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FE65:a hub for neurodevelopment

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Neural Regeneration Research 2024年第9期19卷 1883-1884页

作者： Yuqi zhai Laura Lok-Haang ng Dennis Dik-Long Chau Kwok-Fai Lau School of Life sciences Faculty of ScienceThe Chinese University of Hong KongHong Kong Special Administrative RegionChina

FE65,initially identified as a binding partner of amyloid precursor protein(APP),is an adaptor protein enriched in the brain and regulated during ***65 belongs to the FE65 protein *** family is comprised of three memb... 详细信息

关键词： family development partner

Nondegenerative ML-sequences over ring Z/（2e）

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Science Bulletin 1999年第17期 1557-1561页

作者： yang junhui and zhai Qibin Institute of software , chinese academy of sciences , beij.ng 100080, china State Key Laboratory of Information Security , beij.ng 100080, china

关键词： nondegenerate ML-sequence quasi-period.

Occurrence,Spatial Distribution,Sources and Risk Assessment of Per-and Polyfluoroalkyl Substances in Surface Sediments of the Yellow River Delta Wetland

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Journal of Ocean University of china 2024年第5期23卷 1263-1274页

作者： SUN Yu SHEN Nan ZHAng Dahai CHEN junhui HE Xiuping JI Yinli WAng Haiyang LI Xianguo Key Laboratory of Marine Chemistry Theory and Technology(Ocean University of china) Ministry of EducationQingdao 266100China Key Laboratory of Marine Eco-Environmental Science and Technology First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Qingdao Key Laboratory of Analytical Technology Development and Offshore Eco-Environment Conservation Qingdao 266061China The Yellow River Delta Sustainable Development Institute of Shandong Province Dongying 257100China

Per-and polyfluoroalkyl substances(PFASs)are emerging persistent organic pollutants(POPs).In this study,47 surface sediment samples were collected from the Yellow River Delta wetland(YRDW)to investigate the occurrence,spatial distribution,potential sources,and ecological risks of ***-three out of 26 targeted PFASs were detected in surface sediment samples from the YRDW,with totalΣ23PFASs concentrations ranging from 0.23 to 16.30 ng g^(-1) dw and a median value of 2.27 ng g^(-1) *** acid(PFOA),perfluorobutanoic acid(PFBA)and perfluorooctanesulfonic acid(PFOS)were the main *** detection frequency and concentration of perfluoroalkyl carboxylic acids(PFCAs)were higher than those of perfluoroal-kanesulfonic acids(PFSAs),while those of long-chain PFASs were higher than those of short-chain *** emerging PFASs substitutes were dominated by 6:2 chlorinated polyfluoroalkyl ether sulfonic acid(6:2 Cl-PFESA).The distribution of PFASs is significantly influenced by the total organic carbon content in the *** concentration of PFASs seems to be related to human activities,with high concentration levels of PFASs near locations such as beaches and *** using a positive matrix factorization model,the potential sources of PFASs in the region were identified as metal plating mist inhibitor and fluoropolymer manufacturing sources,metal plating industry and firefighting foam and textile treatment sources,and food packaging material *** risk assessment indicated that PFASs in YRDW sediments do not pose a significant ecological risk to benthic organisms in the region overall,but PFOA and PFOS exert a low to moderate risk at individual stations.

关键词： per-and polyfluoroalkyl substances Yellow River Delta wetland sediment source identification risk assessment

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第二磨牙萌出障碍的检出率变化及病因调查

口腔医学研究 2024年第2期40卷 147-151页

作者：刘世颖翟俊辉姜洪涛王明锋刘琳刘筱琳大连医科大学附属大连市口腔医院正畸科大连市口腔疾病预防控制中心辽宁大连116021

目的:调查近年相对于二十多年前第二磨牙萌出障碍的检出率变化,并分析病因。方法:以在作者所在医院就诊的患者病历资料为研究对象,并按照就诊年代分为二十年前组和近年组。比较两组第二磨牙萌出障碍的检出率,分析主要病因以及与错牙合... 详细信息

