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Chinese Journal of Biomedical Engineering(English Edition) 2024年第1期33卷 27-32,39页

作者： yan xiao-shuai LUO Chao yanG Fang The Fifth Hospital of Xianmen Xiamen Fujian 361101China

Objective:To construct methotrexate(MTX)-chitosan(CS)-chuanxiongmuizine(TMP)nano-delivery system MTX-CS-TMP-NPs,and to investigate its effect on the telomerase activity of cervical cancer Hela ***:MTX-CS and MTX-CS-TMP-NPs were prepared by amide reaction and ionic gel method,and the encapsulation rate and drug loading rate were *** method and TRAP method were used to detect Hela cells and telomerase activity,and to compare the difference of telomerase activity of MTX,MTX-CS,and MTX-CS-TMP-NPs on cervical cancer Hela ***:In this study,the total amount of TMP was 150μg,of which the amount of free TMP was(26.46±1.72)μg,the encapsulation rate of TMP was(82.36±0.01)%,and the drug loading was(17.62±0.23)*** activity of Hela cells increased with the extension of time,and the OD value of Hela cell activity(1.24±0.05)was lower than that of the other three groups at 72 h of treatment,and the difference was statistically significant(P<0.05).The telomerase activity of He La cells in the MTX-CS-TMP-NPs solution treatment group was(0.23±0.12)%lower than that of the other three groups,with statistically significant difference(P<0.05).Conclusion:MTX-CS-TMP-NPs may effectively reduce the activity and telomerase activity of cervical cancer Hela cells,showing its potential anti-cervical cancer effect.

关键词： cervical cancer(CC) Docetaxel MTX telomerase nano-drug delivery system cell cycle

Research on blade tip clearance cavitation and turbulent kinetic energy characteristics of axial flow pump based on the partially-averaged Navier-Stokes model

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Journal of Hydrodynamics 2024年第1期36卷 184-201页

作者： xiao-qi Jia shuai-kang Zhang Zu-chao Zhu Key Laboratory of Fluid Transmission Technology of Zhejiang Province Zhejiang Sci-Tech UniversityHangzhou310018China

To reveal the cavitation forms of tip leakage vortex(TLV)of the axial flow pump and the flow mechanism of the flow field,this research adopts the partially-averaged Navier-Stokes(PANS)model to simulate the cavitation values of an axial flow pump,followed by experimental *** experimental result shows that compared with the shear stress transport(SST)k-ωmodel,the PANS model significantly reduces the eddy viscosity of the flow field to make the vortex structure clearer and allow the turbulence scale to be more robustly *** cavitation area within the axial flow pump mainly comprises of TLV cavitation,clearance cavitation and tip leakage flows combined effect of triangular cloud cavitation *** formation and development of cavitation are accompanied by the formation and evolution of vortex,and variations in vortex structure also generate and promote the development of *** addition,an in-depth analysis of the relationship between the turbulent kinetic energy(TKE)transport equation and cavitation patterns was also conducted,finding that the regions with relatively high TKE are mainly distributed around gas/liquid boundaries with serious cavitation and evident gas-liquid *** phenomenon is mainly attributed to the combined effect of the pressure action term,stress diffusion term and TKE production term.

关键词： Cavitation axial flow pump tip leakage vortex(TLV) partially-averaged Navier-Stokes(PANS)model turbulent kinetic energy(TKE)

Evaluating the use of three-dimensional reconstruction visualization technology for precise laparoscopic resection in gastroesophageal junction cancer

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1311-1319页

作者： Dan Guo xiao-yan Zhu shuai Han Yu-Shu Liu Da-Peng Cui Department of Hepatobiliary Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Department of Anesthesiology The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Laparoscopic gastrectomy for esophagogastric junction(EGJ)carcinoma enables the removal of the carcinoma at the junction between the stomach and esophagus while preserving the gastric function,thereby providing patients with better treatment outcomes and quality of ***,this surgical technique also presents some challenges and ***,three-dimensional reconstruction visualization technology(3D RVT)has been introduced into the procedure,providing doctors with more comprehensive and intuitive anatomical information that helps with surgical planning,navigation,and outcome *** To discuss the application and advantages of 3D RVT in precise laparoscopic resection of EGJ *** Data were obtained from the electronic or paper-based medical records at The First Affiliated Hospital of Hebei North University from January 2020 to June 2022.A total of 120 patients diagnosed with EGJ carcinoma were included in the *** these,68 underwent laparoscopic resection after computed tomography(CT)-enhanced scanning and were categorized into the 2D group,whereas 52 underwent laparoscopic resection after CT-enhanced scanning and 3D RVT and were categorized into the 3D *** study had two outcome measures:the deviation between tumor-related factors(such as maximum tumor diameter and infiltration length)in 3D RVT and clinical reality,and surgical outcome indicators(such as operative time,intraoperative blood loss,number of lymph node dissections,R0 resection rate,postoperative hospital stay,postoperative gas discharge time,drainage tube removal time,and related complications)between the 2D and 3D *** Among patients included in the 3D group,27 had a maximum tumor diameter of less than 3 cm,whereas 25 had a diameter of 3 cm or *** actual surgical observations,24 had a diameter of less than 3 cm,whereas 28 had a diameter of 3 cm or *** findings were consistent between the two methods(χ^(2)=0.346,P=0.556),w

