After DJB,whole body blood glucose metabolism and insulin sensitivity in adipose tissue *** cell volume in both visceral adipose tissue(VAT)and SAT *** to SAT,VAT showed more significantly functional alterations after DJB and KEGG analysis indicated growth hormone(GH)pathway and downstream adiponectin secretion were involved in metabolic *** circulating GH and adiponectin levels and GH receptor and adiponectin levels in VAT *** experiment showed that GH stimulated adiponectin secretion and improve insulin *** GH improves insulin resistance in VAT in male diabetic rats after receiving DJB,possibly by increasing adiponectin secretion.

关键词： Growth hormone Insulin resistance Bariatric surgery Adipose tissue Adiponectin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Roles of Cu doping in YbZn_(2)Sb_(2) for thermoelectric performance enhancement

引用

Rare Metals 2024年第6期43卷 2869-2875页

作者： Xiong Zhang Hai-Hui Li Xiao-Liang Cao Bin Zhang Hong Wu yu Zhang guang Han Guo-yu Wang Hao-Shuang Gu Xiao-yuan Zhou College of Physics and Electronic Science Hubei Normal UniversityHuangshi 435002China Analytical and Testing Center Chongqing UniversityChongqing401331China School of Science Chongqing University of Posts and Telecommunications.Chongqing 400065 China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials-Hubei Key Laboratory of Ferro&Piezoelectric Materials and Devices Faculty of Physical and Electronic SciencesHubei UniversityWuhan 430062China College of Physics Chongqing UniversityChongqing 401331China

Recent research shows that increasing the carrier density after orbital alignment in AZn_(2)Sb_(2) (A=Ca,Yb,Eu,Sr,Mg)Zintl compounds yields remarkable results with regard to enhanced thermoelectric ***,research on carrier density increase via doping in these compounds is *** this study,we introduced Cu into the Zn sites in YbZn_(2)Sb_(2) and examined the thermoelectric properties.

关键词： properties doping performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TRAIL and Celastrol Combinational Treatment Suppresses Proliferation, Migration, and Invasion of Human Glioblastoma Cells via Targeting Wnt/β-catenin Signaling Pathway

引用

Chinese Journal of Integrative Medicine 2024年第4期30卷 322-329页

作者： QIN Jing-jing NIU Meng-da CHA Zhe GENG Qing-hua LI yu-lin REN Chun-guang David P.Molloy yu Hua-rong Research Center of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China

Objective To investigate the mechanistic basis for the anti-proliferation and anti-invasion effect of tumor necrosis factor-related apoptosis-induced ligand(TRAIL)and celastrol combination treatment(TCCT)in glioblastoma *** Cell counting kit-8 was used to detect the effects of different concentrations of celastrol(0-16µmol/L)and TRAIL(0-500 ng/mL)on the cell viability of glioblastoma cells.U87 cells were randomly divided into 4 groups,namely control,TRAIL(TRAIL 100 ng/mL),Cel(celastrol 0.5µmol/L)and TCCT(TRAIL 100 ng/mL+celastrol 0.5µmol/L).Cell proliferation,migration,and invasion were detected by colony formation,wound healing,and Transwell assays,*** reverse transcription polymerase chain reaction and Western blotting were performed to assess the levels of epithelial-mesenchymal transition(EMT)markers(zona occludens,N-cadherin,vimentin,zinc finger E-box-binding homeobox,Slug,and β-catenin).Wnt pathway was activated by lithium chloride(LiCl,20 mol/L)and the mechanism for action of TCCT was *** Celastrol and TRAIL synergistically inhibited the proliferation,migration,invasion,and EMT of U87 cells(P<0.01).TCCT up-regulated the expression of GSK-3β and down-regulated the expression of β-catenin and its associated proteins(P<0.05 or P<0.01),including c-Myc,Cyclin-D1,and matrix metalloproteinase(MMP)-*** addition,LiCl,an activator of the Wnt signaling pathway,restored the inhibitory effects of TCCT on the expression of β-catenin and its downstream genes,as well as the migration and invasion of glioblastoma cells(P<0.05 or P<0.01).Conclusions Celastrol and TRAIL can synergistically suppress glioblastoma cell migration,invasion,and EMT,potentially through inhibition of Wnt/β-catenin *** underlies a novel mechanism of action for TCCT as an effective therapy for glioblastoma.

