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Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy

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Chinese Chemical Letters 2024年第7期35卷 400-406页

作者： Zhaomin Tang Qian He Jianren Zhou Shuang Yan Li Jiang Yudong Wang Chenxing Yao Huangzhao Wei keda yang Jiajia Wang School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310015China Department of Laboratory Medicine Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China

Fe-based Fenton agents can generate highly reactive and toxic hydroxyl radicals(·OH)in the tumor microenvironment(TME)for chemodynamic therapy(CDT)with high ***,the low pH environment and insufficient endogenous hydrogen peroxide(H_(2)O_(2))of the highly efficient Fenton reaction limits its practical application in ***,a Cu(Ⅱ)-doped mesoporous silica nanoagent(Cu-MSN)with excellent dispersity was successfully *** loaded with doxorubicin(DOX)and ascorbate(AA),Cu-MSN@DA was coated with active targeting ligand folic acid(FA),dimethyl maleic an-hydride(DMMA)and carboxymethyl chitosan(CMC)to obtain an active transporting nanoagent(FCDC@Cu-MSN@DA)with tunable charge-reversal property,which is more adaptable to the pH value of TME than Fe-based Fenton agents,and can self-supply exogenous H_(2)O_(2)by ascorbate to produce more toxic·OH to trigger the apoptosis of cancer ***,the high level of glutathione(GSH)in TME can reduce Cu(Ⅱ)to Cu(I)by Fenton-like reaction,increasing the generation rate of·OH and relieving tumor antioxidant *** supply of exogenous H_(2)O_(2)significantly enhanced the synergistic effect of CDT by oxidative *** with DOX-induced cell apoptosis,this novel nanoagent FCDC@Cu-MSN@DA can achieve maximum therapeutic efficacy,creating a new model of safe and effective tumor treatment with high specificity.

关键词： Cu(Ⅱ)-doped Ascorbate Hydrogen peroxide Charge-reversal Oxidative damage

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Phase behavior and interfacial properties of symmetric polymeric ternary blends A/B/AB

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Science China Chemistry 2013年第12期56卷 1710-1721页

作者： LIU XiaoHan BAI ZhiQiang yang keda SU JiaYe GUO HongXia Beijing National Laboratory for Molecular Sciences Joint Laboratory of Polymer Sciences and Materials State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences

In this paper, the phase behavior and interracial properties of symmetric ternary polymeric blends A/B/AB are studied by dissipative particle dynamics （DPD） simulations. By using the structure factor and nematic order parameter, we carefully characterized the diversified phases and phase transitions, and established the phase diagram of such symmetric ternary blends. It can be generally divided into four regions： disordered phase （DIS） region at high temperature, ordered lameUar phase （LAM） region, bicontinuous microemulsion （BμE） channel and phase-separated phase （2P） region at low temperature with the increase of the total volume fractions of homopolymers φn, which shows good accordance with that in previous experimental and theoretical reports. Furthermore, we calculated the elastic constants of 2P and LAM phase, and discussed the transition mechanisms from 2P and LAM to BμE phase, respectively. The results show a direct relevance between the phase transitions and the change of interfacial properties. Finally, we also demonstrate that the B,uE channel becomes narrower in lower temperature caused by the temperature dependence of interfacial properties of ternary blends.

关键词： symmetric ternary blend phase behavior bicontinuous microemulsion dissipative particle dynamics

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Theoretical study on rotary-sliding disk triboelectric nanogenerators in contact and non-contact modes

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Nano Research 2016年第4期9卷 1057-1070页

作者： Tao Jiang Xiangyu Chen keda yang Changbao Han Wei Tang Zhong Lin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 100083 China Computer Network Information Center Chinese Academy of Sciences Beijing 100190 China School of Materials Science and Engineering Georgia Institute of Technology Atlanta GA 30332-0245 USA

The triboelectric nanogenerator （TENG） has emerged as a new and effective mechanical energy harvesting technology. In this work, a theoretical model for a rotary-sliding disk TENG with grating structure was constructed, including the dielectric-to-dielectric and conductor-to-dielectric cases. The finite element method （FEM） was utilized to characterize the fundamental physics of the rotary- sliding disk TENG working in both contact and non-contact modes. The basic properties of disk TENG were found to be controlled by the structural parameters such as tribo-surface spacing, grating number, and geometric size. From the FEM calculations, an approximate V-Q-a relationship was built through the inter- polation method, and then the TENG dynamic output characteristics with arbitrary load resistance were numerically calculated. Finall~ the dependencies of output power and matched resistance on the structural parameters and rotation rate were revealed. The present work provides an in-depth understanding of the working principle of the rotary-sliding disk TENG and serves as important guidance for optimizing TENG output performance in specific applications.