关键词： Gastroesophageal junction cancer Endoscopy Tumor resection Three-dimensional reconstruction visualization Two-dimensional imaging computed tomography

Effects of microplastic polystyrene,simulated acid rain and arbuscular mycorrhizal fungi on Trifolium repens growth and soil microbial community composition

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Pedosphere 2024年第2期34卷 424-437页

作者： Wanlin LI yan xiao College of Agro-grassland Science Nanjing Agricultural UniversityNanjing 210095China

Microplastic pollution is a global and ubiquitous environmental problem in the oceans as well as in the terrestrial *** examined the fate of microplastic polystyrene(MPS)beads in experimental soil in the presence and absence of symbiotic arbuscular mycorrhizal fungi(AMF)and simulated acid rain(SAR)to determine whether the combinations of these three factors altered the growth of white clover Trifolium *** found that MPS,SAR,or AMF added singly to soil did not alter *** growth or *** contrast,MPS and AMF together significantly reduced shoot biomass,while SAR and MPS together significantly reduced soil available phosphorus independent of AMF *** polystyrene,AMF,and SAR together significantly reduced soil NO_(3)^(-)-*** mycorrhizal fungi added singly also enriched the beneficial soil bacteria(genus Solirubrobacter),while MPS combined with AMF significantly enriched the potential plant pathogenic fungus *** mycorrhizal fungi inoculation with MPS increased the abundance of soil hydrocarbon degraders independent of the presence of *** addition,the abundance of soil nitrate reducers was increased by MPS,especially in the presence of AMF and ***,SAR alone increased the abundance of soil pathogens within the fungal community including antibiotic *** findings indicate that the coexistence of MPS,SAR,and AMF may exacerbate the adverse effects of MPS on soil and plant health.

关键词： acid deposition arbuscular mycorrhizal fungi symbiosis hydrocarbon degradation microbial alpha diversity microplastic pollution pathogen

Urgent one-stage endoscopic treatment for choledocholithiasis related moderate to severe acute cholangitis: A propensity scorematched analysis

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World Journal of Gastroenterology 2024年第15期30卷 2118-2127页

作者： yang Zhou Yin-Qiu Zhang shuai-Jing Huang yan Liang xiao Liang Masoom Wali Ya-Dong Feng Department of Gastroenterology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Department of Gastroenterology BenQ Medical CenterThe Affiliated BenQ Hospital of Nanjing Medical UniversityNanjing 210019Jiangsu ProvinceChina

BACKGROUND During emergency endoscopic retrograde cholangiopancreatography(ERCP),the safety and feasibility of performing one-stage endoscopic treatment for patients with acute cholangitis(AC)due to choledocholithiasis are *** To investigate the safety and feasibility of one-stage endoscopic treatment for moderate to severe *** We enrolled all patients diagnosed with moderate to severe cholangitis due to common bile duct stones from January 2019 to July *** outcomes were compared in this study between patients who underwent ERCP within 24 h and those who underwent ERCP 24 h later,employing a propensity score(PS)*** primary outcomes were intensive care unit(ICU)admission rates,ICU length of stay,and duration of antibiotic *** In total,we included 254 patients and categorized them into two groups based on the time elapsed between admission and intervention:The urgent group(≤24 h,n=102)and the elective group(>24 h,n=152).Ninety-three pairs of patients with similar characteristics were selected by PS *** urgent ERCP group had more ICU admissions(34.4%vs 21.5%,P=0.05),shorter ICU stays(3 d vs 9 d,P<0.001),fewer antibiotic use(6 d vs 9 d,P<0.001),and shorter hospital stays(9 d vs 18.5 d,P<0.001).There were no significant differences observed in adverse events,in-hospital mortality,recurrent cholangitis occurrence,30-d readmission rate or 30-d *** Urgent one-stage ERCP provides the advantages of a shorter ICU stay,a shorter duration of antibiotic use,and a shorter hospital stay.