关键词： celastrol Chinese medicine tumor necrosis factor-related apoptosis-induced ligand glioblastoma β-catenin Tripterygium wilfordii

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mg-5Zn-3Al-0.2Mn铸造合金的组织和室温力学性能

引用

中国有色金属学报 2006年第2期16卷 205-212页

作者：杨光昱介万奇郝启堂西北工业大学材料科学与工程学院西安710071

研究了砂型铸造Mg-5Zn-3Al-0.2Mn合金的显微组织,发现其主要相组成为δ-Mg基体相和τ(Mg32(Al,Zn)49)化合物相,τ相以半连续网状骨骼形态沿δ相的晶界分布。实验合金中加入少量Sr,Ti,B元素后,合金组织细化,τ相形态转变为断续的短条状... 详细信息

研究了砂型铸造Mg-5Zn-3Al-0.2Mn合金的显微组织,发现其主要相组成为δ-Mg基体相和τ(Mg32(Al,Zn)49)化合物相,τ相以半连续网状骨骼形态沿δ相的晶界分布。实验合金中加入少量Sr,Ti,B元素后,合金组织细化,τ相形态转变为断续的短条状或粒状,并且分布更加均匀。在本实验条件下,当炉前加入0.06%Ti、0.012%B、0.1%Sr时,合金的组织形态得到显著改善,合金的室温力学性能最佳。不同温度下对Mg-5Zn-3Al-0.2Mn合金进行的固溶处理实验发现,在335℃固溶17 h淬火后,合金的室温抗拉强度和塑性得到了大幅度提高;在343℃固溶17 h淬火后,合金组织完全转变为单相固溶体,合金的室温力学性能较好,bσ为245MPa,δ为12%。

关键词：铸造镁合金显微组织室温力学性能变质固溶处理

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

2-羟基萘-1-亚甲基若丹宁固相萃取光度法测定环境样品中铅

引用

冶金分析 2006年第1期26卷 21-24页

作者：李明林洪杨艳胡秋芬杨光宇玉溪师范学院化学与环境科学系云南玉溪653100 云南大学化学系云南昆明650091

研究了2-羟基萘-1-亚甲基若丹宁（HNR）与铅的显色反应。在pH4．5的盐酸-六次甲基四胺缓冲介质中，吐温-80存在下，HNR与铅反应生成组成比为2：1的稳定络合物，该络合物可被Waters Sep-PakC18小柱固相萃取．用N-N-二甲基甲酰氨（DMF）... 详细信息

研究了2-羟基萘-1-亚甲基若丹宁（HNR）与铅的显色反应。在pH4．5的盐酸-六次甲基四胺缓冲介质中，吐温-80存在下，HNR与铅反应生成组成比为2：1的稳定络合物，该络合物可被Waters Sep-PakC18小柱固相萃取．用N-N-二甲基甲酰氨（DMF）洗脱后光度法测定，在洗脱液介质中络合物最大吸收波长λmax=548nm，体系表观摩尔吸光系数ε=1．04×10^5L·mol^-1·cm^-1。铅量在O．05～4．0μg／mL内符合比尔定律，方法已用于环境样品中铅的测定，加标回收率为96．0％～104．0％．相对标准偏差≤2．5％。

关键词： 2-羟基萘-1-亚甲基若丹宁铅固相萃取光度法环境样品

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于参数估计误差的鲁棒自适应律设计及验证

引用

控制理论与应用 2016年第7期33卷 956-964页

作者：那靖杨光宇高贯斌张金岗昆明理工大学机电工程学院云南昆明650500

针对传统自适应控制系统设计的自适应律参数收敛慢进而影响控制系统瞬态性能的问题,研究一类新的基于参数估计误差修正的鲁棒自适应律设计.首先引入滤波操作给出参数估计误差的提取方法,构建出含参数估计误差修正项的自适应律,进而将该... 详细信息

