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Water Dissociation Phenomena on a Bipolar Membrane──Current-voltage Curve in Relation with IonicTransport and Limiting Current Density

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Chemical Research in Chinese Universities 2001年第4期17卷 457-464页

作者： XU Tong-wen yang wei-hua Department of Applied Chemistry University of Science and Technology of ChinaHefei 230026P.R.China

The water dissociation mechanism on a bipolar membrane under the electrical field was investigated and characterized in terms of ionic transport and limiting current density. It is considered that the depletion layer exists at the junction of a bipolar membrane, which is coincided with the viewpoint of the most literatures, but we also consider that the thickness and conductivity of this layer is not only related with the increase of the applied voltage but also with the limiting current density. Below the limiting current density, the thickness of the depletion layer keeps a constant and the conductivity decreases with the increase of the applied voltage; while above the limiting current density, the depletion thickness will increase with the increase of the applied voltage and the conductivity keeps a very low constant. Based on the data reported in the literatures and independent determinations, the limiting current density was calculated and the experimental curves Ⅰ-Ⅴ in the two directions were com

关键词： Bipolar membrane Water dissociation Ionic transport Limiting current density

基于iFEM和虚实结合的加筋板应变场构建研究

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船舶力学 2024年第3期28卷 409-421页

作者：陈国材汪雪良杨华伟蒋镇涛张涛张正中国船舶科学研究中心江苏无锡214082 深海技术科学太湖实验室江苏无锡214082 武汉理工大学武汉430070

iFEM(inverse finite element method)是目前进行结构应变场构建最有前景的方法之一,其目的是在结构离散应变采集过程中,以最少的实际测点获取满足精度要求的结构应变场。在一些局部区域应变数据不易采集时,可尝试采用虚实结合的方式进... 详细信息

iFEM(inverse finite element method)是目前进行结构应变场构建最有前景的方法之一,其目的是在结构离散应变采集过程中,以最少的实际测点获取满足精度要求的结构应变场。在一些局部区域应变数据不易采集时,可尝试采用虚实结合的方式进行离散应变数据的采集。本文以船舶典型结构加筋板为例,根据实测数据,结合仿真模型,依据Xgboost的测点回归方法,基于iFEM技术依次计算实测、仿真和虚实结合三种方法的应变场重构精度,分析误差原因。通过预测,当47个物理测点时平均误差最低,为1.92%,以虚实结合路径输入15个点和21个点时结果与验证点的误差均小于3%,验证了虚实结合快速补充缺失数据的应变场重构的方法操作性强、准确度高。

关键词： iFEM 加筋板虚实结合方法应变场 Xgboost回归方法

Cloning and Sequence Analysis of the Full-length cDNA of a Novel yp05 Gene Associated With Citrinin Production in Monascus aurantiacus

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Biomedical and Environmental Sciences 2007年第2期20卷 135-140页

作者： YONG-hua XIONG yang XU wei-hua LAI YAN-PIN LI hua wei Sino-Germany Joint Research Institute National Key Laboratory of Food Science （Nanchang University） Ministry of Education Nanchang 330047 Jiangxi China

Objective To obtain the full-length cDNA of a novel gene （named yp05） associated with citrinin production-related genes in Monascus aurantiacus. Methods Total RNA was extracted from mycelium, 3＇ and 5＇ cDNA end of yp05 gene was amplified using smartTM trace cDNA amplification kit, and the full-length cDNA of a novel gene （named yp05） was obtained from the electronic assembly of 3＇-RACE and 5＇- RACE products. Results This yp05 gene was 787 bp including a 597 bp open reading frame （ORF） and encoded a deduced protein with 199 amino acid residues, and the amino acid sequence of this protein was found similar with the sequences of many fungal manganese-superoxide dismutases in the GenBank with the aid of BLASTp. The transcription ofyp05 gene in Monascus strains was analyzed with the aid of Northern blotting. The transcription of yp05 gene was only detected in Monascus strains, provided that citrinin was produced. Conclusion The transcription of yp05 gene belongs to differential expression genes of citfinin yielded from Monascus and has no correlation with the biosynthesis pathway of red pigments.