目的:调查近年相对于二十多年前第二磨牙萌出障碍的检出率变化,并分析病因。方法:以在作者所在医院就诊的患者病历资料为研究对象,并按照就诊年代分为二十年前组和近年组。比较两组第二磨牙萌出障碍的检出率,分析主要病因以及与错牙合畸形类型的关系。结果:近年组的检出率及患牙数明显高于二十年前组(P<0.01)。两组中,由萌出方向异常和或间隙不足而导致的患牙数明显高于其他原因导致的患牙数(P<0.05)。第二磨牙萌出障碍好发于下颌,与第三磨牙存在与否无明显关系。在第二磨牙萌出障碍的病例中,骨性Ⅰ类均角最多见,骨性Ⅱ类多于骨性Ⅲ类,高角多于低角。结论:近年第二磨牙萌出障碍的检出率与二十多年前相比明显增加,主要病因为第二磨牙的萌出方向异常和/或间隙不足。第二磨牙萌出障碍好发于骨性Ⅱ类和高角的患者。

关键词：第二磨牙萌出障碍检出率病因错牙合畸形类型

Fluorescence determination of platinum with dibromohydroxyphenyl-fluorone in microemulsion after separation and enrichment by sulfhydryl dextrose gel

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Rare Metals 2008年第1期27卷 101-105页

作者： LI Huizhi zhai Yubo zhai Diantang School of Chemistry and Chemical Engineering Jinan University Jinan 250022 China School of Life Science Nanjing University Nanjing 210093 China

A new fluorescence quenching method has been developed for the determination of platinum in nonionic microemulsion *** method is based on the fact that platinum can form a stable chelate with dibromohydroxyphenyl-fluorine（DBHPF） when they are in the molar ratio of 1：2 in the nonionic microemulsion *** optimum conditions,the system,having the maximum excitation and emission wavelengths at 468 nm and 532 nm,respectively,shows constant fluorescence intensity in the pH range of 3.5-4.0 and high selectivity and sensitivity as well as low interference from foreign ***,this fluorescence intensity is a linear function of Pt（IV） concentration in the range of 0.002-1.00 μg·mL^-1 and the limit of detection is 2.90 ng·mL^-1.

关键词： analytical chemistry separation and enrichment fluorescence determination microemulsion platinum(IV)

Microbe-derived carbon materials for electrical energy storage and conversion

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Journal of Energy Chemistry 2016年第2期25卷 189-196页

作者： Li Wei H.Enis Karahan Shengli zhai yang Yuan Qihui Qian Kunli Goh Andrew Keong ng Yuan Chen School of Chemical and Biomedical Engineering Nanyang Technological University 62 Nanyang Drive 637459 Singapore Singapore Institute of Technology 10 Dover Drive 138683 Singapore School of Chemical and Biomolecular Engineering The University of Sydney NSW 2006 Australia

Microbes are microscopic living organisms that surround us which include bacteria, archaea, most protozoa, and some fungi and algae. In recent years, microbes have been explored as novel precursors to synthesize carbon-based（nano）materials and as substrates or templates to produce carbon-containing（nano）composites. Being greener and more affordable, microbe-derived carbons（MDCs） offer good potential for energy applications. In this review, we describe the unique advantages of MDCs and outline the common procedures to prepare them. We also extensively discuss the energy applications of MDCs including their use as electrodes in supercapacitors and lithium-ion batteries, and as electrocatalysts for processes such as oxygen reduction, oxygen evolution, and hydrogen evolution reactions which are essential for fuel cell and water electrochemical splitting cells. Based on the literature trend and our group＇s expertise, we propose potential research directions for developing new types of MDCs. This review, therefore, provides the state-of-the-art of a new energy chemistry concept. We expect to stimulate future research on the applications of MDCs that may address energy and environmental challenges that our societies are facing.