针对传统自适应控制系统设计的自适应律参数收敛慢进而影响控制系统瞬态性能的问题,研究一类新的基于参数估计误差修正的鲁棒自适应律设计.首先引入滤波操作给出参数估计误差的提取方法,构建出含参数估计误差修正项的自适应律,进而将该自适应律用于控制器设计和分析中,可同时实现控制误差和参数估计误差指数收敛.对比分析了几类传统自适应律和所提出自适应律的收敛性和鲁棒性,并给出了保证参数收敛所需持续激励条件的一种直观、简便的在线判别方法.数值仿真及基于自制三自由度直升机系统俯仰轴实验结果表明,基于参数误差修正的自适应律及控制器可得到优于传统自适应方法的跟踪控制和参数估计性能.

关键词：自适应控制参数估计非线性系统三自由度直升机

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

小儿气管异物合并气管破裂的手术治疗

引用

中华耳鼻咽喉头颈外科杂志 2011年第8期46卷 686-688页

作者：尹志华杨光煜河南省人民医院耳鼻咽喉科郑州450003 河南省人民医院胸外科郑州450003

气管、支气管异物临床常见，是耳鼻咽喉科的危急重症，多发生于儿童，严重危及儿童的生命安全。但气管、支气管异物合并气管破裂却鲜有报道。2004年7月至2009年7月，我院收治支气管异物合并气管破裂患儿3例，均予开胸手术，取出异物并... 详细信息

气管、支气管异物临床常见，是耳鼻咽喉科的危急重症，多发生于儿童，严重危及儿童的生命安全。但气管、支气管异物合并气管破裂却鲜有报道。2004年7月至2009年7月，我院收治支气管异物合并气管破裂患儿3例，均予开胸手术，取出异物并修补气管破裂口，取得满意疗效，现将治疗及体会报告如下。

关键词：气管破裂手术治疗小儿气管异物支气管异物耳鼻咽喉科 2009年危急重症生命安全

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Predictive visual field outcomes after optic chiasm decompressive surgery by retinal vessels parameters using optical coherence tomography angiography

引用

International Journal of Ophthalmology(English edition) 2024年第2期17卷 365-373页

作者： Wen-Juan yu Jin Xiao guang-Xin Wang Chang Jiang Wei Zha Rong-Feng Liao Department of Ophthalmology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Neurosurgery the First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Ophthalmology the First People’s Hospital of HefeiHefei 230061Anhui ProvinceChina

AIM:To evaluate the predictive value of superficial retinal capillary plexus(SRCP)and radial peripapillary capillary(RPC)for visual field recovery after optic cross decompression and compare them with peripapillary nerve fiber layer(pRNFL)and ganglion cell complex(GCC).METHODS:This prospective longitudinal observational study included patients with chiasmal compression due to sellar region mass scheduled for decompressive *** estimating equations were used to compare retinal vessel density and retinal layer thickness preand post-operatively and with healthy *** regression models were used to assess the relationship between preoperative GCC,pRNFL,SRCP,and RPC parameters and visual field recovery after ***:The study included 43 eyes of 24 patients and 48 eyes of 24 healthy *** RPC and SRCP vessel density and pRNFL and GCC thickness were lower than healthy controls and higher than postoperative *** best predictive GCC and pRNFL models were based on the superior GCC[area under the curve(AUC)=0.866]and the tempo-inferior pRNFL(AUC=0.824),and the best predictive SRCP and RPC models were based on the nasal SRCP(AUC=0.718)and tempo-inferior RPC(AUC=0.825).There was no statistical difference in the predictive value of the superior GCC,tempo-inferior pRNFL,and tempo-inferior RPC(all P>0.05).CONCLUSION:Compression of the optic chiasm by tumors in the saddle area can reduce retinal thickness and blood *** reduction persists despite the recovery of the visual field after decompression ***,pRNFL,and RPC can be used as sensitive predictors of visual field recovery after decompression surgery.