关键词： Monascus aurantiacus Citrinin RACE Manganese-superoxide dismutases

Partition Equilibrium on the Interface Between a Charged Membrane and a Mixed Electrolyte Aqueous Solution

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Chemical Research in Chinese Universities 2003年第1期19卷 63-69页

作者： XU Tong wen yang wei hua Department of Chemistry University of Science and Technology of ChinaHefei 230026P.R.China

Ionic partition equilibrium on a charged membrane immersed in a mixed electrolyte solution was systematically investigated and several models were established for the determination of partition coefficients. On the basis of theoretical models, the effects of the concentration ratio λ of the fixed group(charged density) to reference electrolyte, the concentration ratio η between the two electrolytes existing in the solution and the valence of the electrolyte ions on the partition equilibrium in a positively charged membrane were analyzed and simulated within the chosen parameters in detail. The obtainable results can also be applicable to a sytem of mixed electrolytes contacting with a negatively charged membrane. The theoretical calculations were confirmed with the experimental data of model mixed electrolytes, NaCl+HCl and CaCl 2+NaCl partitioned in the system of self made negatively charged membrane sulphonated poly(phenylene oxide)(SPPO) with different charge densities.

关键词： Partition coefficient Donnan equilibrium Mixed electrolyte Charged membrane

On the extra edge-connectivity of hypercubes

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Applied Mathematics(A Journal of Chinese Universities) 2016年第2期31卷 198-204页

作者： ZHANG Ming-zu MENG Ji-xiang yang wei-hua College of Mathematics and System Sciences Xinjiang University Department of Mathematics Taiyuan University of Technology

The classical hypercube structure is a popular topological architecture in parallel computing environments and a large number of variations based on the hypercube were posed in the past three decades. Reliability evaluation of systems is important to the design and maintenance of multiprocessor systems. The h-extra edge-connectivity of graph G（V, E） is a kind of measure for the reliability of interconnection systems, which is defined as the minimum cardinality of a subset of edge set, if any, whose deletion disconnects G and such that every re- maining component has at least h vertices. This paper shows that the h-extra edge-connectivity 2n-1 2n-1 of the hypercube Qn is a constant 2n-1 for 2n-1/3≤ h2n-1, and n ≥ 4, which extends the result of [Bounding the size of the subgraph induced by m vertices and extra edge-connectivity of hypercubes, Discrete Applied Mathematics, 2013, 161（16）： 2753-2757].

关键词： Edge fault tolerance Extra edge-connectivity Hypercube

微创种植牙在牙列游离端缺失患者中的应用效果评价

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中国口腔颌面外科杂志 2024年第4期22卷 390-393页

作者：杨伟华姜晟波周莺莺嘉善县中医医院口腔科浙江嘉兴314100

目的:探讨微创种植牙在牙列游离端缺失患者中的应用效果。方法:选择2021年1月—2022年4月在嘉善县中医医院治疗的牙列游离端缺失患者80例,其中接受微创种植牙治疗42例(试验组),接受常规种植牙治疗38例(对照组)。比较2组患者的手术时间... 详细信息

目的:探讨微创种植牙在牙列游离端缺失患者中的应用效果。方法:选择2021年1月—2022年4月在嘉善县中医医院治疗的牙列游离端缺失患者80例,其中接受微创种植牙治疗42例(试验组),接受常规种植牙治疗38例(对照组)。比较2组患者的手术时间、术后疼痛、创口愈合时间、咀嚼功能、种植体稳定度、牙槽嵴顶骨吸收量等的差异。采用SPSS 22.0软件包对数据进行统计学分析。结果:试验组手术时间、创口愈合时间、术后红肿时间和术后疼痛VAS评分分别为(24.12±3.06) min、(3.50±0.61) d、(1.22±0.32) d和(2.50±0.46)分,均显著低于对照组(P<0.05)。试验组治疗后咬合力、咀嚼效率分别为(129.87±20.05) Ibs和(89.96±9.11)%,显著高于对照组(P<0.05)。试验组种植体稳定系数(ISQ)为70.05±4.15,显著高于对照组的63.35±5.21(P<0.05);试验组牙槽嵴顶骨吸收量为(0.56±0.14) mm,显著低于对照组的(0.63±0.12) mm(P<0.05)。结论:微创种植牙在牙列游离端缺失治疗中有较好的效果,能明显改善患者咬合效率,种植体稳定性好。