关键词： rotary-sliding disk triboelectric nanogenerator finite element method output characteristics continuous fraction interpolation

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颈段椎管内神经鞘瘤引起蛛网膜下腔出血病例报告并文献复习

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中风与神经疾病杂志 2024年第7期41卷 646-650页

作者：谭娟英杨可达柳茵胡中扬中南大学湘雅三医院神经内科湖南长沙410000 中南大学湘雅医院病理科湖南长沙410000 中南大学湘雅三医院放射科湖南长沙410000

分析中南大学湘雅三医院收治及文献报道的表现为蛛网膜下腔出血(SAH)的椎管内神经鞘瘤病例共19例,以总结椎管内神经鞘瘤引起蛛网膜下腔出血的临床特征。本报道涉及的患者临床表现为剧烈头痛呕吐,无脊髓及神经根受压症状,腰穿结果证实了S... 详细信息

分析中南大学湘雅三医院收治及文献报道的表现为蛛网膜下腔出血(SAH)的椎管内神经鞘瘤病例共19例,以总结椎管内神经鞘瘤引起蛛网膜下腔出血的临床特征。本报道涉及的患者临床表现为剧烈头痛呕吐,无脊髓及神经根受压症状,腰穿结果证实了SAH,患者全脑血管造影未提示颅内动脉瘤及血管畸形,脊髓MRI示颈段髓外硬膜内肿瘤,经手术治疗,病理活检结果诊断神经鞘瘤。文献报道的部分病例除了SAH,还有脊髓及神经根受压症状。该类疾病的临床特点提示临床医生颅内影像学检查阴性的SAH患者应明确有无神经根或脊髓受压的症状体征,并运用合理的检查排查椎管内病变,早期诊断和完全切除肿瘤不仅可以防止出血复发,还可以有效避免椎管内占位性病变的压迫所带来的脊髓及神经根的不可逆损伤,有利于改善患者的预后。

关键词：脊髓神经鞘瘤蛛网膜下腔出血病因影像学检查机制

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数字病理切片库平台建设及其在临床病理住院医师规范培训中的应用

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创新创业理论研究与实践 2024年第8期7卷 179-182页

作者：罗柏花陈慧李青玲杨可达周海燕中南大学湘雅医院病理科湖南长沙410008 中南大学基础医学院病理学系湖南长沙410013

临床病理住培是重要的毕业后教育阶段,旨在培养合格的病理医师。目前,临床病理住培授课课时少、内容多,传统病理教学方法存在诸多局限和弊端,因此,改革势在必行。随着网络信息技术的发展,信息化、数字化教学手段逐渐应用于教学实践中,... 详细信息

临床病理住培是重要的毕业后教育阶段,旨在培养合格的病理医师。目前,临床病理住培授课课时少、内容多,传统病理教学方法存在诸多局限和弊端,因此,改革势在必行。随着网络信息技术的发展,信息化、数字化教学手段逐渐应用于教学实践中,相关研究亦成为教育界关注的热点。数字化病理切片库的建立将给病理教学带来革新,建立规范的数字病理切片平台充实临床病理住培专业学习,是实践教学和住院医师培养的重要内容,该文就数字病理切片库平台建设及其在临床病理住培中的应用进行阐述,以期为临床病理住培教学提供参考。

关键词：临床病理科数字病理切片库互联网住院医师规范化培训精准医疗病理诊断

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显微同步镜像在临床病理科住培教学阅片中的应用

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中国毕业后医学教育 2024年第9期8卷 674-676页

作者：李青玲杨可达肖德胜周建华周海燕中南大学湘雅医院病理科湖南长沙410008 中南大学基础医学院病理学系湖南长沙410013

该文探讨显微同步镜像技术在临床病理科住院医师规范化培训中的应用。该技术通过连接显微镜镜头,有关人员使用移动终端微信或者APP便能查看实时超高清图片,可线上讨论,并可将该阅片过程上传至教学平台。该技术能够突破时间和空间限制,... 详细信息