关键词： sellar region mass retinal vessels optic chiasm optical coherence tomography angiography visual field decompressive surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatic arterial infusion chemotherapy with anti-angiogenesis agents and immune checkpoint inhibitors for unresectable hepatocellular carcinoma and meta-analysis

引用

World Journal of Gastroenterology 2024年第4期30卷 318-331页

作者： yu-Zhe Cao guang-Lei Zheng Tian-Qi Zhang Hong-Yan Shao Jia-yu Pan Zi-Lin Huang Meng-Xuan Zuo Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy State Key Laboratory of Oncology in South ChinaGuangzhou 510060Guangdong ProvinceChina Department of Minimally Invasive Interventional Therapy Guangdong Provincial Clinical Research Center for CancerGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatic arterial infusion chemotherapy(HAIC)has been proven to be an ideal choice for treating unresectable hepatocellular carcinoma(uHCC).HAIC-based treatment showed great potential for treating ***,large-scale studies on HAIC-based treatments and meta-analyses of first-line treatments for uHCC are *** To investigate better first-line treatment options for uHCC and to assess the safety and efficacy of HAIC combined with angiogenesis inhibitors,programmed cell death of protein 1(PD-1)and its ligand(PD-L1)blockers(triple therapy)under real-world *** Several electronic databases were searched to identify eligible randomized controlled trials for this ***-level pooled analyses of hazard ratios(HRs)and odds ratios(ORs)were *** was a retrospective single-center study involving 442 patients with uHCC who received triple therapy or angiogenesis inhibitors plus PD-1/PD-L1 blockades(AIPB)at Sun Yat-sen University Cancer Center from January 2018 to April *** score matching(PSM)was performed to balance the bias between the *** Kaplan-Meier method and cox regression were used to analyse the survival data,and the log-rank test was used to compare the suvival time between the *** A total of 13 randomized controlled trials were *** alone and in combination with sorafenib were found to be effective treatments(P values for ORs:HAIC,0.95;for HRs:HAIC+sorafenib,0.04).After PSM,176 HCC patients were included in the *** triple therapy group(n=88)had a longer median overall survival than the AIPB group(n=88)(31.6 months vs 14.6 months,P<0.001)and a greater incidence of adverse events(94.3%vs 75.4%,P<0.001).CONCLUSION This meta-analysis suggests that HAIC-based treatments are likely to be the best choice for *** findings confirm that triple therapy is more effective for uHCC patients than AIPB.

关键词： Unresectable hepatocellular carcinoma Hepatic arterial infusion chemotherapy Angiogenesis inhibitors Programmed cell death protein 1 Programmed death ligand 1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于实车数据的电动汽车电池剩余使用寿命预测

引用

交通运输系统工程与信息 2022年第1期22卷 292-300页

作者：胡杰何陈朱雪玲杨光宇武汉理工大学现代汽车零部件技术湖北省重点实验室武汉430070 武汉理工大学汽车零部件技术湖北省协同创新中心武汉430070 武汉理工大学湖北省新能源与智能网联车工程技术研究中心武汉430070

电动汽车电池剩余使用寿命预测是当下电池研究领域的热点内容,现有电池剩余使用寿命预测模型大多基于单一预测指标,预测精度较低,模型的泛化性能较差。本文通过实车数据构建了GM-LSTM的Stacking融合模型,实现电动汽车电池剩余使用寿命... 详细信息

电动汽车电池剩余使用寿命预测是当下电池研究领域的热点内容,现有电池剩余使用寿命预测模型大多基于单一预测指标,预测精度较低,模型的泛化性能较差。本文通过实车数据构建了GM-LSTM的Stacking融合模型,实现电动汽车电池剩余使用寿命的准确预测。首先根据电池剩余使用寿命影响因素,提取车辆真实的运行参数和环境参数,基于随机森林算法筛选最优特征集合作为模型输入,其次选择差分整合移动平均自回归算法对所选特征进行惯性延伸,克服数据时间维度上的限制,最后基于数据特点,分别建立灰色预测模型和长短时记忆神经网络模型实现电池剩余使用寿命预测,并通过Stacking模型融合进一步降低预测误差。结果表明:模型融合后平均相对误差为1.6%,平均绝对误差为0.013,能够稳定可靠的实现电动汽车电池剩余使用寿命预测。

关键词：城市交通剩余使用寿命预测数据驱动电动汽车模型融合

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：