关键词：微创种植不翻瓣牙列游离端缺失种植体稳定度

LINE-1 family member GCRG123 gene is up-regulated in human gastric signet-ring cell carcinoma

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World Journal of Gastroenterology 2008年第5期14卷 758-763页

作者： Gang-Shi Wang Meng-wei Wang Ben-Yan Wu Xin-Yan yang wei-hua Wang wei-Di You Department of Gerontal Gastroenterology General Hospital of Chinese PLA Beijing 100853 China

AIM： To analyze the expression profiles of a human gastriccancer-related gene, GCRG123, in human gastric signetring cell carcinoma tissues, and to perform bioinformatics analysis on GCRG123.METHODS： In situ hybridization was used to explore the GCRG123 expression pattern in paraffin-embedded gastric tissues, including 15 cases of signet-ring cell carcinoma, 15 of intestinal-type adenocarcinoma, and 15 of normal gastric mucosa. Northern blotting was used to analyze the differences in GCRG123 expression between stomach signet-ring cell carcinoma and intestinal-type adenocarcinoma tissues. Online software, including BLAST, Multalin and BLAT, were applied for bioinformatics analysis. National Center for Biotechnology Information （NCBI） and the University of California Santa Cruz （UCSC） databases were used for the analyses.RESULTS： The in situ hybridization signal appeared as blue precipitates restricted to the cytoplasm. Ten out of 15 cases of gastric signet ring cell carcinoma, normal gastric mucosal epithelium and pyloric glands showed high GCRG123 expression. Low GCRG123 expression was observed in gastric intestinal-type adenocarcinoma and normal gastric glands. Northern blotting revealed that GCRG123 was up-regulated in signet-ring cell carcinoma tissue but down-regulated in intestinal-type adenocarcinoma tissue. BLAST and Multalin analyses revealed that the GCRG123 sequence had 92% similarity with the ORF2 sequence of human long interspersed nuclear element retrotransposons （LINE-1, L1）. BLAT analysis indicated that GCRG123 mapped to all chromosomes. GCRG123 was found to integrate in the intron-17 and -23 of Rb, 5＇ flanking region of IL-2 and clotting factor Ⅸ genes.CONCLUSION： GCRG123, an active member of the Lt family, was up-regulated in human gastric signet-ring cell carcinoma.

关键词： Stomach Signet-ring cell carcinoma GCRG123 LINE-1 In situ hybridization Bioinformatics

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行业高校管理学科研究生培养质量提升研究

教育教学论坛 2024年第3期 169-172页

作者：范晓男鲍晓娜杨卫华大连工业大学管理学院辽宁大连116034

行业高校肩负着为地方经济、行业企业发展培养高素质管理人才的重要使命,但管理学科研究生培养却始终存在着培养目标大同小异、特色不明显、人才培养质量不高等问题。围绕行业高校如何提高管理学科研究生培养质量的关键问题,结合长期教... 详细信息

行业高校肩负着为地方经济、行业企业发展培养高素质管理人才的重要使命,但管理学科研究生培养却始终存在着培养目标大同小异、特色不明显、人才培养质量不高等问题。围绕行业高校如何提高管理学科研究生培养质量的关键问题,结合长期教育教学理论研究和实践,重塑研究生培养目标,实施学科“交叉融合”新战略,构建以“科教融合、产教融合”为引领的人才培养模式,探索出适合并符合新时代行业高校管理学科研究生培养质量提升的路径,更好地服务于行业企业,支撑区域经济发展。

关键词：管理学科研究生培养质量行业高校

Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： Feng Li Yuan yang hua Yue Shuang Wang Xiao Zhang wei wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery