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The Journal of China Universities of Posts and Telecommunications 2024年第2期31卷 105-112页

作者： Feng Zhenfu Zhang yaying Yang Lele Xing Lidong School of Electronic Engineering Xi'an University of Posts and TelecommunicationsXi'an 710121China

For studying and optimizing the performance of general-purpose computing on graphics processing units(GPGPU)based on single instruction multiple threads(SIMT)processor about the neural network application,this work contributes a self-developed SIMT processor named Pomelo and correlated assembly *** parallel mechanism of SIMT computing mode and self-developed Pomelo processor is briefly introduced.A common convolutional neural network(CNN)is built to verify the compatibility and functionality of the Pomelo *** computing flow with task level and hardware level optimization is adopted on the Pomelo processor.A specific algorithm for organizing a Z-shaped memory structure is developed,which addresses reducing memory access in mass data computing *** the above-combined adaptation and optimization strategy,the experimental result demonstrates that reducing memory access in SIMT computing mode plays a crucial role in improving performance.A 6.52 times performance is achieved on the 4 processing elements case.

关键词： parallel computing single instruction multiple threads(SIMT) convolutional neural network(CNN) memory optimization

材料、能源、机械工程中高效的电流变技术——从机理到应用

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Engineering 2023年第5期24卷 151-171,I0004页

作者： Yudai Liang Dongyang Huang Xuefeng Zhou Ziqiu Wang Quan Shi yaying hong Huayan Pu Mengying Zhang Jinbo Wu Weijia Wen Materials Genome Institute Shanghai UniversityShanghai 200444China Zhejiang Laboratory Hangzhou 311100China Fok Ying Tung Research Institute The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511458China School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444China Department of Physics Shanghai UniversityShanghai 200444China Department of Physics The Hong Kong University of Science and TechnologyHong Kong 999077China The Advanced Material Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511458China

电流变(ER)技术是一种基于电流变效应的先进技术。电流变技术中最常见的材料是电流变液(ERF)。电流变液是一种软物质智能材料,其黏度可以通过施加电场来可逆地调节。电流变液的衍生物、一种新型的电响应软物质材料——电流变弹性体(ERE)... 详细信息

电流变(ER)技术是一种基于电流变效应的先进技术。电流变技术中最常见的材料是电流变液(ERF)。电流变液是一种软物质智能材料,其黏度可以通过施加电场来可逆地调节。电流变液的衍生物、一种新型的电响应软物质材料——电流变弹性体(ERE),由于其不沉降、易封装的优点也得到了越来越多的关注。电流变材料由于其可逆可调、快速响应、低能耗等特性在机械工程中有着广泛的应用。除了基础的电流变材料的合成和应用以外,电流变技术还应用在了能源材料制备、石油运输、储能等诸多领域。电流变技术在能源领域的应用为其在其他领域的潜在应用提供了一个很好的范例。本文结合最新的研究成果,从机理到应用,系统地综述了电流变技术在材料、能源和机械工程等领域的研究现状和未来发展前景。

关键词：电流变技术电流变弹性体电流变材料机械工程石油运输电流变液电流变效应智能材料

Towards a hybrid model-driven platform based on flux balance analysis and a machine learning pipeline for biosystem design

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Synthetic and Systems Biotechnology 2024年第1期9卷 33-42页

作者： Debiao Wu Feng Xu yaying Xu Mingzhi Huang Zhimin Li Ju Chu State Key Laboratory of Bioreactor Engineering East China University of Science and Technology130 Meilong RoadShanghai200237People’s Republic of China

Metabolic modeling and machine learning(ML)are crucial components of the evolving next-generation tools in systems and synthetic biology,aiming to unravel the intricate relationship between genotype,phenotype,and the ***,the comprehensive exploration of integrating these two frameworks,and fully harnessing the potential of fluxomic data,remains an unexplored *** this study,we present,rigorously evaluate,and compare ML-based techniques for data *** hybrid model revealed that the overexpression of six target genes and the knockout of seven target genes contribute to enhanced ethanol ***,we investigated the influence of succinate dehydrogenase(SDH)on ethanol biosynthesis in Saccharomyces cerevisiae through shake flask *** findings indicate a noticeable increase in ethanol yield,ranging from 6%to 10%,in SDH subunit gene knockout strains compared to the wild-type ***,in pursuit of a high-yielding strain for ethanol production,dual-gene deletion experiments were conducted targeting glycerol-3-phosphate dehydrogenase(GPD)and *** results unequivocally demonstrate significant enhancements in ethanol production for the engineered strains Δsdh4Δgpd1,Δsdh5Δgpd1,Δsdh6Δgpd1,Δsdh4Δgpd2,Δsdh5Δgpd2,and Δsdh6Δgpd2,with improvements of 21.6%,27.9%,and 22.7%,***,the results highlighted that integrating mechanistic flux features substantially improves the prediction of gene knockout strains not accounted for in metabolic *** addition,the finding in this study delivers valuable tools for comprehending and manipulating intricate phenotypes,thereby enhancing prediction accuracy and facilitating deeper insights into mechanistic aspects within the field of synthetic biology.