该文探讨显微同步镜像技术在临床病理科住院医师规范化培训中的应用。该技术通过连接显微镜镜头,有关人员使用移动终端微信或者APP便能查看实时超高清图片,可线上讨论,并可将该阅片过程上传至教学平台。该技术能够突破时间和空间限制,促进师生交流互动,方便回顾和复习,有助于提升教学阅片的效果,加快临床病理科人才培养。

关键词：临床病理科教学阅片显微同步镜像住院医师规范化培训

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Membrane vesicles derived from Streptococcus suis serotype 2 induce cell pyroptosis in endothelial cells via the NLRP3/Caspase-1/GSDMD pathway

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Journal of Integrative Agriculture 2024年第4期23卷 1338-1353页

作者： keda Shi Yan Li Minsheng Xu Kunli Zhang Hongchao Gou Chunling Li Shaolun Zhai Institute of Animal Health Guangdong Academy of Agricultural Sciences/Key Laboratory of Livestock Disease Prevention ofGuangdong Province/Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of GuangdongProvinceMinistry of Agriculture and Rural AffairsGuangzhou 510640China Maoming Branch Guangdong Laboratory for Lingnan Modern Agricultural Science and TechnologyMaoming 525000China College of Animal Science&Technology Zhongkai University of Agriculture and EngineeringGuangzhou 510225China

Streptococcus suis serotype 2(*** 2)is a zoonotic pathogen that clinically causes severe swine and human infections(such as meningitis,endocarditis,and septicemia).In order to cause widespread diseases in different organs,*** 2 must colonize the host,break the blood barrier,and cause exaggerated *** the last few years,most studies have focused on a single virulence factor and its influences on the *** vesicles(MVs)can be actively secreted into the extracellular environment contributing to bacteria-host ***-negative bacteria-derived outer membrane vesicles(OMVs)were recently shown to activate host Caspase-11-mediated non-canonical inflammasome pathway via deliverance of OMV-bound lipopolysaccharide(LPS),causing host cell ***,little is known about the effect of the MVs from *** 2(Gram-positive bacteria without LPS)on cell ***,we investigated the molecular mechanism by which *** 2 MVs participate in endothelial cell *** this study,we used proteomics,electron scanning microscopy,fluorescence microscope,Western blotting,and bioassays,to investigate the MVs secreted by *** ***,we demonstrated that *** 2 secreted MVs with an average diameter of 72.04 nm,and 200 proteins in MVs were ***,we showed that MVs were transported to cells via mainly dynamin-dependent *** *** 2 MVs activated NLRP3/Caspase-1/GSDMD canonical inflammasome signaling pathway,resulting in cell pyroptosis,but it did not activate the Caspase-4/-5 *** importantly,endothelial cells produce large amounts of reactive oxygen species(ROS)and lost their mitochondrial membrane potential under induction by *** 2 *** results in this study suggest for the first time that MVs from *** 2 were internalized by endothelial cells via mainly dynamin-dependent endocytosis and might promote NLRP3/Caspase-1/GSDMD pathway by mitochondrial damage,which produced mtDNA and ROS under induction,

关键词： Streptococcus suis serotype 2 membrane vesicles endocytosis pyroptosis NLRP3 inflammasomes mitochondrial damage endothelial cell

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Experimental study on the variation of optical remote sensing imaging characteristics of internal solitary waves with wind speed

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Journal of Oceanology and Limnology 2024年第2期42卷 408-420页

作者： Zhe CHANG Lina SUN Tengfei LIU Meng ZHANG keda LIANG Junmin MENG Jing WANG School of Physics and Optoelectronic Engineering Ocean University of ChinaQingdao 266100China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Technology Innovation Center for Ocean Telemetry Ministry of Natural ResourcesQingdao 266061China