关键词： Microbe Carbon materials Supercapacitor Lithium-ion battery Oxygen reduction reaction Hydrogen evolution reaction

急性心肌梗死患者经皮冠状动脉介入术前后血清CTRP12水平变化及其与支架内再狭窄的关系

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实用医学杂志 2024年第12期40卷 1671-1676页

作者：张友明龚军辉朱红涛常州市妇幼保健院心内科常州医学中心南京医科大学江苏常州213003 江苏省丹阳市人民医院心内科江苏镇江212300

目的探讨急性心肌梗死(AMI)患者经皮冠状动脉介入术(PCI)前后血清补体C1肿瘤坏死因子相关蛋白家族12(CTRP12)水平的变化及与对支架内再狭窄(ISR)的关系。方法选取2021年1月至2023年6月江苏省丹阳市人民医院确诊为AMI并行PCI的患者104例... 详细信息

目的探讨急性心肌梗死(AMI)患者经皮冠状动脉介入术(PCI)前后血清补体C1肿瘤坏死因子相关蛋白家族12(CTRP12)水平的变化及与对支架内再狭窄(ISR)的关系。方法选取2021年1月至2023年6月江苏省丹阳市人民医院确诊为AMI并行PCI的患者104例,统计术后12个月内ISR发生率,并根据复查冠脉造影结果将其分为ISR组和非ISR组。比较两组患者PCI术前和出院前日血清CTRP12水平。Logistic回归分析AMI患者PCI术后ISR的影响因素,受试者工作特征(ROC)曲线分析CTRP12对AMI患者PCI术后ISR的预测价值。结果104例AMI患者PCI术后12个月ISR发生率为14.4%(15/104)。ISR组术前TIMI血流≤1比例、白细胞计数、中性粒细胞计数、TC、LDL-C较非ISR组显著升高,出院前日血清CTRP12水平低于非ISR组(P0.05)。Logistic回归分析显示,出院前日血清CTRP12水平降低是AMI患者PCI术后ISR的独立危险因素(Png/mL(敏感度93.3%,特异度73.0%),ROC曲线下面积(AUC)为0.849。结论出院前日血清CTRP12水平对AMI患者PCI术后ISR发生具有一定预测价值,CTRP12可能是AMI患者PCI术后ISR的治疗靶分子。

关键词：急性心肌梗死经皮冠状动脉介入术补体C1肿瘤坏死因子相关蛋白家族12 支架内再狭窄

猪圆环病毒3型四川株Cap蛋白的截短表达及其抗体间接ELISA方法的建立

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中国畜牧兽医 2024年第7期51卷 3056-3066页

作者：欧云文潘琴汪洋代军飞任绍科张洋翟佳佳张杰开江县动物疫病预防控制中心达州636250 中国农业科学院兰州兽医研究所兰州大学动物医学与生物安全学院动物疫病防控全国重点实验室兰州730046 河北科技师范学院河北省预防兽医学重点实验室秦皇岛066004

【目的】原核截短表达猪圆环病毒3型(Porcine circovirus type 3,PCV3)四川株Cap蛋白(1-197位氨基酸),并建立其抗体间接ELISA检测方法,为PCV3血清学调查提供材料。【方法】以PCV3四川分离株基因组为模板,PCR扩增获得Cap蛋白编码基因片段... 详细信息