关键词： Metabolic modeling Machine learning Flux balance analysis Biosystems design Saccharomyces cerevisiae Succinate dehydrogenase

Soil amendment strategies determining microbial community composition and their assembly processes in a continuously cropped soil

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Soil Ecology Letters 2024年第3期6卷 85-95页

作者： hongkai Liao Chunli Zheng Juan Li Jian Long yaying Li Guizhou Provincial Key Laboratory of Mountain Environment Guizhou Normal UniversityGuiyang 550001China The Key Laboratory of Environmental Pollution Monitoring and Disease Control Ministry of EducationDepartment of ToxicologySchool of Public HealthGuizhou Medical UniversityGuiyang 550025China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Laboratory of Urban Environmental Processes and Pollution Control Ningbo(Beilun)Zhongke Haixi Industry Technology Innovation CenterNingbo 315800China

Reductive soil disinfestation(RSD)is an important tool for sustainable agricultural ***,the differences in soil bacterial communities and their community assembly processes among RSD and other treatment strategies(e.g.,biochar and chemical fumigation)are still subject to open *** this study,soils subjected to various treatments–un-treated control(CK),chemical soil fumigation with CaCN2(CF),1%biochar(1%B),3%biochar(3%B),and reductive soil disinfestation(RSD)are *** samples were collected,incubated,and then used for growth of tomato *** Sloan neutral community model indicates that stochastic processes dominate in bacterial community assembly for both biochar and CF *** contrast,this work shows that RSD treatment can have a strong impact on soil bacterial community *** relative abundance of Firmicutes increased during unplanted soil incubation,whereas Proteobacteria and Bacteroidetes dominated in the rhizosphere after planting of *** stochasticity ratio reveals that deterministic selection played an important role in the bacterial assembly under RSD *** found that RSD amendment yielded lower biomass than that for other treatments after 28 days of tomato *** results suggest that although RSD treatment has great potential to rebuild soil bacterial ecology by shaping bacterial communities and their assembly processes,it is important to monitor and manage soil conditions(e.g.,soil nutrients or physical properties)before planting to ensure plant productivity.

关键词： amendment strategy reductive soil disinfestation bacterial community assembly processes

An Efficient Multifunctional Soluble Catalyst for Li-O_(2) Batteries

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CCS Chemistry 2024年第7期6卷 1810-1820页

作者： Shuochao Xing Zhengcai Zhang yaying Dou Minghui Li Jing Wu Zhang Zhang Zhen Zhou Interdisciplinary Research Center for Sustainable Energy Science and Engineering(IRC4SE2) School of Chemical EngineeringZhengzhou UniversityZhengzhou 450001 Key Laboratory of Advanced Energy Materials Chemistry Ministry of EducationCollege of ChemistryNankai UniversityTianjin 300071

Aprotic lithium-oxygen(Li-O_(2))batteries have a high theoretical energy density,but they face challenges such as cathode blockage,high charge overpotential,and poor cycling *** are caused by sluggish reaction kinetics and severe parasitic *** the performance of Li-O_(2) batteries necessitates the development of efficient *** catalysts not only augment both the oxygen reduction reaction(ORR)and the oxygen evolution reaction(OER)but also inhibit undesirable parasitic *** this work,we demonstrated for the first time a multifunctional soluble catalyst of iridium(III)acetylacetonate(Ir(acac)_(3))that could speed up oxygen ***(acac)_(3) regulated the ORR pathway and the reactivity of superoxide radical species by forming a reversible intermediate complex(Ir(acac)_(3)-O_(2)^(−)).During charging,Ir(acac)_(3) acted as a redox mediator and aided in Li_(2)O_(2) decomposition by reacting with superoxide ***,as demonstrated by operando UV-visible spectroscopy,the lower charge potential significantly reduced the generation of highly reactive singlet oxygen(^(1)O_(2))*** a result,the Ir(acac)_(3)-mediated Li-O_(2) battery showed low overpotential,large capacity,and stable *** study offers a new approach to achieving efficient Li-O_(2) batteries and provides an opportunity to suppress parasitic reactions.