关键词： Acute cholangitis Endoscopic retrograde cholangiopancreatography One-stage treatment Optimal time

High-Temperature Stability of Mg-1Al-12Y Alloy Containing LPSO Phase and Mechanism of Its Portevin-Le Chatelier(PLC)Effect

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 982-998页

作者： Qian-Long Ren shuai Yuan Shi-Yu Luan Jin-Hui Wang xiao-Wei Li xiao-Yu Liu Qinghai Provincial Key Laboratory of New Light Alloys Qinghai Provincial Engineering Research Center of High Performance Light Metal Alloys and FormingQinghai UniversityXining810016China School of Materials Science and Engineering Shenyang University of TechnologyShenyang110870China

In this study,the high-temperature stability and the generation mechanism of the Portevin-Le Chatelier(PLC)effect in solid-solution Mg-1Al-12Y alloy with different heat treatment processes were investigated by adjusting the content of long-period stacking ordered(LPSO)*** was found that the content of LPSO phases in the alloys differed the most after heat treatment at 530℃for 16 h and 24 h,with values of 13.56%and 3.93%***,high-temperature tensile experiments were conducted on these two alloys at temperatures of 150℃,200℃,250℃,and 300℃.The results showed that both alloys exhibited the PLC effect at temperatures ranging from 150 to 250℃.However,at a temperature 300℃,only the alloy with a greater concentration of LPSO phases exhibited the PLC effect,whereas the alloy with a lower proportion of LPSO phases did not exhibit this ***,both alloys exhibited remarkable high-temperature stability,with the alloy containing a greater percentage of LPSO phases also demonstrating superior *** underlying mechanism for this phenomenon lies in the exceptional high-temperature stability exhibited by the second phase within the ***,the LPSO phase effectively obstructs the movement of dislocations,and it also undergoing kinking to facilitate plastic deformation of the *** results indicate that the PLC effect can be suppressed by reducing dislocation pile-up at grain boundaries,which leads to a decrease in alloy plasticity but an increase in *** presence of the PLC effect in the WA121 alloy is attributed to the abundant dispersed second phase within the alloy,which initially hinders the movement of dislocations,leading to an increase in stress,and subsequently releases the dislocations,allowing them to continue their movement and thereby reducing in stress.

关键词： Magnesium alloy Long-period stacking ordered(LPSO)phase Portevin-Le Chatelier effect High temperature

High-throughput screening of single-atom catalysts confined in monolayer black phosphorus for efficient nitrogen reduction reaction

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Nano Research 2024年第4期17卷 2360-2367页

作者： xiao-yan Li Manyi Duan Pengfei Ou Department of Electrical and Computer Engineering University of TorontoTorontoOntario M5S 1A4Canada School of Physics and Electronic Engineering Sichuan Normal UniversityChengdu 610101China Department of Chemistry Northwestern UniversityEvanstonIL 60208USA

The discovery of metal-nitrogen centers as the active sites for electrolysis has aroused significant interest in utilizing single-atom catalysts for nitrogen reduction reaction(NRR).Properly designed nanostructured catalysts that strongly interact with nitrogen molecules(N_(2))can promote adsorption and activation,thereby resulting in efficient catalysts with high stability,activity,and *** this study,using density functional theory calculations,we selected monolayer black phosphorus(BP)as the substrate and screened a series of single-atom transition metals confined in tri-coordinated and tetra-coordinated active centers(without and with N dopants)to electro-catalyze *** a result,we have identified two promising candidates(Hf_(1)-N_(1)P_(2)-1 and Tc_(1)-N_(4)),which exhibit not only low overpotentials of 0.56 and 0.49 V but also high thermodynamic and electrochemical stability,as well as good selectivity towards NRR over the competing hydrogen evolution *** also demonstrate the ability of Hf_(1)-N_(1)P_(2)-1 and Tc_(1)-N_(4) to activate and hydrogenate N_(2) by donating electrons and regulating charge *** study not only predicts new BP-based promising catalysts but also provides guidance for the rational design of high-performance NRR electrocatalysts under ambient conditions.

关键词： N_(2) electroreduction reaction single-atom catalysts black phosphorus density functional theory high-throughput calculations

UPLC-Q-TOF/MS-Based Serum Metabolomics Reveals Potential Anti-tumor Mechanism of Banxia Xiexin Decoction in Colorectal Cancer Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 623-632页

作者： YUE Yin-zi LI Ming-xuan WANG xiao-hui QIN Yuan-yuan WANG Ya-hui TAN Jin-hua SU Lian-lin yan shuai Department of General Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China School of Pharmacy Nanjing University of Chinese MedicineNanjing210023China Department of General Surgery Bayinguoleng Mongolian Autonomous Prefecture People’s HospitalXinjiang Uygur Autonomous RegionKorla841000China Department of Pharmacy Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China Department of Anorectal Surgery Suzhou TCM Hospital Affiliated to Nanjing University of Chinese MedicineSuzhou215009China