Optical remote sensing has been widely used to study internal solitary waves(ISWs).Wind speed has an important effect on ISW imaging of optical remote *** light and dark bands of ISWs cannot be observed by optical remote sensing when the wind is too *** relationship between the characteristics of ISWs bands in optical remote sensing images and the wind speed is still *** influence of wind speeds on the characteristics of the ISWs bands is investigated based on the physical simulation experiments with the wind speeds of 1.6,3.1,3.5,3.8,and 3.9 m/*** experimental results show that when the wind speed is 3.9 m/s,the ISWs bands cannot be observed in optical remote sensing images with the stratification of h_(1)∶h_(2)=7∶58,ρ_(1)∶ρ_(2)=1∶*** the wind speeds are 3.1,3.5,and 3.8 m/s,which is lower than 3.9 m/s,the ISWs bands can be obtained in the simulated optical remote sensing *** location of the band’s dark and light extremum and the band’s peak-to-peak spacing are almost not affected by wind ***-significant wind speeds can cause a greater gray difference of the light-dark *** provided a scientific basis for further understanding of ISW optical remote sensing imaging.

关键词： internal solitary wave(ISW) optical remote sensing wind speed characteristics of ISWs bands

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Experimental Study on the Variation of Optical Imaging Characteristics with Zenith Angle due to Internal Solitary Waves in Sunglint

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Journal of Ocean University of China 2024年第4期23卷 943-952页

作者： LIU Tengfei SUN Lina CHANG Zhe ZHANG Meng LIANG keda MENG Junmin WANG Jing School of Physics and Optoelectronic Engineering Ocean University of ChinaQingdao 266100China First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Technology Innovation Center for Ocean Telemetry Ministry of Natural ResourcesQingdao 266061China

Internal solitary waves(ISWs)change the roughness of the sea surface,thus producing dark and bright bands in optical ***,reasons for changes in imaging characteristics with the solar zenith angle remain *** this paper,the optical imaging pattern of ISWs in sunglint under different zenith angles of the light source is investigated by collecting optical images of ISWs through physical *** experiment involves setting 10 zenith angles of the light source,which are divided into area a the optical images of ISWs in the three areas show dark-bright mode,single bright band,and bright-dark mode,which are consistent with those observed by optical remote *** addition,this study analyzed the percentage of the dark and bright areas of the bands and the change in the relative gray difference and found changes in both areas under different zenith angles of the light *** MODIS and ASAR images display a similar brightness-darkness distance of the same ***,the relationship between the brightness-darkness distance and the characteristic half-width of ISWs is determined in accordance with the eKdV theory and the imaging mechanism of ISWs of the SAR ***,the relationship between them in the experiment is almost consistent with the theoretical result.

关键词： internal solitary waves optical imaging characteristic laboratory simulation zenith angle sunglint

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肺局灶性磨玻璃结节CT特征在不同时期肺腺癌诊断中的价值

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中国医师杂志 2021年第6期23卷 898-902页

作者：李恺杨可达中南大学湘雅医院放射科长沙410008

目的探讨CT在肺局灶性磨玻璃结节(GGN)不同时期肺腺癌中的诊断价值。方法回顾性分析中南大学湘雅医院从2017年—2020年经手术病理证实的153例肺部局灶性磨玻璃样结节肺腺癌,通过统计学处理,分析病变的部位、大小、形态、边界、密度、血... 详细信息

目的探讨CT在肺局灶性磨玻璃结节(GGN)不同时期肺腺癌中的诊断价值。方法回顾性分析中南大学湘雅医院从2017年—2020年经手术病理证实的153例肺部局灶性磨玻璃样结节肺腺癌,通过统计学处理,分析病变的部位、大小、形态、边界、密度、血管及支气管等变化,判断CT特征与不同时期肺腺癌之间的相关性。结果153例局灶性磨玻璃结节表现为纯磨玻璃样结节(pGGN)21例,混合磨玻璃样结节(mGGN)132例。不同时期的肺腺癌中浸润前病变32例,其中非典型腺瘤样增生(AAH)13例,原位癌(AIS)19例;浸润性病变121例,其中微浸润腺癌(MIA)35例,浸润性腺癌(IA)86例;四种不同时期的肺磨玻璃结节腺癌患者的病变CT影像特征在边缘分叶、粗短毛刺,支气管正常穿行、闭塞,血管增粗、纠集方面差异有统计学意义(P0.05)。153例肺磨玻璃样结节患者中,浸润前病变和浸润性病变的最大层面长径及CT值差异有统计学意义(P13.04 mm、平均CT值>-447.48 Hu,高度提示浸润性肺腺癌。

关键词：腺癌肺结节磨玻璃结节体层摄影术

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