关键词： Li-O_(2)battery soluble catalyst superoxide species organometallics singlet oxygen

Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy

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Chinese Chemical Letters 2024年第6期35卷 427-432页

作者： Yihan Zhou Duo Gao yaying Wang Li Liang Qingyu Zhang Wenwen Han Jie Wang Chunliu Zhu Xinxin Zhang Yong Gan State Key Laboratory of Drug Research and Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug ControlBeijing 100050China School of Pharmacy Shanghai University of Traditional Chinese MedicineShanghai 201203China

Local delivery of nanoparticles holds promise for colorectal cancer(CRC)***,the presence of the mucus layer on the epithelium poses a significant challenge to drug delivery,thereby adversely affecting treatment *** is crucial to develop efficient drug delivery carriers that can effectively overcome mucus barriers to treat colorectal ***,we utilized poly(1,4-butadiene)-b-poly(ethylene oxide)polymers to prepare four distinct geometries of polymeric micelles,namely linear micelles(LMs),worm-like micelles(WLMs),large spherical micelles(LSMs),and small spherical micelles(SSMs)to investigate the influence of shape effects on overcoming colonic mucosal *** found that the carriers exhibited diverse shapes while maintaining comparable physicochemical *** these,WLMs had an aspect ratio similar to segmented filamentous bacteria,which exhibited superior mucus penetration ability,leading to prolonged drug release kinetics and faster entry into epithelial cells compared to ***,rectally administrated 10-hydroxycamptothecin-loaded WLMs traversed the colorectal mucus in orthotopic CRC nude mice model,penetrated and accumulated within tumor tissue,and effectively aggregated within cancer cells,thereby inducing significantly robust antitumor outcomes in *** findings underscore the significance of shape design in overcoming colonic mucosal absorption barriers,offering a novel approach for the development of drug delivery carriers tailored for effective tumor therapy.

关键词： Worm-like micelles Mucus penetration Shape dependent Transmucosal delivery Colorectal cancer

Flexible wearable sensors:An emerging platform for monitoring of bacterial infection in skin wounds

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Engineered Regeneration 2024年第2期5卷 186-198页

作者： Hao Meng Weicheng Zhong Kui Ma Jianlong Su Liqian Ma yaying Hao Yufeng Jiang Xi Liu Xiaobing Fu Cuiping Zhang Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical CollegeBeijing 100048PR China PLA Key Laboratory of Tissue Repair and Regenerative Medicine Beijing 100048PR China Beijing Key Research Laboratory of Skin Injury Repair and RegenerationBeijing 100048PR China Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048PR China College of Graduate Tianjin Medical UniversityTianjin300070PR China Department of Tissue Regeneration and Wound Repair PLA General HospitalBeijingPR China

Persistent inflammatory responses often occur when bacteria and other microorganisms frequently invade and colonize open wounds and eventually result in the formation of chronic ***,achieving real-time detection of invasive bacteria accurately and promptly is essential for efficient wound management and accelerat-ing the healing ***,flexible wearable sensors have garnered significant attention,especially those designed for monitoring real-time biophysical or biochemical signals in wound sites in a minimally invasive *** provide more precise and continuous monitoring data,making them as emerging tools for clinical *** this review,we first discuss the species and community distribution of different types of bacteria in chronic ***,we introduce currently developed techniques for detecting bacteria at wound ***-lowing that,we discuss the recent progress and unresolved issues of various flexible wearable sensors in detecting bacteria at wound *** believe that this review can provide meaningful guidance for the development of flexible wearable sensors for bacteria detection.