【目的】原核截短表达猪圆环病毒3型(Porcine circovirus type 3,PCV3)四川株Cap蛋白(1-197位氨基酸),并建立其抗体间接ELISA检测方法,为PCV3血清学调查提供材料。【方法】以PCV3四川分离株基因组为模板,PCR扩增获得Cap蛋白编码基因片段,将其克隆至原核表达载体pET-30a(+)中构建重组质粒pET30a-PCV3-Cap。经酶切和测序鉴定后,将重组质粒转化大肠杆菌BL21(DE3)感受态细胞,IPTG诱导表达,Ni-NTA树脂亲和层析纯化,获得具有良好抗原性的重组Cap蛋白。基于纯化的重组Cap蛋白建立间接ELISA方法,确定最佳抗原包被浓度、待检血清最佳稀释比例、酶标抗体稀释比例和阴阳性临界值,对间接ELISA方法的特异性、敏感性、重复性、相关性和符合率进行分析,并对2018-2022年采自川东北地区猪场的351份临床猪血清进行检测,分析该区域PCV3流行情况。【结果】试验成功构建pET30a-PCV3-Cap重组表达载体,实现重组Cap蛋白(1-197位氨基酸)的原核截短表达,蛋白大小约为26 ku,可与PCV3阳性猪血清发生特异性反应;确定最佳抗原包被浓度为1 ng/μL,待检血清最佳稀释比例为1∶100,酶标抗体稀释比例为1∶60000,阴阳性临界值D_(450 nm)为0.684;建立的间接ELISA方法与猪瘟病毒(CSFV)、猪繁殖与呼吸综合征病毒(PRRSV)、猪圆环病毒2型(PCV2)、猪伪狂犬病病毒(PRV)、日本乙型脑炎病毒(JEV)和猪细小病毒1型(PPV1)阳性猪血清均不发生交叉反应,敏感度达1∶1600,批内变异系数和批间变异系数均ng方法的阳性符合率为95.8%;2018-2022年川东北地区的351份猪血清样品阳性率为7.12%。【结论】本研究成功截短表达了PCV3四川株Cap蛋白(1-197位氨基酸),建立了特异性强、灵敏度高、重复性好和符合率高的PCV3间接ELISA方法,为PCV3的血清学调查和检测试剂盒的开发提供了材料。

关键词：猪圆环病毒3型(PCV3) Cap蛋白截短表达 ELISA

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胰腺肿瘤伴血糖异常对肿瘤标志物的影响分析

中国实用医药 2024年第19期19卷 78-81页

作者：翟婷婷盐城市大丰中医院检验科 224100

目的探讨胰腺肿瘤伴血糖异常患者检验肿瘤标志物指标的影响。方法选取80例胰腺肿瘤患者,其中良性胰腺肿瘤患者40例(血糖正常患者20例,血糖异常患者20例),恶性胰腺肿瘤患者40例(血糖正常患者20例,血糖异常患者20例)。两组患者均开展肿... 详细信息

目的探讨胰腺肿瘤伴血糖异常患者检验肿瘤标志物指标的影响。方法选取80例胰腺肿瘤患者,其中良性胰腺肿瘤患者40例(血糖正常患者20例,血糖异常患者20例),恶性胰腺肿瘤患者40例(血糖正常患者20例,血糖异常患者20例)。两组患者均开展肿瘤标志物检查。比较良性胰腺肿瘤患者与恶性胰腺癌患者以及良性肿瘤、恶性肿瘤患者中血糖正常和血糖异常患者的糖类抗原199(CA199)、癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原125(CA125)、糖类抗原153(CA153)水平。结果恶性胰腺肿瘤患者CA199(76.37±10.16)U/ml、CEA(26.13±6.38)ng/ml、AFP(22.32±7.19)ng/ml、CA125(63.85±12.11)U/ml、CA153(45.96±10.27)U/ml均明显高于良性胰腺肿瘤患者的(13.20±2.11)U/ml、(2.65±0.35)ng/ml、(3.37±0.13)ng/ml、(13.79±2.02)U/ml、(7.92±1.21)U/ml(Png/ml、AFP(28.13±8.27)ng/ml、CA125(68.77±3.10)U/ml、CA153(50.16±4.24)U/ml均高于血糖正常患者的(66.33±10.14)U/ml、(21.63±7.22)ng/ml、(16.51±7.24)ng/ml、(58.93±3.02)U/ml、(41.76±4.21)U/ml(P0.05)。结论对于胰腺肿瘤患者来讲,血糖异常对肿瘤标志物指标有明显影响,应予以重点关注,合理控制血糖,从而为疾病的进一步治疗奠定良好条件。

关键词：胰腺肿瘤血糖异常肿瘤标志物癌胚抗原