Objective To clarify the potential mechanism of Banxia Xiexin Decoction(BXD)on colorectal cancer(CRC)from the perspective of *** Forty male C57BL/6 mice were randomly divided into normal control(NC),azoxymethane/dextran sulfate sodium(AOM/DSS)model,low-dose BXD(L-BXD),high-dose BXD(H-BXD)and mesalamine(MS)groups according to a random number table,8 mice in each *** cancer model was induced by AOM/*** was administered daily at doses of 3.915(L-BXD)and 15.66 g/kg(H-BXD)by gavage for consecutive 21 days,and 100 mg/kg MS was used as positive *** the entire modeling cycle,colon length of mice was measured and quantity of colorectal tumors were *** spleen and thymus index were determined by calculating the spleen/thymus weight to body *** cytokine and changes of serum metabolites were analyzed by enzyme-linked immunosorbent assay kits and ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry(UPLC-Q/TOF-MS),*** Notably,BXD supplementation protected against weight loss,mitigated tumor formation,and diminished histologic damage in mice treated with AOM/DSS(P<0.05 or P<0.01).Moreover,BXD suppressed expression of serum inflammatory enzymes,and improved the spleen and thymus index(P<0.05).Compared with the normal group,102 kinds of differential metabolites were screened in the AOM/DSS group,including 48 potential biomarkers,involving 18 main metabolic *** 18 potential biomarkers related to CRC were identified,and the anti-CRC mechanism of BXD was closely related to D-glutamine and D-glutamate metabolism,phenylalanine,tyrosine and tryptophan biosynthesis,arginine biosynthesis,nitrogen metabolism and so *** BXD exerts partial protective effects on AOM/DSS-induced CRC by reducing inflammation,protecting organism immunity ability,and regulating amino acid metabolism.

关键词： colorectal cancer metabolomics ultra performance liquid chromatography-quadrupole/time-of-flight mass spectrometry azoxymethane dextran sulfate sodium Banxia Xiexin Decoction Chinese medicine

Ammonia storage and slip under steady and transient state in close-coupled SCR

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Journal of Environmental Sciences 2024年第4期138卷 470-481页

作者： Shiyu Liu Zhaohuan Zhang Zexian Guo Boyuan Wang Buyu Wang xiao Ma Shijin shuai State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Institute for Aero Engine Tsinghua UniversityBeijing 100084China

The close-coupled selective catalytic reduction(cc-SCR)catalyst is an effective technology to reduce tailpipe NOx emission during cold *** paper investigated the optimal ammonia storage under steady and transient state in the *** study showed that a trade-off between NOx conversion efficiency and ammonia slip is observed on the pareto solutions under steady state,and the optimal ammonia storage is calculated with ammonia slip less than 10μL/L based on the ChinaⅥemission *** rapid temperature increase will lead to severe ammonia slip in the transient test cycle.A simplified 0-D calculation method on ammonia slip under transient state is proposed based on kinetic model of ammonia adsorption and *** addition,the effect of ammonia storage,catalyst temperature and temperature increasing rate on ammonia slip are *** optimal ammonia storage is calculated with maximum ammonia slip less than 100μL/L according to the oxidation efficiency of ammonia slip catalyst(ASC)downstream *** was found that the optimal ammonia storage under transient state is much lower than that under steady state in cc-SCR at lower temperature,and a phase diagram is established to analyze the influence of temperature and temperature increasing rate on optimal ammonia storage.

关键词： Close-coupled SCR Ammonia storage and slip Steady and transient state Generic algorithm

Correlation between the charge radii difference in mirror partner nuclei and thesymmetry energy slope

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Chinese Physics C 2024年第8期48卷 177-184页

作者： xiao-Rong Ma shuai Sun Rong An Li-Gang Cao School of Physics Ningxia UniversityYinchuan 750021China Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Key Laboratory of Beam Technology of Ministry of Education Institute of Radiation TechnologyBeijing Academy of Science and TechnologyBeijing 100875China

A correlation between the charge radii difference of mirror partner nucleiΔR_(ch) and the slope parameter L of symmetry energy has been built to ascertain the equation of state of isospin asymmetric nuclear *** this work,the influences of pairing correlations and isoscalar compression modulus on theΔRch are systematically investigated based on the Skyrme energy density functional *** calculated results suggest that the linear correlation betweenΔR_(ch) and L is decreased by the surface pairing *** slope parameter deduced from the difference of charge radii of mirror-pair nuclei ^(32)Ar-^(32)Si,^(36)Ca-^(36)S,^(38)Ca-^(38)Ar,and ^(54)Ni-^(54)Fe falls into the range of L=42.57−50.64 MeV,that is,the rather soft equation of state of asymmetric nuclear ***,the range of the slope parameter can also be influenced by the effective forces classified by various isoscalar incompressibility coefficients.

关键词： symmetry energy charge radius mirror-pair nuclei slope parameter