关键词： Flexible wearable sensors Chronic wounds Bacterial infections Real-time detection

Cardiovascular risk burden,dementia risk and brain structural imaging markers:a study from UK Biobank

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General Psychiatry 2024年第1期37卷 94-102页

作者： yaying Cao Gaohong Zhu Chengwu Feng Jing Chen Wei Gan Yuan Ma Yonghua Hu Klodian Dhana Trudy Voortman Jie Shen Ting Li Yan Zheng Changzheng Yuan Geng Zong Department of Food Nutrition and Health School of Medicine and HealthHarbin Institute of TechnologyHarbinHeilongjiangChina CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina Department of Nuclear Medicine First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina Neurology Department Zhongshan Hospital Affliated with Fudan UniversityShanghaiChina Medical Research Council Population Health Research Unit University of OxfordOxfordUK Department of Genetics Novo Nordisk Research Centre OxfordOxfordUK Harvard University T H Chan School of Public Health BostonMassachusettsUSA Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Internal Medicine Rush University Medical CenterChicagolinoisUSA Department of Epidemiology rasmus MCUniversity Medical Center RotterdamRotterdamThe Netherlands Division of Human Nutrition and Health Wageningen University&ResearchWageningenThe Netherlands School of Public Health the Second Afliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina First Afiliated Hospital of Kunming Medical University KunmingYunnanChina State Key Laboratory of Genetic Engineering School f ife SCciencesFudan UniversityShanghaiChina Ministry of Education Key Laboratory of Public Health Safety School of Public HealthFudan UniversityShanghaiChina The Key Laboratory of Inteligent Preventive Medicine of Zhejang Province HangzhouZhejiangChina Shanghai Jiao Tong University Affiliated Sixth People's Hospital ShanghaiChina

Background Cardiovascular risk burden is associated with dementia risk and neurodegeneration-related brain structure,while the role of genetics and incident cardiovascular disease(CVD)remains *** To examine the association of overall cardiovascular risk burden with the risk of major dementia subtypes and volumes of related brain regions in a large sample,and to explore the role of genetics and CVD *** A prospective study among 354 654 participants free of CVD and dementia(2006-2010,mean age 56.4 years)was conducted within the UK Biobank,with brain magnetic resonance imaging(MRl)measurement availablefor 15104participants since *** risk burden was evaluated by the Framingham General Cardiovascular Risk Score(FGCRS).Dementia diagnosis was ascertained from inpatient and death register *** Overamedian 12.0-yearfollow-up,3998 all-cause dementia cases were *** FGCRS was associated with increasedall-cause dementia risk after adjusting for demographic,major lifestyle,clinical factors and the polygenic risk score(PRS)of Alzheimer's *** the high versus low tertile of FGCRS,the odds ratios(ORs)and 95%confidence intervals(Cls)were 1.26(1.12 to 1.41)for all-cause dementia,1.67(1.33 to 2.09)for Alzheimer's disease and 1.53(1.07 to 2.16)for vascular dementia(all p_(treng)<0.05).Incident stroke and coronary heart disease accounted for 14%(95%Cl:9% to 21%)of the association between FGCRS and all-cause *** were not detected for FGCRS and PRS on the risk of any dementia *** observed an 83%(95%Cl:47%to 128%)higher all-cause dementia risk comparing the high-high versus low-low FGCRS-PRS *** brain volumes,higher FGCRS was associated with greater log-transformed white matter hyperintensities,smaller cortical volume and smaller grey matter *** Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes.T

关键词： Cardiovascular diagnosis burden

瑞马唑仑在围术期器官和系统保护作用中的研究进展

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临床麻醉学杂志 2024年第5期40卷 545-548页

作者：安文仙解雅英内蒙古医科大学第一临床医学院呼和浩特市010050 内蒙古医科大学附属医院麻醉科

瑞马唑仑是一种新型、超短效的苯二氮䓬类镇静麻醉药,作用于γ-氨基丁酸A受体(GABAAR)α亚单位上的苯二氮䓬类受体,具有镇静、催眠、抗焦虑、心肺影响轻微的效应,在无痛内镜和全身麻醉中的临床应用越来越广泛。器官保护是围术期关注的焦点... 详细信息

瑞马唑仑是一种新型、超短效的苯二氮䓬类镇静麻醉药,作用于γ-氨基丁酸A受体(GABAAR)α亚单位上的苯二氮䓬类受体,具有镇静、催眠、抗焦虑、心肺影响轻微的效应,在无痛内镜和全身麻醉中的临床应用越来越广泛。器官保护是围术期关注的焦点,对于促进术后恢复、改善预后有重要作用。瑞马唑仑对机体神经系统及心、肺、肝、胃肠道等重要器官具有保护作用,其机制可能与抗炎、抗凋亡、减轻应激反应等有关。本文就瑞马唑仑的器官和系统保护作用及其机制作一综述,为临床应用提供参考。

关键词：瑞马唑仑器官保护围术期